AESS estudiants

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Implementación del sistema de gestión de seguridad y salud en el trabajo en el área de producción de envasado en la empresa Anpay del Grupo Anypsa Corporation S.A

RESUMEN El presente proyecto investiga las apreciaciones para mejorar las condiciones de trabajo y asignar un ambiente seguro y saludable implementando un sistema de gestión de seguridad y salud en el trabajo gestionando una mejora continua de las políticas, procesos y los procedimientos de la empresa Anpay del grupo Anypsa Corporation S.A. El marco teórico nos indica la importancia de la seguridad, en este caso son medibles por indicadores que nos guían para reducir los accidentes, riesgos humanos y económicos. Es por ello, para obtener una mejora de la planta se reúne información como el histórico de accidentes, se visita el área de producción y usando la técnica de observación se evalúa su sistema de gestión, que nos agilizara las medidas de control que requiere la empresa. De acuerdo a lo indicado, se implementara un sistema de gestión de seguridad y salud en el trabajo que regule la identificación de los peligros, evalúe sus riesgos, implemente controles y sean supervisados con la finalidad de cumplir con la política y objetivos de la seguridad y salud en el trabajo. Por último, las conclusiones de la implementación, donde se resalta que el éxito del sistema dependerán del compromiso de la organización y colaboradores

Workshop "Art therapy for an art therapist"

"Art Therapy for an Art Therapist" was an experiential workshop presented at the 5thInternational Health Humanities Conference, Arts and Humanities for improving Social Inclusion, Education and Health: creative practice and mutuality – held in Seville (Spain), from September 15th to 17th, 2016. The main enquiry proposed to the audience was how to conduct an art therapy workshop for an art therapist. This key question addressed an important role in our teaching model, since it was designed to promote an autonomous and critical thinking among the participants to an almost Socratic style and to some more committed conjunctures according to Bain theory (2005: 118) and following the Experiential Learning (Kolb, Boyatzis & Mainemelis, 2000). The method used involved different phases and techniques, as a gymkhana or an art exhibition. The results pointed out the vision and thoughts of the ideal art therapists and the descriptions of the main capacities and abilities needed

Determination of nevirapine in the presence of cucurbit(7)uril with a gold electrode

The electrochemical oxidation of nevirapine, an anti-HIV drug, at a gold electrode was studied by voltammetric techniques. Nevirapine showed a signal that interfered with a working electrode wave. This interference was solved by the use of cucurbit(7)uril allowing nevirapine to be determined in tablets (80.4 % recovery, presence of stavudine and lamivudine) and urine (98.4 %)

Durum wheat in the Mediterranean Rim: historical evolution and genetic resources

Durum wheat (Triticum turgidum L. subsp. durum (Desf.) van Slageren) is an important crop in the Mediterranean Rim, and it is deeply rooted in the history and tradition of this region. Recently, several studies that examined DNA markers on Mediterranean landrace collections have successfully elucidated the pathways of this crop across the Mediterranean Rim, but the historical frame is still rather diffuse. This paper aims at tracing the historical evolution of durum wheat throughout the Mediterranean Rim since its commencement as a crop until present times. A search was carried out through archaeological references where durum wheat remains were found. Historical descriptions about cultivation of this crop, references to products made from its grain, and articles interpreting DNA marker information from Mediterranean landraces were also consulted. The present article also examines the currently available durum wheat genetic resources. Durum wheat was domesticated in the Levant area. Phoenicians, Greeks, and above all Romans were active in the expansion and success of durum cultivation in all Mediterranean Rim that started displaced emmer by the mid first millennium BCE. Early Arab empire expanded in the area of durum wheat cultivation promoting food types based on semolina (dry pasta and couscous). Up to 1955 most durum areas in this area were planted with landraces, but several breeding programs were initiated in Italy, and later at CIMMYT and at ICARDA. Landrace collection and conservation efforts were carried out along the Mediterranean Rim countries to preserve the legacy of this crop.info:eu-repo/semantics/acceptedVersio

A novel familial mutation in the PCSK1 gene that alters the oxyanion hole residue of proprotein convertase 1/3 and impairs its enzymatic activity.

Four siblings presented with congenital diarrhea and various endocrinopathies. Exome sequencing and homozygosity mapping identified five regions, comprising 337 protein-coding genes that were shared by three affected siblings. Exome sequencing identified a novel homozygous N309K mutation in the proprotein convertase subtilisin/kexin type 1 (PCSK1) gene, encoding the neuroendocrine convertase 1 precursor (PC1/3) which was recently reported as a cause of Congenital Diarrhea Disorder (CDD). The PCSK1 mutation affected the oxyanion hole transition state-stabilizing amino acid within the active site, which is critical for appropriate proprotein maturation and enzyme activity. Unexpectedly, the N309K mutant protein exhibited normal, though slowed, prodomain removal and was secreted from both HEK293 and Neuro2A cells. However, the secreted enzyme showed no catalytic activity, and was not processed into the 66 kDa form. We conclude that the N309K enzyme is able to cleave its own propeptide but is catalytically inert against in trans substrates, and that this variant accounts for the enteric and systemic endocrinopathies seen in this large consanguineous kindred

Santiago Sierra y los sistemas colaborativos de trabajo

Este artículo re!exiona sobre los sistemas colaborativos de trabajo a través del análisis conceptual de algunas obras de Santiago Sierra (Madrid, 1966) que exploran sintáctica y semánticamente los límites entre las prácticas de creación participativa, el em-pleo y la explotación desde las contradiccio-nes y paradojas del sistema capitalista

Impartir docencia universitaria a través del arte como vía alternativa de conocimiento: un estudio de campo aplicado en la universidad de Sevilla

El objetivo de este trabajo se centra en revisitar y destacar el rol fundamental del Arte cuando se emplea como herramienta pedagógica transversal en todos los ámbitos del saber en el contexto sociocultural y tecnológico actual. Con este fin, muestra, de manera sintética y esquemática, la experiencia piloto que con dicho objetivo se llevó a cabo en el pasado curso académico 2015/2016 en el Instituto de Ciencias de la Educación de la Universidad de Sevilla. Dicha experiencia consistió en la impartición de un curso de diez horas dirigido a sus profesores, adscritos a cualquier área de conocimiento, y que llevó por título el mismo que adopta este trabajo. Desde una metodología expositiva-descriptiva, se explican los objetivos, contenidos, métodos didácticos, cronograma y resultados de la experiencia, intercalándolos con referencias de autores como Kagan, Bain, Mayer, Salovey y Egea, para complementar el discurso aportando perspectivas didácticas más actuales. Como sistema de evaluación del curso, se realizaron dos cuestionarios dirigidos a los participantes (docentes universitarios), uno en la parte inicial y otro en la parte final del curso. Según los resultados y como conclusión, se plasman las grandes posibilidades derivadas de esta forma de abordar el sistema de enseñanza-aprendizaje en la universidad, como la potenciación emocional de los estudiantes o la empatía generada entre profesor-alumno.The goal of this work is to revisit and highlight the main role of Art when it is used as a transversal pedagogical tool in all areas of knowledge in the current sociocultural and technological context. For this purpose, it shows, in a synthetic and schematic way, the first experience that was carried out in the past academic year 2015/2016 at the Institute of Educational Sciences of the University of Seville. This experience consisted in teaching a course of ten hours addressed to professors from any area of knowledge and that took by title the same one that adopts this paper. From an expository-descriptive methodology; goals, contents, didactic methods, timeline and results of the experience are explained, with references by authors such as Kagan, Bain, Mayer, Salovey and Egea, to complement the discourse by providing didactic perspectives more modern. As evaluation system of the course, two questionnaires were conducted to participants (university teachers), one in the initial part and the other one in the final part of the course. According to their results and as a conclusion, the great possibilities derived from this way of approaching the teaching-learning system in the university are captured, such as the emotional empowerment of students or the empathy generated between professor-student

On-Surface Cucurbit[n]uril Supramolecular Recognition for an Optical Sensor Design

This is the peer reviewed version of the following article: ChemistrySelect 2019, 4, 7036 7041, which has been published in final form at https://doi.org/10.1002/slct.201901127. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.[EN] A novel optical sensor, based on the use of the macrocyclic receptor cucurbit[7]uril as molecular selector taking part of a sensing poly(vinyl chloride)-based membrane immobilized onto a quartz slide surface, has been developed and tested to thiabendazole analysis. The method is built upon the increase of the thiabendazole fluorescence as a result of the supramolecular recognition event. Variables involved in the membrane construction and fluorescence measurements have been evaluated and optimized. The sensing membrane is prepared by a spin-coating procedure (1 min at 800 r.p.m.). An increase of more than 2 fold in the fluorescence signal is observed when the supramolecular complex is immobilized into the membrane respect to that observed for the free guest. Under optimized conditions, the dispositive responds in a few seconds to thiabendazole concentrations at 10(-7) M level. In addition, the characterization of the supramolecular complex together with lifetime measurements is included.The authors would like to thank the Comunidad Autonoma de Madrid (P2018/NMT-4349, TRANSNANOAVANSENS-CM) for financial support.Jiménez, J.; Blasco, S.; Blanco, E.; Atienzar Corvillo, PE.; Del Pozo, M.; Quintana, C. (2019). On-Surface Cucurbit[n]uril Supramolecular Recognition for an Optical Sensor Design. ChemistrySelect. 4(24):7036-7041. https://doi.org/10.1002/slct.201901127S70367041424Montes-Navajas, P., Baumes, L. A., Corma, A., & Garcia, H. (2009). Dual-response colorimetric sensor array for the identification of amines in water based on supramolecular host–guest complexation. Tetrahedron Letters, 50(20), 2301-2304. doi:10.1016/j.tetlet.2009.02.189Telting-Diaz, M., & Bakker, E. (2002). Mass-Produced Ionophore-Based Fluorescent Microspheres for Trace Level Determination of Lead Ions. Analytical Chemistry, 74(20), 5251-5256. doi:10.1021/ac025596iUttam, B., Hussain, M. A., Joshi, S., & Rao, C. P. (2018). Physicochemical and Ion-Sensing Properties of Benzofurazan-Appended Calix[4]arene in Solution and on Gold Nanoparticles: Spectroscopy, Microscopy, and DFT Computations in Support of the Species of Recognition. ACS Omega, 3(12), 16989-16999. doi:10.1021/acsomega.8b02848Shamsipur, M., Sadeghi, M., Beyzavi, M. H., & Sharghi, H. (2015). Development of a novel fluorimetric bulk optode membrane based on meso-tetrakis(2-hydroxynaphthyl) porphyrin (MTHNP) for highly sensitive and selective monitoring of trace amounts of Hg2+ ions. Materials Science and Engineering: C, 48, 424-433. doi:10.1016/j.msec.2014.12.030Cano-Raya, C., Fernández-Ramos, M. D., Gómez-Sánchez, J., & Capitán-Vallvey, L. F. (2006). Irreversible optical sensor for mercury determination based on tetraarylborate decomposition. Sensors and Actuators B: Chemical, 117(1), 135-142. doi:10.1016/j.snb.2005.11.009Sahari, A., Ruckh, T. T., Hutchings, R., & Clark, H. A. (2015). Development of an Optical Nanosensor Incorporating a pH-Sensitive Quencher Dye for Potassium Imaging. Analytical Chemistry, 87(21), 10684-10687. doi:10.1021/acs.analchem.5b03080Assaf, K. I., & Nau, W. M. (2015). Cucurbiturils: from synthesis to high-affinity binding and catalysis. Chemical Society Reviews, 44(2), 394-418. doi:10.1039/c4cs00273cGanguly, A., Ghosh, S., & Guchhait, N. (2016). Inclusion of an Anthracene-based Fluorophore within Molecular Containers: A Comparative Study of the Cucurbituril and Cyclodextrin Host Families. The Journal of Physical Chemistry B, 120(19), 4421-4430. doi:10.1021/acs.jpcb.6b04178Rankin, M. A., & Wagner, B. D. (2004). Fluorescence Enhancement of Curcumin upon Inclusion into Cucurbituril. Supramolecular Chemistry, 16(7), 513-519. doi:10.1080/10610270412331283583Geng, Q.-X., Cong, H., Tao, Z., Lindoy, L. F., & Wei, G. (2015). Cucurbit[7]uril-improved recognition by a fluorescent sensor for cadmium and zinc cations. Supramolecular Chemistry, 28(9-10), 784-791. doi:10.1080/10610278.2015.1117614Smith, L. C., Leach, D. G., Blaylock, B. E., Ali, O. A., & Urbach, A. R. (2015). Sequence-Specific, Nanomolar Peptide Binding via Cucurbit[8]uril-Induced Folding and Inclusion of Neighboring Side Chains. Journal of the American Chemical Society, 137(10), 3663-3669. doi:10.1021/jacs.5b00718Lazar, A. I., Biedermann, F., Mustafina, K. R., Assaf, K. I., Hennig, A., & Nau, W. M. (2016). Nanomolar Binding of Steroids to Cucurbit[n]urils: Selectivity and Applications. Journal of the American Chemical Society, 138(39), 13022-13029. doi:10.1021/jacs.6b07655Del Pozo, M., Fernández, Á., & Quintana, C. (2018). On-line competitive host-guest interactions in a turn-on fluorometric method to amantadine determination in human serum and pharmaceutical formulations. Talanta, 179, 124-130. doi:10.1016/j.talanta.2017.10.064Pozo, M. del, Blanco, E., Fatás, E., Hernández, P., & Quintana, C. (2012). New supramolecular interactions for electrochemical sensors development: different cucurbit[8]uril sensing platform designs. The Analyst, 137(18), 4302. doi:10.1039/c2an35325cDel Pozo, M., Hernández, P., Hernández, L., & Quintana, C. (2011). The use of cucurbit[8]uril host–guest interactions in the development of an electrochemical sensor: characterization and application to tryptophan determination. Journal of Materials Chemistry, 21(35), 13657. doi:10.1039/c1jm12063hDel Pozo, M., Mejías, J., Hernández, P., & Quintana, C. (2014). Cucurbit[8]uril-based electrochemical sensors as detectors in flow injection analysis. Application to dopamine determination in serum samples. Sensors and Actuators B: Chemical, 193, 62-69. doi:10.1016/j.snb.2013.11.074Demets, G. J.-F., Schneider, B. V. S., Correia, H. D., Gonçalves, R. R., Nobre, T. M., & Darbello Zaniquelli, M. E. (2008). A Technique to Produce Thin Cucurbit[6]uril Films. Journal of Nanoscience and Nanotechnology, 8(1), 432-435. doi:10.1166/jnn.2008.051Liu, M., Kan, J., Yao, Y., Zhang, Y., Bian, B., Tao, Z., … Xiao, X. (2019). Facile preparation and application of luminescent cucurbit[10]uril-based porous supramolecular frameworks. Sensors and Actuators B: Chemical, 283, 290-297. doi:10.1016/j.snb.2018.12.024Nicolas, H., Yuan, B., Zhang, J., Zhang, X., & Schönhoff, M. (2015). Cucurbit[8]uril as Nanocontainer in a Polyelectrolyte Multilayer Film: A Quantitative and Kinetic Study of Guest Uptake. Langmuir, 31(39), 10734-10742. doi:10.1021/acs.langmuir.5b02806Nicolas, H., Yuan, B., Zhang, X., & Schönhoff, M. (2016). Cucurbit[8]uril-Containing Multilayer Films for the Photocontrolled Binding and Release of a Guest Molecule. Langmuir, 32(10), 2410-2418. doi:10.1021/acs.langmuir.6b00128Del Pozo, M., Alonso, M., Hernández, L., & Quintana, C. (2010). An Electrochemical Approach for the Cucurbit[7]uril/Carbendazim Supramolecular Inclusion Complex. Application to Carbendazim Determination in Apples. Electroanalysis, 23(1), 189-195. doi:10.1002/elan.201000442Saleh, N., Koner, A. L., & Nau, W. M. (2008). Activation and Stabilization of Drugs by Supramolecular pKaShifts: Drug‐Delivery Applications Tailored for Cucurbiturils. Angewandte Chemie International Edition, 47(29), 5398-5401. doi:10.1002/anie.200801054http://ec.europa.eu/food/plant/pesticides/eu-pesticides-database/;Yu, F., Su, M., Tian, L., Wang, H., & Liu, H. (2018). Organic Solvent as Internal Standards for Quantitative and High-Throughput Liquid Interfacial SERS Analysis in Complex Media. Analytical Chemistry, 90(8), 5232-5238. doi:10.1021/acs.analchem.8b00008Chen, Q., Zuo, J., He, X., Mo, X., Tong, P., & Zhang, L. (2017). Enhanced fluorescence of terbium with thiabendazole and application in determining trace amounts of terbium and thiabendazole. Talanta, 162, 540-546. doi:10.1016/j.talanta.2016.10.036ASGHAR, M., YAQOOB, M., MUNAWAR, N., & NABI, A. (2016). Flow-Injection Determination of Thiabendazole Fungicide in Water Samples Using a Diperiodatocuprate(III)–Sulfuric Acid–Chemiluminescence System. Analytical Sciences, 32(3), 337-342. doi:10.2116/analsci.32.337Sousa, E. S., Pinto, L., & de Araujo, M. C. U. (2017). A chemometric cleanup using multivariate curve resolution in liquid chromatography: Quantification of pesticide residues in vegetables. Microchemical Journal, 134, 131-139. doi:10.1016/j.microc.2017.05.017Oliveira, A. M., Loureiro, H. C., de Jesus, F. F. S., & de Jesus, D. P. (2017). Electromembrane extraction and preconcentration of carbendazim and thiabendazole in water samples before capillary electrophoresis analysis. Journal of Separation Science, 40(7), 1532-1539. doi:10.1002/jssc.201601305Smitka, J., Lemos, A., Porel, M., Jockusch, S., Belderrain, T. R., Tesařová, E., & Da Silva, J. P. (2014). Phototransformation of benzimidazole and thiabendazole inside cucurbit[8]uril. Photochem. Photobiol. Sci., 13(2), 310-315. doi:10.1039/c3pp50336dMontes-Navajas, P., Corma, A., & Garcia, H. (2008). Complexation and Fluorescence of Tricyclic Basic Dyes Encapsulated in Cucurbiturils. ChemPhysChem, 9(5), 713-720. doi:10.1002/cphc.200700735Shewale, M. N., Lande, D. N., & Gejji, S. P. (2016). Encapsulation of benzimidazole derivatives within cucurbit[7]uril: Density functional investigations. Journal of Molecular Liquids, 216, 309-317. doi:10.1016/j.molliq.2015.12.076An, Q., Dong, C., Zhu, W., Tao, C., Yang, H., Wang, Y., & Li, G. (2012). Cucurbit[8]uril as Building Block for Facile Fabrication of Well-Defined Organic Crystalline Nano-objects with Multiple Morphologies and Compositions. Small, 8(4), 562-568. doi:10.1002/smll.20110193