Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment

We analyzed structural magnetic resonance imaging data from 58 cognitively normal and 101 mild cognitive impairment subjects. We used a general linear regression model to study the association between cognitive performance with hippocampal atrophy and ventricular enlargement using the radial distance method. Bilateral hippocampal atrophy was associated with baseline and longitudinal memory performance. Left hippocampal atrophy predicted longitudinal decline in visuospatial function. The multidomain ventricular analysis did not reveal any significant predictors

Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7 T MRI

Hippocampal atrophy, amyloid plaques, and neurofibrillary tangles are established pathologic markers of Alzheimer's disease. We analyzed the temporal lobes of 9 Alzheimer's dementia (AD) and 7 cognitively normal (NC) subjects. Brains were scanned post-mortem at 7 Tesla. We extracted hippocampal volumes and radial distances using automated segmentation techniques. Hippocampal slices were stained for amyloid beta (Aβ), tau, and cresyl violet to evaluate neuronal counts. The hippocampal subfields, CA1, CA2, CA3, CA4, and subiculum were manually traced so that the neuronal counts, Aβ, and tau burden could be obtained for each region. We used linear regression to detect associations between hippocampal atrophy in 3D, clinical diagnosis and total as well as subfield pathology burden measures. As expected, we found significant correlations between hippocampal radial distance and mean neuronal count, as well as diagnosis. There were subfield specific associations between hippocampal radial distance and tau in CA2, and cresyl violet neuronal counts in CA1 and subiculum. These results provide further validation for the European Alzheimer's Disease Consortium Alzheimer's Disease Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP)

Control of NTMs and integrated multi-actuator plasma control on TCV

The control of 2/1 neoclassical tearing modes (NTMs) with electron cyclotron (EC) waves has been studied both experimentally and numerically on TCV. Dynamic evolutions of NTMs along with time-varying deposition locations of the control beam have been studied in detail. The prevention of NTMs by means of preemptive EC (i.e. the control beam is switched on before the mode onset) has also been explored. A small sinusoidal sweeping with full amplitude of 0.07 (normalized to the minor radius) has been added to the control beam in two of the experiments to facilitate the comparison between NTM stabilization and prevention. It is shown that the prevention of NTMs is more efficient than NTM stabilization in terms of the minimum EC power required. Interpretative simulations with the Modified Rutherford Equation (MRE) have been performed to better quantify various effects, with coefficients well defined by dedicated experiments. Specifically, in order to obtain more insight on the dominant dependencies, a simple ad-hoc analytical model has been proposed to evaluate the time-varying classical stability index Δ' in the test discharges, based on the Δ'-triggered nature of these 2/1 NTMs. This allows simulating well the entire island width evolution with the MRE, starting from zero width and including both NTM stabilization and prevention cases for the first time. The exploration of NTM physics and control has facilitated the development of an NTM controller that is independent of the particular features of TCV and has been included in a generic plasma control system (PCS) framework. Integrated control of 2/1 NTMs, plasma β (the ratio of plasma pressure to magnetic pressure) and model-estimated safety factor q profiles has been demonstrated on TCV

Real-time model-based plasma state estimation, monitoring and integrated control in TCV, ASDEX-Upgrade and ITER

To maintain a high-performance, long-duration tokamak plasma scenario, it is necessary to maintain desired profiles while respecting operational limits. This requires real-time estimation of the profiles, monitoring of their evolution with respect to predictions and known limits, and their active control to remain within the desired envelope. Model-based techniques are particularly suitable to tackle such problems due to the nonlinear nature of the processes and the tight coupling among the various physical variables. A suite of physics-based, control-oriented models for the core plasma proles in a tokamak is presented, with models formulated in such a way that powerful methods from the systems and control engineering community can be leveraged to design ancient algorithms. We report on new development and applications of these models for real-time reconstruction, monitoring and integrated control of plasma proles on TCV, ASDEX-Upgrade and simulations for ITER

The ladies trial: laparoscopic peritoneal lavage or resection for purulent peritonitisA and Hartmann's procedure or resection with primary anastomosis for purulent or faecal peritonitisB in perforated diverticulitis (NTR2037)

Background: Recently, excellent results are reported on laparoscopic lavage in patients with purulent perforated diverticulitis as an alternative for sigmoidectomy and ostomy. The objective of this study is to determine whether LaparOscopic LAvage and drainage is a safe and effective treatment for patients with purulent peritonitis (LOLA-arm) and to determine the optimal resectional strategy in patients with a purulent or faecal peritonitis (DIVA-arm: perforated DIVerticulitis: sigmoidresection with or without Anastomosis). Methods/Design: In this multicentre randomised trial all patients with perforated diverticulitis are included. Upon laparoscopy, patients with purulent peritonitis are treated with laparoscopic lavage and drainage, Hartmann's procedure or sigmoidectomy with primary anastomosis in a ratio of 2:1:1 (LOLA-arm). Patients with faecal peritonitis will be randomised 1:1 between Hartmann's procedure and resection with primary anastomosis (DIVA-arm). The primary combined endpoint of the LOLA-arm is major morbidity and mortality. A sample size of 132:66:66 patients will be able to detect a difference in the primary endpoint from 25% in resectional groups compared to 10% in the laparoscopic lavage group (two sided alpha = 5%, power = 90%). Endpoint of the DIVA-arm is stoma free survival one year after initial surgery. In this arm 212 patients are needed to significantly demonstrate a difference of 30% (log rank test two sided alpha = 5% and powe