A importância do reconhecimento familiar dos idosos estudantes na decisão de ingressar e permanecer no Ensino Superior

A longevidade etária dos brasileiros tem gerado novas demandas de ingresso no Ensino Superior de cidadãos com mais de sessenta anos de idade. Este artigo resulta de duas pesquisas realizadas com os idosos regularmente matriculados na Universidade Federal de Viçosa, sendo esse trabalho um desdobramento original baseado nos discursos dos estudantes sobre o apoio familiar como elemento de motivação para o ingresso e permanência. A metodologia empregada foi a Análise do Discurso de linha francesa e a técnica de coleta de dados foi a entrevista semiestruturada. O principal referencial utilizado para a análise teórica foi a Teoria do Reconhecimento, proposta por Axel Honneth, pois buscou-se entender como os idosos universitários relataram seus processos de vínculo social com a instituição. A análise do material discursivo dos entrevistados identificou a importância do reconhecimento familiar dos idosos, principalmente no estímulo ao ingresso e permanência no Ensino Superior na instituição pesquisada. Conclui-se que políticas públicas brasileiras de inserção dos idosos no Ensino Superior precisam levar em consideração a conscientização dos familiares para que haja reconhecimento e apoio para permanência.The age longevity of Brazilians has created new demands for entry into Higher Education by citizens over sixty years of age. This article results from two surveys conducted with the elderly regularly enrolled at the Federal University of Viçosa, this work being an original development based on students´ speeches about family support as an element of motivation for admission and permanence. The methodology used was the French Discourse Analysis and the data collection technique was the semi-structured interview. The main reference used for the theoretical analysis was the Theory of Recognition, proposed by Axel Honneth, because it sought to understand how the elderly university students reported their processes of social bonding with the institution. The analysis of the interviewees´ discursive material identified the importance of family recognition of the elderly, especially in stimulating the entry and permanence in Higher Education at the researched institution. It is concluded that Brazilian public policies for the insertion of the elderly in Higher Education need to take into account the awareness of family members so that there is recognition and support for permanence.info:eu-repo/semantics/publishedVersio

Growth and rupture of an intracranial aneurysm: the role of wall aneurysmal enhancement and CD68+

IntroductionIntracranial aneurysms occur in 3%–5% of the general population. While the precise biological mechanisms underlying the formation, growth, and sudden rupture of intracranial aneurysms remain partially unknown, recent research has shed light on the potential role of inflammation in aneurysm development and rupture. In addition, there are ongoing investigations exploring the feasibility of employing new drug therapies for controlling the risk factors associated with aneurysms. CD68, a glycosylated glycoprotein and the human homolog of macrosialin, is prominently expressed in monocyte/macrophages within inflamed tissues and has shown potential application in oncology. An observational study was conducted with the aim of comparing the histological characteristics of aneurysm walls with preoperative MRI scans, specifically focusing on CD68 activity.MethodAn observational pilot study was conducted to investigate the histological characteristics of the aneurysm wall that could be potentially associated with aneurysm growth and rupture. A total of 22 patients diagnosed with ruptured and unruptured intracranial aneurysms who had undergone conventional clipping between January 2017 and December 2022 were included in the study.ResultsA histopathological analysis of the aneurysm wall was performed in all patients, particularly focusing on the presence of CD68. A preoperative MRI with gadolinium was conducted in 10 patients with unruptured aneurysms and six patients with ruptured aneurysms. An emergency clipping was performed in the remaining six patients. The results showed that CD68 positivity and wall enhancement were significantly associated with intracranial aneurysm wall degeneration, growth, and rupture.ConclusionThe histological and radiological inflammatory findings observed in the wall of cerebral aneurysms, as well as the CD68 positivity, are significantly associated with the risk of intracranial aneurysm growth and rupture. This study highlights the crucial importance of considering clinical and medical data when making treatment decisions for intracranial aneurysms. Furthermore, it emphasizes the relevance of evaluating wall enhancement in MRI scans as part of the diagnostic and prognostic process

Mixtures of bentonite with tropical soil and mining tailings for sanitary landfill liners

O intuito da presente pesquisa foi avaliar o potencial de aplicação de misturas de bentonita com um solo tropical e com um rejeito de mineração, para uso como barreiras impermeabilizantes de aterros sanitários. Para tal, desenvolveu-se um programa experimental de forma a analisar o comportamento mecânico e hidráulico dos materiais em seu estado puro (sem aditivo) e em misturas com 2%, 4%, 6% e 8% de bentonita, em termos de massa seca do material. Nos materiais no estado puro e suas misturas foram realizados ensaios de compactação na energia Proctor Normal, de condutividade hidráulica em permeâmetro de parede flexível, triaxiais adensados e não drenados (CIU) e de adensamento com deformação controlada (CRS). As curvas de compactação mostraram que, tanto para as misturas de solo tropical-bentonita como de rejeito-bentonita, houve um aumento no teor de umidade ótimo e uma redução no peso específico seco máximo, conforme o aumento no teor de bentonita. Os valores de condutividade hidráulica indicaram uma diminuição com o acréscimo de bentonita, tanto para o solo quanto para o rejeito. Observou-se que, com o aumento da tensão de adensamento dos corpos de prova, houve redução na condutividade hidráulica, tanto para as misturas solo-bentonita como rejeito- bentonita. Com relação ao solo, o teor de 8% de bentonita reduziu sua permeabilidade para valores aceitáveis para revestimento de fundo de aterros sanitários. Já para as misturas de rejeito-bentonita, os resultados indicaram uma redução da permeabilidade com a adição de bentonita. Contudo, mesmo o maior teor de bentonita utilizado (8%) não resultou em redução da permeabilidade para os valores recomendados. Em relação à resistência ao cisalhamento, constatou-se que, tanto para as misturas solo-bentonita como rejeito-bentonita, houve, no geral, uma redução desta com o aumento no teor de bentonita. A compressibilidade do solo tropical aumentou com o acréscimo de bentonita. Já para o rejeito, somente foram constatados aumentos na compressibilidade para as misturas com 4% e 6% de bentonita, sendo observada uma ligeira redução na mistura com 8% de bentonita. Palavras-chave: Solo-bentonita. Rejeito-bentonita. Impermeabilização. Aterros sanitários.The intent of this research was to evaluate the potential of application of bentonite mixtures with a tropical soil and with a mining tailings, for use as sanitary landfill liners. For this, an experimental program was developed in order to analyze the mechanical and hydraulic behavior of the materials in pure state (no additive) and in mixtures of 2%, 4%, 6% and 8% of bentonite, in terms of the dry mass of the material. In the pure state materials and their mixtures, compaction tests were performed using Proctor Normal energy, hydraulic conductivity in a flexible wall permeameter, consolidated undrained triaxial tests (CIU) and constant rate-of- strain tests (CRS). The compaction curves showed that, for both tropical soil-bentonite and tailings-bentonite mixtures, there was an increase in the optimum moisture content and a reduction in the maximum dry specific weight, according to the increase in bentonite content. The hydraulic conductivity values indicated a decrease with the addition of bentonite, both for the soil and for the tailings. With the increase in the values of consolidation stresses, it was observed that there was a reduction in hydraulic conductivity for both soil-bentonite and tailings-bentonite mixtures. Regarding the soil, the 8% content of bentonite reduced its permeability to acceptable values for sanitary landfill liner. For the tailings-bentonite mixtures, the results indicated a reduction in permeability with the addition of bentonite. However, these results indicated that even the highest content of bentonite used (8%) did not reduce the permeability to recommended values. Regarding shear strength, it was found that, for both soil- bentonite and tailings-bentonite mixtures, there was, in general, a reduction as the bentonite content increased. The compressibility of the tropical soil increased with the addition of bentonite. As for the tailings, there were only increases in compressibility for the mixtures with 4% and 6% of bentonite, with a slight reduction being observed in the mixture with 8% of bentonite. Keywords: Soil-bentonite. Tailings-bentonite. Impermeabilization. Sanitary landfills

The process of decision for buying women\'s clothing online: a study of differences in behavior among generations

O presente estudo investigou se há diferenças nas avaliações das consumidoras em relação à compra de roupa no ambiente online de acordo com a geração que pertencem. Buscou-se identificar se a preferência pela experiência de compra proporcionada pela loja física dificulta a escolha do canal virtual, também foi pesquisado sobre o impacto da falta de interação com o produto nas lojas virtuais e quais são os fatores que influenciam cada geração ao optar em comprar roupas pela internet. Para tanto, foi desenvolvido uma pesquisa de abordagem quantitativa, utilizando o método survey para coleta de dados no qual se aplicou um questionário online. Os resultados obtidos por meio de uma análise estatística multivariada demonstraram que, quanto mais velha a geração, menor é a utilização da internet para este tipo de compra, mas ao avaliar os motivos dentro os quais nunca compraram, mesmo aquelas consumidoras que já estão habituadas com o ambiente online para realizar outras tarefas de sua rotina, a impossibilidade de provar os produtos é realmente um impeditivo para esse tipo de compra. Notou-se que embora a Geração Y esteja mais conectada, os motivos pelos quais não compram roupa em lojas virtuais se assemelham aos das Gerações X e Baby Boomer. Entretanto, há aquelas consumidoras que valorizam a praticidade, a comodidade em comprar sem sair de casa e utilizam o canal virtual. A principal diferença no processo de escolha é que as gerações mais velhas utilizam com mais frequência as ferramentas disponíveis nas lojas virtuais para minimizar a distância do produto, como zoom nas fotos para analisar detalhes e tabela de medidas para conferir a numeração das peçasThe present study investigated whether there are differences in consumers\' evaluations regarding the purchase of clothing in the online environment according to the generation they belong to. We tried to identify if the preference for the shopping experience offered by the brick and mortar store made it difficult to choose the virtual channel, we also investigated the impact of the lack of interaction with the product in the virtual stores and what are the factors that influence each generation when opting to buy clothes over the internet. For that, a quantitative approach research was developed, using the survey method for data collection in which an online questionnaire was applied. The results obtained through a multivariate statistical analysis showed that the older the generation, the lower the use of the Internet for this type of purchase, but in evaluating the reasons for which they never bought, even for the consumers who are already used to the online environment to perform other routine tasks, the inability to try on the products is really an impediment to this type of purchase. It was possible to observe that although Generation Y is more connected, the reasons why they do not buy clothes in virtual stores resemble those of Generations X and Baby Boomer. However, there are those consumers who value the practicality, the convenience in buying without leaving home and use the virtual channel. The main difference in the process of choice is that older generations are more likely to use the tools available in virtual stores to minimize product distance, such as zooming in on photos to analyze details and measurement tables to check the numbering of the item

Glioma biopsies Classification Using Raman Spectroscopy and Machine Learning Models on Fresh Tissue Samples

Identifying tumor cells infiltrating normal-appearing brain tissue is critical to achieve a total glioma resection. Raman spectroscopy (RS) is an optical technique with potential for real-time glioma detection. Most RS reports are based on formalin-fixed or frozen samples, with only a few studies deployed on fresh untreated tissue. We aimed to probe RS on untreated brain biopsies exploring novel Raman bands useful in distinguishing glioma and normal brain tissue. Sixty-three fresh tissue biopsies were analyzed within few minutes after resection. A total of 3450 spectra were collected, with 1377 labelled as Healthy and 2073 as Tumor. Machine learning methods were used to classify spectra compared to the histo-pathological standard. The algorithms extracted information from 60 different Raman peaks identified as the most representative among 135 peaks screened. We were able to distinguish between tumor and healthy brain tissue with accuracy and precision of 83% and 82%, respectively. We identified 19 new Raman shifts with known biological significance. Raman spectroscopy was effective and accurate in discriminating glioma tissue from healthy brain ex-vivo in fresh samples. This study added new spectroscopic data that can contribute to further develop Raman Spectroscopy as an intraoperative tool for in-vivo glioma detection

Raman Spectroscopy and Machine Learning for IDH Genotyping of Unprocessed Glioma Biopsies

Isocitrate dehydrogenase (IDH) mutational status is pivotal in the management of gliomas. Patients with IDH-mutated (IDH-MUT) tumors have a better prognosis and benefit more from extended surgical resection than IDH wild-type (IDH-WT). Raman spectroscopy (RS) is a minimally invasive optical technique with great potential for intraoperative diagnosis. We evaluated the RS’s ability to characterize the IDH mutational status onto unprocessed glioma biopsies. We extracted 2073 Raman spectra from thirty-eight unprocessed samples. The classification performance was assessed using the eXtreme Gradient Boosted trees (XGB) and Support Vector Machine with Radial Basis Function kernel (RBF-SVM). Measured Raman spectra displayed differences between IDH-MUT and IDH-WT tumor tissue. From the 103 Raman shifts screened as input features, the cross-validation loop identified 52 shifts with the highest performance in the distinction of the two groups. Raman analysis showed differences in spectral features of lipids, collagen, DNA and cholesterol/phospholipids. We were able to distinguish between IDH-MUT and IDH-WT tumors with an accuracy and precision of 87%. RS is a valuable and accurate tool for characterizing the mutational status of IDH mutation in unprocessed glioma samples. This study improves RS knowledge for future personalized surgical strategy or in situ target therapies for glioma tumors

Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

Group 2 innate lymphoid cells (ILC2s) regulate inflammation, tissue repair and metabolic homeostasis1, and are activated by host-derived cytokines and alarmins1. Discrete subsets of immune cells integrate nervous system cues2, 3, 4, but it remains unclear whether neuron-derived signals control ILC2s. Here we show that neuromedin U (NMU) in mice is a fast and potent regulator of type 2 innate immunity in the context of a functional neuron–ILC2 unit. We found that ILC2s selectively express neuromedin U receptor 1 (Nmur1), and mucosal neurons express NMU. Cell-autonomous activation of ILC2s with NMU resulted in immediate and strong NMUR1-dependent production of innate inflammatory and tissue repair cytokines. NMU controls ILC2s downstream of extracellular signal-regulated kinase and calcium-influx-dependent activation of both calcineurin and nuclear factor of activated T cells (NFAT). NMU treatment in vivo resulted in immediate protective type 2 responses. Accordingly, ILC2-autonomous ablation of Nmur1 led to impaired type 2 responses and poor control of worm infection. Notably, mucosal neurons were found adjacent to ILC2s, and these neurons directly sensed worm products and alarmins to induce NMU and to control innate type 2 cytokines. Our work reveals that neuron–ILC2 cell units confer immediate tissue protection through coordinated neuroimmune sensory responses

Dataset related to article "Identification of a panel of miRNAs associated with resistance to palbociclib and endocrine therapy"

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Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study

(1) Background: We investigated the role of [11C]-methionine PET in a cohort of newly diagnosed glioblastoma multiforme (GBM) patients to evaluate whether it could modify the extent of surgical resection and improve radiation therapy volume delineation. (2) Methods: Newly diagnosed GBM patients, ages 18–70, with a Karnofsky performance scale (KPS) ≥ 70 with available MRI and [11C]-methionine PET were included. Patients were treated with different amounts of surgical resection followed by radio-chemotherapy. The role of [11C]-methionine PET in surgical and RT planning was analyzed. A threshold of SUVmax was searched. (3) Results: From August 2013 to April 2016, 93 patients were treated and included in this analysis. Residual tumor volume was detected in 63 cases on MRI and in 78 on [11C]-methionine PET, including 15 receiving gross total resection. The location of uptake was mainly observed in FLAIR abnormalities. [11C]-methionine uptake changed RT volume in 11% of patients. The presence of [11C]-methionine uptake in patients receiving GTR proved to influence survival (p = 0.029). The threshold of the SUVmax conditioning outcome was five. (4) Conclusions: [11C]-methionine PET allowed to detect areas at higher risk of recurrence located in FLAIR abnormalities in patients affected by GBM. A challenging issue is represented by integrating morphological and functional imaging to better define the extent of surgical resection to perform