The genetic history of Scandinavia from the Roman Iron Age to the present

The authors acknowledge support from the National Genomics Infrastructure in Stockholm funded by Science for Life Laboratory, the Knut and Alice Wallenberg Foundation and the Swedish Research Council, and SNIC/Uppsala Multidisciplinary Center for Advanced Computational Science for assistance with massively parallel sequencing and access to the UPPMAX computational infrastructure. We used resources from projects SNIC 2022/23-132, SNIC 2022/22-117, SNIC 2022/23-163, SNIC 2022/22-299, and SNIC 2021-2-17. This research was supported by the Swedish Research Council project ID 2019-00849_VR and ATLAS (Riksbankens Jubileumsfond). Part of the modern dataset was supported by a research grant from Science Foundation Ireland (SFI), grant number 16/RC/3948, and co-funded under the European Regional Development Fund and by FutureNeuro industry partners.Peer reviewedPublisher PD

Genome-wide association study identified novel candidate loci affecting wood formation in Norway spruce

Norway spruce is a boreal forest tree species of significant ecological and economic importance. Hence there is a strong imperative to dissect the genetics underlying important wood quality traits in the species. We performed a functional genome-wide association study (GWAS) of 17 wood traits in Norway spruce using 178 101 single nucleotide polymorphisms (SNPs) generated from exome genotyping of 517 mother trees. The wood traits were defined using functional modelling of wood properties across annual growth rings. We applied a Least Absolute Shrinkage and Selection Operator (LASSO-based) association mapping method using a functional multilocus mapping approach that utilizes latent traits, with a stability selection probability method as the hypothesis testing approach to determine a significant quantitative trait locus. The analysis provided 52 significant SNPs from 39 candidate genes, including genes previously implicated in wood formation and tree growth in spruce and other species. Our study represents a multilocus GWAS for complex wood traits in Norway spruce. The results advance our understanding of the genetics influencing wood traits and identifies candidate genes for future functional studies.Peer reviewe

En kvalitativ studie om anhörigkontakten på LSS-boenden ur ett professionellt perspektiv

Syftet med undersökningen är att få en förståelse för hur kontakten med anhöriga till brukare vid LSS- boenden ser ut ur de professionellas perspektiv. Genom att fokusera på de professionellas perspektiv, vill vi ta reda på de handlingsstrategier och utgångspunkter för dessa som utmynnar i kommunikation. - Hur ser kontakten med anhöriga ut vad gäller kontinuitet, form och innehåll? - Vad finns det för riktlinjer vad gäller kontakt och kommunikation med anhöriga? - Hur integrerar personalen riktlinjer, arbetsgruppens synsätt och individuell syn i kontakten med anhöriga? - Vad har personalen att säga om förväntningarna från andra professionella och brukarnas anhöriga? - Hur ser personalen på gränsdragningen mellan personligt och privat i kontakten med anhöriga? - Vilka svårigheter upplever personalen när det gäller att planera arbetet med brukarna i samförstånd med anhöriga? Studien har genomförts i form av kvalitativa forskningsintervjuer, med en intervjuguide som fokuserar på centrala teman inom ämnet. I resultatet framgår att samtliga intervjupersoner på olika vis uttrycker att det finns en problematik som utgår från att de upplever att de anhörigas förväntningar inte stämmer överens med den egna synen på den professionella arbetsrollen, vilket försvårar kommunikationen. Resultatet har analyserats utifrån symbolisk interaktionism och rollteori. I analysen har dessa olika förväntningar diskuterats utifrån de olika positioner, roller och sociala identiteter som de professionella och de anhöriga till brukarna befinner sig i

Xboxen som dator

Examensarbetet utfördes för Easygamer i Skoghall vilket är ett företag som bl.a. sysslar med modifiering av de flesta av dagens spelkonsoler samt försäljning av olika datorprodukter. Företaget ville att vi skulle göra om en Xbox till en ”studentdator” som de kallade det. Detta för att man ska kunna få en ganska kraftfull dator för inte så mycket pengar. Med en sådan dator skulle man sedan kunna använda ordbehandlingsprogram, lyssna på musik, surfa på Internet m.m. men självklart också kunna använda Xboxen som en vanlig spelkonsol, om så önskas.The Degree Project was performed at Easygamer in Skoghall which is a company that among other things modifies most of today’s gaming consoles and sells computer products. They wanted us to transform an Xbox to a “student computer”. You will be able to get a quite powerful computer for not that much money. With this kind of computer you will be able to use “office applications”, listen to music, use the internet etc. But of course, also use the Xbox as a gaming console, if you want to

Experimentally determined and Monte Carlo-calculated energy dependence of NaCl pellets read by optically stimulated luminescence for photon beams in the energy range 30 keV to 1.25 MeV

Ordinary salt, NaCl, has many properties suitable for dosimetry and has been suggested for both retrospective and prospective optically stimulated luminescence (OSL) dosimetry. Lately, the focus has been on NaCl that is compressed into solid pellets, as this improves both its handling and dosimetric properties. In this project, the energy dependence of NaCl pellets produced in-house was investigated for photon energies between 30 and 1.25 MeV. The NaCl pellets were first exposed to free-in-air conditions, and the estimated absorbed dose to the NaCl pellets was compared to the air kerma, K air, at the point of exposure. Second, a backscatter medium of polymethyl methacrylate (PMMA) was added, and NaCl pellets were exposed when positioned on a ISO slab phantom to relate the response in the NaCl to the personal dose equivalent, H p(10). The results show a significant energy dependence for exposure to low-energy photons with a peak over-response compared to K air and H p(10) of up to 18. Comparisons with Monte Carlo simulations show good agreement, even though the simulations cannot account for properties related to the intrinsic luminescence effects of the NaCl pellets or the readout and calibration process. The finite thickness of the NaCl pellet makes it an imperfect Bragg-Grey cavity, which complicates the behaviour of the energy dependence. The results presented here may serve as an important basis for further experimental and theoretical modelling of a build-up layer and filters in efforts to develop a passive personal dosemeter based on NaCl

Control of Gasoline Direct Injection Engines using Torque Feedback: A Simulation Study

Abstract not availabl

Control Of GDI Engines using Torque Feedback Exemplified by Simulations

A novel approach to the control of a GDI engine is presented. Thecontroller consists of a combination of subcontrollers, where torquefeedback is a central part. The subcontrollers are with a fewexceptions designed using simple linear feedback and feedforwardcontrol-design methods, in contrast to traditional table-based enginecontrol. A silent extremum-controller is presented. It is used tominimize the fuel consumption in stratified mode. The controller hasbeen evaluated with good results on the European driving cycle using adynamic simulation model

Models and methodology for optimal vehicle maneuvers applied to a hairpin turn

Abstract—There is currently a strongly growing interest in obtaining optimal control solutions for vehicle maneuvers, both in order to understand optimal vehicle behavior and to devise improved safety systems, either by direct deployment of the solutions or by including mimicked driving techniques of professional drivers. However, it is nontrivial to find the right mix of models, formulations, and optimization tools to get useful results for the above purposes. Here, a platform is developed based on a stateof-the-art optimization tool together with adoption of existing vehicle models, where especially the tire models are in focus. A minimum-time formulation is chosen to the purpose of gaining insight in at-the-limit maneuvers, with the overall aim of possibly finding improved principles for future active safety systems. We present optimal maneuvers for different tire models with a common vehicle motion model, and the results are analyzed and discussed. Our main result is that a few-state single-track model combined with different tire models is able to replicate the behavior of experienced drivers. Further, we show that the different tire models give quantitatively different behavior in the optimal control of the vehicle in the maneuver. I