A tanged point and two blade technologies from Rubha Port an t-Seilich, Isle of Islay, western Scotland

We describe a tanged point and a blade technology from Rubha Port an t-Seilich, Isle of Islay, Scotland that provides further support to a Late Pleistocene or Early Holocene presence in Scotland prior to the establishment of the narrow blade Mesolithic industry. The existing evidence for a Late Pleistocene or early Holocene presence comes from isolated finds of tanged points (Tiree, Shieldig, Brodgar), undated assemblages from disturbed contexts that are most likely Late Pleistocene in date (Howburn, Kilmefort Cave), and undated assemblages containing broad blade microliths (e.g., Glenbatrick, Morton). This article provides a summary of recent excavations and the stratigraphy at Rubha Port an t-Seilich, and a detailed analysis the lithic blade blank production at the site, which is, we believe, the first application of a chaîne opératoire based approach to a Scottish assemblage. The study includes comparisons with contemporary assemblages from north-western Europe. The significance of the Rubha Port an t-Seilich finds is threefold: (1) the relative large size of the assemblage that allows a technological analysis; (2) the finds partially derive from a stratified context below a narrow blade assemblage, associated with radiocarbon dates 9301-7750 cal. BP; and (3) further excavation can increase the sample size and potentially expose an in situ Late Pleistocene or early Holocene cultural horizon

THE NORTHERN FRINGE OF THE SWIDERIAN TECHNOLOGICAL TRADITION: SALASPILS LAUKSKOLA REVISITED

The earliest settlement of Latvia occurred at the very end of the Late Glacial, after the retreat of the ice sheet. Important evidence of this earliest occupation is the well-known site Salaspils Laukskola. Previous research has focused on the typological aspects of this assemblage, and the use of lithic raw materials, suggesting an affiliation to the Swidry tradition. However, a wider technological perspective on this assemblage comprising a rich lithic inventory has recently proven fruitful. We present a detailed new technological analysis of the Laukskola assemblage, as well as five small lithic assemblages from Latvia based on a chaîne opératoire approach. While supporting the Swidry connection, this allows for a renewed discussion of the Final Palaeolithic settlement of Latvia, and its relationship with adjacent areas of northeast Europe.Key words: Final Palaeolithic, lithic technology, lithic raw material, chaîne opératoire, technological tradition, social network, mobility, eastern Baltic.DOI: http://dx.doi.org/10.15181/ab.v26i0.202

Intersucking among dairy cattle in loose housing

Dagens melkekuhold preges av at dyrene så effektivt som mulig skal produsere melk til humant konsum og kalver til rekruttering av nye melkekuer. Det arbeides mye for å maksimere produksjonen og minimere tap, blant annet ved optimalisering av fôring. Effektivisering av melkeproduksjon dreier seg allikevel om mer enn hva som puttes i kua og hva som kommer ut. Utvikler dyrene adferd som uønsket suging, kan dette gi tap av melk, tap av dyr grunnet skader, samt utrangering av dyr som forårsaker melkesvinn, skader og infeksjoner på andre dyr. Målet med oppgaven var å finne hvilke faktorer som gir risiko for uønsket suging, hva kan gjøres for å forebygge denne adferden og om dette kan eller bør gjøres på kalvestadiet? Det ble sendt ut en spørreundersøkelse til bønder med løsdriftfjøs for å finne ut hvordan situasjonen vedrørende uønsket suging blant melkekuer er i norske besetninger, samt hvilke årsaker problemet kunne ha. Svarene ble sammenstilt med en lignende undersøkelse gjort på slutten av åttitallet, samt annen litteratur funnet om temaet. Resultatene viste at uønsket suging blant norske besetninger var vanlig og at det i tråd med annen litteratur var mest suging blant kalvene. Videre viste undersøkelsen at tilgang til noe å suge på i etterkant av at kalven hadde drukket sin melkerasjon var av betydning for forekomsten av suging på andre kalver. Melkefôringsmetode, samt antall dyr per binge i forhold til suging gav ikke signifikant resultat i undersøkelsen, men tendenser, samt annen litteratur gav den samlede konklusjon at det er best at det er langsom melkestrøm når kalven skal drikke og at mange dyr per binge er negativt i forhold til forekomsten av uønsket suging blant kalver og ungdyr. Samlet forteller dette studiet at muligheten til å utøve det som for dyret ville vært naturlig adferd, spesielt i forhold til melkefôring er en viktig faktor med tanke på å redusere problemet. Om ikke problemet kan forebygges helt slik melkeproduksjon foregår i dag, kan det i mange besetninger reduseres. Forebygging må skje på kalvestadiet og forhold rundt fôring og fravenning er viktige i denne sammenhengen.The main goal of keeping dairy cattle today is to produce milk for human consumption as efficiently as possible and to raise calves to ensure recruitment for continuous production. It is made a lot of effort to maximize production and minimize losses. Care is taken to produce feed of good quality, and to optimize combinations of feed. Streamlining milk production will never the less have to do with more than what goes in to the cow and what comes out. If an animal develops stereotyped behaviour, for example intersucking, this may cause loss of milk, culling of animals due to injuries, or because they are causing milk loss, injury or infection to other animals. The aim of this thesis was to identify risk factors for intersucking, the possibility for preventing this behaviour and whether methods of prevention of intersucking among cows should be aimed towards the calves. A questionnaire were sent to dairy farmers with loose housing to map the situation regarding intersucking in Norway, as well as what could have caused the problem. The responses were compiled with a similar survey done in the late eighties, as well as other literature found on the topic. The results showed that intersucking in Norwegian dairy farms were common and as found in several other studies, cross sucking among calves was most commonly observed. The questionnaire also showed that access to artificial teat after a milk meal, was of significance for the occurrence of cross sucking among calves. Milk feeding method, and the number of animals per unit, compared the occurrence of cross sucking, gave no significant result in the questionnaire, but tendencies, as well as other literature gave the overall conclusion that a slow milk flow is best and that many animals per unit has a negative correlation to the occurrence of cross sucking among calves and heifers. In sum this study concludes that the ability to exercise what would be natural behaviour for the calf, particularly in relation to milk feeding is an important factor in terms of reducing the problem. If the problem of intersucking cannot be fully prevented the way dairy farms today are run, it can on many farms be reduced. Prevention has to find place when the animals are young and feeding and weaning are important factors in terms of reducing the problem

Hospitalization following influenza infection and pandemic vaccination in multiple sclerosis patients: a nationwide population-based registry study from Norway

Under embargo until: 2020-12-23Patients with multiple sclerosis (MS) are at increased risk of infections and related worsening of neurological function. Influenza infection has been associated with increased risk of various neurological complications. We conducted a population-based registry study to investigate the risk of acute hospitalization of MS patients in relation to influenza infection or pandemic vaccination in Norway. The entire Norwegian population in the years 2008–2014 was defined as our study population (N = 5,219,296). Information on MS diagnosis, influenza infection and vaccination were provided by Norwegian national registries. The self-controlled case series method was used to estimate incidence rate ratios (IRRs) with 95% confidence intervals (95% CI) in defined risk periods. 6755 MS patients were identified during the study period. Average age at first registration of an MS diagnosis was 51.8 years among men and 49.9 years among females (66.9%). The IRR for emergency hospitalization among MS patients the first week after an influenza diagnosis was 3.4 (95% CI 2.4–4.8). The IRR was 5.6 (95% CI 2.7–11.3) after pandemic influenza, and 4.8 (95% CI 3.1–7.4) after seasonal influenza. Pandemic vaccination did not influence risk of hospitalization [IRR within the first week: 0.7 (95% CI 0.5–1.0)]. Among MS patients, influenza infection was associated with increased risk for acute hospitalization while no increased risk was observed after pandemic vaccination. Influenza vaccination could prevent worsening of MS-related symptoms as well as risk of hospitalization.acceptedVersio

Patterns and roles of lignan and terpenoid accumulation in the reaction zone compartmentalizing pathogen-infected heartwood of Norway spruce

Tree defense against xylem pathogens involves both constitutive and induced phenylpropanoids and terpenoids. The induced defenses include compartmentalization of compromised wood with a reaction zone (RZ) characterized by polyphenol deposition, whereas the role of terpenoids has remained poorly understood. To further elucidate the tree–pathogen interaction, we profiled spatial patterns in lignan (low-molecular-weight polyphenols) and terpenoid content in Norway spruce (Picea abies) trees showing heartwood colonization by the pathogenic white-rot fungus Heterobasidion parviporum. There was pronounced variation in the amount and composition of lignans between different xylem tissue zones of diseased and healthy trees. Intact RZ at basal stem regions, where colonization is the oldest, showed the highest level and diversity of these compounds. The antioxidant properties of lignans obviously hinder oxidative degradation of wood: RZ with lignans removed by extraction showed significantly higher mass loss than unextracted RZ when subjected to Fenton degradation. The reduced diversity and amount of lignans in pathogen-compromised RZ and decaying heartwood in comparison to intact RZ and healthy heartwood suggest that α-conindendrin isomer is an intermediate metabolite in lignan decomposition by H. parviporum. Diterpenes and diterpene alcohols constituted above 90% of the terpenes detected in sapwood of healthy and diseased trees. A significant finding was that traumatic resin canals, predominated by monoterpenes, were commonly associated with RZ. The findings clarify the roles and fate of lignan during wood decay and raise questions about the potential roles of terpenoids in signal transduction, synthesis, and translocation of defense compounds upon wood compartmentalization against decay fungi.publishedVersio

Sources to the history of gardening

The aim of the Nordic Network for the Archaeology and Archaeobotany of Gardening (NTAA), as it was phrased those first days in Alnarp in the beginning of March 2010, is to: ”bring researchers together from different disciplines to discuss the history, archaeology, archaeobotany and cultivation of gardens and plants”. We had no idea, then, how widely appreciated this initiative would become. The fifth seminar in five years was held on Visingsö June 1-3, 2014 and the sixth seminar will take place in Kristiansand, Norway, June 12-14, 2015. We are very pleased to be able to publish this report, Sources to the History of Gardening: Four Interdisciplinary Seminars 2010–2013, Arranged By the Nordic Network for the Archaeology and Archaeobotany of Gardening (NTAA), based on the first four themes and seminars, in total 26 articles. Most of them origins from one of the seminar contributions 2010, 2011, 2012 and 2013 respectively. However, the editorial group has taken the opportunity, with the aim of the network in mind, to add supplementing contributions on some subjects. The articles are arranged in four themes according to the themes of the seminars. The first theme Archaeological Sources to the History of Gardens and the Cultural Landscape is linked to the first seminar in Alnarp, Sweden, 2010 which had a focus on method, the important connections between archaeology and archaeobotany and the interesting progress within garden archaeology during the last decade. The second theme Cabbage Patches and Kitchen Gardens deals with the second seminar in Norrköping, Sweden, 2011. Its focus was on historical, cultural geographical, archaeological and archaeobotanical research concerning utility gardens or kitchen gardens as well as the concept ‘kålgård’ (cabbage patch or kale yard), its shape and content over time. The third theme Cultural and Garden plants: Under Ground, Above Ground, In Herbariums and Archives connects to the third seminar in Uppsala, Sweden, 2012. It focused on sources, source criticism and interdisciplinary research to gain knowledge on the history of garden cultivation and cultural plants. The articles discuss, among other things, herbariums, written sources, DNA and molecular markers, pollen analysis and georadar. The fourth theme for NTAA’s annual seminar was Cultural Relict Plants and was held on Bornholm, Denmark, 2013. The focus on the seminar was on research and conservation of cultural relict plants, that is cultural plants which have survived in the same place for a long time after the actual cultivation has ceased. We dedicate this report to Kjell Lundquist (1955-2011) who were one of the initiators to this network and we hope it will inspire continuous research and new methodological discussions

An anthropomorphic deformable phantom of the vaginal wall and cavity

Brachytherapy is a common treatment in cervical, uterine and vaginal cancer management. The technique is characterised by rapid developments in the fields of medical imaging, dosimetry planning and personalised medical device design. To reduce unnecessary burden on patients, assessments and training of these technologies should preferable be done using high-fidelity physical phantoms. In this study, anthropomorphic deformable phantoms of the vaginal wall and cavity were developed for image-guided adaptive brachytherapy, in which vaginal wall biomechanics were mimicked. Phantoms were produced from both silicone and polyvinyl alcohol materials. Material characterisations were performed with uniaxial tensile tests, via which Young’s moduli and toughness were quantified. In addition, the contrast between adjacent phantom layers was quantified in magnetic resonance images. The results showed that stress-strain curves of the silicone phantoms were within the range of those found in healthy human vaginal wall tissues. Sample preconditioning had a large effect on Young’s moduli, which ranged between 2.13 and 6.94 MPa in silicone. Toughness was a more robust and accurate metric for biomechanical matching, and ranged between 0.23 and 0.28 ·106 J·m-3 as a result of preconditioning. The polyvinyl alcohol phantoms were not stiff or tough enough, with a Young’s modulus of 0.16 MPa and toughness of 0.02 ·106 J·m-3. All materials used could be clearly delineated in magnetic resonance images, although the MRI sequence did affect layer contrast. In conclusion, we developed anthropomorphic deformable phantoms that mimic vaginal wall tissue and are well visible in magnetic resonance images. These phantoms will be used to evaluate the properties and to optimise the development and use of personalised brachytherapy applicators.</p

Time-action and patient experience analyses of locally advanced cervical cancer brachytherapy

BACKGROUND AND PURPOSE: Although MRI-based image guided adaptive brachytherapy (IGABT) for locally advanced cervical cancer (LACC) has resulted in favorable outcomes, it can be logistically complex and time consuming compared to 2D image-based brachytherapy, and both physically and emotionally intensive for patients. This prospective study aims to perform time-action and patient experience analyses during IGABT to guide further improvements. MATERIALS AND METHODS: LACC patients treated with IGABT were included for the time-action (56 patients) and patient experience (29 patients) analyses. Times per treatment step were reported on a standardized form. For the patient experience analysis, a baseline health status was established with the EQ-5D-5L questionnaire and the perceived pain, anxiety and duration for each treatment step were assessed with the NRS-11. RESULTS: The median total procedure time from arrival until discharge was 530 (IQR: 480–565) minutes. Treatment planning (delineation, reconstruction, optimization) required the most time and took 175 (IQR: 145–195) minutes. Highest perceived pain was reported during applicator removal and treatment planning, anxiety during applicator removal, and duration during image acquisition and treatment planning. Perceived pain, anxiety and duration were correlated. Higher pre-treatment pain and anxiety scores were associated with higher perceived pain, anxiety and duration. CONCLUSION: This study highlights the complexity, duration and impact on patient experience of the current IGABT workflow. Patient reported pre-treatment pain and anxiety can help identify patients that may benefit from additional support. Research and implementation of measures aiming at shortening the overall procedure duration, which may include logistical, staffing and technological aspects, should be prioritized.</p

Anti-CD74 antibodies have no diagnostic value in early axial spondyloarthritis: Data from the spondyloarthritis caught early (SPACE) cohort

Anti-CD74 IgG antibodies are reported to be elevated in patients with axial spondyloarthritis (axSpA). This study assessed the diagnostic value of anti-CD74 antibodies in patients with early axSpA. Anti-CD74 IgG and IgA antibodies were first measured in an exploratory cohort of patients with radiographic axSpA (138 patients with ankylosing spondyloarthritis (AS)) and 57 healthy controls and then were measured in patients with early axSpA (n = 274) and with non-SpA chronic back pain (CBP) (n = 319), participating in the spondyloarthritis caught early (SPACE) prospective cohort study of patients under 45 years old with early back pain (for ≥ 3 months, but ≤ 2 years). In the exploratory cohort, anti-CD74 IgG antibodies were present in 79.7% of patients with AS vs. 43.9% of healthy controls (p < 0.001). Anti-CD74 IgA antibodies were present in 28.5% of patients with AS vs. 5.3% of healthy controls (p < 0.001). In the SPACE cohort, anti-CD74 IgG antibody levels were present in 46.4% of the patients with axSpA vs. 47.9% of the patients with CBP (p = 0.71). Anti-CD74 IgA antibodies were present in 54.7% of the patients with axSpA and 37.0% of the patients with CBP (p < 0.001). This resulted in a positive predictive value of 58.8% (compared to a prior probability of 46.2%) and a negative predictive value of 59.1% (compared to a prior probability of 53.8%). In a regression model, total serum IgA was associated with axSpA odds ratio (OR) 1.19, p < 0.001) whereas anti-CD74 IgA was not (OR) 1.01, p = 0.33). Furthermore, anti-CD74 IgA was associated with sacroiliitis on magnetic resonance imaging (MRI) (OR) = 2.50, p = 0.005) and heel enthesitis (OR) = 2.56, p = 0.002). Albeit anti-CD74 IgA is elevated in patients with early axSpA, this elevation is not sufficiently specific to yield significant diagnostic value in patients under 45 years old presenting with early back pai

Time-action and patient experience analyses of locally advanced cervical cancer brachytherapy

BACKGROUND AND PURPOSE: Although MRI-based image guided adaptive brachytherapy (IGABT) for locally advanced cervical cancer (LACC) has resulted in favorable outcomes, it can be logistically complex and time consuming compared to 2D image-based brachytherapy, and both physically and emotionally intensive for patients. This prospective study aims to perform time-action and patient experience analyses during IGABT to guide further improvements. MATERIALS AND METHODS: LACC patients treated with IGABT were included for the time-action (56 patients) and patient experience (29 patients) analyses. Times per treatment step were reported on a standardized form. For the patient experience analysis, a baseline health status was established with the EQ-5D-5L questionnaire and the perceived pain, anxiety and duration for each treatment step were assessed with the NRS-11. RESULTS: The median total procedure time from arrival until discharge was 530 (IQR: 480–565) minutes. Treatment planning (delineation, reconstruction, optimization) required the most time and took 175 (IQR: 145–195) minutes. Highest perceived pain was reported during applicator removal and treatment planning, anxiety during applicator removal, and duration during image acquisition and treatment planning. Perceived pain, anxiety and duration were correlated. Higher pre-treatment pain and anxiety scores were associated with higher perceived pain, anxiety and duration. CONCLUSION: This study highlights the complexity, duration and impact on patient experience of the current IGABT workflow. Patient reported pre-treatment pain and anxiety can help identify patients that may benefit from additional support. Research and implementation of measures aiming at shortening the overall procedure duration, which may include logistical, staffing and technological aspects, should be prioritized.</p