Mobilités contraintes, parcours professionnels, vie privée: Quels enjeux pour les cadres bancaires

Este artículo versa sobre los ejecutivos del sector bancario, grupo socio-profesional considerado privilegiado. Sin embargo, un análisis de las trayectorias de estos ejecutivos, hombres y mujeres, a través de entrevistas en profundidad, evidencian las tensiones entre vida profesional y vida conyugal: están obligados a aceptar mobilidades geográficas para ellos mismos y su familia para asegurarse una carrera. El modelo clásico de la división de la división sexual del trabajo dentro de las parejas pone al asalariado en una doble obligación de éxito frente a su empleador, frente a su familia que consiente seguirle en su nomadismo profesional. Las contradicciones observadas, factores de desestabilización, pueden convertirse en factores de resistencia cuando esos ejecutivos rechazan el coste conyugal de una mobilidad geográfica y que las parejas se opengan a los imperativos manageriales

Multifocal Ectopic Purkinje-Related Premature Contractions: A New SCN5A-Related Cardiac Channelopathy.: MEPPC: a new SCN5A-related cardiac channelopathy

International audienceOBJECTIVES: The aim of this study was to describe a new familial cardiac phenotype and to elucidate the electrophysiological mechanism responsible for the disease. BACKGROUND: Mutations in several genes encoding ion channels, especially SCN5A, have emerged as the basis for a variety of inherited cardiac arrhythmias. METHODS: Three unrelated families comprising 21 individuals affected by multifocal ectopic Purkinje-related premature contractions (MEPPC) characterized by narrow junctional and rare sinus beats competing with numerous premature ventricular contractions with right and/or left bundle branch block patterns were identified. RESULTS: Dilated cardiomyopathy was identified in 6 patients, atrial arrhythmias were detected in 9 patients, and sudden death was reported in 5 individuals. Invasive electrophysiological studies demonstrated that premature ventricular complexes originated from the Purkinje tissue. Hydroquinidine treatment dramatically decreased the number of premature ventricular complexes. It normalized the contractile function in 2 patients. All the affected subjects carried the c.665G>A transition in the SCN5A gene. Patch-clamp studies of resulting p.Arg222Gln (R222Q) Nav1.5 revealed a net gain of function of the sodium channel, leading, in silico, to incomplete repolarization in Purkinje cells responsible for premature ventricular action potentials. In vitro and in silico studies recapitulated the normalization of the ventricular action potentials in the presence of quinidine. CONCLUSIONS: A new SCN5A-related cardiac syndrome, MEPPC, was identified. The SCN5A mutation leads to a gain of function of the sodium channel responsible for hyperexcitability of the fascicular-Purkinje system. The MEPPC syndrome is responsive to hydroquinidine

Impact of clinical and genetic findings on the management of young patients with Brugada syndrome.

BACKGROUND: Brugada syndrome (BrS) is an arrhythmogenic disease associated with sudden cardiac death (SCD) that seldom manifests or is recognized in childhood. OBJECTIVES: The objectives of this study were to describe the clinical presentation of pediatric BrS to identify prognostic factors for risk stratification and to propose a data-based approach management. METHODS: We studied 106 patients younger than 19 years at diagnosis of BrS enrolled from 16 European hospitals. RESULTS: At diagnosis, BrS was spontaneous (n = 36, 34%) or drug-induced (n = 70, 66%). The mean age was 11.1 ± 5.7 years, and most patients were asymptomatic (family screening, (n = 67, 63%; incidental, n = 13, 12%), while 15 (14%) experienced syncope, 6(6%) aborted SCD or symptomatic ventricular tachycardia, and 5 (5%) other symptoms. During follow-up (median 54 months), 10 (9%) patients had life-threatening arrhythmias (LTA), including 3 (3%) deaths. Six (6%) experienced syncope and 4 (4%) supraventricular tachycardia. Fever triggered 27% of LTA events. An implantable cardioverter-defibrillator was implanted in 22 (21%), with major adverse events in 41%. Of the 11 (10%) patients treated with hydroquinidine, 8 remained asymptomatic. Genetic testing was performed in 75 (71%) patients, and SCN5A rare variants were identified in 58 (55%); 15 of 32 tested probands (47%) were genotype positive. Nine of 10 patients with LTA underwent genetic testing, and all were genotype positive, whereas the 17 SCN5A-negative patients remained asymptomatic. Spontaneous Brugada type 1 electrocardiographic (ECG) pattern (P = .005) and symptoms at diagnosis (P = .001) were predictors of LTA. Time to the first LTA event was shorter in patients with both symptoms at diagnosis and spontaneous Brugada type 1 ECG pattern (P = .006). CONCLUSION: Spontaneous Brugada type 1 ECG pattern and symptoms at diagnosis are predictors of LTA events in the young affected by BrS. The management of BrS should become age-specific, and prevention of SCD may involve genetic testing and aggressive use of antipyretics and quinidine, with risk-specific consideration for the implantable cardioverter-defibrillator

Familial et résidentiel : un couple indissociable

Le logement n'est pas un bien de consommation comme les autres et l'attachement affectif et identitaire que peut produire un lieu habité, les significations qui lui sont attribuées débordent son cadre purement physique et sa valeur marchande. Notamment, la perception qu'ont les " ménages ", confrontés à la question du logement et de leurs possibles résidentiels, est profondément marquée par la façon dont les générations familiales précédentes se sont elles-mêmes confrontées à cette question, lui ont apporté des solutions, ont transmis leurs expériences. À partir de quelques biographies individuelles et familiales centrées sur la question résidentielle, cet article s'attache à montrer en quoi l'espace résidentiel familial est un élément de la construction sociale des individus, et comment ces expériences familiales résidentielles fondent des stratégies résidentielles à leur tour constitutives des liens de famille.Housing is not a consumer product like any other, and the attachment both in terms of emotions and identity which can be produced by a place lived in, and the meanings attributed to it go beyond its physical framework and its commercial value. In particular, the perception that "households" have when confronted with the question of their residential possibilities is profoundly marked by the way in which preceding generations of families confronted the question, found solutions, and transmitted their experiences. Based on a number of individual and family biographies centred around the residential question, this paper sets out to show the ways in which family residential space is an element of the social construction of individuals and how these family residential experiences set up residential strategies which in turn are constitutive elements of family ties.La vivienda no es un bien de consumo como los otos y los lazos afectivos y de identidad que un lugar habitado puede producir, las significaciones que le son atribuidas, desbordan su marco putamente físico y su valor mercantil. Particularmente, la percepción que tienen las " familias ", confrontadas al problema de la vivienda y a sus lugares posibles de residencia, se encuentra profundamente marcada por la manera en la que las genvaciones familiares precedentes se confrontaron a este problema, le aportaron soluciones y les transmitieron sus experiencias. A partir de algunas biografías individuales y familiares centradas sobre la cuestión residencial, este artículo muestra de que manera el espacio residencial familiar es un elemento de la construcción social de los individuos, y cómo esas experiencias familiares residenciales fundan estrategias residenciales que en su momento son constitutivas de los lazos de familia

AS RELAÇÕES SOCIAIS DE SEXO: UM OBJETO MASCARADO? A PROPÓSITO DOS CORREIOS E TELÉGRAFOS

Contrastando com outros mundos socio-profissionais, o mundo dos Correios parece marcado pela mixidade e pela característica não sexuada de sua concepção de trabalho. Nada parece distinguir uma funcionária de um funcionário, pelo menos no início de sua carreira profissional. Os Correios serviço público, seria um lugar privilegiado pelo fim da dominação masculina?. A enquete conduzida por entrevistas em aproximadamente uma centena de agentes titulares – nos setores de triagem, distribuição e guichê – mostra que não é tão simples mas que, sem contestar os efeitos estruturantes, o peso das relações sociais de sexo variam no espaço e no tempo. Sublinharemos certa intercambialidade das posições homem-mulher, e em uma certa medida, uma suspensão da primazia classicamente atribuída na carreira profissional dos pares masculinos

Mobilités contraintes, parcours professionnels, vie privée: Quels enjeux pour les cadres bancaires

Este artículo versa sobre los ejecutivos del sector bancario, grupo socio-profesional considerado privilegiado. Sin embargo, un análisis de las trayectorias de estos ejecutivos, hombres y mujeres, a través de entrevistas en profundidad, evidencian las tensiones entre vida profesional y vida conyugal: están obligados a aceptar mobilidades geográficas para ellos mismos y su familia para asegurarse una carrera. El modelo clásico de la división de la división sexual del trabajo dentro de las parejas pone al asalariado en una doble obligación de éxito frente a su empleador, frente a su familia que consiente seguirle en su nomadismo profesional. Las contradicciones observadas, factores de desestabilización, pueden convertirse en factores de resistencia cuando esos ejecutivos rechazan el coste conyugal de una mobilidad geográfica y que las parejas se opengan a los imperativos manageriales

Catherine Omnès, Ouvrières parisiennes. Marchés du travail et trajectoires professionnelles au xxe siècle

Cet ouvrage se propose, à travers une histoire détaillée de l’emploi et des parcours couvrant le xxe siècle, d’identifier le milieu ouvrier féminin en croisant trajectoires socio-géographiques, comportements familiaux et sociaux, itinéraires professionnels. Il propose de comprendre, à la lumière de cette connaissance, la structure et le fonctionnement du marché du travail articulant main d’œuvre, entreprises et postes de travail. Initiative appréciable car le monde ouvrier du travail reste en..