Monopoles and clusters

We define and study certain hyperkaehler manifolds which capture the asymptotic behaviour of the SU(2)-monopole metric in regions where monopoles break down into monopoles of lower charges. The rate at which these new metrics approximate the monopole metric is exponential, as for the Gibbons-Manton metric.Comment: v2.: relation to calorons mentioned; added explanation

Structure, nonlinear properties, and photosensitivity of (GeSe2)​100-​x(Sb2Se3)​x glasses

International audienceChalcogenide glasses from (GeSe2)​100-​x(Sb2Se3)​x system were synthesized, with x varying from 5 to 70, in order to evaluate the influence of antimony selenide addn. on nonlinear optical properties and photosensitivity. Nonlinear refractive index and two photon absorption coeffs. were measured both at 1064 nm in picosecond regime using the Z-​scan technique and at 1.55 μm in femtosecond regime using an original method based on direct anal. of beam profile change while propagating in the chalcogenide glasses. The study of their photosensitivity at 1.55 μm revealed highly glass compn. dependent behavior and quasi-​photostable compns. have been identified in femtosecond regime. To better understand these characteristics, the evolution of the glass transition temp., d. and structure with the chem. compn. were detd

Closed forms and multi-moment maps

We extend the notion of multi-moment map to geometries defined by closed forms of arbitrary degree. We give fundamental existence and uniqueness results and discuss a number of essential examples, including geometries related to special holonomy. For forms of degree four, multi-moment maps are guaranteed to exist and are unique when the symmetry group is (3,4)-trivial, meaning that the group is connected and the third and fourth Lie algebra Betti numbers vanish. We give a structural description of some classes of (3,4)-trivial algebras and provide a number of examples.Comment: 36 page

derived neutrophil to lymphocyte ratio dnlr change between baseline and cycle 2 is correlated with benefit during immune checkpoint inhibitors ici in advanced non small cell lung cancer nsclc patients

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New insights into the genetic etiology of Alzheimer's disease and related dementias.

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Techniques logiques de commande et animation de structures matricielles électroluminescentes

This article presents some original techniques for visualisation of static or dynamic information on matrix displays. The used supports are electroluminescent devices composed of ZnS (Cu/Cl) (Destriau effect) or of light emitting diodes (GaAsP). Prototypes showing emitting performances of this supports according to the treatment of information have been made.Cet article traite de différentes techniques originales d'affichage d'informations statiques ou évolutives sur visualisateurs matriciels. Les supports utilisés sont des structures électroluminescentes au ZnS(Cu/Cl) (à effet Destriau) ou à diodes à injection de porteurs au GaAsP. Des réalisations concrètes d'afficheurs ont permis d'évaluer les performances émissives de ces supports en fonction des différentes techniques exposées

Techniques logiques de commande et animation de structures matricielles électroluminescentes

Cet article traite de différentes techniques originales d'affichage d'informations statiques ou évolutives sur visualisateurs matriciels. Les supports utilisés sont des structures électroluminescentes au ZnS(Cu/Cl) (à effet Destriau) ou à diodes à injection de porteurs au GaAsP. Des réalisations concrètes d'afficheurs ont permis d'évaluer les performances émissives de ces supports en fonction des différentes techniques exposées

Forecasting with unequally spaced data by a functional principal component approach

Karhunen-Loève expansion, least-squares linear prediction, orthogonal projection, principal components, 60G25, 60G12, 65F15,