Análisis multiescala de indicadores arqueológicos de Tlajinga, Teotihuacan (México). Desde la percepción remota a la microscopía.

El barrio de Tlajinga es un área ubicada al sur de la ciudad de Teotihuacán, Estado de México, que preserva materiales prehispánicos diseminados en distintas zonas del terreno, así como estructuras arqueológicas enterradas. Las partículas del suelo, al mezclarse con materiales arqueológicos tales como piedra, estuco, cerámica y fragmentos de murales, enriquecen el suelo principalmente con carbonato de calcio, lo que contribuye al aumento de la reflectancia en distintas zonas del terreno, principalmente en zonas donde había estructuras arqueológicas. Este fenómeno es registrado desde un nivel sinóptico por los sensores remotos actuales, con mayor resolución espectral, espacial y radiométrica, correlacionándose a una menor es-cala con la espectrorradiometría y la micromorfología de los suelos. De esta forma se identificaron algunos mine-rales presentes en los pisos y muros, principalmente el estuco arqueológico, ahora transformado en pequeñas partículas de carbonato de calcio. La fluorescencia (FRX) y difracción de rayos X (DRX) complementaron los resultados de la percepcción remota, la espectrorradiometría y la micromorfología, identificando la composición elemental de las partículas del suelo y los minerales asociados, de la que sobresale el carbonato de calcio, un compuesto muy importante utilizado para el recubrimiento de pisos y edificios durante la época teotihuacana.The Tlajinga Barrio is a domestic area situated in the south of Teotihuacan, Estado de México, where preserves original surface materials as well as buried archaeological structures are preserved. Original soil particles mixed with archaeological materials such as stone, stucco, ceramics, and mural fragments enrich the soil mainly with calcium carbonate, contributing to the increase in reflectance in different areas of the terrain, mainly in nearby areas where there were archaeological structures. This is recorded from a synoptic level by the modern remote sensors, with higher spectral, spatial, and radiometric resolution, correlating it to a smaller scale with soil micromorphology analysis. In this way, some minerals present in the floors and walls were identified, mainly the archaeological stucco now transformed into small particles of calcium carbonate. X-ray fluorescence (XFRF) and X-ray diffraction (XRD) complemented the results of remote sensing, spectrometry and micromorphology, identifying the elemental composition of soil particles and associated minerals, mainly calcium carbonate, that were used live in coatings on floors and buildings during the Teotihuacan era.Published versio

Geophysical prospection and aerial photography in La Laguna, Tlaxcala, Mexico

Introduction The paper presents the results of a remote-sensing program at the La Laguna archaeological site, a Late Formative period (c. 600 BC – AD 100) regional center located in northern Tlaxcala (19°30’35” N / 98°00’20” W). The site was the largest community in the region during this period, when adjacent areas of central Mexico witnessed an initial phase of urbanization and state formation (Carballo and Pluckhahn, 2007; Merino Carrión, 1989; Snow, 1966). As such, La Laguna provides a cr..

Estudio de conjuntos departamentales y organización de barrios utilizando sensores remotos y geofísica en el distrito de Tlajinga, Teotihuacan

RESUMEN: Estudios geofísicos, técnicas de sensores remotos y realización de mapas topográficos con GPS diferencial y vehículos aéreos no tripulados (VANT) han proporcionado una mejor comprensión de la organización espacial de los conjuntos departamentales y barrios en Teotihuacán. Nuestras investigaciones demuestran que en contraste con el mapa producido por el Teotihuacan Mapping Project (TMP) (Millon et al. 1973), el distrito de Tlanjinga es más rectangular y está más formalmente organizado, mientras que los conjuntos individuales tienen formas más irregulares, como lo había mostrado la excavación de Tlajinga 33 (Widmer y Storey 1993). Esto difiere de los nítidos cuadrados y rectángulos interpretados por las reconstrucciones arquitectónicas del TMP. El estudio de las imágenes satelitales mostró manchas blanquecinas en el terreno que parecen corresponder con áreas elevadas del mismo y con la desintegración de los aplanados de cal, destruidos por el tiempo y el trabajo agrícola. También verificamos la continuación del trazo de la Calzada de los Muertos que cruza este distrito mediante la modificación del relieve ocasionada por la excavación realizada en la toba volcánica subyacente (tepetate).ABSTRACT: Geophysical studies, remote-sensing techniques and topographic mapping with both differential GPS and UAV (unmanned aerial vehicle) provide a much improved understanding of spatial organization of Teotihuacan’s districts, neighborhoods, and apartment compounds. Our investigations demonstrate that, in contrast to the analog map produced by the Teotihuacan Mapping Project (TMP) (Millon et al. 1973), the central Tlajinga district is more rectangular and formally organized, whereas individual compounds are more irregularly shaped, like the already excavated plan of Tlajinga 33 (Widmer and Storey 1993) and unlike the neat squares and rectangles conveyed by the TMP architectural reconstructions. Inspection of satellite imagery reveals concentrations of whitish surface spots that may correspond to areas where lime plaster has disintegrated as a consequence of time and agriculture, and where the terrain rises. We also verify the continuation of Teotihuacan’s central axis, the Street of the Dead, through the district, where it was excavated into the volcanic tuff substrate (tepetate).Accepted manuscrip

Motivaciones ocupacionales en adultos

Se intentó conocer las motivaciones ocupacionales en sujetos adultos de ambos sexos, cuyas edades fluctuaron entre los 20 y 50 años. Se trabajó con 150 sujetos; hombres y mujeres divididos equitativamente. Se aplicó el Cuestionario de Motivaciones Ocupacionales (Faletty & Moreno, 1999) evaluando de manera individual a los sujetos. Analizamos en este artículo solamente los ítemes de este cuestionario en que se encontraron diferencias significativas entre hombres y mujeres

The EASEL project: Towards educational human-robot symbiotic interaction

This paper presents the EU EASEL project, which explores the potential impact and relevance of a robot in educational settings. We present the project objectives and the theorectical background on which the project builds, briefly introduce the EASEL technological developments, and end with a summary of what we have learned from the evaluation studies carried out in the project so far

Plasma miRNA profile at COVID-19 onset predicts severity status and mortality

BACKGROUND: MicroRNAs (miRNAs) have a crucial role in regulating immune response against infectious diseases, showing changes early in disease onset and before the detection of the pathogen. Thus, we aimed to analyze the plasma miRNA profile at COVID-19 onset to identify miRNAs as early prognostic biomarkers of severity and survival. METHODS AND RESULTS: Plasma miRNome of 96 COVID-19 patients that developed asymptomatic/mild, moderate and severe disease was sequenced together with a group of healthy controls. Plasma immune-related biomarkers were also assessed. COVID-19 patients showed 200 significant differentially expressed (SDE) miRNAs concerning healthy controls, with upregulated putative targets of SARS-CoV-2, and inflammatory miRNAs. Among COVID-19 patients, 75 SDE miRNAs were observed in asymptomatic/mild compared to symptomatic patients, which were involved in platelet aggregation and cytokine pathways, among others. Moreover, 137 SDE miRNAs were identified between severe and moderate patients, where miRNAs targeting the SARS CoV-2 genome were the most strongly disrupted. Finally, we constructed a mortality predictive risk score (miRNA-MRS) with ten miRNAs. Patients with higher values had a higher risk of 90-days mortality (hazard ratio = 4.60; p-value < 0.001). Besides, the discriminant power of miRNA-MRS was significantly higher than the observed for age and gender (AUROC = 0.970 vs. 0.881; p = 0.042). CONCLUSIONS: SARS-CoV-2 infection deeply disturbs the plasma miRNome from an early stage of COVID-19, making miRNAs highly valuable as early predictors of severity and mortality

Economía y finanzas sociales: avances en la investigación

Esta obra colectiva propone un cambio de paradigma en la investigación científica, financiera y económica, cuyo centro de atención es reducir las desigualdades sociales y económicas, mejorar la sostenibilidad ambiental y la creación eficiente de valor económico. Desde un punto de vista crítico y mediante diversos enfoques teóricos, metodológicos y disciplinares, los autores analizan el esquema financiero predominante en las economías de mercado, al tiempo que abordan temas como la inclusión financiera, la banca ética o las experiencias e intervenciones en y sobre la economía social.ITESO, A.C

Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal alpha-toxin

The molecular basis of interindividual clinical variability upon infection with Staphylococcus aureus is unclear. We describe patients with haploinsufficiency for the linear deubiquitinase OTULIN, encoded by a gene on chromosome 5p. Patients suffer from episodes of life-threatening necrosis, typically triggered by S. aureus infection. The disorder is phenocopied in patients with the 5p- (Cri-du-Chat) chromosomal deletion syndrome. OTULIN haploinsufficiency causes an accumulation of linear ubiquitin in dermal fibroblasts, but tumor necrosis factor receptor-mediated nuclear factor kappa B signaling remains intact. Blood leukocyte subsets are unaffected. The OTULIN-dependent accumulation of caveolin-1 in dermal fibroblasts, but not leukocytes, facilitates the cytotoxic damage inflicted by the staphylococcal virulence factor alpha-toxin. Naturally elicited antibodies against alpha-toxin contribute to incomplete clinical penetrance. Human OTULIN haploinsufficiency underlies life-threatening staphylococcal disease by disrupting cell-intrinsic immunity to alpha-toxin in nonleukocytic cells.Peer reviewe

Trends in the epidemiology of catheter-related bloodstream infections; towards a paradigm shift, Spain, 2007 to 2019

Altres ajuts: Departament de Salut. Generalitat de Catalunya ("Pla estratègic de recerca i innovació en salut (PERIS) 2019-2021"); Ministerio de Asuntos Económicos y Transformación Digital; Red Española de Investigación en Patología Infecciosa (REIPI).Background: Catheter-related bloodstream infections (CRBSI) are frequent healthcare-associated infections and an important cause of death. Aim: To analyse changes in CRBSI epidemiology observed by the Infection Control Catalan Programme (VINCat). Methods: A cohort study including all hospital-acquired CRBSI episodes diagnosed at 55 hospitals (2007-2019) in Catalonia, Spain, was prospectively conducted. CRBSI incidence rates were adjusted per 1,000patientdays. To assess the CRBSI rate trend per year, negative binomial models were used, with the number of events as the dependent variable, and the year as the main independent variable. From each model, the annual rate of CRBSI diagnosed per 1,000patientdays and the incidence rate ratio (IRR) with its 95% confidence intervals (CI) were reported. Results: During the study, 9,290 CRBSI episodes were diagnosed (mean annual incidence rate:0.20episodes/1,000patientdays). Patients' median age was 64.1years; 36.6% (3,403/9,290) were female. In total, 73.7% (n=6,845) of CRBSI occurred in non-intensive care unit (ICU) wards, 62.7% (n=5,822) were related to central venous catheter (CVC), 24.1% (n=2,236) to peripheral venous catheters (PVC) and 13.3% (n=1,232) to peripherally-inserted central venous catheters (PICVC). Incidence rate fell over the study period (IRR:0.94;95%CI:0.93-0.96), especially in the ICU (IRR:0.88;95%CI:0.87-0.89). As a whole, while episodes of CVC CRBSI fell significantly (IRR:0.88;95%CI:0.87-0.91), peripherally-inserted catheter CRBSI (PVC and PICVC) rose, especially in medical wards (IRR PICVC:1.08;95%CI:1.05-1.11; IRR PVC: 1.03; 95% 1.00-1.05). Conclusions: Over the study, CRBSIs associated with CVC and diagnosed in ICUs decreased while episodes in conventional wards involving peripherally-inserted catheters increased. Hospitals should implement preventive measures in conventional wards