Development of an Enzyme Linked Immunosorbent Assay Capable of Detecting Antibodies Specific to the Cytomegalovirus

The cytomegalovirus (CMV) is capable of causing serious illness and death in immunocompromised individuals. The objective of this research is to develop a method of detecting antibodies against CMV. This has lead to the development of an Enzyme linked Immunosorbent Assay (ELISA) that is capable of detecting CMV or anti-CMV antibodies. The process in the development of such an assay involves; 1) the purification of Hyperimmune Rabbit Serum containing anti-CMV antibodies, 2) determination of the appropriate concentrations necessary to provide a clear and concise response to the test, and 3) testing of monoclonal antibodies to determine their specificity towards the cytomegalovirus

Free-Roaming Cat Abundance Across a Habitat Gradient

There are an estimated 172 million owned and feral cats in the United States, and wildlife enthusiasts and cat owners are often at odds over how best to manage free-roaming cats. Management is needed because of the documented impacts of free-ranging cats on wildlife. Targeting these management efforts, however, is hampered by an imperfect understanding of cat distribution in the landscape. My study used game cameras and capture-recapture sampling to estimate abundance of free-roaming cats across a habitat gradient in Bulloch County, Georgia, USA. In all, I detected cats at 51% (25/49) sites with a mean of 2.1 cats per site. Cat abundance was significantly related to percentage of forest, distance to buildings, and density of buildings. Ultimately, density of buildings was the single best predictor of free-ranging cat abundance. With free-roaming cats having a significant, positive relationship with density of human buildings as determined by this study, it can be concluded that the free-roaming cat population of Bulloch County can be predicted to be found mostly in urbanized zones. As urbanization increases, current management strategies must be revised based on this data to target areas with high structural density to mitigate free-roaming cat impacts and hasten the removal of the species from the environment

The effect of grape interventions on cognitive and mental performance in healthy participants and those with mild cognitive impairment : a systematic review of randomized controlled trials

Funding: We are grateful to the Scottish Government Rural and Environment Science and Analytical Services (RESAS) and the University of Aberdeen for funding.Peer reviewedPublisher PD

Passenger casualties in non-collision incidents on buses and coaches in Great Britain

Of all the killed or seriously injured (KSI) passengers on buses or coaches in Great Britain, a surprisingly high proportion, 64.3%, are injured in non-collision incidents. A KSI casualty distribution of this sub-sample identifies that 74.2% of the casualties are female and a large proportion, 58.0%, are elderly casualties 60 years of age or over

Empathic brain responses in insula are modulated by levels of alexithymia but not autism

Difficulties in social cognition are well recognized in individuals with autism spectrum conditions (henceforth ‘autism'). Here we focus on one crucial aspect of social cognition: the ability to empathize with the feelings of another. In contrast to theory of mind, a capacity that has often been observed to be impaired in individuals with autism, much less is known about the capacity of individuals with autism for affect sharing. Based on previous data suggesting that empathy deficits in autism are a function of interoceptive deficits related to alexithymia, we aimed to investigate empathic brain responses in autistic and control participants with high and low degrees of alexithymia. Using functional magnetic resonance imaging, we measured empathic brain responses with an ‘empathy for pain' paradigm assessing empathic brain responses in a real-life social setting that does not rely on attention to, or recognition of, facial affect cues. Confirming previous findings, empathic brain responses to the suffering of others were associated with increased activation in left anterior insula and the strength of this signal was predictive of the degree of alexithymia in both autistic and control groups but did not vary as a function of group. Importantly, there was no difference in the degree of empathy between autistic and control groups after accounting for alexithymia. These findings suggest that empathy deficits observed in autism may be due to the large comorbidity between alexithymic traits and autism, rather than representing a necessary feature of the social impairments in autis

Adding Another Dimension to Small Satellite Constellations

Satellite constellations for Earth Observation almost invariably use duplicates of the same satellites to provide higher temporal resolution or greater coverage. The value of Big Data applications often depend on the fusing of different sensor information. If instead constellation satellites are equipped with a variety of sensors, these can be configured to provide more complex data products. Flexibility and in orbit rearrangement can create a range of systems that can be configured on-demand to address a range of new applications. Small satellites and sensor capability have only recently advanced far enough to make such a systems financially viable. Key challenges in such systems are optimising the composition of the constellation with different sensors or capabilities in addressing different applications, and developing methods for fusing non-contemporaneous information to build capabilities that can only be achieved through a distributed system

EQAL to the task: stakeholder responses to a university-wide transformation project

This qualitative case study examines a university change initiative that was unprecedented in pace, scope and scale for the institution concerned: a post-92 UK university. Project documentation, interview and survey data are analysed to present an account of the context, content and process of change; an account that highlights different stakeholder perspectives and offers lessons learned

The low redshift Lyman-α\alpha Forest as a constraint for models of AGN feedback

We study the low redshift Lyman-$\alpha$ Forest in the Illustris and IllustrisTNG (TNG) cosmological simulations to demonstrate their utility in constraining aspects of sub-grid models of feedback from active galactic nuclei (AGN). The two simulations share an identical Ultraviolet Background prescription and similar cosmological parameters, but TNG features an entirely reworked AGN feedback model. Therefore a comparison of these simulations is useful to assess the effects of an altered AGN sub-grid model on the low redshift Lyman-$\alpha$ Forest. We find significant differences in the IGM temperature-density relation between the two simulations due to changes in the gas heating rate due to AGN. We investigate Lyman-$\alpha$ Forest observables such as the column density distribution function, flux PDF, and Doppler width ($b$-parameter) distribution. Due to the AGN radio mode model, the original Illustris simulations have a factor of 2-3 fewer absorbers than TNG at column densities $N_{\rm HI}< 10^{15.5}$ cm$^{-2}$. We show that TNG is in much better agreement with the observed $z=0.1$ flux power spectrum than Illustris. The differences in the amplitude and shape of the flux PDF and power spectrum between Illustris and TNG cannot be attributed to simple changes in the photoheating rate. We also compare the simulated Forest statistics to UV data from the Cosmic Origins Spectrograph (COS) and find that neither simulation can reproduce the slope of the absorber distribution. Both Illustris and TNG also produce significantly smaller $b$-parameter distributions than observed in the COS data, possibly due to unresolved or missing sources of turbulence.Comment: Submitted to ApJL, comments welcom

Health in All Policies: Working Across Sectors in Cooperative Extension to Promote Health for All

A Health in All Policies approach engages cross-sector stakeholders to collaboratively improve systems that drive population health. We, the members of the Extension Committee on Organization and Policy (ECOP)’s Health in All Policies Action Team, propose that adopting a Health in All Policies approach within the national Cooperative Extension System will better prepare us to contribute meaningfully to improving the nation’s health. We first explain the Health in All Policies approach and argue for why and how it is relevant for Extension. We then present insights gathered from Extension Family and Consumer Sciences program leaders and state specialists to assess whether national and state leadership are poised to adopt a Health in All Policies approach within their affiliated programs. Although participant leaders saw the value of the approach in contributing to population health improvement, they generally saw the Extension system as having lower levels of readiness to adopt such an approach. Six themes emerged as ways to increase Extension’s engagement in Health in All Policies: a paradigm shift within Extension, professional development of competencies, transformational leaders and leadership support, continued and new partnerships, information access for all levels and disciplines of Extension