11 research outputs found
Reconciling the stratigraphy and depositional history of the Lycian orogen-top basins, SW Anatolia
Terrestrial fossil records from the SWAnatolian basins are crucial both for regional correlations and palaeoenvironmental reconstructions.
By reassessing biostratigraphic constraints and incorporating new fossil data, we calibrated and reconstructed the late Neogene
andQuaternary palaeoenvironments within a regional palaeogeographical framework. The culmination of the Taurides inSWAnatolia
was followed by a regional crustal extension from the late Tortonian onwards that created a broad array of NE-trending orogen-top
basins with synchronic associations of alluvial fan, fluvial and lacustrine deposits. The terrestrial basins are superimposed on the upper
Burdigalian marine units with a c. 7 myr of hiatus that corresponds to a shift from regional shortening to extension. The initial infill of
these basins is documented by a transition from marginal alluvial fans and axial fluvial systems into central shallow-perennial lakes
coinciding with a climatic shift from warm/humid to arid conditions. The basal alluvial fan deposits abound in fossil macro-mammals
of an early Turolian (MN11–12; late Tortonian) age. The Pliocene epoch in the region was punctuated by subhumid/humid conditions
resulting in a rise of local base levels and expansion of lakes as evidenced by marsh-swamp deposits containing diverse fossilmammal
assemblages indicating late Ruscinian (lateMN15; late Zanclean) ageWe are grateful for the support of the international
bilateral project between The Scientific and Technological Research
Council of Turkey (TUBITAK) and The Russian Scientific Foundation
(RFBR) with grant a number of 111Y192. M.C.A. is grateful to the
Turkish Academy of Sciences (TUBA) for a GEBIP (Young Scientist
Award) grant. T.K. and S.M. are grateful to the Ege University
Scientific Research Center for the TTM/002/2016 and TTM/001/2016
projects. M.C.A., H.A., S.M. and M.B. have obtained Martin and
Temmick Fellowships at Naturalis Biodiversity Center (Leiden). F.A.D.
is supported by a Mehmet Akif Ersoy University Scientific Research
Grant. T.A.N. is supported by an Alexander-von-Humboldt
Scholarship. L.H.O. received support from TUBITAK under the 2221
program for visiting scientists
Late Pleistocene–Holocene evolution of the northern shelf of the Sea of Marmara
Chirp sub-bottom profiling, multibeam bathymetric mapping and a combination of faunal and isotopic analysis of molluscs and foraminifera in sediment cores on the northern shelf of the Sea of Marmara (SoM) provide evidence of sea-level excursions, water exchanges between the adjacent Mediterranean and Black Seas, and oscillating salinity over the last 160ka bp. During the marine isotope stages MIS-2, MIS-3, MIS-4 and MIS-6 the SoM disconnected from the Mediterranean Sea and evolved into a lake. During MIS-1, MIS-5 and MIS-7, the SoM reconnected and became salty once again. Sapropels formed shortly after each invasion of Mediterranean saltwater observed in our cores. Concurrent suboxic–dysoxic conditions prevailed over quite shallow substrates on the shelf. Ancient shorelines are pervasive at −85m on the northern shelf and in the region of Prince Islands coincident with the elevation of the modern bedrock sill in the Çanakkale (Dardanelles) Strait. At times when global (eustatic) sea level dropped below this sill, the surface of the SoM stabilized at its outlet and freshened. Thus this particular shoreline is interpreted as the edge of the most recent SoM lake that existed from about 75ka bp to 12ka bp. The freshening is observed in very light (−6‰) values of δ18O measured on freshwater molluscs and the complete absence of foraminifera. Two brief lacustrine episodes during MIS-5 suggest that the level of the Çanakkale outlet might have been as shallow as −50m in the past, a likelihood supported by submerged terraces along its margins bounding the modern central channel and the presence of an euryhaline biofacies in Unit L4.1 corresponding to MIS-5b. δ18O profiles and carbon-14 dating show that salinification of the SoM and the blossoming of bioherms evolved rapidly after the latest connection with the Mediterranean at 12ka bp. However, freshening proceeded more slowly once the connection was severed
The effects of protein kinase C activator phorbol dibutyrate on traumatic brain edema and aquaporin-4 expression.
Off the record: Margaret van Kleffens and the gendered history of Dutch World War II diplomacy
Design and evaluation of 3D printable patient‐specific applicators for gynecologic HDR brachytherapy
Potent ribonucleotide reductase inhibitors: Thiazole-containing thiosemicarbazone derivatives
The antioxidant, antimalarial, antibacterial, and antitumor activities of thiosemicarbazones have made this class of compounds important for medicinal chemists. In addition, thiosemicarbazones are among the most potent and well-known ribonucleotide reductase inhibitors. In this study, 24 new thiosemicarbazone derivatives were synthesized, and the structures and purity of the compounds were determined by IR, H-1 NMR, C-13 NMR, mass spectroscopy, and elemental analysis. The IC50 values of these 24 compounds were determined with an assay for ribonucleotide reductase inhibition. Compounds 19, 20, and 24 inhibited ribonucleotide reductase enzyme activity at a higher level than metisazone as standard. The cytotoxic effects of these compounds were measured on the MCF7 (human breast adenocarcinoma) and HEK293 (human embryonic kidney) cell lines. Similarly, compounds 19, 20, and 24 had a selective effect on the MCF7 and HEK293 cell lines, killing more cancer cells than cisplatin as standard. The compounds (especially 19, 20, and 24 as the most active ones) were then subjected to docking experiments to identify the probable interactions between the ligands and the enzyme active site. The complex formation was shown qualitatively. The ADME (absorption, distribution, metabolism, and excretion) properties of the compounds were analyzed using in-silico techniques