On the practicality of group dynamic assessment: A seminal enterprise deserving closer scrutiny

This is the final version of the article. Available from the publisher via the DOI in this record.This paper is a preliminary study designed to scrutinize the way Group Dynamic Assessment (G-DA), suggested by Poehner (2009), has been implemented in L2 classrooms regarding its basic premise: moving the group forward in its ZPD while benefiting individuals as well. Since the one-to-one interaction that characterizes DA framework represents an unrealistic model for classroom teachers who must manage classes of 15 to 30 learners, Poehner (2009) suggests the use of DA with groups of L2 learners rather than individuals and offers examples of two approaches to G-DA: concurrent and cumulative. However, the development of group ZPD cannot be easily traced in the presented approaches, and the process of shifting the activity from the individual to the group is not clarified either. To present a more realistic model of G-DA, this paper suggests the application of small group DA to L2 classrooms. To this end, it has initially delved into the concepts of 'group learning', 'group ZPD', and 'group DA'. Next, the areas of ambiguity in the two suggested approaches to G-DA have been identified. Finally, a less complicated model of classroom DA, namely small group DA is presented

Sonic Hedgehog Signaling and Development of the Dentition

Sonic hedgehog (Shh) is an essential signaling peptide required for normal embryonic development. It represents a highly-conserved marker of odontogenesis amongst the toothed vertebrates. Signal transduction is involved in early specification of the tooth-forming epithelium in the oral cavity, and, ultimately, in defining tooth number within the established dentition. Shh also promotes the morphogenetic movement of epithelial cells in the early tooth bud, and influences cell cycle regulation, morphogenesis, and differentiation in the tooth germ. More recently, Shh has been identified as a stem cell regulator in the continuously erupting incisors of mice. Here, we review contemporary data relating to the role of Shh in odontogenesis, focusing on tooth development in mammals and cartilaginous fishes. We also describe the multiple actions of this signaling protein at the cellular level

A survey on peroxide content and acidity level of persian doughnuts in lorestan province, West of Iran

There are different chemical food contaminations that cause detrimental effects on human health. For example, presence of peroxide in fried foods causes free radical formation. Free radicals are not only responsible for food spoilage, but also cause damage to body tissues and cancer, inflammatory diseases, atherosclerosis, aging and so on. The aim of this study was to evaluate the peroxide content and acidity level in Zoolbia and Bamiehin of Lorestan province, West of Iran. 120 samples of Zoolbia and Bamieh doughnuts were purchased of Lorestan province distribution centers, during March 2014 to March 2015 and handled to Laboratory for chemical analysis and determination of their peroxide value and acidity. Present descriptive study results showed 56.92 and 43.07 % of the samples were out of standard limit and not suitable for consumption due to high levels of peroxides and acidity, respectively. The lowest and highest peroxide value were 1.1 and 2.9 mEq/kg, respectively. The minimum and maximum acidity of the samples were 0.7 and 2.9 wt%, respectively. Obtained results showed high peroxide contents in Persian doughnuts in Lorestan province than standard limit. Therefore, it seems educational programs about nutrition and using proper method for cooking and frying of foods is necessary. Continuous planning and surveillance, providing practical solutions by health authorities and regulatory organs, training of food staffs, using oils a few times and especial for food frying are recommended to reduce the peroxide content in Persian doughnuts (Zoolbia and Bamieh)

Demand Response Based Model for Optimal Decision Making for Distribution Networks

In this paper, a heuristic mathematical model for optimal decision-making of a Distribution Company (DisCo) is proposed that employs demand response (DR) programs in order to participate in a day-ahead market, taking into account elastic and inelastic load models. The proposed model is an extended responsive load modeling that is based on price elasticity and customers’ incentives in which they participate in demand response program, voluntarily and would be paid according to their declared load curtailment amounts. It is supposed that DisCo has the ability to trade with the wholesale market and it can also use its own distributed generation (DG), while decision making process. In this regard, at first, DisCo’s optimization frameworks in two cases, with and without elastic load modelings are acquired. Subsequently, utilizing Hessian matrix and mathematical optimality conditions, optimal aggregated load curtailment amounts are obtained and accordingly, individual customer’s load reductions are calculated. Furthermore, effects of DG contributions and wholesale electricity market are investigated. An IEEE 18 bus test system is employed to obtain the results and show the accuracy of the proposed model

Gendered Representations of Male and Female Social Actors in Iranian Educational Materials

This research investigates the representations of gendered social actors within the subversionary discourse of equal educational opportunities for males and females in Iranian English as a Foreign Language (EFL) books. Using critical discourse analysis (CDA) as the theoretical framework, the authors blend van Leeuwen’s (Texts and practices: Readings in critical discourse analysis, Routledge, London, 2003) ‘Social Actor Network Model’ and Sunderland’s (Gendered discourses, Palgrave Macmillan, Hampshire, 2004) ‘Gendered Discourses Model’ in order to examine the depictions of male and female social actors within this gendered discourse. The gendered discourse of equal opportunities was buttressed by such representations within a tight perspective in proportion to gender ideologies prevailing in Iran. Resorting to CDA, we can claim that resistance against such gendered discourse in Iranian EFL textbooks militates against such gender norms. These representations of male and female social actors in school books are indicative of an all-encompassing education, reinforcing that the discourse of equal opportunities is yet to be realized in the education system of Iran

Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction.

BackgroundChronic Lung Allograft Dysfunction (CLAD) is the main limitation to long-term survival after lung transplantation. Although CLAD is usually not responsive to treatment, earlier identification may improve treatment prospects.MethodsIn a nested case control study, 1-year post transplant surveillance bronchoalveolar lavage (BAL) fluid samples were obtained from incipient CLAD (n = 9) and CLAD free (n = 8) lung transplant recipients. Incipient CLAD cases were diagnosed with CLAD within 2 years, while controls were free from CLAD for at least 4 years following bronchoscopy. Transcription profiles in the BAL cell pellets were assayed with the HG-U133 Plus 2.0 microarray (Affymetrix). Differential gene expression analysis, based on an absolute fold change (incipient CLAD vs no CLAD) >2.0 and an unadjusted p-value ≤0.05, generated a candidate list containing 55 differentially expressed probe sets (51 up-regulated, 4 down-regulated).ResultsThe cell pellets in incipient CLAD cases were skewed toward immune response pathways, dominated by genes related to recruitment, retention, activation and proliferation of cytotoxic lymphocytes (CD8+ T-cells and natural killer cells). Both hierarchical clustering and a supervised machine learning tool were able to correctly categorize most samples (82.3% and 94.1% respectively) into incipient CLAD and CLAD-free categories.ConclusionsThese findings suggest that a pathobiology, similar to AR, precedes a clinical diagnosis of CLAD. A larger prospective investigation of the BAL cell pellet transcriptome as a biomarker for CLAD risk stratification is warranted

Comparison of anthro-metabolic indicators for predicting the risk of metabolic syndrome in the elderly population: Bushehr Elderly Health (BEH) program

Background Metabolic syndrome (MetS) is a cluster metabolic disorder that includes central obesity, insulin resistance, hypertension, and dyslipidemia, and is highly associated with an increased risk of developing non-communicable diseases (NCDs). This study aimed to compare the reliability of anthro-metabolic indices [visceral adiposity index (VAI), body roundness index (BRI), and a body shape index (BSI), body adiposity index (BAI), lipid accumulation product (LAP), waist to hip ratio, and waist to height ratio] in predicting MetS in Iranian older people. Methods This cross-sectional study was conducted based on the data of 2426 adults aged ≥60 years that participated in the second stage of the Bushehr Elderly Health (BEH) program, a population-based prospective cohort study being conducted in Bushehr, Iran. MetS was defined based on the revised National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria. The receiver operating characteristic (ROC) curve analysis was used to assess predictive performance of anthro-metabolic indices and determine optimal cutoff values. Logistic regression analysis was applied to determine the associations between MetS and indices. Results 2426 subjects (48.1% men) with mean ± SD age of 69.34 ± 6.40 years were included in the study. According to ATP III criteria, 34.8% of men and 65.2% of women had MetS (P < 0.001). Of the seven examined indices, the AUCs of VAI and LAP in both genders were higher than AUCs of other anthro-metabolic indices. Also, in general population, VAI and LAP had the greatest predictive power for MetS with AUC 0.87(0.86–0.89) and 0.87(0.85–0.88), respectively. The lowest AUC in total population belonged to BSI with the area under the curve of 0.60(0.58–0.62). After adjusting for potential confounders (e.g. age, sex, education, physical activity, current smoking) in the logistic regression model, the highest OR in the total population was observed for VAI and LAP, which was 16.63 (13.31–20.79) and 12.56 (10.23–15.43) respectively. The lowest OR for MetS was 1.93(1.61–2.30) for BSI. Conclusion This study indicated that both VAI and LAP are the most valuable indices among the anthro-metabolic indices to identify MetS among the elderly in both genders. So, they could be used as proper assessment tools for MetS in clinical practice. However, the cost-benefit of these indices compared to the ATP III criteria need further studies

Biallelic loss of LDB3 leads to a lethal pediatric dilated cardiomyopathy

Autosomal dominant variants in LDB3 (also known as ZASP), encoding the PDZ-LIM domain-binding factor, have been linked to a late onset phenotype of cardiomyopathy and myofibrillar myopathy in humans. However, despite knockout mice displaying a much more severe phenotype with premature death, bi-allelic variants in LDB3 have not yet been reported. Here we identify biallelic loss-of-function variants in five unrelated cardiomyopathy families by next-generation sequencing. In the first family, we identified compound heterozygous LOF variants in LDB3 in a fetus with bilateral talipes and mild left cardiac ventricular enlargement. Ultra-structural examination revealed highly irregular Z-disc formation, and RNA analysis demonstrated little/no expression of LDB3 protein with a functional C-terminal LIM domain in muscle tissue from the affected fetus. In a second family, a homozygous LDB3 nonsense variant was identified in a young girl with severe early-onset dilated cardiomyopathy with left ventricular non-compaction; the same homozygous nonsense variant was identified in a third unrelated female infant with dilated cardiomyopathy. We further identified homozygous LDB3 frameshift variants in two unrelated probands diagnosed with cardiomegaly and severely reduced left ventricular ejection fraction. Our findings demonstrate that recessive LDB3 variants can lead to an early-onset severe human phenotype of cardiomyopathy and myopathy, reminiscent of the knockout mouse phenotype, and supporting a loss of function mechanism