810 research outputs found
АНАЛІЗ ХІРУРГІЧНОГО ЛІКУВАННЯ ДІТЕЙ З КІСТАМИ ПЕЧІНКИ В НАЦІОНАЛЬНІЙ ДИТЯЧІЙ СПЕЦІАЛІЗОВАНІЙ ЛІКАРНІ «ОХМАТДИТ»
The article analyzes the results of diagnostics and treatment of children with liver cysts.У статті проаналізовано результати діагностики та лікування дітей з кістами печінки
Significance of basic clinical tests changing after the Hypec procedure in patients with gastric cancer and some other tumors
Hyperthermic intraperitoneal chemotherapy is a popular method of
palliative treatment in patients with malignant abdominal tumors. This
review is devoted to trace changes in general clinical tests in patients with
carcinomatosis. The patients were operated on at the Clinic of Reconstructive
and Plastic Medicine of the Odessa National Medical University. All patients
satisfactorily tolerated this procedure. The object of the study was to track
those changes with patients that took place in the immediate (prior to
discharge) postoperative period. 25 patients have recruited to the study. In
the group changes in 11 basic clinical and laboratory parameters among those
included were monitored in the study. Hemoglobin, leukocytes, platelets,
total protein, bilirubin, serum glucose concentration, liver enzymes alanine
aminotransferase and aspartate aminotransferase levels, thymol test and
coagulogram indices. Thus, the most significant indicators, such as the
concentration of hemoglobin, leukocytes and platelets, have not undergone
significant changes after HIPEC. Hemoglobin decreased by 6 units (g / l), the
concentration of leukocytes, on the contrary, increased by 2 units (T/l),
platelet levels dropped by 61 units (also G/l). The concentration of total
protein decreased by 7 units. The concentration of total bilirubin practically
did not change, decreasing by about 1 unit. Indicators of AST and ALT did
not increase, decreasing by 8 and 3 units, respectively. The average
concentration value of blood glucose level slightly increased by almost 1
unit. Thymol levels have not changed. The prothrombin index decreased by 3
units; the concentration of fibrinogen in serum remained at approximately the
same level. HIPEC procedure does not significantly affect the clinical and
laboratory parameters. However, the tendency of this category of patients to
hypercoagulation, hypoproteinemia and hyperglucosemia was noted
Molecular genetic characteristics of gastric cancers from the surgeon’s point of view
Dubinina V. G., Mashukov A. A., Lukyanchuk O. V., Bilenko A. A., Zgura A. N., Raciborsky D. V., Lee S. N. Molecular genetic characteristics of gastric cancers from the surgeon’s point of view. Journal of Education, Health and Sport. 2016;6(11):592-621. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.200394
http://ojs.ukw.edu.pl/index.php/johs/article/view/4063
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).
755 Journal of Education, Health and Sport eISSN 2391-8306 7
© The Author (s) 2016;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 02.11.2016. Revised 22.11.2016. Accepted: 30.11.2016.
MOLECULAR GENETIC CHARACTERISTICS OF GASTRIC CANCERS FROM THE SURGEON’S POINT OF VIEW
V. G. Dubinina1, A. A. Mashukov2, O. V. Lukyanchuk2, A. A. Bilenko1, A. N. Zgura2,
D. V. Raciborsky2, S. N. Lee2
1Odessa National Medical university
2Odessa Regional Oncology center
Summary
A study on the expression of oncoproteins in stomach` carcinomas, has been turned into a real research basically due to the abundance of results and their comprehensive interpretations. The study carried out on the abdominal onco-surgical department of Odessa Regional Oncology Center, included a study of 188 patients operated on for gastric cancer (GC) between 2007-2011. In all cases was performed the so-called lymphadenectomy for the principal reason of extensive preventive biopsy of visually unchanged lymph nodes. We spend a multivariate analysis of interactions between the expression of oncoproteins p53, VEGFR-3, erbB2, Ki67 and micro involvement of tumor vasculature (ly, v), the local growth (T), the presence of residual tumor tissue (the R), the degree of tumor differentiation (the G) the degree of regional lymph nodes involvement (N) and type of infiltration (Inf α, β, Inf Υ).
Keywords: Stomach cancer, Immunohistochemistry and Oncoproteins
Comparison of survival rates made by the 6-th and 7-th editions of TNM classification in stomach cancer patients
The available classifications of malignant tumors reflect various aspects of their
growth and some biological features. The most commonly used in Ukraine is the 6-th revision of TNM
classification, which differs from the previous classifications of the section "Gastric cancer", mainly
staging of category N, reflecting the presence of metastases in regional lymph nodes. Transition to the
7-th classification of TNM translates a part of patients from one stage to another, there is a so-called
"stage migration" phenomenon. The famous mathematical phenomenon of Will Rogers describes this
transition and theoretically substantiates its objectivity. The authors tracked the migration of patients
and the change in the stage mainly from the point of view of the effect of this event on the survival of
patients with stomach cancer
Some novel ways of gastric cancer patients treatment personification
In this paper the authors perform the analysis of molecular and morphological factors
influencing the survival of patients with gastric cancer (n = 221). They analyzed the survival
rate in this group of patients based on the analysis of molecular markers VEGFR, p53, Her2,
Ki-67. Measured role in the survival such factors as the degree of differentiation of primary
gastric tumors, the presence of microscopic tumor involvement of perineural and perivascular
spaces, the degree of invasion to gastric wall by T1 = 1 and to T4a = 4, T4b = 5, number of
regional lymph nodes affected by metastasis, and other factors. As an arbitrator used survival
curves calculated by the method of R. J. Cox, time of lifespan, measured in months, as well as
a comparison of the areas under the curves of survival
Novel data according Will Roger`s phenomenon in stomach cancer patients
Mostly Will Roger`s phenomenon means existence of so-called "jumping" or "jumping over the stages"
regional metastases in the stomach cancer patients. N1 in the 6th edition means 16 regional lymph nodes
involvement, while the N1 seventh edition – only 1-2 of regional lymph nodes involvement. This means that
T1N1Mo \ 6th and T1N1Mo \ 7th - not quite the same, and the survival of the two groups will be different.
The study, made on the abdominal oncosurgical department of Odessa Regional Oncology Center, included
188 patients operated for gastric cancer in the period 2007-2011. The study included only radically treated
patients. Comparison of survival in patients with gastric cancer between 6th revision groups of 7th has been
reviewed. The classification mission is to provide differences in the survival rates between the groups.
Regression multivariate Cox analysis showed that 7th UICC classification showed different capability of
stratifying survival groups of UICC N classification (P \ 0.01)
The original formula for predicting the survival of gastric cancer patients undergoing surgical treatment
The purpose of this work was to find ways to predict the survival of gastric cancer
patients. The study included 221 patients who were radically operated in the abdominal department of
the Odessa Regional Oncology Center from 2007 to 2013. The life expectancy of this group of patients
was measured in months. From the factors given in the article, only the age of the patient, the
presence and invasion in neighboring organs and the number of organs resected during the operation
were those factors that had a significant impact on the prognosis. A formula was obtained for the
formal evaluation of the duration of patients. The results are preliminary. Conclusions. As a result of
the regression analysis, a polynomial (formula) was obtained, which can be used to predict the
survival of patients who underwent surgery for gastric cancer. There is a need to create clearer
gradations of survival dependencies of cancer patients from different clinical and morphological
situations. A mathematical apparatus with many variables can be used to create similar models for the
analysis of survival in other types of pathology
Lymph node dissection impact on long-term survival rate of gastric cancer patients in Ukraine
Over a period of 2007-2011 188 stomach cancer (SC) patients have been
included in the research in abdominal oncosurgical department of Odessa
oncological center. Volume of lymph node dissections differed by quantity of
lymph nodes to be removed. All patients were divided into three groups.
Patients with D1 or D1+ lymph node dissections have been performed, totally
90 patients are included in group of historical control. In all cases so-called
lymph node dissections for principal reasons have been executed. The
multifactorial analysis of patients survival is implemented depending on a type
of a lymph node dissections, a stage of the cancer, number of involved lymph
nodes, involvement of the tumoral microcirculatory net (ly is carried out, v)
signs of a perinevral invasion (Nev), availability of residual tumoral tissue (R),
degree of a differentiation (G). Regardless of a disease stage, SC at 60 % of
patients, represented with initially hematologicaly disseminated disease. 40 %
of SC`s had no signs of intratumoral microcirculatory net involvement even in
case of more than 15 regional lymph nodes are involved
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Search for intermediate mass black hole binaries in the first and second observing runs of the Advanced LIGO and Virgo network
Gravitational-wave astronomy has been firmly established with the detection of gravitational waves from the merger of ten stellar-mass binary black holes and a neutron star binary. This paper reports on the all-sky search for gravitational waves from intermediate mass black hole binaries in the first and second observing runs of the Advanced LIGO and Virgo network. The search uses three independent algorithms: two based on matched filtering of the data with waveform templates of gravitational-wave signals from compact binaries, and a third, model-independent algorithm that employs no signal model for the incoming signal. No intermediate mass black hole binary event is detected in this search. Consequently, we place upper limits on the merger rate density for a family of intermediate mass black hole binaries. In particular, we choose sources with total masses M=m1+m2ϵ[120,800] M and mass ratios q=m2/m1ϵ[0.1,1.0]. For the first time, this calculation is done using numerical relativity waveforms (which include higher modes) as models of the real emitted signal. We place a most stringent upper limit of 0.20 Gpc-3 yr-1 (in comoving units at the 90% confidence level) for equal-mass binaries with individual masses m1,2=100 M and dimensionless spins χ1,2=0.8 aligned with the orbital angular momentum of the binary. This improves by a factor of ∼5 that reported after Advanced LIGO's first observing run
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