Design and hardware implementation of a cooperative communication system

Multiple Input, Multiple Output (MIMO) antenna systems have been widely studied. They play a key role in the next generation communication systems because of their capability to provide an extremely high capacity. However, the cost of using a large number of antennas should be considered when MIMO is put into practice. In order to reduce the cost of devices, there is another method called cooperative communication. In a cooperative communication system, each single antenna (node) shares its information with its nearby antennas (nodes), and then those antennas transmit together their data towards the destination, therefore, they generate a virtual MIMO system. In this thesis, we present a new framework, which is a combination of the detect-forward cooperative method, channel coding, and space time coding methods. We assume that the cooperative system includes an inter-user channel (between nodes) and an uplink channel (from the nodes to the destination) that are subject to independently distributed, slowly-varying and flat Rayleigh fading. Due to the fact that the inter-user channel is less noisy than the uplink channel, we apply the 16 QAM modulation in the inter-user channel in order to acquire higher data rate. In the uplink channel, one user and its collaborator send bits together to the destination. Therefore, Alamouti space time code can be used. To obtain a better performance and keep the same bandwidth, we utilize a Rate-compatible punctured convolutional code (RCPC). Simulation shows that improved performance can be achieved compared with that of a non-cooperative system. Based on this new system scheme, we implement the uplink receiver, which consists of a pair of parallel Square Root Raise Cosine (SRRC) filters, the Alamouti decoder, and the Viterbi decoder for decoding of the RCPC codes. In order to save the area, a parallel sequence of Alamouti decoder is controlled by the Moore state machine; a simplified method of the Branch Metric Unit (BMU) is introduced; the in-place scheduling is used in the Path Metric Unit (PMU). The design is modeled in Very high speed integrated circuit Hardware Description Language (VHDL) and synthesized on a single chip FPGA (Xilinx Virtex 2 Pro). According to the RTL level and the gate level simulation results, the receiver can work at a speed of 12 Mbps with Virtex 2 pro FPG

Modelling and finite element simulation for FDSC multi-point forming based on ABAQUS

This paper introduces the modeling and FEM simulation of FDSC Multi-Point Forming based on ABAQUS. Python is used as programming languages to secondary develop the software and to establish a simulation platform. An additional module was developed for the automatic modeling with the functions of: (a) basic parameters input such as material performance, plate size (b) rapid assembly of MPF punches and sheet automatically (c)automatic definition of the analytical step and the output of variables and (d)automatic definition of interaction conditions, loading and meshing. The additional module developed was used to simulate the forming of different curved surfaces to verify its efficiency and accuracy. The results showed that the pre-treatment modeling for FDSC MPF can be established automatically and quickly. The simulation can be accomplished within a receivable speed in ABAQUS. Future more, experimental deformations were carried out and the simulating results are compared with that of experiment. Comparison shows a good consistency between the experimental data and simulation data

Surface Adjustment Strategy for a Large Radio Telescope with Adjustable Dual Reflectors

With the development of large-aperture and high-frequency radio telescopes, a surface adjustment procedure for the compensation of surface deformations has become of great importance. In this study, an innovative surface adjustment strategy is proposed to achieve an automated adjustment for the large radio telescope with adjustable dual reflectors. In the proposed strategy, a high-precision and long-distance measurement instrument is adopted and installed on the back of the sub-reflector to measure the distances and elevation angles of the target points on the main reflector. Here, two surface adjustment purposes are discussed. The first purpose is to ensure that the main reflector and sub-reflector are always positioned at their ideal locations during operation. The second purpose is to adjust the main reflector to the location of the best fitting reflector, and the sub-reflector to the focus of the best fitting reflector. Next, the calculation procedures for the adjustments of the main reflector and the sub-reflector are discussed in detail, and corresponding simulations are carried out to verify the proposed method. The results show that the proposed strategy is effective. This study can provide helpful guidance for the design of automated surface adjustments for large telescopes

Mitochondrial Dysfunction Promotes Breast Cancer Cell Migration and Invasion through HIF1α Accumulation via Increased Production of Reactive Oxygen Species

Although mitochondrial dysfunction has been observed in various types of human cancer cells, the molecular mechanism underlying mitochondrial dysfunction mediated tumorigenesis remains largely elusive. To further explore the function of mitochondria and their involvement in the pathogenic mechanisms of cancer development, mitochondrial dysfunction clones of breast cancer cells were generated by rotenone treatment, a specific inhibitor of mitochondrial electron transport complex I. These clones were verified by mitochondrial respiratory defect measurement. Moreover, those clones exhibited increased reactive oxygen species (ROS), and showed higher migration and invasive behaviors compared with their parental cells. Furthermore, antioxidant N-acetyl cysteine, PEG-catalase, and mito-TEMPO effectively inhibited cell migration and invasion in these clones. Notably, ROS regulated malignant cellular behavior was in part mediated through upregulation of hypoxia-inducible factor-1 α and vascular endothelial growth factor. Our results suggest that mitochondrial dysfunction promotes cancer cell motility partly through HIF1α accumulation mediated via increased production of reactive oxygen species

Coexistence of ferromagnetism, antiferromagnetism, and superconductivity in magnetically anisotropic (Eu,La)FeAs2

Materials with exceptional magnetism and superconductivity usually conceive emergent physical phenomena. Here, we investigate the physical properties of the (Eu,La)FeAs2 system with double magnetic sublattices. The parent EuFeAs2 shows anisotropy-associated magnetic behaviors, such as Eu-related moment canting and exchange bias. Through La doping, the magnetic anisotropy is enhanced with ferromagnetism of Eu2+ realized in the overdoped region, and a special exchange bias of the superposed ferromagnetic/superconducting loop revealed in Eu0.8La0.2FeAs2. Meanwhile, the Fe-related antiferromagnetism shows unusual robustness against La doping. Theoretical calculation and 57Fe M\"ossbauer spectroscopy investigation reveal a doping-tunable dual itinerant/localized nature of the Fe-related antiferromagnetism. Coexistence of the Eu-related ferromagnetism, Fe-related robust antiferromagnetism, and superconductivity is further revealed in Eu0.8La0.2FeAs2, providing a platform for further exploration of potential applications and emergent physics. Finally, an electronic phase diagram is established for (Eu,La)FeAs2 with the whole superconducting dome adjacent to the Fe-related antiferromagnetic phase, which is of benefit for seeking underlying clues to high-temperature superconductivity.Comment: 13 pages, 6 figures for the main tex

PRMT2 promotes dextran sulfate sodium-induced colitis by inhibiting SOCS3 via histone H3R8 asymmetric dimethylation

BACKGROUND AND PURPOSE: There is emerging evidence for critical roles of epigenetic modifiers in development of inflammatory bowel disease (IBD). Protein arginine methyltransferase 2 (PRMT2) is responsible for methylation of arginine residues on histones and targets transcription factors critically involved in many cellular processes, including gene transcription, mRNA splicing, cell proliferation and differentiation. However, its role in colitis remains unknown. In this study, the role and underlying mechanisms of PRMT2 in colitis was studied. EXPERIMENTAL APPROACH: A mouse dextran sulfate sodium (DSS)-induced experimental colitis model was applied to study PRMT2 in colitis. Lentivirus induced PRMT2 silencing or overexpression in vivo was applied to address the role of PRMT2 in colitis. Detailed western blot and expression analysis was done to understand epigenetic changes induced by PRMT2 in colitis. KEY RESULTS: PRMT2 is highly expressed in patients with IBD, inflamed colon of mice and TNF-α stimulated mice gut epithelial cells. PRMT2 overexpression aggravates while knockdown alleviates DSS-induced colitis in mice, suggesting that PRMT2 is a pivotal mediator of colitis development. Mechanistically, PRMT2 mediates colitis by increasing repressive histone mark H3R8 asymmetric methylation (H3R8me2a) at the promoter region of the suppressor of cytokine signaling 3 (SOCS3) promoter. Resultant inhibition of SOCS3 expression and SOCS3-mediated degradation of TNF receptor associated factor 5 (TRAF5) via ubiquitination led to elevated TRAF5 expression and TRAF5-mediated downstream NF-κB/MAPK activation. CONCLUSION AND IMPLICATIONS: Our study demonstrates that PRMT2 acts as a transcriptional co-activator for proinflammatory genes during colitis. Hence targeting PRMT2 may provide a novel therapeutic approach for colitis

Early arteriosclerosis and its risk factors in subjects with prediabetes and new-onset diabetes

Background: We aimed to investigate early arteriosclerosis and its risk factors in populations with prediabetes and new-onset diabetes. Materials and methods: A total of 148 participants who did not have diabetes mellitus were assigned to three groups through an oral glucose tolerance test: the normal glucose tolerance (NGT) group; the impaired glucose regulation, also known as prediabetes group and the new-onset type 2 diabetes mellitus group. The insulin resistance index was assessed using the homeostatic model assessment of insulin resistance (HOMA-IR). An ELISA was used to determine the level of fibroblast growth factor 21 (FGF21). An arteriosclerosis detector was used to measure the brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI). The baPWV, ABI, and FGF21 were used to assess early arteriosclerosis. Results: Significant differences in age, systolic blood pressure (SBP), fa sting plasma glucose (FPG), 2-h plasma glucose (2hPG), 2-h insulin (2hINS), and HOMA-IR were found between the NGT group and the prediabetes and new-onset diabetes groups. All of the above, except 2hINS, showed an increasing trend. Moreover, the FGF21 was higher in the new-onset diabetes group than in the NGT group. The baPWV was higher in the new-onset diabetes group than in the other two groups, but no s ignificant difference was noted in the ABI. Age, SBP, diastolic blood pressure, FPG, 2hPG, and FGF21 were positively correlated with the baPWV. In addition, FPG, SBP, FGF21, and HOMA-IR were independent risk factors for the baPWV. Conclusions: Patients with prediabetes and new-onset diabetes may have more significant early arteriosclerosis. The blood glucose level and insulin resistance index may be independent risk factors for early arteriosclerosis

Panel Adjustment and Error Analysis for a Large Active Main Reflector Antenna by Using the Panel Adjustment Matrix

Active panels are generally applied in large aperture and high-frequency reflector antennas, and the precise calculation of the actuator adjustment value is of great importance. First, the approximation relationship between the adjustment value and panel elastic deformation is established. Subsequently, a panel adjustment matrix for the whole reflector is derived to calculate the reflector deformation caused by the actuator adjustment. Next, the root mean square (rms) error of the deformed reflector is expressed as a quadratic form in the matrix form, and the adjustment value can be derived easily and promptly from the corresponding extreme value. The solution is expected to be unique and optimal since the aforementioned quadratic form is a convex function. Finally, a 35 m reflector antenna is adopted to perform the panel adjustments, and the effect of the adjustment errors is discussed. The results show that compared with the traditional model, where the panel elastic deformation is not considered, the proposed method exhibits a higher accuracy and is more suitable for use in large reflectors with a high operation frequency. The adjustment errors in different rings exert different influences on the gain and sidelobe level, which can help determine the actuator distribution with different precisions

Insights into the active sites and catalytic mechanism of oxidative esterification of 5-hydroxymethylfurfural by metal-organic frameworks-derived N-doped carbon

Abstract(#br)Directly oxidative esterification of Biomass-derived 5-hydroxymethylfurfural (HMF) into dimethyl furan dicarboxylate (DMFDCA) is a promising route for the replacement of petroleum-derived commodity chemical terephthalic acid (TPA) extensively employed in polyester synthesis. Co-based N-doped carbon materials are one of the most promising applied catalysts for oxidative esterification reaction, however, the active sites and reaction pathway of these catalysts have not been clearly clarified, which is crucial to the practical application. Herein, we report that ZIF-67 (a zeolitic imidazolate framework (ZIF)-type cobalt-containing MOF) derived Co@C-N material is a highly effective catalyst for the selective conversion of HMF into DMFDCA in 95% yield. The high activity of the ZIF-67 derived nanocarbon composites Co@C-N can be attributed to the electron transfer between nitrogen-doped carbon shells and Co nanoparticles. The appropriate graphitic N and pyridinic N doping increases the electronic mobility and active sites. Density functional theory (DFT) simulations indicated that oxygen, HMF and methanol molecules are adsorbed and activated on C-N materials. Furthermore, no 2, 5-diformylfuran (DFF) was captured as an intermediate because the oxidative esterification of aldehyde preferentially occurred than the oxidation of hydroxyl group in HMF. We anticipate that these results can drive progress in the bio-based polymers sector and oxidative esterification reaction