67 research outputs found

    Cardiovascular risk associated with the use of glitazones, metformin and sufonylureas: meta-analysis of published observational studies

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    BACKGROUND: The results of observational studies evaluating and comparing the cardiovascular safety of glitazones, metformin and sufonylureas are inconsistent.To conduct and evaluate heterogeneity in a meta-analysis of observational studies on the risk of acute myocardial infarction (AMI) or stroke in patients with type 2 diabetes using non-insulin blood glucose–lowering drugs (NIBGLD). METHODS: We systematically identified and reviewed studies evaluating NIBGLD in patients with type 2 diabetes indexed in Medline, Embase, or the Cochrane Library that met prespecified criteria. The quality of included studies was assessed with the RTI item bank. Results were combined using fixed- and random-effects models, and the Higgins I(2) statistic was used to evaluate heterogeneity. Sensitivity analyses by study quality were conducted. RESULTS: The summary relative risk (sRR) (95 % CI) of AMI for rosiglitazone versus pioglitazone was 1.13 (1.04–1.24) [I(2) = 55 %]. In the sensitivity analysis, heterogeneity was reduced [I(2) = 16 %]. The sRR (95 % CI) of stroke for rosiglitazone versus pioglitazone was 1.18 (1.02–1.36) [I(2) = 42 %]. There was strong evidence of heterogeneity related to study quality in the comparisons of rosiglitazone versus metformin and rosiglitazone versus sulfonylureas (I(2) ≥ 70 %). The sRR (95 % CI) of AMI for sulfonylurea versus metformin was 1.24 (1.14–1.34) [I(2) = 41 %] and for pioglitazone versus metformin was 1.02 (0.75–1.38) [I(2) = 17 %]. Sensitivity analyses decreased heterogeneity in most comparisons. CONCLUSION/INTERPRETATION: Sulfonylureas increased the risk of AMI by 24 % compared with metformin; an imprecise point estimate indicated no difference in risk of AMI when comparing pioglitazone with metformin. The presence of heterogeneity precluded any conclusions on the other comparisons. The quality assessment was valuable in identifying methodological problems in the individual studies and for analysing potential sources of heterogeneity. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12872-016-0187-5) contains supplementary material, which is available to authorized users

    Calibrating the Six-Port Reflectometer Using a Matched Load And Four Unity-Reflection Standards (Part 2)

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    A convenient and exact method of using a sliding load to the calibration of the single six-port reflectometer is described. Neither reflection coefficient nor positions of the sliding load settings need be known. Reflection coefficient of the load is not limited to small values. No numerical iterations are involved in the calibration

    Strategic directions of increase of innovative potential of region are in the conditions of market economy

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    В даній статті розроблено модель формування моделі інноваційного потенціалу підприємств регіону, що робить можливим всебічно обґрунтований і зважений вибір варіанта інноваційної інфраструктури, визначено перспективні напрями нарощування інноваційного потенціалу регіону, сформульовано завдання регіональних органів влади у даному процесі. The model of forming of model of innovative potential of enterprises of region which does possible the comprehensively grounded and self-weighted choice of variant of innovative infrastructure is developed in this article, certainly perspective directions of increase of innovative potential of region, the task of regional organs of power is formulated in this process

    Fracture of roof rock over a production face

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    Polyformaldehyde as an antifriction material

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