Atomic Force Microscope

The scanning tunneling microscope is proposed as a method to measure forces as small as 10−18 N. As one application for this concept, we introduce a new type of microscope capable of investigating surfaces of insulators on an atomic scale. The atomic force microscope is a combination of the principles of the scanning tunneling microscope and the stylus profilometer. It incorporates a probe that does not damage the surface. Our preliminary results in air demonstrate a lateral resolution of 30 ÅA and a vertical resolution less than 1 Å

INCMap: A Journey towards ontology-based data integration

Ontology-based data integration (OBDI) allows users to federate over heterogeneous data sources using a semantic rich conceptual data model. An important challenge in ODBI is the curation of mappings between the data sources and the global ontology. In the last years, we have built IncMap, a system to semi-automatically create mappings between relational data sources and a global ontology. IncMap has since been put into practice, both for academic and in industrial applications. Based on the experience of the last years, we have extended the original version of IncMap in several dimensions to enhance the mapping quality: (1) IncMap can detect and leverage semantic-rich patterns in the relational data sources such as inheritance for the mapping creation. (2) IncMap is able to leverage reasoning rules in the ontology to overcome structural differences from the relational data sources. (3) IncMap now includes a fully automatic mode that is often necessary to bootstrap mappings for a new data source. Our experimental evaluation shows that the new version of IncMap outperforms its previous version as well as other state-of-the-art systems

X-Ray Computed Tomography: Semiautomated Volumetric Analysis of Late-Stage Lung Tumors as a Basis for Response Assessments

Background. This study presents a semiautomated approach for volumetric analysis of lung tumors and evaluates the feasibility of using volumes as an alternative to line lengths as a basis for response evaluation criteria in solid tumors (RECIST). The overall goal for the implementation was to accurately, precisely, and efficiently enable the analyses of lesions in the lung under the guidance of an operator. Methods. An anthropomorphic phantom with embedded model masses and 71 time points in 10 clinical cases with advanced lung cancer was analyzed using a semi-automated workflow. The implementation was done using the Cognition Network Technology. Results. Analysis of the phantom showed an average accuracy of 97%. The analyses of the clinical cases showed both intra- and interreader variabilities of approximately 5% on average with an upper 95% confidence interval of 14% and 19%, respectively. Compared to line lengths, the use of volumes clearly shows enhanced sensitivity with respect to determining response to therapy. Conclusions. It is feasible to perform volumetric analysis efficiently with high accuracy and low variability, even in patients with late-stage cancer who have complex lesions

Carbon fibre tips for scanning probe microscopy based on quartz tuning fork force sensors

We report the fabrication and the characterization of carbon fibre tips for their use in combined scanning tunnelling and force microscopy based on piezoelectric quartz tuning fork force sensors. We find that the use of carbon fibre tips results in a minimum impact on the dynamics of quartz tuning fork force sensors yielding a high quality factor and consequently a high force gradient sensitivity. This high force sensitivity in combination with high electrical conductivity and oxidation resistance of carbon fibre tips make them very convenient for combined and simultaneous scanning tunnelling microscopy and atomic force microscopy measurements. Interestingly, these tips are quite robust against occasionally occurring tip crashes. An electrochemical fabrication procedure to etch the tips is presented that produces a sub-100 nm apex radius in a reproducible way which can yield high resolution images.Comment: 14 pages, 10 figure

Phase imaging with intermodulation atomic force microscopy

Intermodulation atomic force microscopy (IMAFM) is a dynamic mode of atomic force microscopy (AFM) with two-tone excitation. The oscillating AFM cantilever in close proximity to a surface experiences the nonlinear tip-sample force which mixes the drive tones and generates new frequency components in the cantilever response known as intermodulation products (IMPs). We present a procedure for extracting the phase at each IMP and demonstrate phase images made by recording this phase while scanning. Amplitude and phase images at intermodulation frequencies exhibit enhanced topographic and material contrast.Comment: 6 pages, 6 page

Quantum shot-noise at local tunneling contacts on mesoscopic multiprobe conductors

New experiments that measure the low-frequency shot-noise spectrum at local tunneling contacts on mesoscopic structures are proposed. The current fluctuation spectrum at a single tunneling tip is determined by local partial densities of states. The current-correlation spectrum between two tunneling tips is sensitive to non-diagonal density of states elements which are expressed in terms of products of scattering states of the conductor. Thus such an experiment permits to investigate correlations of electronic wave functions. We present specific results for a clean wire with a single barrier and for metallic diffusive conductors.Comment: 4 pages REVTeX, 2 figure

Dynamic image potential at an Al(111) surface

We evaluate the electronic self-energy Sigma(E) at an Al(111) surface using the GW space-time method. This self-energy automatically includes the image potential V-im not present in any local-density approximation for exchange and correlation. We solve the energy-dependent quasiparticle equations and calculate the effective local potential experienced by electrons in the near-surface region. The relative contribution of exchange proves to be very different for states above the Fermi level. The image-plane position for interacting electrons is closer to the surface than for the purely electrostatic effects felt by test charges, and, like its classical counterpart, is drawn inwards by the effects of atomic structure

Atomic Scale Sliding and Rolling of Carbon Nanotubes

A carbon nanotube is an ideal object for understanding the atomic scale aspects of interface interaction and friction. Using molecular statics and dynamics methods different types of motion of nanotubes on a graphite surface are investigated. We found that each nanotube has unique equilibrium orientations with sharp potential energy minima. This leads to atomic scale locking of the nanotube. The effective contact area and the total interaction energy scale with the square root of the radius. Sliding and rolling of nanotubes have different characters. The potential energy barriers for sliding nanotubes are higher than that for perfect rolling. When the nanotube is pushed, we observe a combination of atomic scale spinning and sliding motion. The result is rolling with the friction force comparable to sliding.Comment: 4 pages (two column) 6 figures - one ep

Theoretical Study of Friction: A Case of One-Dimensional Clean Surfaces

A new method has been proposed to evaluate the frictional force in the stationary state. This method is applied to the 1-dimensional model of clean surfaces. The kinetic frictional force is seen to depend on velocity in general, but the dependence becomes weaker as the maximum static frictional force increases and in the limiting case the kinetic friction gets only weakly dependent on velocity as described by one of the laws of friction. It is also shown that there is a phase transition between state with vanishing maximum static frictional force and that with finite one. The role of randomness at the interface and the relation to the impurity pinning of the sliding Charge-Density-Wave are discussed. to appear in Phys.Rev.B. abstract only. Full text is available upon request. E-mail: [email protected]: 2 pages, Plain TEX, OUCMT-94-

Investigation of Living Cells in the Nanometer Regime with the Scanning Force Microscope

Membrane structures of different types of cells are imaged in the nanometer regime by scanning force microscopy (SFM). The images are compared to those obtained with a scanning electron microscope (SEM). The SFM imaging can be done on the outer cell membrane under conditions that keep the cells alive in aqueous solutions. This opens up the possibility of observing the kinematics of the structures that determine the interaction of a cell with its environment. Therefore, STM observations, together with information obtained with the electron microscope, open up new ways of studying the development of biological structures. With the currently possible resolution, the SFM gives access to processes such as antibody binding or endo- and exocytosis, including processes correlated to the infection of cells by viruses