1,048 research outputs found

    Solar Energy for Heating Farm Structures in Kentucky

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    This report is intended to summarize the important decisions which must be made by farmers in Kentucky, who are considering the utilization of solar energy for heating farm buildings or drying grain

    Effect of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice.

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    IntroductionPrevious studies in animal models of osteoarthritis suggest that alendronate (ALN) has antiresorptive and chondroprotective effects, and can reduce osteophyte formation. However, these studies used non-physiologic injury methods, and did not investigate early time points during which bone is rapidly remodeled prior to cartilage degeneration. The current study utilized a non-invasive model of knee injury in mice to investigate the effect of ALN treatment on subchondral bone changes, articular cartilage degeneration, and osteophyte formation following injury.MethodsNon-invasive knee injury via tibial compression overload or sham injury was performed on a total of 90 mice. Mice were treated with twice weekly subcutaneous injections of low-dose ALN (40 Î¼g/kg/dose), high-dose ALN (1,000 Î¼g/kg/dose), or vehicle, starting immediately after injury until sacrifice at 7, 14 or 56 days. Trabecular bone of the femoral epiphysis, subchondral cortical bone, and osteophyte volume were quantified using micro-computed tomography (μCT). Whole-joint histology was performed at all time points to analyze articular cartilage and joint degeneration. Blood was collected at sacrifice, and serum was analyzed for biomarkers of bone formation and resorption.ResultsμCT analysis revealed significant loss of trabecular bone from the femoral epiphysis 7 and 14 days post-injury, which was effectively prevented by high-dose ALN treatment. High-dose ALN treatment was also able to reduce subchondral bone thickening 56 days post-injury, and was able to partially preserve articular cartilage 14 days post-injury. However, ALN treatment was not able to reduce osteophyte formation at 56 days post-injury, nor was it able to prevent articular cartilage and joint degeneration at this time point. Analysis of serum biomarkers revealed an increase in bone resorption at 7 and 14 days post-injury, with no change in bone formation at any time points.ConclusionsHigh-dose ALN treatment was able to prevent early trabecular bone loss and cartilage degeneration following non-invasive knee injury, but was not able to mitigate long-term joint degeneration. These data contribute to understanding the effect of bisphosphonates on the development of osteoarthritis, and may support the use of anti-resorptive drugs to prevent joint degeneration following injury, although further investigation is warranted

    Ground and space based optical analysis of materials degradation in low-Earth-orbit

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    There is strong interest in being able to accurately and sensitively monitor materials degradation in both ground-based and space-based environments. Two optical techniques for sensitive degradation monitoring are reviewed: spectroscopic ellipsometry and photothermal spectroscopy. These techniques complement each other in that ellipsometry is sensitive to atomically thin surface and subsurface changes, and photothermal spectroscopy is sensitive to local defects, pin-holes, subsurface defects, and delamination. Progress in applying these spectroscopies (both ex situ and in situ) to atomic oxygen degradation of space materials is reviewed

    Selectvie Modification of Membrane Pore and External Surfaces

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    Modification of membrane surfaces by grafting polymer brushes from the surface has been shown to impart unique surface properties. These polymer brushes can be used as ligands in membrane for adsorbers, they can be used to reduce membrane fouling as well as for the development of responsive membranes that can change their conformation in response to an external stimulus1,2. Here we focus on magnetically responsive membranes where magnetically responsive polymer chains are grown from the membrane surface. We have developed a range of microfiltration3, ultrafiltration and nanofiltration4,5 membranes by grafting magnetically responsive polymer brushes from the membrane surface. Here we focus on regenerated cellulose based ultrafiltration membranes. Atom transfer radical polymerization (ATRP) has been used to graft poly-hydroxyethyl methacrylate (polyHEMA) from the surface of the membrane. Superparamagnetic particles have been attached to the chain ends. In an oscillating magnetic field, movement of the magnetically responsive nanobrushes leads to suppression of concentration polarization resulting in higher permeate fluxes and better rejection. We have also grafted with poly(N-isopropylacrylamide) a thermo-responsive polymer that exhibits a lower critical solution temperature, using ATRP, from the surface of the membrane. By carefully choosing the frequency of the oscillating magnetic field, movement of the polymer chains can used to induce mixing. Using much higher frequencies, around 1,000 Hz, heating will lead to collapse of poly(N-isopropylacrylamide) layer as the temperature of the grafted polymer layer increase above the lower critical solution temperature of the grafted poly(N-isopropylacrylamide). Unlike nanofiltration and microfiltration membranes where the majority the polymer chains are grafted from the barrier layer or the inside pore surface respectively, in the case of ultrafiltration membranes significant grafting can occur from both the barrier layer and the internal pore surface. In addition given the smaller pore sizes compared to microfiltration membranes, pore plugging by the grafted polymer chains must be avoided We have developed a novel technique to selectively graft from the external barrier layer or the internal membrane pore surface. We show that the magnetically responsive polymer brushes can have a significant different effect on rejection and flux of model feed streams consisting of proteins such as bovine serum albumin, depending on their location on the membrane barrier layer or in the pores. Our work highlights the importance of being able to control not only the three dimensional structure of the grafted polymers but also their location; from the membrane barrier layer or from the inside pore surface References 1. D. Bhattacharyya, T. Schäfer, S. R. Wickramasinghe, S. Daunert, eds., Responsive Membranes and Materials, John Wiley & Sons, 2013, West Sussex, UK. 2. S. Darvishmanesh, , Qian, X., Wickramasinghe, S. R. (2015), ‘Responsive membranes for advanced separations’, Current Opinions in Chemical Engineering, 8, 98-104. 3. H. H. Himstedt, Q. Yang, X. Qian, S. R. Wickramasinghe, M. Ulbricht, M., Toward remote-controlled valve functions via magnetically responsive capillary pore membranes’, J Membr. Sc., 423 (2012) 257-266. 4. Q. Yang, Q., H. H. Himstedt, M. Ulbricht, X. Qian, X., S. R. Wickramasinghe, Designing magnetic field responsive nanofiltration membranes, J Membr. Sc., 430 (2013) 70-78. 5. X. Qian, Yang, Q., Vu, A. T., Wickramasinghe, S. R. (2016), ‘Localized Heat generation from Magnetically Responsive Membranes’, Industrial & Engineering Research, 55 (33), 9015–9027

    Impacts of crop insurance on cash rents

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    This study examines the degree to which net payments from federal crop insurance products impact cash rents paid for farmland. A spatial panel model is employed to control for spatial dependence and heterogeneity in cash rental rates. Results show that producers factor a statistically significant proportion of the value received from crop insurance into cash rents. However, the directly measurable rate is lower than found in previous studies. This result likely reflects the complexity in the relationship between losses and crop insurance rates, and the aggregation across producers in both measured rent and estimates of the net value of crop insurance to a producer. Further, the indirect effects of crop insurance and the ancillary impacts of a producer’s risk profile are difficult to identify independently due to the highly variable nature of crop insurance payments, and the smoothed nature of cash rental values. Nonetheless, even as the model removes much of the variation in the data, this analysis shows crop insurance is an important factor in a producer’s expected revenue, as cash rents are positively affected in counties that receive consistent and positive net value

    APPLICATIONOFSPECTROSCOPIC ELLIPSOMETRY TO IN-STU. REAL-TIME FABRICATION OF MULTIPLE LAYER ALTERNATING HIGH/LOW REFRACTIVE INDEX FILTERS

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    Disclosed is application of oblique angle of incidence, reflection and/or transmission mode spectroscopic ellipsometry PSI and/or DELTA, (including combinations thereof and/or mathematical equivalents), vs. wavelength data to monitor and/or control fabrication of multiple layer high/low refractive index band-pass, band-reject and varied attenuation vs. wavelength filters, either alone or in combination with transmissive non-ellipsometric electromagnetic beam turning point vs. layer data obtained at an essentially normal angle of incidence

    Hidden Consequence of Active Local Lorentz Invariance

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    In this paper we investigate a hidden consequence of the hypothesis that Lagrangians and field equations must be invariant under active local Lorentz transformations. We show that this hypothesis implies in an equivalence between spacetime structures with several curvature and torsion possibilities.Comment: Some misprints appearing in the published version have been correcte
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