Attitudes to Three Weight Maintenance Strategies:A Qualitative Study

Weight loss maintenance can be difficult and ultimately unsuccessful, due to psychological, behavioural, social, and physiological influences. The present study investigated three strategies with the potential to improve weight maintenance success: daily weighing, missing an occasional meal, habitually changing high energy foods. The principal aim was to gain an understanding of attitudes to these strategies in participants who had recent experience of weight loss attempts, with or without maintenance. This was a qualitative study involving semi-structured interviews, with 20 participants aged 18–67 (twelve females), analysed using thematic analysis. Most participants disliked daily weighing and missing an occasional meal for long-term maintenance and were concerned about potential negative effects on mental health. All participants had experience of habitual changes to high energy foods and regarded this strategy as obvious and straightforward. Replacement of high energy foods was favoured over elimination. Participants preferred strategies that felt flexible, “normal” and intuitive and disliked those that were thought to have a negative impact on mental health. Further investigation is needed on whether concerns regarding mental health are well founded and, if not, how the strategies can be made more acceptable and useful

Landownership and settlement change in south-west Cheshire from 1750 to 2000

This work analyses the impact of landownership on the physical development and other factors affecting settlements in south-west Cheshire between 1750 and 2000, seeking to demonstrate the hypothesis that landownership was the overriding influence on settlement growth or decline. To assist in this the work also addresses the related problem of how most accurately to analyse landownership in townships. It therefore presents an original methodology using the Herfmdahl-Hirschman Index (HHI) in an historical context to determine the amount of landowner concentration in a township. The use of HHI as a measure of landownership concentration (indicating the extent of large landowner control) is presented as a more accurate, easy to use, quantifiable method of analysis than the traditional distinction between 'open' and 'closed'. Following a demonstration of HHI's superiority over the traditional terms using examples in south-west Cheshire, HHI is used to analyse the effect on settlement development of landownership trends in the area. HHI is then used to analyse the effect of dominant landowners on the main population trends, transport infrastructure, farming, enclosure and twentieth-century planning and legislation in relation to settlement development in the area. HHI supports the main conclusion that decisions made by large landowners and subsequently planners in south-west Cheshire had a continuous and profound effect on settlement patterns and development from the mid-eighteenth century up to the end of the twentieth century. The intervention and influence of the major landowners and twentieth-century planners hindered settlement growth. Landowners had both a direct influence on settlement development through the buying and selling of land and an indirect influence through their role in determining the transport infrastructure and their bequest of a prevailing pattern of land use, which in turn was preserved via modern planning decisions. Following the decline of major landowners during the early twentieth century, planning laws restricted building in agricultural areas with the aim of preserving agricultural land. Analysis of land tax records in conjunction with HHI shows that although landownership consolidation took place, the number of smaller landowners was maintained and even increased in places and such building as took place was focussed on the increasing number of smaller plots. HHI also demonstrates the discernible trend that in south-west Cheshire the settlements that were the larger, more open settlements of the eighteenth and nineteenth centuries were those that increased in size both physically and in terms of population throughout the period while the smaller closed settlements tended to stagnate or decline. Overall the research has demonstrated that settlements flourished in low HHI townships with less control by large landowners, that settlements in high HHI townships were rarely allowed to grow, and that patterns established in the eighteenth and nineteenth centuries were perpetuated into the late twentieth and early twenty-first century by a conservative approach to planning.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Palaeogeography and voyage modeling indicates early human colonization of Australia was likely from Timor-Roti

Anatomically Modern Humans (AMHs) dispersed rapidly through island southeast Asia (Sunda and Wallacea) and into Sahul (Australia, New Guinea and the Aru Islands), before 50,000 years ago. Multiple routes have been proposed for this dispersal and all involve at least one multi-day maritime voyage approaching 100 km. Here we use new regional-scale bathymetry data, palaeoenvironmental reconstruction, an assessment of vertical land movements and drift modeling to assess the potential for an initial entry into northwest Australia from southern Wallacea (Timor-Roti). From ∼70,000 until ∼10,000 years ago, a chain of habitable, resource-rich islands were emergent off the coast of northwest Australia (now mostly submerged). These were visible from high points close to the coast on Timor-Roti and as close as 87 km. Drift models suggest the probability of accidental arrival on these islands from Timor-Roti was low at any time. However, purposeful voyages in the summer monsoon season were very likely to be successful over 4–7 days. Genomic data suggests the colonizing population size was >72–100 individuals, thereby indicating deliberate colonization. This is arguably the most dramatic early demonstration of the advanced cognitive abilities and technological capabilities of AMHs, but one that could leave little material imprint in the archaeological record beyond the evidence that colonization occurred

Current-carrying cosmic string loops 3D simulation: towards a reduction of the vorton excess problem

The dynamical evolution of superconducting cosmic string loops with specific equations of state describing timelike and spacelike currents is studied numerically. This analysis extends previous work in two directions: first it shows results coming from a fully three dimensional simulation (as opposed to the two dimensional case already studied), and it now includes fermionic as well as bosonic currents. We confirm that in the case of bosonic currents, shocks are formed in the magnetic regime and kinks in the electric regime. For a loop endowed with a fermionic current with zero-mode carriers, we show that only kinks form along the string worldsheet, therefore making these loops slightly more stable against charge carrier radiation, the likely outcome of either shocks or kinks. All these combined effects tend to reduce the number density of stable loops and contribute to ease the vorton excess problem. As a bonus, these effects also may provide new ways of producing high energy cosmic rays.Comment: 11 pages, RevTeX 4 format, 8 figures, submitted to PR

In vitro rooting of regenerants of blue poplar

The article presents the research results of the influence of hormonal composition of the culture medium and cultivation duration on regenerants of Populus pruinosa at the stage of rooting in vitro. 98,3±1,7 % of regenerants rooted on MS culture medium with 1,0 mg L−1 IMА during 8 weeks of cultivation.Приведены результаты исследований влияния гормонального состава питательной среды и длительности культивирования на растения-регенеранты тополя сизолистного на этапе укоренения in vitro; 98,3±1,7 % регенерантов укоренялись на питательной среде МС, дополненной 1,0 мг/л ИМК, в течение 8 недель культивирования

Alpha-fetoprotein detection of hepatocellular carcinoma leads to a standardized analysis of dynamic AFP to improve screening based detection

Detection of hepatocellular carcinoma (HCC) through screening can improve outcomes. However, HCC surveillance remains costly, cumbersome and suboptimal. We tested whether and how serum Alpha-Fetoprotein (AFP) should be used in HCC surveillance. Record linkage, dedicated pathways for management and AFP data-storage identified i) consecutive highly characterised cases of HCC diagnosed in 2009-14 and ii) a cohort of ongoing HCC-free patients undergoing regular HCC surveillance from 2009. These two well-defined Scottish patient cohorts enabled us to test the utility of AFP surveillance. Of 04 cases of HCC diagnosed over 6 years, 42% (129) were identified by a dedicated HCC surveillance programme. Of these 129, 47% (61) had a detectable lesion first identified by screening ultrasound (US) but 38% (49) were prompted by elevated AFP. Despite pre-HCC diagnosis AFP >20kU/L being associated with poor outcome, 'AFP-detected' tumours were offered potentially curative management as frequently as 'US-detected' HCCs; and had comparable survival. Linearity of serial log10 -transformed AFPs in HCC cases and in the screening 'HCC-free' cohort (n = 1509) provided indicators of high-risk AFP behaviour in HCC cases. An algorithm was devised in static mode, then tested dynamically. A case/control series in hepatitis C related disease demonstrated highly significant detection (p-5) of patients at high risk of developing HCC. These data support the use of AFP in HCC surveillance. We show proof-of-principle that an automated and further refineable algorithmic interpretation of AFP can identify patients at higher risk of HCC. This approach could provide a cost-effective, user-friendly and much needed addition to US surveillance

Correlation between Compact Radio Quasars and Ultra-High Energy Cosmic Rays

Some proposals to account for the highest energy cosmic rays predict that they should point to their sources. We study the five highest energy events (E>10^20 eV) and find they are all aligned with compact, radio-loud quasars. The probability that these alignments are coincidental is 0.005, given the accuracy of the position measurements and the rarity of such sources. The source quasars have redshifts between 0.3 and 2.2. If the correlation pointed out here is confirmed by further data, the primary must be a new hadron or one produced by a novel mechanism.Comment: 8 pages, 3 tables, revtex. with some versions of latex it's necessary to break out the tables and latex them separately using article.sty rather than revtex.st

HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES1 Is Required for Circadian Periodicity through the Promotion of Nucleo-Cytoplasmic mRNA Export in Arabidopsis.

notes: PMCID: PMC3875725This is an open access article that is freely available in ORE or from the publisher's web site. Please cite the published version. © 2013 American Society of Plant Biologists. All rights reserved.Cold acclimation has been shown to be attenuated by the degradation of the INDUCER OF CBF EXPRESSION1 protein by the E3 ubiquitin ligase HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES1 (HOS1). However, recent work has suggested that HOS1 may have a wider range of roles in plants than previously appreciated. Here, we show that hos1 mutants are affected in circadian clock function, exhibiting a long-period phenotype in a wide range of temperature and light environments. We demonstrate that hos1 mutants accumulate polyadenylated mRNA in the nucleus and that the circadian defect in hos1 is shared by multiple mutants with aberrant mRNA export, but not in a mutant attenuated in nucleo-cytoplasmic transport of microRNAs. As revealed by RNA sequencing, hos1 exhibits gross changes to the transcriptome with genes in multiple functional categories being affected. In addition, we show that hos1 and other previously described mutants with altered mRNA export affect cold signaling in a similar manner. Our data support a model in which altered mRNA export is important for the manifestation of hos1 circadian clock defects and suggest that HOS1 may indirectly affect cold signaling through disruption of the circadian clock.Biotechnology and Biological Science Research Counci