Global Networks of Trade and Bits

Considerable efforts have been made in recent years to produce detailed topologies of the Internet. Although Internet topology data have been brought to the attention of a wide and somewhat diverse audience of scholars, so far they have been overlooked by economists. In this paper, we suggest that such data could be effectively treated as a proxy to characterize the size of the "digital economy" at country level and outsourcing: thus, we analyse the topological structure of the network of trade in digital services (trade in bits) and compare it with that of the more traditional flow of manufactured goods across countries. To perform meaningful comparisons across networks with different characteristics, we define a stochastic benchmark for the number of connections among each country-pair, based on hypergeometric distribution. Original data are thus filtered by means of different thresholds, so that we only focus on the strongest links, i.e., statistically significant links. We find that trade in bits displays a sparser and less hierarchical network structure, which is more similar to trade in high-skill manufactured goods than total trade. Lastly, distance plays a more prominent role in shaping the network of international trade in physical goods than trade in digital services.Comment: 25 pages, 6 figure

Phenylketonuria in Portugal: Genotype-Phenotype Correlations Using Molecular, Biochemical, and Haplotypic Analyses

The impairment of the hepatic enzyme phenylalanine hydroxylase (PAH) causes elevation of phenylalanine levels in blood and other body fluids resulting in the most common inborn error of amino acid metabolism (phenylketonuria). Persistently high levels of phenylalanine lead to irreversible damage to the nervous system. Therefore, early diagnosis of the affected individuals is important, as it can prevent clinical manifestations of the disease.info:eu-repo/semantics/publishedVersio

Performance and layout effects of SiGe channel in 14nm UTBB FDSOI: SiGe-first vs. SiGe-last integration

cited By 0International audienceWe report on the layout effects in strained SiGe channel FDSOI pMOSFETS down to 20nm gate length. Two SiGe integration schemes are compared: the SiGe-first approach, with Ge-enrichment performed prior to the STI module and the SiGe-last approach using only a SiGe epitaxy after the STI module. We evidence reduced layout effects in the SiGe-last integration featuring Si/SiGe bilayer. SiGe-last shows -39% mobility for 170nm narrow 2μm long channel, but +21% Ieff at Lg=20nm and gate-to-STI distance of 59nm. It is translated into a -15% delay reduction for ring oscillators of 1-finger inverters. Layout dependences are explained by physical strain measurements and reproduced by a stress-based electrical model. © 2016 IEEE

Toward the use of LES for industrial complex geometries. Part I: automatic mesh definition

International audienceWith the constant increase of computational power for the past years, Computational Fluid Dynamics (CFD) has become an essential part of the design in complex industrial processes. In this context, among the scale resolving numerical methods, Large-Eddy Simulation (LES) has become a valuable tool for the simulation of complex unsteady flows. To generalise the industrial use of LES, two main limitations are identified. First, the generation of a proper mesh can be a difficult task, which often relies on user-experience. Secondly, the ‘time-to-solution’ associated with the LES approach can be prohibitive in an industrial context. In this work, these two challenges are addressed in two parts. In this Part I, an automatic procedure for mesh definition is proposed, whereas the Part II is devoted to numerical technique to reduce the LES ‘time-to-solution’. The main goal of these works is then to develop an accurate LES strategy at an optimised computational cost. Concerning the mesh definition, because LES is based on separation between resolved and modelled subgrid-scales, the quality of the computed solution is then directly linked to the quality of the mesh. However, the definition of an adequate mesh is still an issue when LES is used to predict the flow in an industrial complex geometry without a priori knowledge of the flow dynamics. This first part presents a user-independent approach for both the generation of an initial mesh and the convergence of the mesh in the LES framework. An automatic mesh convergence strategy is proposed to ensure LES accuracy. This strategy is built to guarantee a mesh-independent mean field kinetic energy budget. The mean field kinetic energy is indeed expected to be mesh independent since only turbulent scales should be unresolved in LES. The approach is validated on canonical cases, a turbulent round jet and a turbulent pipe flow. Finally, the PRECCINSTA swirl burner is considered as a representative case of complex geometry. First, an algorithm for the generation of an unstructured mesh from a STL file is proposed to generate a coarse initial mesh, before applying the mesh convergence procedure. The overall strategy including automatic first mesh generation and its automatic adaptation paves the way to use LES approach as a decision support tool for various applications, provided that the ‘time-to-solution’ is compatible with the applications constraint. A second paper, referred as Part II, is devoted to the reduction of this time

An Overview of the Use of Music Therapy in the Context of Alzheimer\u27s Disease: A Report of a French Expert Group

OBJECTIVES: The aim of this overview is to present the developments of music therapy in France, its techniques, mechanisms and principal indications, mainly in the context of Alzheimer\u27s disease. METHODS: An international review of the literature on music therapy applied to Alzheimer\u27s disease was conducted using the principal scientific search engines. A work group of experts in music therapy and psychosocial techniques then considered the different points highlighted in the review of literature and discussed them. RESULTS AND DISCUSSION: Clinical and neurophysiological studies have enlightened some positive benefits of music in providing support for people with Alzheimer\u27s disease or related disorders. Music therapy acts mainly through emotional and psycho-physiological pathways. It includes a series of techniques that can respond to targeted therapeutic objectives. Some studies have shown that music therapy reduces anxiety, alleviates periods of depression and aggressive behaviour and thus significantly improves mood, communication and autonomy of patients. CONCLUSION: Psychosocial interventions, such as music therapy, can contribute to maintain or rehabilitate functional cognitive and sensory abilities, as well as emotional and social skills and to reduce the severity of some behavioural disorders