Recommendations for reporting ion mobility Mass Spectrometry measurements

Here we present a guide to ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties of mobility and collision cross section values. The guide aims to clarify some possibly confusing concepts, and the reporting recommendations should help researchers, authors and reviewers to contribute comprehensive reports, so that the ion mobility data can be reused more confidently. Starting from the concept of the definition of the measurand, we emphasize that (i) mobility values (K0) depend intrinsically on ion structure, the nature of the bath gas, temperature, and E/N; (ii) ion mobility does not measure molecular surfaces directly, but collision cross section (CCS) values are derived from mobility values using a physical model; (iii) methods relying on calibration are empirical (and thus may provide method‐dependent results) only if the gas nature, temperature or E/N cannot match those of the primary method. Our analysis highlights the urgency of a community effort toward establishing primary standards and reference materials for ion mobility, and provides recommendations to do so. © 2019 The Authors. Mass Spectrometry Reviews Published by Wiley Periodicals, Inc

Multinet : enabler for next generation enterprise wireless services

Wireless communications are currently experiencing a fast migration toward the beyond third-generation (B3G)/fourth generation (4G) era. This represents a generational change in wireless systems: new capabilities related to mobility and new services support is required and new concepts as individual-centric, user-centric or ambient-aware communications are included. One of the main restrictions associated to wireless technology is mobility management, this feature was not considered in the design phase; for this reason, a complete solution is not already found, although different solutions are proposed and are being proposed. In MULTINET project, features as mobility and multihoming are applied to wireless network to provide the necessary network and application functionality enhancements for seamless data communication mobility considering end-user scenario and preferences. The aim of this paper is to show the benefits of these functionalities from the Service Providers and final User point of view

Velocity shear instability and plasma billows at the Earth\u27s magnetic boundary

The Kelvin-Helmoltz instability (KH) with formation of vortices appears in a wide variety of terrestrial, interplanetary, and astrophysical contexts. We study a series of iterated rolled-up coherent plasma structures (15) that flow in the equatorial Earth\u27s boundary layer (BL), observed on October 24, 2001. The data were recorded during a 1.5 hour-long Wind crossing of the BL at the dawn magnetospheric flank, tailward of the terminator (X≈−13 RE). The interplanetary magnetic field (IMF) was radially directed, almost antiparallel to the magnetosheath (MS) flow. This configuration is expected to be adverse to the KH instability because of the collinearity of field and flow, and the high compressibility of the MS. We analyze the BL stability with compressible MHD theory using continuous profiles for the physical quantities. Upstream, at near Earth sites, we input parameters derived from an exact MHD solution for collinear flows. Further downtail at Wind position we input measured parameters. The BL is found KH unstable in spite of unfavorable features of the external flow. On the experimental side, the passage of vortices is inferred from the presence of low density - hot plasma being accelerated to speeds higher than that of the contiguous MS. It is further supported by the peculiar correlation of relative motions (in the bulk velocity frame): cold-dense plasma drifts sunward, while hot-tenuous plasma moves tailward. This event differs from many other studies that reported BL vortices under strongly northward IMF orientations. This is a case of KH vortices observed under an almost radial IMF, with implicit significance for the more common Parker\u27s spiral fields, and the problem of plasma entry in the magnetosphere

Characterization and controlled combustion of carbonaceous deactivating species deposited on an activated carbon-based catalyst

The composition of the carbonaceous deactivating species (coke) deposited on a Pt and Pd supported P-containing activated carbon catalyst has been studied. These deactivating species were deposited on the catalyst during the hydrocracking of scrap tire pyrolysis oil at 400-500 degrees C, and it has been selectively characterized by means of temperature-programmed oxidation (TPO), temperature-programmed desorption/gas chromatography (TPD/GC) and laser desorption-ionization/mass spectroscopy (LDI/MS). In addition, the evolution of the textural properties and the acidity of the deactivated catalysts have been evaluated. The high thermal and oxidation resistance of the catalytic support has allowed to combust the coke in the TPO and calculate its intrinsic activation energy as a function of the extent of the combustion. Combined TPO and LDI/MS results have shown that an increase in the hydrocracking temperature attenuates the catalyst deactivation due to the hydrocracking of coke precursors. Coke aging, by evolving towards a more condensed structure, is also favored at higher hydrocracking temperatures. The combustion of the most condensed coke requires of higher temperatures than 375 degrees C, which hinders the complete regeneration of the activated carbon-based catalyst. (C) 2017 Elsevier B.V. All rights reserved

Location Based Indoor and Outdoor Lightweight Activity Recognition System

In intelligent environments one of the most relevant information that can be gathered about users is their location. Their position can be easily captured without the need for a large infrastructure through devices such as smartphones or smartwatches that we easily carry around in our daily life, providing new opportunities and services in the field of pervasive computing and sensing. Location data can be very useful to infer additional information in some cases such as elderly or sick care, where inferring additional information such as the activities or types of activities they perform can provide daily indicators about their behavior and habits. To do so, we present a system able to infer user activities in indoor and outdoor environments using Global Positioning System (GPS) data together with open data sources such as OpenStreetMaps (OSM) to analyse the user’s daily activities, requiring a minimal infrastructure

Behavior modeling for a beacon-based indoor location system

In this work we performed a comparison between two different approaches to track a person in indoor environments using a locating system based on BLE technology with a smartphone and a smartwatch as monitoring devices. To do so, we provide the system architecture we designed and describe how the different elements of the proposed system interact with each other. Moreover, we have evaluated the system’s performance by computing the mean percentage error in the detection of the indoor position. Finally, we present a novel location prediction system based on neural embeddings, and a soft-attention mechanism, which is able to predict user’s next location with 67% accuracy

Heat Treatment Process Energy Efficient Design and Optimisation

AbstractEnergy efficiency optimization ICT (Information and Communication Technology) solutions are currently being developed for energy saving in buildings and, to some ex-tent, also for the manufacturing domain. This paper describes an approach and ICT tool developed for manufacturing process energy efficiency optimization, in particular focused on the heat treatment process of steel casting parts. Traditionally this manufacturing process is designed based on experts experience selecting a predefined temperature-time curve provided customer specifications for the resulting steel parts. However this curve can actually be optimised in terms of energy consumption while keeping required mechanical properties. This improved design is what the tool here described provides, using knowledge based approach for process design and multivariate optimisation and simulation techniques for process optimisation

Combined Analysis of Methylation and Gene Expression Profiles in Separate Compartments of Small Bowel Mucosa Identified Celiac Disease Patients' Signatures

By GWAS studies on celiac disease, gene expression was studied at the level of the whole intestinal mucosa, composed by two different compartments: epithelium and lamina propria. Our aim is to analyse the gene-expression and DNA methylation of candidate genes in each of these compartments. Epithelium was separated from lamina propria in biopsies of CeD patients and CTRs using magnetic beads. Gene-expression was analysed by RT-PC; methylation analysis required bisulfite conversion and NGS. Reverse modulation of gene-expression and methylation in the same cellular compartment was observed for the IL21 and SH2B3 genes in CeD patients relative to CTRs. Bioinformatics analysis highlighted the regulatory elements in the genomic region of SH2B3 that altered methylation levels. The cREL and TNFAIP3 genes showed methylation patterns that were significantly different between CeD patients and CTRs. In CeD, the genes linked to inflammatory processes are up-regulated, whereas the genes involved in the cell adhesion/ integrity of the intestinal barrier are down-regulated. These findings suggest a correlation between gene-expression and methylation profile for the IL21 and SH2B3 genes. We identified a "gene-expression phenotype" of CeD and showed that the abnormal response to dietary antigens in CeD might be related not to abnormalities of gene structure but to the regulation of molecular pathways.This work was funded by the FC-Grant2013. Programma di mobilita nell'ambito delle reti di eccellenza POR Campania FSE 2007-2013 Asse V. The authors thank the European Laboratory for Food-induced Disease (ELFID). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript