Evolución y complicaciones de los niños tratados con trasplante de progenitores hematopoyéticos y su relación con el estado nutricional y soporte empleado

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Pediatría. Fecha de lectura: 01/07/201

Examining associations between obesity and mental health disorders from childhood to adolescence: A case-control prospective study

Childhood obesity and mental disorders often co-exist. To date, most of the studies are cross-sectional, involve the assessment of a specific disorder, and rely on self-report questionnaires. This study aimed to provide a comprehensive psychological assessment to examine the concurrent and prospective association between childhood obesity and mental health problems. We compared 34 children with obesity with 37 children with normal weight at baseline, and at a five-year follow-up, to examine the development of mental health disorders from childhood (8–12 years) to adolescence (13–18 years). Both assessments included a clinical interview and self-reported measures of psychosocial and family markers. Findings showed that the obesity group had a higher prevalence of mental disorders, and psychological comorbidity increased in five years. Prospectively, childhood obesity was associated with a psychological diagnosis in adolescence. Moreover, the obesity group displayed higher severity of symptoms at both times. Finally, body esteem contributed to predicting mental health disorders in adolescence regardless of weight status, while eating symptomatology was a specific marker for the obesity group. Therefore, in the management of childhood obesity is suggested to address also psychosocial variables such as weight-related teasing and body esteem, to prevent the onset or development of mental health problem

A model for the biochemical degradation of inosine monophosphate in hake (Merluccius merluccius)

7 páginas, 3 tablas, 3 figuras, 1 apéndiceATP-derived products are typically used as early indicators of fish quality loss during storage. In this work, we explore different biochemical routes that are potentially relevant in contributing to nucleotide degradation in hake (Merluccius merluccius). A major motivation of this study is to get more insight on the biochemical degradation mechanisms of nucleotide catabolites in hake muscle at fish storage and transport conditions. This requires the identification of its relevant pathways. To that purpose, different degradation routes proposed in the literature are considered and a mathematical model for the degradation process is derived. First order kinetics are assumed for all the reactions and temperature dependence is taken into account through the Arrhenius equation. Unknown model parameters, namely activation energies and pre-exponential Arrhenius coefficients, are estimated via fitting to experimental data. From the estimation results, relevant routes are identified. The kinetic study is performed on sterile fish juice to avoid coupling with microbial degradation mechanisms or possible interferences of the food matrix that might hide biochemical interactions. The proposed scheme adequately describes biochemical changes in nucleotide catabolites under variable temperature profiles. It also reveals a pathway which at least seems relevant for nucleotide degradation in hakeThe authors acknowledge financial support from the Spanish Ministry of Science and Innovation (Projects ISFORQUALITY AGL2012-39951-C02-01, PIE 201230E042 and RESISTANCE DPI2014-54085-JIN)Peer reviewe

Triángulo del Arlanza. Proyectando en Sad Hill: Propuestas de hostería & film commission, Covarrubias. Intervenciones mínimas en el paisaje, Santo Domingo de Silos

El presente volumen contiene una recopilación de Proyectos Académicos desarrollados en el curso 2018-2019 en la Asignatura de Proyectos Arquitectónicos VII: Arquitecturas de programas mixto residencial e institucional. Los trabajos incluidos fueron realizados en la villa de Covarrubias y el paraje de Sad Hill, provincia de Burgos.Departamento de Teoría de la Arquitectura y Proyectos ArquitectónicosCoacyle BurgosAyuntamiento de CovarrubiasAsociación Cultural Sad Hil

Caracterización clínica y epidemiológica de pacientes con diagnóstico post-mortem de colitis pseudomembranosa

Introducción: La incidencia de infecciones asociadas a clostridium difficile en el contexto mundial, incluida Cuba, varía entre 0,6 y 2,1% del total de pacientes hospitalizados.Objetivo:Caracterizar clínica y epidemiológicamente a los pacientes con diagnóstico post-mortem de colitis pseudomembranosa.Material y Métodos: Se realizó un estudio observacional, descriptivo, de corte transversal, utilizando un universo de 49 pacientes fallecidos en el Hospital “Abel Santamaría Cuadrado” a los cuales se les diagnosticó colitis pseudomembranosa a través de necropsia. Las variables estudiadas fueron: sexo, edad, estadía, servicio de procedencia, prescripción antibiótica, incidencia del padecimiento, uso de nutrición a través de sonda nasogástrica y el empleo de Omeprazol.Resultados: El promedio de edades fue de 73,2 años y predominaron los que tenían 65 o más. La estadía promedio fue de 38 días y más del 70% procedieron de unidades de cuidados intensivos. En el 63,2% se empleó IBP en el tratamiento y el 71,4% necesitó alimentación a través de sonda nasogástrica. Los grupos de antibióticos más usados fueros las cefalosporinas de tercera generación, seguidas por las quinolonas, las cefalosporinas de cuarta generación y los carbapenémicos.Conclusiones: Las características clínicas y epidemiológicas de los pacientes diagnosticados de infecciones asociadas a clostridium difficile corresponden generalmente a pacientes ancianos, con larga estadía hospitalaria, uso reciente de antibióticos, estancia en unidades de cuidados intensivos, con alimentación a través de sonda nasogástrica y tratamiento con IBP

Centro de Estudios Hidrológicos : Propuestas en la dársena del Canal de Castilla, Valladolid

Producción CientíficaDurante el curso 2020/2021, en la asignatura de Proyectos VI, se desarrollaron dentro de la programación docente un conjunto de proyectos, que tenían como objetivo la intervención en la zona de la dársena del Canal de Castilla, en Valladolid, caracterizada por una gran multiplicidad de factores. El programa que se planteaba trataba de poner en valor dicho enclave, a través de la creación de un Centro de Estudios Hidrológicos para la Confederación Hidrográfica del Duero. Se trataba de reflexionar sobre el cauce y las zonas adyacentes, con proyectos que albergaran diversos servicios, ahora dispersos por las inmediaciones, además de ordenar los espacios libres e integrarlos en la trama urbana.During the 2020/2021 academic year, in the subject of Projects VI, a set of projects were developed within the teaching program, which aimed to intervene in the area of the Canal de Castilla dock, in Valladolid, characterized by a large multiplicity of factors. The program that was proposed tried to value said enclave, through the creation of a Center for Hydrological Studies for the Duero Hydrographic Confederation. It was a matter of reflecting on the riverbed and the adjacent areas, with projects that housed various services, now scattered around the vicinity, in addition to ordering the free spaces and integrating them into the urban plot.Departamento de Teoría de la Arquitectura y Proyectos ArquitectónicosZaparaín Hernández, F.; Rodríguez Andrés, J.; Paniagua García, A.; Ruiz Íñigo, M.; Fernández Catalina, M.; Llamazares Blanco, P. (coords.). Rodríguez Andrés, J.; Fernández Catalina, M.; Llamazares Blanco, P. (diseño gráfico y maquetación). Rodríguez Andrés, J.; Llamazares Blanco, P. (diseño de la colección

Percepción de los usuarios de la farmacia comunitaria sobre la COVID-19 al final de la alarma y comparación con la situación al inicio

Objetivos: evaluar la percepción de los usuarios de las farmacias sobre la repercusión de la COVID-19 en su salud al final del confinamiento y comparar los resultados con los obtenidos al inicio. Material y métodos: estudio observacional transversal aleatorizado, en farmacias de Pontevedra y Ourense, del 10 al 25 de junio de 2020. Sujetos: ≥18 años que acuden en demanda de medicamentos y/o material de protección. Procedimiento: el usuario cumplimentaba un cuestionario anónimo, depositándolo en una bandeja desinfectada diariamente. Resultados: 839 encuestas. 492 (58,6 %) mujeres, edad media 54,6 (DE=17,4) años. 144 (17,2 %) viven solos. 771 (91,9 %) creen que la COVID-19 es más peligrosa que la gripe, 233 (27,7 %) desconocen estar en algún grupo de riesgo. 137 (16,4 %) dicen sentirse mal/muy mal con el aislamiento. Aspectos más afectados: familiar 429 (51,1 %) y emocional 377 (44,9 %). La afectación de los aspectos físico 210 (25,0 %) y laboral 183 (21,8 %) mejoraron significativamente en fase final. En 2020/21 piensan vacunarse de la gripe 376 (44,4 %), en 2019/20 lo hicieron 243 (34,4 %). 541 (64,5 %) se vacunarán frente a la COVID-19 cuando exista vacuna. Aumentan los que se vacunarán, aunque no esté financiada: 511 (60,9 %) / 280 (39,7 %). Conclusiones: no ha variado significativamente la percepción sobre la peligrosidad de la COVID-19 y la repercusión en su salud. Los aspectos del bienestar más afectados siguen siendo el familiar y el emocional. Aumenta el número de los que se sintieron mal/muy mal con el confinamiento y el de mayores afectados por la soledad. Aumenta la intención de vacunarse del SARS-CoV-2, aunque no sea financiada

Prokaryotic and viral community of the sulfate‐rich crust from Peñahueca ephemeral lake, an astrobiology analogue

Peñahueca is an athalassohaline hypersaline inland ephemeral lake originated under semiarid conditions in the central Iberian Peninsula (Spain). Its chemical composition makes it extreme for microbial life as well as a terrestrial analogue of other planetary environments. To investigate the persistence of microbial life associated with sulfate‐rich crusts, we applied cultivation‐independent methods (optical and electron microscopy, 16S rRNA gene profiling and metagenomics) to describe the prokaryotic community and its associated viruses. The diversity for Bacteria was very low and was vastly dominated by endospore formers related to Pontibacillus marinus of the Firmicutes phylum. The archaeal assemblage was more diverse and included taxa related to those normally found in hypersaline environments. Several ‘metagenome assembled genomes’ were recovered, corresponding to new species of Pontibacillus, several species from the Halobacteria and one new member of the Nanohaloarchaeota. The viral assemblage, although composed of the morphotypes typical of high salt systems, showed little similarity to previously isolated/reconstructed halophages. Several putative prophages of Pontibacillus and haloarchaeal hosts were identified. Remarkably, the Peñahueca sulfate‐rich metagenome contained CRISPR‐associated proteins and repetitions which were over 10‐fold higher than in most hypersaline systems analysed so far.This research was supported by the Spanish Ministry of Economy projects CLG2015_66686-C3-1 (to RRM) CLG2015_66686-C3-3 (to JA), CGL2015-66455-R (to MAGC, MESM, JPRA), AYA2011-24803 and ESP2015-69540-R (to VP) which were also supported by the European Regional Development Fund and the MDM-2017-0737 Unidad de Excelencia “María de Maeztu”- Centro de Astrobiología (INTA-CSIC)

Propuestas en las ruinas del Convento de San Antón. Castrojeriz

Propuestas de intervención en las ruinas del Convento de San Antón de Castrojeriz.Departamento de Teoría de la Arquitectura y Proyectos ArquitectónicosDepartamento de Teoría de la Arquitectura y Proyectos ArquitectónicosAsociación Hospital de Peregrinos San AntónDemarcación de Burgos del COACYL

The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo-controlled, randomized clinical trial.

Background Ivermectin inhibits the replication of SARS-CoV-2 in vitro at concentrations not readily achievable with currently approved doses. There is limited evidence to support its clinical use in COVID-19 patients. We conducted a Pilot, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of a single dose of ivermectin reduce the transmission of SARS-CoV-2 when administered early after disease onset. Methods Consecutive patients with non-severe COVID-19 and no risk factors for complicated disease attending the emergency room of the Clínica Universidad de Navarra between July 31, 2020 and September 11, 2020 were enrolled. All enrollments occurred within 72 h of onset of fever or cough. Patients were randomized 1:1 to receive ivermectin, 400 mcg/kg, single dose (n = 12) or placebo (n = 12). The primary outcome measure was the proportion of patients with detectable SARS-CoV-2 RNA by PCR from nasopharyngeal swab at day 7 post-treatment. The primary outcome was supported by determination of the viral load and infectivity of each sample. The differences between ivermectin and placebo were calculated using Fisher's exact test and presented as a relative risk ratio. This study is registered at ClinicalTrials.gov: NCT04390022. Findings All patients recruited completed the trial (median age, 26 [IQR 19-36 in the ivermectin and 21-44 in the controls] years; 12 [50%] women; 100% had symptoms at recruitment, 70% reported headache, 62% reported fever, 50% reported general malaise and 25% reported cough). At day 7, there was no difference in the proportion of PCR positive patients (RR 0·92, 95% CI: 0·77-1·09, p = 1·0). The ivermectin group had non-statistically significant lower viral loads at day 4 (p = 0·24 for gene E; p = 0·18 for gene N) and day 7 (p = 0·16 for gene E; p = 0·18 for gene N) post treatment as well as lower IgG titers at day 21 post treatment (p = 0·24). Patients in the ivermectin group recovered earlier from hyposmia/anosmia (76 vs 158 patient-days; p < 0.001). Interpretation Among patients with non-severe COVID-19 and no risk factors for severe disease receiving a single 400 mcg/kg dose of ivermectin within 72 h of fever or cough onset there was no difference in the proportion of PCR positives. There was however a marked reduction of self-reported anosmia/hyposmia, a reduction of cough and a tendency to lower viral loads and lower IgG titers which warrants assessment in larger trials. Funding ISGlobal, Barcelona Institute for Global Health and Clínica Universidad de Navarra