BIOMARCADORES LABORATORIAIS NA COVID-19 COMO NORTEADORES PARA PLANO DE CUIDADOS DE ENFERMAGEM: ESTUDO DE REVISÃO

Objetivo:pesquisar, na literatura, o perfil laboratorial dos pacientes acometidos gravemente pela COVID-19,bem como organizar um plano de cuidados de enfermagem de acordo com as alterações de biomarcadores elencados nessa revisão. Método:revisão integrativa realizada nas bases de dados MEDLINE e PubMed. Incluíram-se artigos envolvendo pacientes adultos e hospitalizados.Excluíram-se aqueles que não responderam à questão norteadora, estudos genéticos ou imunológicos, estudos repetidos e artigos de opinião. Posteriormente, foram elencados diagnósticos e intervenções de enfermagem para alterações laboratoriais encontradas. Resultados:revisados 25 artigos, que mostraram alterações laboratoriais em biomarcadores inflamatórios,de coagulação, bioquímicos e hematológicos capazes de interferir na funcionalidade do organismo, podendo acarretar complicações clínicas, como sangramentos, edemas e tromboembolismos, tornando fundamental a elaboração de plano de cuidados pelo Enfermeiro.Considerações finais:biomarcadores laboratoriais são importantes para identificação de pacientes com risco de gravidade e mortalidade, contribuindo para definição de diagnósticos e condutas de enfermagem em terapia intensiva. Descritores:COVID-19.Biomarcadores.Unidade de Terapia Intensiva.Cuidados de Enfermagem.Diagnóstico de Enfermagem

O método instrução ao sósia(ias) na pesquisa sobre o trabalho docente

Este estudio explora el procedimiento de instrucción al sosia en pesquisas acerca del trabajo docente. Esto es un recurso utilizado, muchas veces para reunir dados de trabajos, los cuáles analizan las reconfiguraciones del actuar docente en textos orales y escritos, como documentos oficiales, discurso de profesores y de alumnos; libros didácticos, medios de comu-nicación, entre otros recursos pertinentes para la actividad educacional. Así, nos dedicamos a mostrar la origen y la reformulación de este método y, por otro lado, examinamos dos teses que la utilizaron como un recurso metodológico útil para la comprensión del trabajo docente. De esa forma, presentamos las ventajas y las limitaciones de la utilización de esta metodología en eses trabajos, asimismo como aspectos relevantes que serán utilizados y/o adaptados en el análisis de las representaciones del trabajo del profesor de portugués de la educación básica

Quels sont les avantages et les inconvénients des technologies de l'information et de la communication (TIC) pour l'enfant de 3 à 6 ans et quelles sont les représentations des professionnels vis-à-vis de celles-ci ?

Les nouvelles technologies ne cessant de se développer, nous avons voulu, par le biais de ce travail, faire ressortir les impacts, tout autant positifs que négatifs, influençant le développement global d’un enfant de 3 à 6 ans. Par la suite, nous avons tenté de mettre en évidence les principales conditions d’utilisation des TIC devant être respectées afin d’assurer à l’enfant un bon développement. Dans une seconde partie, nous avons interrogé des professionnels de l’enfance afin d’analyser quelles sont leurs représentations à ce sujet. Nous nous sommes également intéressées au rôle qu’une éducatrice de l’enfance devrait jouer auprès des enfants. Finalement, l’utilisation inadéquate de l’outil ainsi que l’absence de la sensibilisation de l’adulte pourraient engendrer des comportements inappropriés. Les représentations des professionnels divergent encore, mais tendent néanmoins vers une certaine ouverture plus positive

Annurca apple (M. pumila Miller cv Annurca) extracts act against stress and ageing in S. cerevisiae yeast cells

During the past years, a number of studies have demonstrated the positive effect of apple on ageing and different diseases such as cancer, degenerative and cardiovascular diseases. The unicellular yeast Saccharomyces cerevisiae represents a simple eukaryotic model to study the effects of different compounds on lifespan. We previously demonstrated that apple extracts have anti-ageing effects in this organism because of their antioxidant properties. In particular, the effect is related to the presence in this fruit of polyphenols, which give a large contribution to the antioxidant activity of apples

Grau de transparência pública nas empresas estatais do Sul do Brasil

Esta pesquisa tem como objetivo analisar o grau de aderência aos requisitos de transparência e acesso à informação nos portais eletrônicos das empresas estatais pertencentes aos governos dos Estados do Rio Grande do Sul (RS), Paraná (PR) e Santa Catarina (SC). A partir de uma pesquisa quantitativa, descritiva e documental, foi possível evidenciar que as estatais do PR atingiram 76% de aderência à transparência, seguida pelas estatais do RS e de SC, com 64% e 62%, respectivamente. Ainda, 68% da amostra observa as exigências requeridas para os sítios eletrônicos, sendo classificadas como de médio grau de aderência. Ainda não há, no entanto, aderência plena, nem mesmo alto grau de aderência para todos os indicadores analisados, demonstrando que a fiscalização dos portais eletrônicos precisa ser mais efetiva.The objective of this research is to analyze the degree of adherence to transparency requirements and access to information in the electronic portals of the state-owned companies belonging to the states of Rio Grande do Sul (RS), Paraná (PR) and Santa Catarina (SC). From a quantitative, descriptive and documentary research, it was possible to show that the state-owned PR companies achieved 76% adherence to transparency, followed by RS and SC state, with 64% and 62%, respectively. Still, 68% of the sample meets the requirements required for electronic sites, being classified as medium degree of adhesion. However, there is still no full adherence, nor even a high degree of adherence to all the analyzed indicators, demonstrating that the supervision of electronic portals needs to be more effective

Aspectos basilares do interacionismo sociodiscursivo: conceitos vygotskyanos revisitados

In this paper, we will revisit some Vygostkian concepts which underpin the theoretical framework of Socio-Discursive Interactionism (SDI), proposed by Bronckart. From a resumption of studies on Vygotsky about higher mental processes, we will seek to understand the relevance of social relations for language acquisition and, from this, for human psychological development, for their insertion on social activities, and, consequently, for their citizenship education

Nacre, a natural, multi-use, and timely biomaterial for bone graft substitution

International audienceDuring the past two decades, with a huge and rapidly increasing clinical need for bone regeneration and repair, bone substitutes are more and more seen as a potential solution. Major innovation efforts are being made to develop such substitutes , some having advanced even to clinical practice. It is now time to turn to natural biomaterials. Nacre, or mother-of-pearl, is an organic matrix-calcium carbonate coupled shell structure produced by molluscs. In vivo and in vitro studies have revealed that nacre is osteoinductive, osteoconductive, biocompatible, and biodegradable. With many other outstanding qualities, nacre represents a natural and multi-use biomaterial as a bone graft substitute. This review aims at summarising the current needs in orthopaedic clinics and the challenges for the development of bone substitutes; most of all, we systematically review the physiological characteristics and biological evidence of nacre's effects centred on osteogen-esis, and finally we put forward the potential use of nacre as a bone graft substitute

The transmission of visceral leishmaniasis in the municipality of Guarujá, on the Coast of São Paulo state, Brazil

OBJECTIVE: To perform an entomological survey, evaluating the circulation of Leishmania spp. in sand flies captured from the new foci of visceral leishmaniasis (VL) in the coastal region of São Paulo state. METHODS: Sand flies were captured from November 2016 to September 2018 using light traps of the Centers for Disease Control (CDC), in the neighborhood where VL cases were reported. Leishmania spp. circulation was evaluated by gut dissection and molecular analysis of the females captured. RESULTS: Nyssomyia intermedia was the more frequent species (90,7%) within the 1,203 sand flies captured. We found no flagellates in dissected females, but two pools containing females of Ny. Intermedia presented DNA of L. infantum. CONCLUSION: Our results suggest that Ny. intermedia might be involved in the establishment of this new VL focus in Sao Paulo. However, before incriminating this species as a L. infantum vector, further studies should investigate other vectorial capacity parameters, including competence, survival, and feeding habits

Survival Benefit for Individuals with Constitutional Mismatch Repair Deficiency Syndrome and Brain Tumors Who Undergo Surveillance Protocol. A Report from the International Replication Repair Consortium

BACKGROUND Constitutional mismatch repair deficiency syndrome (CMMRD) is a severe cancer predisposition syndrome resulting in early onset central nervous system (CNS) and other cancers. International guidelines for surveillance exist but no study has systematically evaluated the efficacy of this protocol. METHODS We surveyed all confirmed CMMRD patients in the International Replication Repair Deficiency Consortium. A surveillance protocol consisting of frequent biochemical, endoscopic and imaging (CNS and total body MRI) studies were employed. Survival analyses and efficacy of each method were assessed. RESULTS Surveillance data were collected from 105 CMMRD individuals from 41 countries. Of the 193 malignant tumors, CNS malignancies were the most common (44%). The surveillance protocol uncovered 49 asymptomatic tumors including 16 glioblastomas and medulloblastomas. Five-year overall survival was 89% for tumors discovered by surveillance, and 61% for symptomatic tumors (p\u3c0.004). Similarly, 5-year survival was 82+/-11% and 24+/-6% for surveillance and non-surveillance of brain tumors (p=0.005). Yearly total body and q6 month brain MRI detected asymptomatic cancers in all but 3 symptomatic CNS gliomas. These were tumors uncovered when time between scans was \u3e6 months as per protocol. Finally, of the low grade tumors identified asymptomatically, 5 were low grade gliomas. All of the low grade gliomas, which were not resected transformed to high grade tumors at a median of 1.6 ± 0.9 years. CONCLUSION These data support a survival benefit in CMMRD patients undergoing a surveillance protocol. Adherence to protocol and resection of lower grade lesions may improve survival for patients with CNS tumors