4,560 research outputs found
From human Megakaryocytes to platelets: Effects of aspirin on high-mobility group Box 1/receptor for advanced glycation end products axis
Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis. Megakaryocytes (MKs) synthesize HMGB1 and transfer both protein and mRNA into PLTs and PLT-derived microvesicles (MV). Free HMGB1 found in supernatants of in vitro differentiated MKs and in a megakaryoblastic cell line (DAMI cells). Aspirin “in vivo” and “in vitro” not only reduces HMGB1 and receptor for advanced glycation end products expression on MKs and PLTs but also drives the movement of HMGB1 from MKs into PLTs and PLT-derived MV. These findings suggest that consumption of low doses of aspirin reduces the risk of atherosclerosis complications as well as reducing PLT aggregation by the inhibition of COX-1
Impact of a harbour construction on the benthic community of two shallow marine caves
Marine caves are unique and vulnerable habitats, threatened by multiple global and local disturbances. Whilst the effects of climate change on marine caves have already been investigated, no information exists about the effects of local human impacts, such as coastal development, on these habitats. This study investigated the impact of the construction of a touristic harbour on two shallow underwater marine caves in the Ligurian Sea (NW Mediterranean). As a standard methodology for monitoring marine caves does not exist yet, changes over time on the benthic community were assessed adopting two different non-taxonomic descriptors: trophic guilds and growth forms. Harbour construction caused an increase of sediment load within the caves, with a consequent decline of filter feeder organisms. Abundance of small organisms, such as encrusting and flattened sponges, was greatly reduced in comparison to organisms with larger and erect growth forms, such as domed mounds and pedunculated sponges. Our study indicated that growth forms and trophic guilds are effective descriptors for evaluating changes over time in marine caves, and could be easily standardised and applied in monitoring plans. In addition, as the harbour construction impacted differently according to the cave topography, the use of a systematic sampling in different zones of an underwater cave is recommended
Crystalline and electronic structure of single-layer TaS
Single-layer TaS is epitaxially grown on Au(111) substrates. The
resulting two-dimensional crystals adopt the 1H polymorph. The electronic
structure is determined by angle-resolved photoemission spectroscopy and found
to be in excellent agreement with density functional theory calculations. The
single layer TaS is found to be strongly n-doped, with a carrier
concentration of 0.3(1) extra electrons per unit cell. No superconducting or
charge density wave state is observed by scanning tunneling microscopy at
temperatures down to 4.7 K.Comment: 6 pages, 4 figure
Multiwavelength campaign on Mrk 509: testing realistic comptonization models
Mrk 509 was observed by XMM-Newton and INTEGRAL in October/November 2009, with one observation every four days for a total of ten observations. Each observation has been fitted with a realistic thermal Comptonization model for the continuum emission. Prompted by the correlation between the UV and soft X-ray flux, we used a thermal Comptonization component for the soft X-ray excess. The UV to X-ray/gamma-ray emission of Mrk 509 can be well fitted by these components, pointing to the existence of a hot (kT ∼ 100 keV), optically-thin (τ ∼ 0.5) corona producing the primary continuum. In contrast, the soft X-ray component requires a warm (kT ∼ 1 keV), optically-thick (τ ∼ 10-20) plasma. Estimates of the amplification ratio for this warm plasma support a configuration relatively close to the “theoretical” configuration of a slab corona above a passive disk. This plasma could be the warm upper layer of the accretion disk. In contrast, the hot corona has a more photon-starved geometry. The high temperature (∼ 100 eV) of the soft-photon field entering and cooling it favors a localization of the hot corona in the inner flow. This soft-photon field could be part of the comptonized emission produced by the warm plasma
Multiwavelength campaign on Mrk 509 XV. A global modeling of the broad emission lines in the Optical, UV and X-ray bands
We model the broad emission lines present in the optical, UV and X-ray
spectra of Mrk 509, a bright type 1 Seyfert galaxy. The broad lines were
simultaneously observed during a large multiwavelength campaign, using the
XMM-Newton-OM for the optical lines, HST-COS for the UV lines and
XMM-Newton-RGS and Epic for the X-ray lines respectively. We also used FUSE
archival data for the broad lines observed in the far-ultra-violet. The goal is
to find a physical connection among the lines measured at different wavelengths
and determine the size and the distance from the central source of the emitting
gas components. We used the "Locally optimally emission Cloud" (LOC) model
which interprets the emissivity of the broad line region (BLR) as regulated by
powerlaw distributions of both gas density and distances from the central
source. We find that one LOC component cannot model all the lines
simultaneously. In particular, we find that the X-ray and UV lines likely may
originate in the more internal part of the AGN, at radii in the range
~5x10^{14}-3x10^{17} cm, while the optical lines and part of the UV lines may
likely be originating further out, at radii ~3x10^{17}-3x^{18} cm. These two
gas components are parametrized by a radial distribution of the luminosities
with a slope gamma of ~1.15 and ~1.10, respectively, both of them covering at
least 60% of the source. This simple parameterization points to a structured
broad line region, with the higher ionized emission coming from closer in,
while the emission of the low-ionization lines is more concentrated in the
outskirts of the broad line region.Comment: 10 pages, 5 figures, accepted for publication in Astronomy and
Astrophysic
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