125 research outputs found
Regression of Left Ventricular Hypertrophy in a Case of Sarcomeric Hypertrophic Cardiomyopathy: An Unexpected Outcome.
We present a case of sarcomeric hypertrophy cardiomyopathy diagnosed in a child who had hypertrophy degree regression during adolescence, with no left ventricular dysfunction and no increase of the ventricular diameters. (Level of Difficulty: Intermediate.).S
Aplicaciones web para prácticas de esquemas algorítmicos
Debido a las dificuldades del aprendizaje inicial
de las asignaturas de algoritmos en las
carreras de Informática, se trabaja en el desarrollo
de una aplicación Web que guíe y mejore
el aprendizaje y la resolución de problemas
mediante esquemas algorítmicos. La idea
es dar soporte a un ambiente de desarrollo común para alumnos y profesores, en el que se seguirá una estructura definida previamente en la utilización de los esquemas algorítmicos. El
alumno deberá utilizar en el desarrollo de las
prácticas los esquemas proporcionados, completando
los huecos correspondientes a las funciones
que aparecen en ellos, con lo que se pretende
corregir la tendencia en una aproximación
inicial a los algoritmos de alejarse de los
esquemas, lo que produce un gasto de tiempo
importante hasta que se comprende la importancia de los esquemas algorítmicos básicos.Peer Reviewe
Propuesta de una estrategia de Gestión del Conocimiento para la empresa MANUSERVICES S.A con el apoyo de una herramienta web, durante el primer semestre 2016
El aumento del conocimiento y de la información en las empresas durante estos últimos años ha sido tal, que hemos sido testigos de un avance acelerado en la tecnología, en la medicina, en la sociedad, etc. Existen empresas cuyo éxito radica en "organizar la información y lograr que sea útil y accesible para todo el mundo" como es el caso de la empresa estadounidense Google Inc.
Para algunos empresarios, la necesidad de mantener una muy buena gestión del conocimiento en sus empresas, es tan primordial, como el éxito mismo de ellas y es por ello, que han tenido que recurrir a la invención de modelos que les facilite organizar y distribuir de forma correcta este tan valioso recurso.
El presente trabajo constituye un estudio realizado por sus autores sobre la cultura organizacional y la proposición de un modelo de Gestión del conocimiento, que en conjunto con una herramienta informática daría a la empresa MANUSERVICES S.A. valores agregados y un mayor aprovechamiento de los recursos con que cuenta actualmente.
MANUSERVICES S.A es una empresa del sector industrial, dedicada a ofrecer sistemas Integrales de Limpieza Profesional al sector Industrial, Hospitalario, Proceso de Alimentos e Institucional, ha recibido distintas certificaciones de empresas extranjeras y nacionales por ser una empresa comprometida con la alta calidad de sus proceso
Quality Control of the Thermal Properties of Superstructures in Accommodation Spaces in Naval Constructions
The application of passive design strategies in ships, such as the use of superstructures with high thermal insulation, allows the energy demand of heating, ventilation, and air conditioning systems to be reduced. There is a knowledge gap in the scientific literature on the possibilities to thermally characterize superstructures. Knowing such possibilities would make a methodology available for the quality control of naval constructions and for the inspection of the appropriate state of insulations in existing ships. For this purpose, a total of three different typologies of ship superstructures were monitored, and the data obtained were analyzed by using various existing approaches for the thermal characterization of facades: the heat flow meter method and temperature measurement methods. The results showed that the heat flow meter method constitutes a valid methodology to obtain representative results. In addition, guaranteeing a thermal gradient dependent of the wall typology and placing probes in zones not influenced by thermal bridges ensure that representative results are achieved
Influence of temperature on PA 6−steel contacts in the presence of an ionic liquid lubricant. Poster
Room−temperature ionic liquids (ILs) are salts with a melting point lower than room temperature
and are called green solvents because they have properties such as:
♦ Non−flammability,
♦ Negligible volatility, and
♦ High thermal stability.
The high thermal stability range (from −74 ºC to 370 ºC in our case) of ILs makes them suitable
candidates as high temperature and extreme temperature lubricants. In this work we present the
mechanical and tribological properties of polyamide 6−IL dispersion (PA 6+3wt.% IL) under variable
load and temperature conditions, against AISI 52100 steel or AISI 316L stainless steel.We wish to thank MEC (Spain) and the EU FEDER program (MAT2002−03947 and MAT2005−00067) and the
Fundación Séneca (Región de Murcia, Spain) (PI/00447/FS/04) for financial support. A.E. Jiménez is grateful for a
research grant
PARP inhibition promotes endothelial-like traits in melanoma cells and modulates pericyte coverage dynamics during vasculogenic mimicry
Vasculogenic mimicry (VM) describes the ability of highly aggressive tumor cells to develop pseudovascular structures
without the participation of endothelial cells. PARP1 is implicated in the activation of hypoxia-inducible factors,
which are crucial in tumor neovascularization. We have explored the role of hypoxia and PARP inhibition in VM.
In uveal melanoma xenografts, the PARP inhibitor olaparib improved in vivo pericyte coverage specifically of VM
channels. This was concomitant with reduced metastasis in olaparib-treated VM+ tumors. PARP inhibition and hypoxia
modulated melanoma tube formation in vitro, inducing a more sparse and regular tubular architecture. Wholetranscriptome
profiling revealed that olaparib treatment under hypoxic conditions modulated the expression of
genes implicated in vasculogenesis during tube formation, enhancing the endothelial-like phenotype of VM+ uveal
melanoma cells. PARP inhibition, especially during hypoxia, upregulated PDGFβ, which is essential for pericyte
recruitment. Our study indicates that PARP inhibitors may enhance the endothelial characteristics of VM+ cells,
modulate pericyte coverage, and reduce metastatic spread in VM+ melanoma.Spanish Government
Ministry of Science and Innovation, Spain (MICINN)
Spanish Government SAF2015-70520-R
RTI2018-098968-B-I00
RTICC RD12/0036/0026CIBER Cancer ISCIII CB16/12/00421Junta de Andalucia PY20_01179Fundacion Domingo Martine
Apparent coordination of isocitrate dehydrogenase and glutamate decarboxylase expression in early stages of tree development
Prevalence of bleeding secondary to anticoagulation and mortality in patients with atrial fibrillation admitted with SARS-CoV-2 infection
Supplementary data associated with this article can befound, in the online version, at
https://doi.org/10.1016/j.medcli.2021.06.015Introduction and purpose: Atrial fibrillation (AF) is common in patients admitted with severe COVID-
19. However, there is limited data about the management of chronic anticoagulation therapy in these
patients. We assessed the anticoagulation and incidence of major cardiovascular events in hospitalized
patients with AF and COVID-19.
Methods: We retrospectively investigated all consecutive patients with AF admitted with COVID-19
between March and May 2020 in 9 Spanish hospitals. We selected a control group of non-AF patients
consecutively admitted with COVID-19. We compared baseline characteristics, incidence of major bleed-
ing, thrombotic events and mortality. We used propensity score matching (PSM) to minimize potential
confounding variables, as well as a multivariate analysis to predict major bleeding and death.
Results: 305 patients admitted with AF and COVID-19 were included. After PSM, 151 AF patients were
matched with 151 control group patients. During admission, low-molecular-weight heparin was the
principal anticoagulant and the incidence of major bleeding and mortality were higher in the AF group
[16 (10.6%) vs 3 (2%), p = 0.003; 52 (34.4%) vs 35 (23.2%), p = 0.03, respectively]. The multivariate analysis
showed the presence of AF as independent predictor of in-hospital major bleeding and mortality in
COVID-19 patients. In AF group, a secondary multivariate analysis identified high levels of D-dimer as
independent predictor of in-hospital major bleeding.
Conclusions: AF patients admitted with COVID-19 represent a population at high risk for bleeding and
mortality during admission. It seems advisable to individualize anticoagulation therapy during admission,
considering patient specific bleeding and thrombotic risk.Antecedentes y objetivos: La fibrilación auricular (FA) es frecuente en pacientes ingresados por COVID-19
grave. Sin embargo, los datos sobre el manejo de la anticoagulación crónica en estos pacientes son escasos.
Analizamos la anticoagulación y la incidencia de episodios cardiovasculares mayores en pacientes con FA
ingresados por la COVID-19.
Métodos: Retrospectivamente, se identificaron todos los pacientes con FA ingresados por la COVID-19
entre marzo y mayo de 2020, en 9 hospitales espa ̃noles. Se seleccionó un grupo control de pacientes
ingresados consecutivamente por la COVID-19 sin FA. Se compararon las características basales, inci-
dencia de hemorragias mayores, episodios trombóticos y mortalidad. Para reducir potenciales factores de
confusión se realizó un emparejamiento por puntuación de propensión, así como un análisis multivariante
para predecir hemorragia mayor y mortalidad.
Resultados: Se incluyeron 305 pacientes con FA ingresados por la COVID-19. Tras el emparejamiento
por puntuación de propensión, 151 pacientes con FA fueron emparejados con 151 controles. Durante el
ingreso, la heparina de bajo peso molecular fue el principal anticoagulante y la incidencia de hemorragia
mayor y mortalidad fue mayor en el grupo de FA (16[10,6%] vs. 3[2%], p = 0,003; 52[34,4%] vs. 35[23,2%],
p = 0,03, respectivamente). El análisis multivariante demostró la presencia de FA como predictor indepen-
diente de sangrados y mortalidad intrahospitalaria en los pacientes con la COVID-19. En el grupo de FA,
un segundo análisis multivariante identificó valores elevados de dímero-D como predictor independiente
de hemorragia mayor intrahospitalaria.
Conclusiones: Los pacientes con FA ingresados por la COVID-19 representan una población de alto riesgo
de sangrado y mortalidad durante el ingreso. Parece recomendable individualizar la anticoagulación
durante el ingreso, considerando el riesgo específico de sangrado y trombosis
Seed Viability, Spikelet Dispersal, Seed Banks and Seed Storage Requirements for Native and Invasive Cordgrasses (Genus Spartina) in Southwest Iberian Peninsula
Seed banks play an important role in determining the spatial and temporal distribution of halophytes in salt marshes. We
tested the ability of native Spartina maritima and invasive S. densiflora spikelets to disperse by flotation on water with different
salinity concentrations, and the longevity of spikelet viability relative to environmental conditions including dry or
wet storage at low or moderate temperatures, and aqueous salinity concentrations from fresh to sea water. We quantified
pre-dispersal seed production and pre- and post-dispersal focal Spartina spp. presence in seed banks along intertidal gradients
within salt marshes at the Gulf of Cádiz (Southwest Iberian Peninsula). Spartina densiflora spikelets, especially from
middle and high elevation marshes, showed greater ability than S. maritima to remain afloat, which suggests this species
could be dispersed over longer distances. Wet-stored Spartina seeds were able to maintain viability for months, while seeds
under dry storage rapidly lost viability. This decline was most significant for S. maritima, and for seeds stored at moderate
temperatures. Storage of spikelets under wet and cold conditions optimized spikelet viability. Native S. maritima did not
establish transient or persistent seed banks, while invasive S. densiflora established transient seed banks mainly at higher
marsh elevations. Our results on the dynamics of seed dispersal and seed banks and seedling recruitment provide fundamental
knowledge that can be applied for conservation of native S. maritima, management of invasive S. densiflora, and ecological
restoration of tidal salt marshes.Funding for open access publishing: Universidad de Sevilla / CBUA Open Access funding enabled and organized by Universidad de Sevilla. M.D. Infante-Izquierdo acknowledges to Ministerio de Educación, Cultura y Deporte of Spanish Government for the FPU Grant (FPU14/06556)
Heterozygous Arrhythmogenic Cardiomyopathy-desmoplakin Mutation Carriers Exhibit a Subclinical Cutaneous Phenotype with Cell Membrane Disruption and Lack of Intercellular Adhesion
Genetic variants that result in truncation in desmoplakin (DSP) are a known cause of
arrhythmogenic cardiomyopathy (AC). In homozygous carriers, the combined involvement of skin
and heart muscle is well defined, however, this is not the case in heterozygous carriers. The aim of
this work is to describe cutaneous findings and analyze the molecular and ultrastructural cutaneous
changes in this group of patients. Four women and eight men with a mean age of 48 ± 14 years
were included. Eight met definitive criteria for AC, one was borderline and three were silent carriers.
No relevant macroscopic changes in skin and hair were detected. However, significantly lower skin
temperature (29.56 vs. 30.97 ◦C, p = 0.036) and higher transepidermal water loss (TEWL) (37.62 vs.
23.95 g m 2 h 1, p = 0.028) were observed compared to sex- and age-matched controls. Histopathology
of the skin biopsy showed widening of intercellular spaces and acantholysis of keratinocytes in the
spinous layer. Immunohistochemistry showed a strongly reduced expression of DSP in all samples.
Trichogram showed regular nodules (thickening) compatible with pseudomonilethrix. Therefore,
regardless of cardiac involvement, heterozygous patients with truncation-type variants in DSP have
lower skin temperature and higher TEWL, constant microscopic skin involvement with specific
patterns and pseudomonilethrix in the trichogram.Andalusian Society of Cardiology with a “beca de
Investigación general
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