Radiação fotossinteticamente ativa (PAR) contida na radiação solar global incidente e refletida pela alfafa no Rio Grande do Sul

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process innovation alliances and the interplay of firm age early evidence from italian small firms

We investigate whether and how process innovation of small enterprises is influenced by allying with another firm. Drawing on resource-based view of the firm and integrating findings from studies on the liabilities of age and newness, we argue: 1) for a direct association between strategic alliances and process innovation, and 2) in favor of a moderating role of firm age on this relationship. The results from a representative sample of 159 Italian small firms shed new light on the role of strategic alliances in explaining process innovation, and support this proposal. We find a significant and positive relationship between strategic alliances and process innovation, and a moderating effect of firm age on this relationship. This suggests that a younger firm benefits more than an older one from the increase in process innovation activities occurring as a result of alliances with other firms. The age of the firm appears to dictate the nature of relationship between strategic alliances and process innovation. Significant and novel theoretical and managerial implications are discussed.</p

Estimating HIV-1 incidence using the serologic testing algorithm for recent HIV infections at HIV counseling and testing centers in the city of São Paulo, Brazil

The network of HIV counseling and testing centers in São Paulo, Brazil is a major source of data used to build epidemiological profiles of the client population. We examined HIV-1 incidence from November 2000 to April 2001, comparing epidemiological and socio-behavioral data of recently-infected individuals with those with long-standing infection. A less sensitive ELISA was employed to identify recent infection. The overall incidence of HIV-1 infection was 0.53/100/year (95% CI: 0.31-0.85/100/year): 0.77/100/year for males (95% CI: 0.42-1.27/100/year) and 0.22/100/ year (95% CI: 0.05-0.59/100/year) for females. Overall HIV-1 prevalence was 3.2% (95% CI: 2.8-3.7%), being 4.0% among males (95% CI: 3.3-4.7%) and 2.1% among females (95% CI: 1.6-2.8%). Recent infections accounted for 15% of the total (95% CI: 10.2-20.8%). Recent infection correlated with being younger and male (p = 0.019). Therefore, recent infection was more common among younger males and older females.Secretaria Municipal de Saúde de São PauloUniversidade de São Paulo Faculdade de Saúde Pública Departamento de EpidemiologiaSanta Casa de São Paulo Faculdade de Ciências Médicas Departamento de Medicina SocialUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Laboratório de RetrovirologiaUNIFESP, EPM, Laboratório de RetrovirologiaSciEL

PEDESIGN: a construção de um objeto de aprendizagem baseado no design pedagógico

Os recursos digitais vêm sendo cada vez mais aplicados ao uso educacional.Porém, o simples uso da tecnologia pela tecnologia não é suficiente para possibilitaruma aprendizagem significativa, tornando-se necessário a aplicação de novas práticaspedagógicas. Neste contexto, o design de interface é um dos fatores mais importantespara a contemplação de uma boa interatividade entre o computador e o usuário, assimcomo interação entre sujeitos. No entanto, a sua função é normalmente reduzida aobjetivos decorativos. A partir dessas questões, o presente artigo relata a aplicação dodesign pedagógico no processo de construção do objeto de aprendizagem PEDESIGN.Através dessa prática, objetiva-se divulgar a importância do equilíbrio entre oplanejamento técnico, gráfico e pedagógico na elaboração de materiais educacionaisdigitais

PLANETA ROODA: uma nova prototipagem baseada na WEB 2.0

A socialização da internet gera uma facilidade de acesso às informações emaior interação entre as pessoas, antes limitada por distanciamentos culturais ougeográficos. A educação, por sua vez, acompanha essas modificações da sociedade,tentando se inovar a passos muito lentos. Dentro deste quadro de mudanças, o PlanetaROODA 2.0 surge como uma forma de unir a tecnologia da web com a interação sociale autônoma do usuário, possibilitando que o aluno construa o seu conhecimento evalorize o seu aprendizado. Desse modo, este estudo propõe a elaboração de umambiente virtual de aprendizagem baseado na Web 2.0

Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10.

BACKGROUND: Interleukin-15 (IL-15) promotes growth and activation of cytotoxic CD8 METHODS: The antitumor activity of hetIL-15 produced from mammalian cells was tested in mouse tumor models (MC38 colon carcinoma and TC-1 epithelial carcinoma). The functional diversity of the immune infiltrate and the cytokine/chemokine network within the tumor was evaluated by flow cytometry, multicolor immunohistochemistry (IHC), gene expression profiling by Nanostring Technologies, and protein analysis by electrochemiluminescence and ELISA assays. RESULTS: hetIL-15 treatment resulted in delayed primary tumor growth. Increased NK and CD8 CONCLUSIONS: Our results show that hetIL-15 administration enhances T cell entry into tumors, increasing the success rate of immunotherapy interventions. Our study further supports the incorporation of hetIL-15 in tumor immunotherapy approaches to promote the development of antitumor responses by favoring effector over regulatory cells and by promoting lymphocyte and DC localization into tumors through the modification of the tumor chemokine and cytokine milieu

Persistent Inflammation Alters the Function of the Endogenous Brain Stem Cell Compartment

Endogenous neural stem/precursor cells (NPCs) are considered a functional reservoir for promoting tissue homeostasis and repair after injury, therefore regenerative strategies that mobilize these cells have recently been proposed. Despite evidence of increased neurogenesis upon acute inflammatory insults (e.g. ischaemic stroke), the plasticity of the endogenous brain stem cell compartment in chronic CNS inflammatory disorders remains poorly characterized. Here we show that persistent brain inflammation, induced by immune cells targeting myelin, extensively alters the proliferative and migratory properties of subventricular zone (SVZ)-resident NPCs in vivo leading to significant accumulation of non-migratory neuroblasts within the SVZ germinal niche. In parallel, we demonstrate a quantitative reduction of the putative brain stem cells proliferation in the SVZ during persistent brain inflammation, which is completely reversed after in vitro culture of the isolated NPCs. Together, these data indicate that the inflamed brain microenvironment sustains a non cell-autonomous dysfunction of the endogenous CNS stem cell compartment and challenge the potential efficacy of proposed therapies aimed at mobilizing endogenous precursors in chronic inflammatory brain disorders

The Effects of Transcutaneous Spinal Direct Current Stimulation on Neuropathic Pain in Multiple Sclerosis: Clinical and Neurophysiological Assessment

Background: Central neuropathic pain represents one of the most common symptoms in multiple sclerosis (MS) and it seriously affects quality of life. Spinal mechanisms may contribute to the pathogenesis of neuropathic pain in MS. Converging evidence from animal models and neurophysiological and clinical studies in humans suggests a potential effect of transcranial direct current stimulation (tc-DCS) on neuropathic pain. Spinal application of DCS, i.e., transcutaneous spinal DCS (ts-DCS), may modulate nociception through inhibition of spinal reflexes. Therefore, ts-DCS could represents an effective, safe and well-tolerated treatment for neuropathic pain in MS, a largely unexplored topic. This study is a pilot randomized double-blind sham-controlled trial to evaluate the efficacy of ts-DCS on central neuropathic pain in MS patients.Methods: Thirty-three MS patients with central neuropathic pain were enrolled and randomly assigned to two groups in a double-blind sham-controlled design: anodal ts-DCS group (n = 19, 10 daily 20-min sessions, 2 mA) or sham ts-DCS group (n = 14, 10 daily 20-min sessions, 0 mA). The following clinical outcomes were evaluated before ts-DCS treatment (T0), after 10 days of treatment (T1) and 1 month after the end of treatment (T2): neuropathic pain symptoms inventory (NPSI), Ashworth Scale (AS) for spasticity and Fatigue Severity Scale (FSS). A subgroup of patients treated with anodal ts-DCS (n = 12) and sham ts-DCS (n = 11) also underwent a parallel neurophysiological study of the nociceptive withdrawal reflex (NWR) and the NWR temporal summation threshold (TST), two objective markers of pain processing at spinal level.Results: Anodal ts-DCS group showed a significant improvement in NPSI at T1, which persisted at T2, while we did not detect any significant change in AS and FSS. Sham ts-DCS group did not show any significant change in clinical scales. We observed a non-significant trend towards an inhibition of NWR responses in the anodal ts-DCS group at T1 and T2 when compared to baseline.Conclusions: Anodal ts-DCS seems to have an early and persisting (i.e., 1 month after treatment) clinical efficacy on central neuropathic pain in MS patients, probably through modulation of spinal nociception.Clinical Trial Registration:www.ClinicalTrials.gov, identifier #NCT02331654