Traditional Herbal Medicine in Mesoamerica: Toward Its Evidence Base for Improving Universal Health Coverage

The quality of health care in Mesoamerica is influenced by its rich cultural diversity and characterized by social inequalities. Especially indigenous and rural communities confront diverse barriers to accessing formal health services, leading to often conflicting plurimedical systems. Fostering integrative medicine is a fundamental pillar for achieving universal health coverage (UHC) for marginalized populations. Recent developments toward health sovereignty in the region are concerned with assessing the role of traditional medicines, and particularly herbal medicines, to foster accessible and culturally pertinent healthcare provision models. In Mesoamerica, as in most regions of the world, a wealth of information on traditional and complementary medicine has been recorded. Yet these data are often scattered, making it difficult for policy makers to regulate and integrate traditionally used botanical products into primary health care. This critical review is based on a quantitative analysis of 28 survey papers focusing on the traditional use of botanical drugs in Mesoamerica used for the compilation of the “Mesoamerican Medicinal Plant Database” (MAMPDB), which includes a total of 12,537 use-records for 2188 plant taxa. Our approach presents a fundamental step toward UHC by presenting a pharmacological and toxicological review of the cross-culturally salient plant taxa and associated botanical drugs used in traditional medicine in Mesoamerica. Especially for native herbal drugs, data about safety and effectiveness are limited. Commonly used cross-culturally salient botanical drugs, which are considered safe but for which data on effectiveness is lacking constitute ideal candidates for treatment outcome studies

Green Health in Guatemala - How can we build mutual trust and partnerships for developing local medicines’ evidence-base and potential?

The implementation of access and benefit-sharing (ABS) protocols and especially the Nagoya Protocol has created new hurdles for collaborations around Indigenous Traditional Knowledge and international collaborations. Overall, these frameworks push for the development of novel collaborative North-South agendas in order to improve the fair distribution of benefits. The Green Health project (Guatemala) aims to implement a culturally pertinent and mutually accepted framework for sustainable use, access and benefit-sharing (ABS) of traditional medicinal plants. It involves developing a consensus among indigenous groups, government officials, industry, and academia. We describe steps undertaken to design and implement an intercultural transdisciplinary process that promotes trust building and advances herbal medicine research in a respectful and innovative way. This involves joint definition of goals and methods. The consortium co-researched Q’eqchi’ Maya traditional medicine, collected voucher specimens of medicinal plants with traditional healers, identified their taxa, and later developed a literature-based evaluation identifying species for potential product development. No samples for further research and development are collected. By applying the emic-etic concept, the project was able to understand the main drivers of each stakeholder and the associated obstacles for reaching an ABS agreement. This results in the emergence of potential new drivers for developing evidence-based herbal medicine from the perspective of academia, policy and cooperation and grass-roots indigenous movements

Leptogenesis and Low-energy Observables

We relate leptogenesis in a class of theories to low-energy experimental observables: quark and lepton masses and mixings. With reasonable assumptions motivated by grand unification, one can show that the CP-asymmetry parameter takes a universal form. Furthermore the dilution mass is related to the light neutrino masses. Overall, these models offer a natural explanation for a lepton asymmetry in the early universe.Comment: 10 pages, revised discussion on light neutrino masse

Transport Properties through Double Barrier Structure in Graphene

The mode-dependent transmission of relativistic ballistic massless Dirac fermion through a graphene based double barrier structure is being investigated for various barrier parameters. We compare our results with already published work and point out the relevance of these findings to a systematic study of the transport properties in double barrier structures. An interesting situation arises when we set the potential in the leads to zero, then our 2D problem reduces effectively to a 1D massive Dirac equation with an effective mass proportional to the quantized wave number along the transverse direction. Furthermore we have shown that the minimal conductivity and maximal Fano factor remain insensitive to the ratio between the two potentials V_2/V_1=\alpha.Comment: 18 pages, 12 figures, clarifications and reference added, misprints corrected. Version to appear in JLT

Numerical Approaches to Spacetime Singularities

This Living Review updates a previous version which its itself an update of a review article. Numerical exploration of the properties of singularities could, in principle, yield detailed understanding of their nature in physically realistic cases. Examples of numerical investigations into the formation of naked singularities, critical behavior in collapse, passage through the Cauchy horizon, chaos of the Mixmaster singularity, and singularities in spatially inhomogeneous cosmologies are discussed.Comment: 51 pages, 6 figures may be found in online version: Living Rev. Relativity 2002-1 at www.livingreviews.or

Relativistic Hartree-Bogoliubov description of ground-state properties of Ni and Sn isotopes

The Relativistic Hartree Bogoliubov (RHB) theory is applied in the description of ground-state properties of Ni and Sn isotopes. The NL3 parameter set is used for the effective mean-field Lagrangian, and pairing correlations are described by the pairing part of the finite range Gogny interaction D1S. Fully self-consistent RHB solutions are calculated for the Ni ($28\leq N\leq 50$) and Sn ($50\leq N\leq 82$) isotopes. Binding energies, neutron separation energies, and proton and neutron $rms$ radii are compared with experimental data. The model predicts a reduction of the spin-orbit potential with the increase of the number of neutrons. The resulting energy splittings between spin-orbit partners are discussed, as well as pairing properties calculated with the finite range effective interaction in the $pp$ channel.Comment: 11 pages, RevTex, 12 p.s figures, submitted to Phys. Rev.

A New Parameterization for the Lagrangian Density of Relativistic Mean Field Theory

A new parameterization for an effective non-linear Lagrangian density of relativistic mean field (RMF) theory is proposed, which is able to provide an excellent description not only for the properties of stable nuclei but also for those far from the valley of beta-stability. In addition recently measured superdeformed mimima in the Hg-region are reproduced with high accuracy.Comment: 8 pages, Latex, 1 ps figur

Gas and dust properties in the afterglow spectra of GRB 050730

We present early WHT ISIS optical spectroscopy of the afterglow of gamma-ray burst GRB 050730. The spectrum shows a DLA system with the highest measured hydrogen column to date: N(HI) = 22.1 +/- 0.1 at the third-highest GRB redshift z = 3.968. Our analysis of the Swift XRT X-ray observations of the early afterglow show X-ray flares accompanied by decreasing X-ray absorption. From both the optical and the X-ray spectra we constrain the dust and gas properties of the host galaxy. We find the host to be a low metallicity galaxy, with low dust content. Much of the X-ray absorbing gas is situated close to the GRB, whilst the HI absorption causing the DLA is most likely located further out.Comment: 5 pages, 2 figures. Accepted for A&A Letter

Identifying the Higgs Boson in Electron--Photon Collisions

We analyze the production and detection of the Higgs boson in the next generation of linear $e^+e^-$ colliders operating in the $e\gamma$ mode. In particular, we study the production mechanism $e + \gamma \rightarrow e \gamma \gamma \rightarrow e + H$, where one photon is generated via the laser backscattering mechanism, while the other is radiated via the usual bremsstrahlung process. We show that this is the most important mechanism for Higgs boson production in a $500$ GeV $e\gamma$ collider for M_H\raisebox{-.4ex}{\rlap{\sim}} \raisebox{.4ex}{>}140 GeV. We also study the signals and backgrounds for detection of the Higgs in the different decay channels, $b \bar b$, $W^+W^-$, and $ZZ$, and suggest kinematical cuts to improve the signature of an intermediate mass Higgs boson.Comment: (REVTEX 2.0, 12 pages and 9 figures available upon request, Preprint MAD/PH/753

Leptogenesis and low energy observables in left-right symmetric models

In the context of left-right symmetric models we study the connection of leptogenesis and low energy parameters such as neutrinoless double beta decay and leptonic CP violation. Upon imposition of a unitarity constraint, the neutrino parameters are significantly restricted and the Majorana phases are determined within a narrow range, depending on the kind of solar solution. One of the Majorana phases gets determined to a good accuracy and thereby the second phase can be probed from the results of neutrinoless double beta decay experiments. We examine the contributions of the solar and atmospheric mass squared differences to the asymmetry and find that in general the solar scale dominates. In order to let the atmospheric scale dominate, some finetuning between one of the Majorana phases and the Dirac CP phase is required. In this case, one of the Majorana phases is determined by the amount of CP violation in oscillation experiments.Comment: 18 pages, 6 figures. Matches version to appear in PR