Structural and Mössbauer study of (Sb0.70Te0.30)100-x Snx alloys with x = 0, 2.5, 5.0 and 7.5

(Sb 0.70 Te 0.30 ) 100-x Sn x alloys (with x = 0, 2.5, 5.0 and 7.5 at. %)have been synthesized and characterized in order to determine the crystalline structure and properties of materials obtained upon solidification and to extract information about the location of the Sn atom in the Sb-Te matrix. Powder X-ray diffraction (XRD)has been used to determine the crystalline structure, whereas Mössbauer spectroscopy has been utilized to determine the localization and the local structure of the Sn atom in the Sb-Te matrix through the hyperfine interactions of the 119 Sn probe with its environment. We found that Sb 70 Te 30 crystallizes in a trigonal structure belonging to P-3m1 space group, while the doping with Sn leads to structural distortions of the unit cell that can be described, for all the Sn concentrations, with the C2/m space group. The hyperfine parameters indicate that tin behaves as Sn(II)and has a slightly distorted environment. Finally, in order to extract all the information that the experimental results contain and to determine the preferential site occupied by the Sn impurities in the Sb-Te matrix, we have performed ab-initio calculations within the framework of the Density Functional Theory. The theoretical results enable us to determine the structural and electronic ground state of (Sb 0.70 Te 0.30 ) 100-x Sn x compounds and to confirm that Sn atoms substitute Sb atoms in the Sb-Te host.Fil: Rocca, Javier Alejandro. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long". Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long"; ArgentinaFil: Bilovol, Vitaliy. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long". Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long"; ArgentinaFil: Errandonea, Alfredo Mario. Universidad de Valencia; EspañaFil: Gil Rebaza, Arles Víctor. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Mudarra Navarro, Azucena Marisol. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Medina Chanduvi, Hugo Harold. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Errico, Leonardo Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Arcondo, B.. Universidad Nacional del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Fontana, Marcelo. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long". Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long"; ArgentinaFil: Rodríguez Cuellar, O.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long". Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long"; Argentina. Universidad de Buenos Aires; ArgentinaFil: Ureña, María Andrea. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long". Universidad de Buenos Aires. Facultad de Ingeniería. Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long"; Argentin

Гормональний дисбаланс жирової тканини та кардіогемодинамічні зміни на тлі порушень вуглеводного обміну у хворих на гіпертонічну хворобу

The authors have studied the levels of visfatin, TNF-α, the cardiohemodynamics state in hypertensive patients complicated by diabetes mellitus type 2 which will be conducive both to the introduction of new approaches in an assessment of the severity of the condition and an opportunity of prognosticating further progression of carbohydrate metabolism disorders and will avoid an increased cardiovascular risk.Изучены уровни висфатина, ФНО-α и состояние кардиогемодинамики у больных гипертонической болезнью, осложненную сахарным диабетом 2-го типа, что будет способствовать внедрению новых подходов в оценке тяжести состояния и возможности прогнозирования дальнейшего прогрессирования нарушения углеводного обмена и предупредит возрастание кардиоваскулярного риска.Вивчено рівні вісфатину, ФНП-α та стан кардіогемодинаміки у хворих на гіпертонічну хворобу, ускладнену цукровим діабетом 2-го типу, що сприятиме впровадженню нових підходів в оцінці тяжкості стану і можливості прогнозування подальшого прогресування порушення вуглеводного обміну та запобігатиме зростанню кардіоваскулярного ризику

Лікування порушень сну в пацієнтів з артеріальною гіпертензією та ожирінням

TThe aim of the study is to improve the efficacy of the treatment of sleep disorders in patients with arterial hypertension (AH) and obesity.Materials and methods. In total, 62 patients were examined (mean age 58.3 ± 2.3 years) with AH and obesity. All of the surveyed persons underwent general clinical examination, daily BP monitoring, life quality assessment (General Well-Being Questionnaire). The ICSD-2 (2005) criteria were used to identify sleep disorders (dyssomnia) and subjective sleep characteristics questionnaires – for circadian “sleep –wake” rhythm disturbances assessment. Sleep disorders were found in all the examined patients at baseline. After the baseline data registration, the patients were prescribed basic therapy, 32 (group 1) of whom additionally received melatonin at a dose of 3 mg for 4 weeks; 30 patients were included in group 2.Results. After treatment, in group 1, the levels of office SBP and DBP were 6.9 % and 6.7 % (P < 0.05), and the average daily SBP and DBP (according to DMBP data) were 7.9 % and 6.7 % (P < 0.05) lower, respectively, than in group2. In patients of group 1, positive changes in lipid and carbohydrate metabolism, a significant improvement in subjective sleep characteristics and circadian “sleep – wake” rhythm were registered along with an improvement in the quality of life.Conclusions. Thus, melatonin add-on treatment in patients with AH and obesity with sleep disorders increases the efficacy of antihypertensive therapy, has a beneficial effect on glucometabolic parameters, subjective assessment of sleep quality and the quality of life.  Цель работы – повышение эффективности лечения нарушений сна у пациентов с артериальной гипертензией (АГ) и ожирением.Материалы и методы. Обследованы 62 больных (средний возраст – 58,3 ± 2,3 лет) с АГ и ожирением. Всем обследованным проведено общеклиническое обследование, суточный мониторинг АД, оценка качества жизни (опросник «General Well – Being Questionnaire»). Для выявления нарушений сна (диссомния) использовали критерии МКРС-2 (2005), а оценки нарушений циркадного ритма «сон – бодрствование» – анкеты балльной оценки субъективных характеристик сна. У пациентов обеих групп в исходных условиях отмечены нарушения сна. После регистрации исходных данных пациентам назначали базисную терапию, из них 32 (1 группа) дополнительно получала препарат мелатонин в дозе 3 мг в течение 4 недель; 30 пациентов составили 2 группу.Результаты. После лечения в 1 группе уровни офисного САД и ДАД были на 6,9 % и на 6,7 % (p < 0,05), а среднесуточные САД и ДАД (по данным СМАД) – на 7,9 % и 6,7 % (p < 0,05) ниже, чем во 2 группе. У пациентов 1 группы отмечены позитивные изменения показателей липидного, углеводного обмена и достоверное улучшение субъективных характеристик сна и циркадного ритма «сон – бодрствование» наряду с улучшением показателей качества жизни.Выводы. Таким образом, назначение мелатонина пациентам с АГ и ожирением с нарушениями сна повышает эффективность гипотензивной терапии, положительно влияет на глюкометаболические параметры, субъективную оценку качества сна и качество жизни. Мета роботи – підвищення ефективності лікування порушень сну в пацієнтів з артеріальною гіпертензією (АГ) та ожирінням.Матеріали та методи. Обстежили 62 особи (середній вік – 58,3 ± 2,3 року) з АГ та ожирінням. Усім провели загальноклінічне обстеження, добовий моніторинг АТ, оцінювання якості життя (опитувальник «General Well – Being Questionnaire»). Для виявлення порушень сну (дисомнія) використовували критерії МКРС-2 (2005), а оцінювання порушень циркадного ритму «сон – неспання» – анкети бального оцінювання суб'єктивних характеристик сну. В пацієнтів обох груп у вихідних умовах відзначені порушення сну. Після реєстрації вихідних даних пацієнтам призначали базисну терапію, з них 32 (1 група) отримували додатково препарат мелатонін у дозі по 3 мг протягом 4 тижнів; 2 групу становили 30 пацієнтів.  Результати. Після лікування в 1 групі рівні офісного САТ і ДАТ були на 6,9 % і на 6,7 % (p < 0,05), а середньодобові САТ і ДАТ (за даними ДМАТ) – на 7,9 % і 6,7 % (р < 0,05) нижчі, ніж у 2 групі. У пацієнтів 1 групи відзначили позитивні зміни показників ліпідного та вуглеводного обміну, вірогідне покращення суб'єктивних характеристик сну та циркадного ритму «сон – неспання» поряд з поліпшенням показників якості життя.Висновки. Додавання мелатоніну пацієнтам з АГ та ожирінням із порушеннями сну підвищує ефективність гіпотензивної терапії, позитивно впливає на глюкометаболічні параметри, суб'єктивне оцінювання якості сну та якість життя.

Development of the Method of Structural and Parametric Synthesis of the Quanton Diagnostic and Health Complex

The synthesis method based on the use of information invariants is proposed, and structural-parametric synthesis of the Quanton diagnostic and health complex is performed. Structural and parametric optimization of the complex is carried out according to the performance criterion. As information invariants, complete (within the accepted classification) sets of methods to obtain the functional properties of the complex, phase cycles of the life cycle, structures of technical subsystems and methods for controlling the technicalization levels, productivity and energy efficiency of processes are used. The sets of methods to obtain the functional properties of the complex and phase cycles of the life cycle are formed by elementwise complication of the corresponding attributes. The set of structures of technical subsystems corresponding to certain levels of technicalization of functions is determined on the basis of the periodic system of technical elements. Complete sets of possible structural solutions for methods of controlling the productivity and energy efficiency of processes are obtained by the topological product of the sets of types of objects by the types of methods for ensuring the required properties or qualities of objects. For each structurally different variant, the usual object parameterization procedure and the system of dependencies of the deductive parametric optimization problem are applied. The system of dependencies is a specific case of parametric information invariants. The dependencies are specified using the information about the necessary source data and target transformations occurring in the Quanton complex during the interaction of subsystems. The algorithm for finding an extremely effective solution is step-by-step. This algorithm assumes a step-by-step determination of the optimal process performance parameters within the limiting contours and subsequent improvement of energy efficiency and quality. Due to the use of complete sets of process structures, elements and discrete-continuum procedure of search for the optimal solution, the integration of the optimization of technical innovation is achieved

Development of the Method of Structural and Parametric Synthesis of the Quanton Diagnostic and Health Complex

The synthesis method based on the use of information invariants is proposed, and structural-parametric synthesis of the Quanton diagnostic and health complex is performed. Structural and parametric optimization of the complex is carried out according to the performance criterion. As information invariants, complete (within the accepted classification) sets of methods to obtain the functional properties of the complex, phase cycles of the life cycle, structures of technical subsystems and methods for controlling the technicalization levels, productivity and energy efficiency of processes are used. The sets of methods to obtain the functional properties of the complex and phase cycles of the life cycle are formed by elementwise complication of the corresponding attributes. The set of structures of technical subsystems corresponding to certain levels of technicalization of functions is determined on the basis of the periodic system of technical elements. Complete sets of possible structural solutions for methods of controlling the productivity and energy efficiency of processes are obtained by the topological product of the sets of types of objects by the types of methods for ensuring the required properties or qualities of objects. For each structurally different variant, the usual object parameterization procedure and the system of dependencies of the deductive parametric optimization problem are applied. The system of dependencies is a specific case of parametric information invariants. The dependencies are specified using the information about the necessary source data and target transformations occurring in the Quanton complex during the interaction of subsystems. The algorithm for finding an extremely effective solution is step-by-step. This algorithm assumes a step-by-step determination of the optimal process performance parameters within the limiting contours and subsequent improvement of energy efficiency and quality. Due to the use of complete sets of process structures, elements and discrete-continuum procedure of search for the optimal solution, the integration of the optimization of technical innovation is achieved

Hepatic Fibrosis as an Additional Risk Factor for the Development of Cardiovascular Disorders in Patients with Type 2 Diabetes Mellitus with Non-alcoholic Fatty Liver Disease

The aim of the study was to determine the relationship between the degree of progression of liver fibrosis and the risk of cardiovascular complications in patients with Type 2 diabetes mellitus (DM) with non-alcoholic fatty liver disease (NAFLD). The study included 110 patients with Type 2 diabetes (62 men and 48 women), the average age of the subjects was 52.07±1.11 years. All patients were divided into 2 groups: the main group included 72 patients with Type 2 diabetes with concomitant NAFLD (38 men and 34 women); the control group included 38 patients with Type 2 diabetes without clinical manifestations of NAFLD (24 men and 14 women). Patients of the main group were divided into 3 subgroups, taking into account the predominant pathological processes in the clinical picture. The division into subgroups was carried out in 2 stages: at the first stage, those with predominant manifestations of liver fibrosis (F2 or more) were selected from the general population of patients with Type 2 diabetes with NAFLD according to the results of liver elastography and the use of Bonacini and Metavir scales. The number of such patients was 29, which accounted for 40.3% of the total number of patients in the main group. The remaining patients were divided into 2 subgroups: 11 patients (15.3%) had non-alcoholic liver steatosis, and 32 patients (44.4%) had signs of non-alcoholic steatohepatitis (NASH). As a result of the study, it was found that the presence of liver fibrosis in patients with Type 2 diabetes with NAFLD is significantly more often associated with cardiovascular complications, such as arterial hypertension, coronary heart disease, myocardial infarction, stroke, diabetic retinopathy and nephropathy. A significant decrease in the ejection fraction (EF) was found in patients with Type 2 diabetes with concomitant NAFLD. At the same time, the number of patients with EF disorders of varying degrees in the main group significantly exceeded that in the comparison group (33.3% and 6.7%, respectively, p<0.001). The average values of left ventricular myocardial mass are significantly lower in patients with NASH and fibrosis formation compared to patients with NAFLD at the stage of fatty hepatosis. There was also a significant decrease in the size of the left and right atria in patients with NASH compared to both patients with steatosis and patients with fibrotic liver changes. Patients with predominant fibrotic changes in the liver are characterized by a relative decrease in myocardial mass, a decrease in final diastolic and systolic volumes and EF, which may indicate the development of diastolic dysfunction in them. It is shown that it is necessary to take into account in clinical practice not only the generally accepted stages of NAFLD, but also the predominant pathological process in the liver in patients with Type 2 diabetes, namely steatosis, manifestations of inflammation and fibrotic disorders. It is proved that fibrotic changes in the liver can develop at all stages of liver tissue damage