Dispositif de contrôle de l'articulation d'une orthèse ou prothèse de membre supérieur ou inférieur

L'invention concerne un mécanisme d'articulation de deux éléments (1,4) d'une orthèse ou d'une prothèse, l'un des éléments (1) étant solidaire de la cuisse d'un sujet, l'autre (4) étant solidaire de ou appartenant à la jambe de ce dernier, caractérisé en ce que qu'il comprend une bague intérieure (6) portée par l'un (1) des éléments et une bague extérieure (2) portée par l'autre élément (4), les bagues étant accouplées à rotation par l'intermédiaire d'un embrayage (7,8,8a) à coincement intercalé entre elles et pourvu d'un moyen de neutralisation (9,10,11) de l'accouplement des deux bagues comportant une roue (9) de commande coopérant par enroulement sans glissement avec au moins un lien (12) d'indexation de la roue dans l'une ou l'autre de deux positions de celle-ci par rapport à l'embrayage

Dispositif de contrôle de l'articulation d'une orthèse ou prothèse de membre supérieur ou inférieur

L'invention concerne un mécanisme d'articulation de deux éléments (1,4) d'une orthèse ou d'une prothèse, l'un des éléments (1) étant solidaire de la cuisse d'un sujet, l'autre (4) étant solidaire de ou appartenant à la jambe de ce dernier, caractérisé en ce que qu'il comprend une bague intérieure (6) portée par l'un (1) des éléments et une bague extérieure (2) portée par l'autre élément (4), les bagues étant accouplées à rotation par l'intermédiaire d'un embrayage (7,8,8a) à coincement intercalé entre elles et pourvu d'un moyen de neutralisation (9,10,11) de l'accouplement des deux bagues comportant une roue (9) de commande coopérant par enroulement sans glissement avec au moins un lien (12) d'indexation de la roue dans l'une ou l'autre de deux positions de celle-ci par rapport à l'embrayage

Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system

The bacterial human pathogen Helicobacter pylori produces a type IV secretion system ( cag T4SS) to inject the oncoprotein CagA into gastric cells. The cag T4SS external pilus mediates attachment of the apparatus to the target cell and the delivery of CagA. While the composition of the pilus is unclear, CagI is present at the surface of the bacterium and required for pilus formation. Here, we have investigated the properties of CagI by an integrative structural biology approach. Using Alpha Fold 2 and Small Angle X-ray scattering, it was found that CagI forms elongated dimers mediated by rod-shape N-terminal domains (CagI N ) prolonged by globular C-terminal domains (CagI C ). Three Designed Ankyrin Repeat Proteins (DARPins) K2, K5 and K8 selected against CagI interacted with CagI C with subnanomolar affinities. The crystal structures of the CagI:K2 and CagI:K5 complexes were solved and identified the interfaces between the molecules, thereby providing a structural explanation for the difference in affinity between the two binders. Purified CagI and CagI C were found to interact with adenocarcinoma gastric (AGS) cells, induced cell spreading and the interaction was inhibited by K2. The same DARPin inhibited CagA translocation by up to 65% in AGS cells while inhibition levels were 40% and 30% with K8 and K5, respectively. Our study suggests that CagI C plays a key role in cag T4SS-mediated CagA translocation and that DARPins targeting CagI represent potent inhibitors of the cag T4SS, a crucial risk factor for gastric cancer development.Bases structurale du système de secretion de type IV d'Helicobacter pyloriBases structurales et moléculaires de l'exploitation de l'integrin a5ß1 par le système de sécrétion de type IV d'Helicobacter pylor

Statismo - A framework for PCA based statistical models

This paper describes the Statismo framework, which is a framework for PCA based statistical models.Statistical models are used to describe the variability of an object within a population, learned from a set of training samples. Originally developed to model shapes, statistical models are now increasingly used to model the variation in different kind of data, such as for example images, volumetric meshes or deformation fields. Statismo has been developed with the following main goals in mind: 1) To provide generic tools for learning different kinds of PCA based statistical models, such as shape, appearance or deformations models. 2) To make the exchange of such models easier among different research groups and to improve the reproducibility of the models. 3) To allow for easy integration of new methods for model building into the framework. To achieve the first goal, we have abstracted all the aspects that are specific to a given model and data representation, into a user defined class. This does not only make it possible to use Statismo to create different kinds of PCA models, but also allows Statismo to be used with any toolkit and data format. To facilitate data exchange, Statismo defines a storage format based on HDF5, which includes all the information necessary to use the model, as well as meta-data about the model creation, which helps to make model building reproducible. The last goal is achieved by providing a clear separation between data management, model building and model representation. In addition to the standard method for building PCA models, Statismo already includes two recently proposed algorithms for building conditional models, as well as convenience tools for facilitating cross-validation studies. Although Statismo has been designed to be independent of a particular toolkit, special efforts have been made to make it directly useful for VTK and ITK. Besides supporting model building for most data representations used by VTK and ITK, it also provides an ITK transform class, which allows for the integration of Statismo with the ITK registration framework. This leverages the efforts from the ITK project to readily access powerful methods for model fitting

Influence of pH on the formation of organic colloïds and the associated release of various elements from surface sludge deposits of vertical flow constructed wetlands.

Online conference due to the COVID-19 pandemicInternational audienc

Release of Metals from Wastewater Residue at Different pHs: An Ultrafiltration Investigation

International audienceVertical flow constructed wetlands (VFCW) areworldwide used ecological technologies designed to treatwastewaters. During their operating time, a sludge layer isformed at the surface of the first-stage filters by the retentionof wastewater’s suspended solids. The deposit constitutingthis layer is now known to accumulate and degrade a largevariety of contaminants during regular conditions ofoperation. The resilience and potential release of thesecontaminants during varying operational conditions istherefore of major concern. When the sludge deposit issubject to water flows, elements can be released underdissolved form or associated to colloidal carrier phases. Thisstudy investigated the influence of pH variations on thespeciation and transport of toxic metals and major elementsbound to VFCW surface sludge deposits.The acid/base neutralisation capacity (environmentalassessment procedure ANC/BNC) (according to CEN/TS14429) was carried out to assess the release at different pHvalues. Samples of sludge deposits were put in contact withsolutions in a wide pH range; the suspensions were filteredthrough 0.45 μm acetate cellulose filters an weresubsequently analyzed. In addition, the suspensions were alsotreated by ultrafiltration using successively membranes ofdecreasing pore size (30 kDa, 10 kDa and 3 kDa). Thepermeates were analyzed for major and trace elements andorganic molecules.Depending on their affinity with the organic and/ormineral colloidal carrier phases and the different pHconditions, three groups of elements were defined : (i) As, P,B, V, Na, K were mostly present in solutions as free species,(ii) Co, Cu, Ni, Cd, Zn were partially affected by colloidaltransport and (iii) Cr, Ba, Mn, Ca, Li, Mg, Sr were stronglyaffected by colloidal co-transport. Accompanied bygeochemical modelling tools, these results provide importantinformation on the speciation of released pollutants. Thequantity of released pollutants, their mobility and potentialtoxicity help to define critical pH ranges that should not beexceeded in order to limit the impact of pollutant release onthe environment