Opportunities for Land-based Carbon Sequestration in Slovakia

Land use and land cover change practices contribute to climate change mitigation initiatives by increasing biotic carbon storage, and by producing biomass for bioenergy, as a substitute for fossil fuels. In this paper we examine opportunities in Slovakia for two land use activities, reforestation and short-rotation forest plantation, using four scenarios. In order to evaluate alternative GHG emission reduction policies, of carbon sequestration supply curves were constructed for both activities, for all regions in the country. Our regionally detailed results apply novel modeling approaches involving spatially explicit analyses of land biophysical and economic productivity that are easily applicable to other transition countries. The overall theoretical maximum sequestration potential on agricultural land by reforestation in Slovakia accounts for approximately 10% of national CO2 emissions. More realistic scenarios, focusing on lower quality marginal land have a potential for carbon sequestration of approximately 1.7%-2.4% of total CO2 emissions. In our estimations, potential maximum use of biomass for bio-energy, using all available agricultural land, would be 64% of renewable energy consumption, with reference to average usage during 1997-2002. Realistic potentials of bio-energy generation on lower quality land may cover about 6% of total demand. We conclude by discussing needs to integrate biophysical and economic model estimates of carbon sequestration potential with local and regional information collected through a stakeholder engagement process. Overall, we argue that there is a necessity to embed carbon sequestration activities within regional development plans, and to back up land use and forest policies with adequate economic incentives and public engagement in environmental decisionmaking

The Social Dimensions of Adaptation to Climate Change in Mozambique

The purpose of the Economics of Adaptation to Climate Change (EACC) study is to better understand and estimate the true costs of adapting to climate change in less developed countries. The study is made up of three components. At a global level, there is an analysis of costs across different economic sectors. At a country level, there is an economic component and a social component, taking place in a set of representative case study countries. Mozambique is one of these countries. The economic component of the Mozambique country study has the objective of identifying a set of robust adaptation options for the country, then comparing the direct costs and benefits of those options. To calculate the costs, the team has utilized a computable general equilibrium method. This method is data intensive, it requires a good model of the national economy, but can generate an estimate of the costs of targeted government interventions, in terms of reduced overall economic growth, once those effects have trickled through the labor and capital markets and the economy has returned to equilibrium. The economic team considered a range of adaptation options, which were gathered from the literature and from interactions with national level policy makers and other stakeholders

Immunopathogenesis of canine chronic ulcerative stomatitis.

Canine Chronic Ulcerative Stomatitis is a spontaneously occurring inflammatory disease of the oral mucosa. An immune-mediated pathogenesis is suspected though not yet proven. We have recently reported on the clinical and histologic features, and identification of select leukocyte cell populations within the lesion. A clinical and histologic similarity to oral lichen planus of people was proposed. In the present study, these initial observations are extended by examining lesions from 24 dogs with clinical evidence of chronic ulcerative stomatitis. Because dogs with chronic ulcerative stomatitis often have concurrent periodontal disease, we wondered if dental plaque/biofilm may be a common instigator of inflammation in both lesions. We hypothesized that dogs with chronic ulcerative stomatitis would exhibit a spectrum of pathologic changes and phenotype of infiltrating leukocytes that would inform lesion pathogenesis and that these changes would differ from inflammatory phenotypes in periodontitis. Previously we identified chronic ulcerative stomatitis lesions to be rich in FoxP3+ and IL17+ cells. As such, we suspect that these leukocytes play an important role in lesion pathogenesis. The current study confirms the presence of moderate to large numbers of FoxP3+ T cells and IL17+ cells in all ulcerative stomatitis lesions using confocal immunofluorescence. Interestingly, the majority of IL17+ cells were determined to be non-T cells and IL17+ cell frequencies were negatively correlated with severity on the clinical scoring system. Three histologic subtypes of ulcerative stomatitis were determined; lichenoid, deep stomatitis and granulomatous. Periodontitis lesions, like stomatitis lesions, were B cell and plasma cell rich, but otherwise differed from the stomatitis lesions. Direct immunofluorescence results did not support an autoantibody-mediated autoimmune disease process. This investigation contributes to the body of literature regarding leukocyte involvement in canine idiopathic inflammatory disease pathogenesis

Systematic Review Approach to identifying key trends in adaptation governance at the supranational level

In this paper authors have analyzed peer-reviewed literature on adaptation governance focused on food security at the supranational level. A total of 281 papers were collected, of which 52 met our focus. We used 10 criteria (and 74 sub-criteria) to categorize the included papers. With research presented in these papers as our focus, we looked at key aspects of food security explored, identified types of governance measures and major challenges, and finally developed an understanding of the location of the research teams and involved countries. Overall, we found that the supranational focus in the context of adaptation governance on food security is not prevalent in current peer-reviewed literature—only approximately 16 per cent of the papers focus on this topic. In terms of the identified trends, there was a strong focus on developed countries and research led by teams from these countries; the governance systems aimed to prepare for a range of climate change impacts; and finally, there was limited interest in exploring the role of regional agencies in adaptation governance. In terms of future research needs, there is a strong need to develop processes for the integration of diverse sectors and issues when designing policies on food security in the context of climate change. It is also important to improve the skills and opportunities of research teams in the Global South to engage effectively in research on food security and governance

Climate and southern Africa's water-energy-food nexus

In southern Africa, the connections between climate and the water-energy-food nexus are strong. Physical and socioeconomic exposure to climate is high in many areas and in crucial economic sectors. Spatial interdependence is also high, driven for example, by the regional extent of many climate anomalies and river basins and aquifers that span national boundaries. There is now strong evidence of the effects of individual climate anomalies, but associations between national rainfall and Gross Domestic Product and crop production remain relatively weak. The majority of climate models project decreases in annual precipitation for southern Africa, typically by as much as 20% by the 2080s. Impact models suggest these changes would propagate into reduced water availability and crop yields. Recognition of spatial and sectoral interdependencies should inform policies, institutions and investments for enhancing water, energy and food security. Three key political and economic instruments could be strengthened for this purpose; the Southern African Development Community, the Southern African Power Pool, and trade of agricultural products amounting to significant transfers of embedded water

Treatment of the feline atopic syndrome – a systematic review

Background - Feline allergic skin disease and asthma occur regularly in small animal practice.Objectives - To provide evidence-based recommendations for small animal practitioners on the treatment of feline atopic syndrome (FAS).Materials and Methods - The authors reviewed the literature available prior to February 2020, prepared a detailed evidence-based literature review and made recommendations based on the evaluated evidence.Results - Sixty-six papers and abstracts were identified describing treatment interventions for FAS and evaluated to establish treatment recommendations. For many treatment options, the papers were retrospective, open studies or case reports.Conclusion and clinical relevance - In this review, there was good evidence for efficacy of systemic glucocorticoids and ciclosporin, and limited evidence for efficacy of topical glucocorticoids, oclacitinib and allergen-specific immunotherapy in feline atopic skin syndrome. Evidence pointed to low to moderate efficacy for antihistamines, fatty acids and palmitoyl ethanolamide. In feline asthma, there was good evidence for efficacy of oral and inhaled glucocorticoids, and limited evidence of moderate efficacy for allergen-specific immunotherapy. Evidence supported low to moderate efficacy of mesenchymal stem cells, inhaled lidocaine and oclacitinib as treatments for feline asthma. For almost all therapeutic options (with the exception of glucocorticoids and ciclosporin) more randomised controlled trials are needed

Subnational climate entrepreneurship: innovative climate action in California and São Paulo

The distinct role of subnational governments such as states and provinces in addressing climate change has been increasingly acknowledged. But while most studies investigate the causes and consequences of particular governments’ actions and networking activities, this article argues that subnational governments can develop climate action as a collective entrepreneurial activity. Addressing many elements explored in this special issue, it focuses on the second question and identifies climate entrepreneurship in two subnational governments—the states of California (USA) and São Paulo (Brazil). Examining internal action, as well as interaction with local authorities, national governments and the international regime, entrepreneurial activities are identified in the invention, diffusion and evaluation of subnational climate policy in each case. The article draws from the recent scholarship on policy innovation, entrepreneurship and climate governance. It contributes to the literature by exploring entrepreneurial subnational government activity in addressing climate change and expanding the understanding of the effects of policy innovation at the subnational level

Farmers’ perceptions of climate change : identifying types

Ambitious targets to reduce greenhouse gas (GHG) emissions from agriculture have been set by both national governments and their respective livestock sectors. We hypothesize that farmer self-identity influences their assessment of climate change and their willingness to im- plement measures which address the issue. Perceptions of climate change were determined from 286 beef/sheep farmers and evaluated using principal component analysis (PCA). The analysis elicits two components which evaluate identity (productivism and environmental responsibility), and two components which evaluate behavioral capacity to adopt mitigation and adaptation measures (awareness and risk perception). Subsequent Cluster Analyses reveal four farmer types based on the PCA scores. ‘The Productivist’ and ‘The Countryside Steward’ portray low levels of awareness of climate change, but differ in their motivation to adopt pro-environmental behavior. Conversely, both ‘The Environmentalist’ and ‘The Dejected’ score higher in their awareness of the issue. In addition, ‘The Dejected’ holds a high sense of perceived risk; however, their awareness is not conflated with an explicit understanding of agricultural GHG sources. With the exception of ‘The Environmentalist’, there is an evident disconnect between perceptions of agricultural emission sources and their contribution towards GHG emissions amongst all types. If such linkages are not con- ceptualized, it is unlikely that behavioral capacities will be realized. Effective communication channels which encour- age action should target farmers based on the groupings depicted. Therefore, understanding farmer types through the constructs used in this study can facilitate effective and tai- lored policy development and implementation

Open trial of Brutons tyrosine kinase inhibitor (PRN1008) in the treatment of canine pemphigus foliaceus.

BACKGROUND: Brutons tyrosine kinase (BTK) is important in B-cell signalling. Efficacy has been reported for BTK inhibitors (BTKi) in human autoimmune diseases. Canine pemphigus foliaceus (cPF) is one of the most common canine autoimmune skin diseases. OBJECTIVES: To determine the safety and efficacy of the BTKi PRN1008 in the treatment of cPF. ANIMALS: Four privately owned dogs. METHODS AND MATERIALS: Four dogs diagnosed with PF were administered BTKi PRN1008. Initial dosages approximated to 15 mg/kg once daily, increased to twice daily if inadequate response was seen. Treatment continued for 20 weeks, attempting to decrease to every other day. Dogs were monitored with complete blood counts, serum biochemistry panels and urinalyses, and evaluated with a modified version of a validated human Pemphigus Disease Activity Index (cPDAI). Serum anti-desmocollin-1 (DSC-1) and desmoglein-1 (DSG-1) immunoglobulin (Ig)G titres were performed before and after the treatment period. Drug bound to target was measured in peripheral blood mononuclear cells (PBMC). RESULTS: All four dogs showed reduction in lesions and cPDAI score during the first two weeks of treatment. Three dogs continued to improve and sustained near complete remission by 20 weeks, at which point three responses were considered good and one fair. Final daily dosages were in the range 17-33 mg/kg. Anti-DSC-1 IgG titre decreased dramatically in one dog, was undetectable in two and was uninterpretable in one dog. No dogs had detectable IgG to DSG1. A possible adverse event occurred in one dog. CONCLUSIONS AND CLINICAL IMPORTANCE: BTKi PRN1008 monotherapy may have some beneficial effects in some cases of cPF