Methylation and loss of Imprinting: Unending rivalries unleashed between “kneaded erasers†and “fate writersâ€Â

Genome is a complex barcode that is interpreted at molecular level. There are various proteins which are modulating the expression or repression of the genes. Miscellaneous proteins work in collaboration to stimulate or repress the gene expression. Chromatin remodeling factors are the artists which chisel, carve and mould the sculpture of genome. In this review we will emphasize on exemptions and extensions which trigger genomic instability in broad range of molecular anomalies. Doubtlessly therapeutic interventions have shown tremendous promise in cancer therapy, but the selectivity profiles of these compounds have largely relied on serendipity or 'off-target' activities rather than rational drug design. Purposefully designed compounds with activity against methyltransferase, demethylase and HDAC will bring us a step closer to personalized medicine

Effect of Multiple Open-End Processing Variables Upon Yarn Quality

ABSTRACT The effect of multiple open end processing variables upon yarn quality was studied in this research work. The results in respect of hairiness indicate that the effect of draw off navel type and yarn count were highly significant while the effect of rotor diameter was only significant. However, for yarn evenness, the results indicate that the effect of yarn count and rotor diameter was highly significant; whereas, the effect of draw-off navel was at par

Layer-By-Layer (LBL) hybrid MOF coating for graphene-based multilayer composite: Synthesis and application as anode for lithium ion batteries

The hybrid anodic materials with high porosity and low charge resistance exhibit high specific capacity and stable cyclic stability for lithium ion battery (LIBs). For this purpose, three-dimensional hollow material, metal organic framework (MOF-199) was coated over the active surface of oxidized derivative of graphene (Graphene oxide, GO), via layer-by-layer (LBL) coating method. Cupric acetate and benzene-1,3,5-tricarboxylic acid [Cu3(BTC)2], were alternatively coated on the active surface of GO as an anode material, to enhance the structural diversity and reduce the synergistic effect of insertion and extraction of Li+ ions for LIBs. Sharp absorption peaks from 1620 cm−1 to 1360 cm−1 and intense ring bends ∼1000 cm−1 was identified through FTIR. Powder XRD provides the evidence for size reduction of Cu3(BTC)2@GO composite (32.6 nm) comparative to GO (43.7 nm). Outcome of EIS analysis shows the charge transfer resistance of simple GO is 2410 Ω, which is 4 times higher than Rct of Cu3(BTC)2@GO composite (590 Ω). Similarly the Warburg impedance co-efficient for simple GO (448.8 Ωs−1/2) is also higher than Aw of Cu3(BTC)2@GO composite (77.64 Ωs−1/2). The synthesized material show high initial charge/discharge capacity, 1200/1420 mAh/g with 85% Coulombic efficiency and reversible discharge capacity, 1296 mAh/g after 100 cycles at 100 mA/g current density. The 98.9% Coulombic efficiency and 91% retaining capacity of composite at 100th cycle with cyclic stability, provides the phenomenon approach towards the rechargeable LIBs for industrial technology

SPSS file with a part of the research data.

(SAV)</p

Socio-demographic characteristics of the study participants.

Socio-demographic characteristics of the study participants.</p

Univariate analyses and logistic regression of barriers to the utilization of ante natal care services.

Univariate analyses and logistic regression of barriers to the utilization of ante natal care services.</p

Questionnaire used for the research.

(DOCX)</p

ANC-related and other variables in study participants.

ANC-related and other variables in study participants.</p