Dulmage-Mendelsohn percolation: Geometry of maximally-packed dimer models and topologically-protected zero modes on diluted bipartite lattices

The classic combinatorial construct of {\em maximum matchings} probes the random geometry of regions with local sublattice imbalance in a site-diluted bipartite lattice. We demonstrate that these regions, which host the monomers of any maximum matching of the lattice, control the localization properties of a zero-energy quantum particle hopping on this lattice. The structure theory of Dulmage and Mendelsohn provides us a way of identifying a complete and non-overlapping set of such regions. This motivates our large-scale computational study of the Dulmage-Mendelsohn decomposition of site-diluted bipartite lattices in two and three dimensions. Our computations uncover an interesting universality class of percolation associated with the end-to-end connectivity of such monomer-carrying regions with local sublattice imbalance, which we dub {\em Dulmage-Mendelsohn percolation}. Our results imply the existence of a monomer percolation transition in the classical statistical mechanics of the associated maximally-packed dimer model and the existence of a phase with area-law entanglement entropy of arbitrary many-body eigenstates of the corresponding quantum dimer model. They also have striking implications for the nature of collective zero-energy Majorana fermion excitations of bipartite networks of Majorana modes localized on sites of diluted lattices, for the character of topologically-protected zero-energy wavefunctions of the bipartite random hopping problem on such lattices, and thence for the corresponding quantum percolation problem, and for the nature of low-energy magnetic excitations in bipartite quantum antiferromagnets diluted by a small density of nonmagnetic impurities.Comment: minor typos and errors fixed; further clarifications added. no substantive changes in result

Penetration of Projectiles in Composite Laminates

This paper deals with the prediction of the penetration phenomenon of a cylindro-conical impactor on the ke;labepoxy-laminated composites using C eight-nded serendipity q&drilateral finite elementbased on first-order shear deformation theory (FSDT). Local as well as global deformations during impact is considered in the evaluation of indentation, penetration, and perforation phases. Local strainsduring impact have been evaluated using the hypothesis made from the available experimental observations of bulging during penetration. A detailed parametric study, considering various projectilesand target plate variables, has been carried out to find their effect on the response of the plate, and ballistic parameters, such as ballistic limit and absorbed energy

Study of management of postpartum hemorrhage and its complications

Background: Postpartum hemorrhage (PPH) is globally one of the most common causes of maternal death, especially in developing country like India. Pregnancy and childbirth involve significant health risks, even to women with no preexisting health problem. The objective of this study was to analyze the role of various interventions in the management of PPH and its complications.Methods: This prospective observational study was conducted in the department of obstetrics and gynecology of Department of Obstetrics and Gynecology, Dr. D Y Patil Medical college, Pimpri, Pune, Maharashtra, India. A total number of 80 cases of postpartum hemorrhage that fulfilled the selection criteria were included. Data collected and analyzed in PPH patients with medical and surgical management.Results: In present study, most of cases were multigravida (60%) and more than 50 percent of patients required blood and blood products. In present study, most of the postpartum bleeding or postpartum hemorrhage (PPH) cases managed by medical methods. Uterotonic drugs (42.5%) This was possible due to early identification and timely intervention.Conclusions: Active management of third stage of labour is recommended in all cases. Seventy percent cases were  managed by medical methods while rest of the cases required surgical management. Among the medical management uterotonic drugs and bimanual uterine compression was used while among the surgical methods repair of cervical and vaginal laceration was mostly required

Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program

BACKGROUND: Single pulse transcranial magnetic stimulation (sTMS) is a novel treatment for acute migraine. Previous randomised controlled data demonstrated that sTMS is effective and well tolerated in the treatment of migraine with aura. The aim of the programme reported here was to evaluate patient responses in the setting of routine clinical practice. METHODS: Migraine patients with and without aura treating with sTMS had an initial review (n = 426) and training call, and then participated in telephone surveys at week six (n = 331) and week 12 during a 3-month treatment period (n = 190). RESULTS: Of patients surveyed with 3 month data (n = 190; episodic, n = 59; chronic, n = 131), 62 % reported pain relief, finding the device effective at reducing or alleviating migraine pain; in addition there was relief reported of associated features: nausea- 52 %; photophobia- 55 %; and phonophobia- 53 %. At 3 months there was a reduction in monthly headache days for episodic migraine, from 12 (median, 8–13 IQ range) to 9 (4–12) and for chronic migraine, a reduction from 24 (median, 16–30 IQ range) to 16 (10–30). There were no serious or unanticipated adverse events. CONCLUSION: sTMS may be a valuable addition to options for the treatment of both episodic and chronic migraine

Slope deviatory alignment, stream network and lineament orientation of the Sabarmati river system- neotectonic activity in the Mid -to Late Quaternary

The Gujarat alluvial plain located in the semi-arid zone is bounded by the arid Thar region in the north and the coastal/estuarine zone fringing the Arabian Sea in the south. It has been built by the rivers originating in the Aravalli Hills in the northeast. The drainages, with an average length of about 300 km, generally follow the NE-SW regional slope. However, the Sabannati River shows a flow deviating from the regional slope and follows a N-S to NNE-SSW trend in the alluvial area. The slope-deviatory trend of the Sabarmati has been investigated with regard to Late Quaternary neotectonics, fluvial-aeolian interaction and sea-level change. Lineament analysis indicates an E-W to WNW-ESE trajectory of maximum principal stress, and that drainage is primarily controlled by geodynamic processes. This is obvious from the correspondence in stress trajectories obtained from the lineament and drainage orientations, respectively. Sub-surface data indicate pre-Neogene faulting in the basin. It is inferred that these faults have been reactivated in the Mid- to Late Quaternary times. The slope-deviatory drainage of the Sabarmati River is, to a large extent, the result of fluvial adjustment to neotectonic reactivation in the region

Design and Performance of INMAS Whole Body Counter

A whole-body counter has been commissioned at INMAS for radiation protection and clinical applications including body potassium estimations. It has 4-crystal bed geometry inside a shielded enclosure. The background index of the system (counts) per minute per cc detector volume in the energy band 0.1-2 me V is about 0.6 comparing favorably with other whole-body monitors in the world. The sensitivity is 0.5 cpm per gram of K. Body potassium can be estimated can be estimated correct to 10 g for one hour counting. The variation in detector response to a point source on the mid-line of the bed is + - 10% of the mean over a length of 170 cm. The usefulness of the large dimensions of the enclosure chosen is discussed

Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia.

The role of Hedgehog signaling in normal and malignant T-cell development is controversial. Recently, Hedgehog pathway mutations have been described in T-ALL, but whether mutational activation of Hedgehog signaling drives T-cell transformation is unknown, hindering the rationale for therapeutic intervention. Here, we show that Hedgehog pathway mutations predict chemotherapy resistance in human T-ALL, and drive oncogenic transformation in a zebrafish model of the disease. We found Hedgehog pathway mutations in 16% of 109 childhood T-ALL cases, most commonly affecting its negative regulator PTCH1. Hedgehog mutations were associated with resistance to induction chemotherapy (P = 0.009). Transduction of wild-type PTCH1 into PTCH1-mutant T-ALL cells induced apoptosis (P = 0.005), a phenotype that was reversed by downstream Hedgehog pathway activation (P = 0.007). Transduction of most mutant PTCH1, SUFU, and GLI alleles into mammalian cells induced aberrant regulation of Hedgehog signaling, indicating that these mutations are pathogenic. Using a CRISPR/Cas9 system for lineage-restricted gene disruption in transgenic zebrafish, we found that ptch1 mutations accelerated the onset of notch1-induced T-ALL (P = 0.0001), and pharmacologic Hedgehog pathway inhibition had therapeutic activity. Thus, Hedgehog-activating mutations are driver oncogenic alterations in high-risk T-ALL, providing a molecular rationale for targeted therapy in this disease

A hierarchical latent response model for inferences about examinee engagement in terms of guessing and item‐level non‐response

In low‐stakes assessments, test performance has few or no consequences for examinees themselves, so that examinees may not be fully engaged when answering the items. Instead of engaging in solution behaviour, disengaged examinees might randomly guess or generate no response at all. When ignored, examinee disengagement poses a severe threat to the validity of results obtained from low‐stakes assessments. Statistical modelling approaches in educational measurement have been proposed that account for non‐response or for guessing, but do not consider both types of disengaged behaviour simultaneously. We bring together research on modelling examinee engagement and research on missing values and present a hierarchical latent response model for identifying and modelling the processes associated with examinee disengagement jointly with the processes associated with engaged responses. To that end, we employ a mixture model that identifies disengagement at the item‐by‐examinee level by assuming different data‐generating processes underlying item responses and omissions, respectively, as well as response times associated with engaged and disengaged behaviour. By modelling examinee engagement with a latent response framework, the model allows assessing how examinee engagement relates to ability and speed as well as to identify items that are likely to evoke disengaged test‐taking behaviour. An illustration of the model by means of an application to real data is presented

Forming a three-dimensional porous organic network via solid-state explosion of organic single crystals

Solid-state reaction of organic molecules holds a considerable advantage over liquid-phase processes in the manufacturing industry. However, the research progress in exploring this benefit is largely staggering, which leaves few liquid-phase systems to work with. Here, we show a synthetic protocol for the formation of a three-dimensional porous organic network via solid-state explosion of organic single crystals. The explosive reaction is realized by the Bergman reaction (cycloaromatization) of three enediyne groups on 2,3,6,7,14,15-hexaethynyl-9,10-dihydro-9,10-[1,2]benzenoanthracene. The origin of the explosion is systematically studied using single-crystal X-ray diffraction and differential scanning calorimetry, along with high-speed camera and density functional theory calculations. The results suggest that the solid-state explosion is triggered by an abrupt change in lattice energy induced by release of primer molecules in the 2,3,6,7,14,15-hexaethynyl-9,10-dihydro-9,10-[1,2]benzenoanthracene crystal lattice

Polarized Neutron Reflectometry of Nickel Corrosion Inhibitors.

Polarized neutron reflectometry has been used to investigate the detailed adsorption behavior and corrosion inhibition mechanism of two surfactants on a nickel surface under acidic conditions. Both the corrosion of the nickel surface and the structure of the adsorbed surfactant layer could be monitored in situ by the use of different solvent contrasts. Layer thicknesses and roughnesses were evaluated over a range of pH values, showing distinctly the superior corrosion inhibition of one negatively charged surfactant (sodium dodecyl sulfate) compared to a positively charged example (dodecyl trimethylammonium bromide) due to its stronger binding interaction with the surface. It was found that adequate corrosion inhibition occurs at significantly less than full surface coverage.X-ray photoelectron spectra were obtained at the National Engineering and Physical Sciences Research Council (EPSRC) XPS User’s Service (NEXUS) at Newcastle University, an EPSRC midrange facility. NR data were obtained on the D17 instrument, and samples were treated in the laboratories of the Partnership for Soft Condensed Matter (PSCM) at the Institut Laue-Langevin. M.H.W. is grateful for funding from the Oppenheimer Trust.This is the final version of the article. It first appeared from the American Chemical Society via http://dx.doi.org/10.1021/acs.langmuir.5b0171