601 research outputs found
Activity-dependent plasticity of transmitter release from nerve terminals in rat fast and slow muscles
Available under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.Peer reviewedPublisher PD
The Influence of Formulation, Buffering, pH and Divalent Cations on the Activity of Endothall on Hydrilla.
Endothall has been used as an aquatic herbicide for more
than 40 years and provides very effective weed control of
many weeds. Early research regarding the mechanism-of-action
of endothall contradicts the symptomology normally associated
with the product. Recent studies suggest endothall
is a respiratory toxin but the mechanism-of-action remains
unknown. To further elucidate the activity of endothall, several
endothall formulations were evaluated for their effects
on ion leakage, oxygen consumption and photosynthetic oxygen
evolution from hydrilla shoot tips. The influence of pH,
buffering and divalent cations was also evaluated. (PDF contains 6 pages.
Factors Affecting Patientsâ Use of Electronic Personal Health Records in England: Cross-Sectional Study
Background: Electronic personal health records (ePHRs) are secure Web-based tools that enable individuals to access, manage, and share their medical records. England recently introduced a nationwide ePHR called Patient Online. As with ePHRs in other countries, adoption rates of Patient Online remain low. Understanding factors affecting patientsâ ePHR use is important to increase adoption rates and improve the implementation success of ePHRs.
Objective: This study aimed to examine factors associated with patientsâ use of ePHRs in England.
Methods: The unified theory of acceptance and use of technology was adapted to the use of ePHRs. To empirically examine the adapted model, a cross-sectional survey of a convenience sample was carried out in 4 general practices in West Yorkshire, England. Factors associated with the use of ePHRs were explored using structural equation modeling.
Results: Of 800 eligible patients invited to take part in the survey, 624 (78.0%) returned a valid questionnaire. Behavioral intention (BI) was significantly influenced by performance expectancy (PE; beta=.57, P<.001), effort expectancy (EE; beta=.16, P<.001), and perceived privacy and security (PPS; beta=.24, P<.001). The path from social influence to BI was not significant (beta=.03, P=.18). Facilitating conditions (FC) and BI significantly influenced use behavior (UB; beta=.25, P<.001 and beta=.53, P<.001, respectively). PE significantly mediated the effect of EE and PPS on BI (beta=.19, P<.001 and beta=.28, P=.001, respectively). Age significantly moderated 3 paths: PEâBI, EEâBI, and FCâUB. Sex significantly moderated only the relationship between PE and BI. A total of 2 paths were significantly moderated by education and internet access: EEâBI and FCâUB. Income moderated the relationship between FC and UB. The adapted model accounted for 51% of the variance in PE, 76% of the variance in BI, and 48% of the variance in UB.
Conclusions: This study identified the main factors that affect patientsâ use of ePHRs in England, which should be taken into account for the successful implementation of these systems. For example, developers of ePHRs should involve patients in the process of designing the system to consider functions and features that fit patientsâ preferences and skills to ensure systems are useful and easy to use. The proposed model accounted for 48% of the variance in UB, indicating the existence of other, as yet unidentified, factors that influence the adoption of ePHRs. Future studies should confirm the effect of the factors included in this model and identify additional factors
Factors that affect the use of electronic personal health records among patients: A systematic review
Background: Electronic personal health records (ePHRs) are web-based tools that enable patients to access parts of their medical records and other services. In spite of the potential benefits of using ePHRs, their adoption rates remain very low. The lack of use of ePHRs among patients leads to implementation failures of these systems. Many studies have been conducted to examine the factors that influence patientsâ use of ePHRs, and they need to be synthesised in a meaningful way.ObjectiveThe current study aimed to systematically review the evidence regarding factors that influence patientsâ use of ePHRs. Methods: The search included: 42 bibliographic databases (e.g. Medline, Embase, CINHAL, and PsycINFO), hand searching, checking reference lists of the included studies and relevant reviews, contacting experts, and searching two general web engines. Study selection, data extraction, and study quality assessment were carried out by two reviewers independently. The quality of studies was appraised using the Mixed Methods Appraisal Tool. The extracted data were synthesised narratively according to the outcome: intention to use, subjective measures of use, and objective measures of use. The identified factors were categorised into groups based on Or and Karshâs conceptual framework. Results: Of 5225 citations retrieved, 97 studies were relevant to this review. These studies examined more than 150 different factors: 59 related to intention to use, 52 regarding subjectively-measured use, and 105 related to objectively-measured use. The current review was able to draw definitive conclusions regarding the effect of only 18 factors. Of these, only three factors have been investigated in connection with every outcome, which are: perceived usefulness, privacy and security concerns, and internet access. Conclusion: Of the numerous factors examined by the included studies, this review concluded the effect of 18 factors: 13 personal factors (e.g. gender, ethnicity, and income), four human-technology factors (e.g. perceived usefulness and ease of use), and one organisational factor (facilitating conditions). These factors should be taken into account by stakeholders for the successful implementation of these systems. For example, patients should be assured that the system is secure and no one can access their records without their permission in order to decrease their concerns about the privacy and security. Further, advertising campaigns should be carried out to increase patientsâ awareness of the system. More studies are needed to conclude the effect of other factors. In addition, researchers should conduct more theory-based longitudinal studies for assessing factors affecting initial use and continuing use of ePHRs among patients
A large pseudoautosomal region on the sex chromosomes of the frog Silurana tropicalis
Sex chromosome divergence has been documented across phylogenetically diverse species, with amphibians typically having cytologically nondiverged (âhomomorphicâ) sex chromosomes. With an aim of further characterizing sex chromosome divergence of an amphibian, we used âRAD-tagsâ and Sanger sequencing to examine sex specificity and heterozygosity in theWestern clawed frog Silurana tropicalis (also known as Xenopus tropicalis). Our findings based on approximately 20 million genotype calls and approximately 200 polymerase chain reaction-amplified regions across multiple male and female genomes failed to identify a substantially sized genomic region with genotypic hallmarks of sex chromosome divergence, including in regions known to be tightly linked to the sex-determining region.Wealso foundthat expression andmolecular evolutionof genes linked to the sex-determining region did not differ substantially from genes in other parts of the genome. This suggests that the pseudoautosomal region, where recombination occurs, comprises a large portion of the sex chromosomes of S. tropicalis. These resultsmay in part explainwhy African clawed frogs have such a high incidence of polyploidization, shed light onwhy amphibians have a high rate of sex chromosome turnover, and raise questions about why homomorphic sex chromosomes are so prevalent in amphibians
Results from the First Science Run of the ZEPLIN-III Dark Matter Search Experiment
The ZEPLIN-III experiment in the Palmer Underground Laboratory at Boulby uses
a 12kg two-phase xenon time projection chamber to search for the weakly
interacting massive particles (WIMPs) that may account for the dark matter of
our Galaxy. The detector measures both scintillation and ionisation produced by
radiation interacting in the liquid to differentiate between the nuclear
recoils expected from WIMPs and the electron recoil background signals down to
~10keV nuclear recoil energy. An analysis of 847kg.days of data acquired
between February 27th 2008 and May 20th 2008 has excluded a WIMP-nucleon
elastic scattering spin-independent cross-section above 8.1x10(-8)pb at
55GeV/c2 with a 90% confidence limit. It has also demonstrated that the
two-phase xenon technique is capable of better discrimination between electron
and nuclear recoils at low-energy than previously achieved by other xenon-based
experiments.Comment: 12 pages, 17 figure
WIMP-nucleon cross-section results from the second science run of ZEPLIN-III
We report experimental upper limits on WIMP-nucleon elastic scattering cross
sections from the second science run of ZEPLIN-III at the Boulby Underground
Laboratory. A raw fiducial exposure of 1,344 kg.days was accrued over 319 days
of continuous operation between June 2010 and May 2011. A total of eight events
was observed in the signal acceptance region in the nuclear recoil energy range
7-29 keV, which is compatible with background expectations. This allows the
exclusion of the scalar cross-section above 4.8E-8 pb near 50 GeV/c^2 WIMP mass
with 90% confidence. Combined with data from the first run, this result
improves to 3.9E-8 pb. The corresponding WIMP-neutron spin-dependent
cross-section limit is 8.0E-3 pb. The ZEPLIN programme reaches thus its
conclusion at Boulby, having deployed and exploited successfully three liquid
xenon experiments of increasing reach
The ZEPLIN-III dark matter detector: instrument design, manufacture and commissioning
We present details of the technical design and manufacture of the ZEPLIN-III
dark matter experiment. ZEPLIN-III is a two-phase xenon detector which measures
both the scintillation light and the ionisation charge generated in the liquid
by interacting particles and radiation. The instrument design is driven by both
the physics requirements and by the technology requirements surrounding the use
of liquid xenon. These include considerations of key performance parameters,
such as the efficiency of scintillation light collection, restrictions placed
on the use of materials to control the inherent radioactivity levels,
attainment of high vacuum levels and chemical contamination control. The
successful solution has involved a number of novel design and manufacturing
features which will be of specific use to future generations of direct dark
matter search experiments as they struggle with similar and progressively more
demanding requirements.Comment: 25 pages, 19 figures. Submitted to Astropart. Phys. Some figures down
sampled to reduce siz
The New Deal: jeopardised by the geography of unemployment?
The New Deal is the Labour government's flagship programme to "end the tragic waste of youth and long-term unemployment" by getting people off welfare benefits and into work. This paper argues that the principal weakness of the New Deal is that it seeks to influence the character of labour supply (i.e. the motivation and skills of the unemployed) while neglecting the state of labour demand, which varies greatly between places. The uneven geography of unemployment in the UK is likely to have a crucial bearing on the programme's impact and effectiveness, but this has been largely ignored in its development. The paper outlines some of the practical consequences of this imbalance and suggests how it could be rectified for the programme to be more effective
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