Propolis: A Wonder Bee Product and Its Pharmacological Potential in Dentistry

The use of natural products in the treatment of sickness has long been emphasised in the medical field. Today's biomedical applications employ a vast range of natural ingredients to treat a wide range of systemic disorders. Researchers have been interested in the natural product "propolis" because of its potential for use in bio-dental applications. Propolis is a non-toxic resinous material with therapeutic qualities like antibacterial, anticancer, antifungal, antiviral, and anti-inflammatory effects. The purpose of this research is to investigate the chemistry and characteristics of propolis in connection to its uses in dentistry and biomedicine. Furthermore, the present and prospective uses of propolis in biodental applications have been examined, along with its status and extent. This review gives the reader some insight into the potential use of propolis in contemporary dentistr

Recent advances in chalcone-triazole hybrids as potential pharmacological agents

Molecular hybridization is one of the recent strategies to synthesize a novel hybrid compound by combining two or more pharmacophoric units. Being a linkage process, it focuses on the synthesis of hybrids which are less toxic and more potent than their parent units. Therefore, nowadays medicinal chemists look forwards for the synthesis of new novel drugs using molecular hybridization. Chalcones are a class of very important structural motifs in medicinal chemistry. Similarly, 1,2,3-triazoles are heterocyclic bio-isostere having vast spectrum of applications due to its ease of synthesis, hydrogen bond formation, inertness towards oxidizing and reducing agents, moderate dipole moment and good binding with several binding agents. In this review, we have summarized the research articles describing the medicinal application of synthetic chalcone-triazole derivatives. The structural-activity relationship has been discussed which may provide helpful guidelines for the future drug synthesis based on chalcone and triazole moieties

Predation on a freshwater crab, Dilocarcinus dentatus (Tricodactylidae), by several tropical wolf spiders, Ancylometes bogotensis (Ctenidae), in Trinidad, WI

On 4 September, 2014, during a nocturnal field trip to the Aripo Savannas, Trinidad, (WGS 84 UTM 0697545 1176021), an unusual observation was made. Three adult spiders, Dilocarcinus dentatus, were observed feeding on an adult freshwater crab, Ancylometes bogotensis. The spiders were on vegetation above a flooded trail and there were many crabs in the water below. The crab was initially held by a female spider; two males were then seen to approach and also feed on the crab

Optical, X-Ray Diffraction, and Magnetic Properties of the Cobalt-Substituted Nickel Chromium Ferrites (FeO 4

Cobalt-substituted nickel chromium ferrites (CrCoNi1−FeO4, =0,0.2,0.4,0.6,0.8,1.0) have been synthesized using sol-gel autocombustion method and annealed at 400 °C, 600 °C, 800 °C, and 1000 °C. All the ferrite samples have been characterized using UV-VIS spectrophotometery, FT-IR spectroscopy, Transmission Electron Microscopy, powder X-Ray Diffraction, and magnetic measurements. Typical FT-IR spectra of the samples annealed at 400°C, 600°C, 800°C, and 1000°C exhibit two frequency bands in the range of ~480 cm−1 and ~590 cm−1 corresponding to the formation of octahedral and tetrahedral clusters of metal oxide, respectively. TEM images reveal that crystallite size increases from ~10 nm to ~45 nm as the annealing temperature is increased from 400°C to 1000°C. The unit cell parameter “a” is found to increase on increasing the cobalt concentration due to larger ionic radius of cobalt. Also, as the cobalt concentration increases, the saturation magnetization increases from 4.32 to 19.85 emu/g. This is due to the fact that cobalt ion replaces the less magnetic nickel ions. However, the coercivity decreases with increase in cobalt concentration due to the decrease in anisotropy field. The band gap has been calculated using UV-VIS spectrophotometry and has been found to decrease with the increase of particle size

Anesthetic management in a patient with Kindler's syndrome

A 35-year-old male with pan-anterior urethral stricture was scheduled to undergo perineal urethrostomy. He was a known case of Kindler's syndrome since infancy. He was having a history of blister formation, extensive poikiloderma and progressive cutaneous atrophy since childhood. He had a tendency of trauma-induced blisters with clear or hemorrhagic contents that healed with scarring. The fingers were sclerodermiform with dystrophic nails and inability to completely clench the fist. Airway examination revealed thyromental distance of 7 cm with limited neck extension, limited mouth opening and mallampatti class III with a fixed large tongue. He was reported as grade IV Cormack and Lehane laryngoscopic on previous anesthesia exposure. We described the anesthetic management of such case on guidelines for epidermolysis bullosa. In the operating room, an 18-G cannula was secured in the right upper limb using Coban™ Wrap. The T-piece of the cannula was than inserted into the slit and the tape was wrapped around the extremity. The ECG electrodes were placed on the limbs and fixed with Coban™. Noninvasive blood pressure cuff was applied over the wrap after wrapping the arm with Webril® cotton. Oral fiberoptic tracheal intubation was done after lubricating the laryngoscope generously with a water-based lubricant with 7-mm endotracheal tube. Surgery proceeded without any complication. After reversing the residual neuromuscular block, trachea was extubated once the patient became awake. He was kept in the postanesthesia care unit for 2 hours and then shifted to urology ward