Doubly-charged particles at the Large Hadron Collider

In this work we investigate the production and signatures of doubly-charged particles at the Large Hadron Collider. We start with the Standard Model particle content and representations and add generic doubly-charged exotic particles. We classify these doubly-charged states according to their spin, considering scalar, fermionic and vectorial fields, and according to their SU(2)L representation, being chosen to be either trivial, fundamental, or adjoint. We write the most general interactions between them and the Standard Model sector and study their production modes and possible decay channels. We then probe how they can most likely be observed and how particles with different spin and SU(2)L representations could be possibly distinguished.Comment: 18 pages, 8 figures, 1 table; version accepted by Phys.Rev.

Automated mass spectrum generation for new physics

We describe an extension of the FeynRules package dedicated to the automatic generation of the mass spectrum associated with any Lagrangian-based quantum field theory. After introducing a simplified way to implement particle mixings, we present a new class of FeynRules functions allowing both for the analytical computation of all the model mass matrices and for the generation of a C++ package, dubbed ASperGe. This program can then be further employed for a numerical evaluation of the rotation matrices necessary to diagonalize the field basis. We illustrate these features in the context of the Two-Higgs-Doublet Model, the Minimal Left-Right Symmetric Standard Model and the Minimal Supersymmetric Standard Model.Comment: 11 pages, 1 table; version accepted by EPJ

World class patents in cutting-edge technologies: The innovation power of East Asia, North America, and Europe

The patent portfolio of an economy forms an import- ant basis for its innovation, and, as a result, competi- tiveness. In this study, we look at how this portfolio of individual countries and regions has developed since the turn of the millennium. We focus on 58 important cutting-edge technologies, sorted into ten subject fields. In contrast to most other studies on this sub- ject, we focus on the world class patents, i.e. the most important 10 percent among all patents, instead of considering all patent applications. We hope to con- tribute to a better assessment of the innovation ca- pacity of large economies, which has become even more important during the coronavirus crisis

Selective hydrogenation of nitroarenes using an electrogenerated polyoxometalate redox mediator

The 2-electron reduced form of the polyoxometalate silicotungstic acid (H6[SiW12O40]) is shown to be an effective and selective hydrogenation agent for a range of nitroarenes without the need for any co-catalyst. The ease of generation of the active species and its recyclability suggest that a new approach to this important class of chemical conversions is possible

IRMA via SDN: Intrusion Response and Monitoring Appliance via Software-Defined Networking

Recent approaches to network intrusion prevention systems (NIPSs) use software-defined networking (SDN) to take advantage of dynamic network reconfigurability and programmability, but issues remain with system component modularity, network size scalability, and response latency. We present IRMA, a novel SDN-based NIPS for enterprise networks, as a network appliance that captures data traffic, checks for intrusions, issues alerts, and responds to alerts by automatically reconfiguring network flows via the SDN control plane. With a composable, modular, and parallelizable service design, we show improved throughput and less than 100 ms average latency between alert detection and response.Roy J. Carver FellowshipOpe

Ascaris suum excretory/secretory products differentially modulate porcine dendritic cell subsets

Helminths produce excretory/secretory products (E/S) which can modulate the immune responses of their hosts. Dendritic cells (DC) are essential for initiating the host T cell response and are thus potential targets for modulation by helminth E/S. Here we study immunomodulation of porcine peripheral blood DC subsets following ex vivo stimulation with E/S from Ascaris suum, a common helminth of pigs with considerable public health and economic importance. Our data showed that the relative frequencies of DC subsets in porcine blood differ, with plasmacytoid DC (pDC) being the most prominent in healthy 6-month-old pigs. pDC are an important cytokine source, and we found that A. suum E/S suppressed production of the type 1 cytokines IL-12p40 and TNF-α by this subset following toll-like receptor (TLR) ligation. In contrast, conventional DC (cDC) are more efficient antigen presenters, and the expression of CD80/86, costimulatory molecules essential for efficient antigen presentation, were modulated differentially by A. suum E/S between cDC subsets. CD80/86 expression by type 1 cDC (cDC1) following TLR ligation was greatly suppressed by the addition of A. suum E/S, while CD80/86 expression by type 2 cDC (cDC2) was upregulated by A. suum E/S. Further, we found that IFN-γ production by natural killer (NK) cells following IL-12 and IL-18 stimulation was suppressed by A. suum E/S. Finally, in the presence of E/S, IFN-γ production by CD4+ T cells co-cultured with autologous blood-derived DC was significantly impaired. Together, these data provide a coherent picture regarding the regulation of type 1 responses by A. suum E/S. Responsiveness of pDC and cDC1 to microbial ligands is reduced in the presence of E/S, effector functions of Th1 cells are impaired, and cytokine-driven IFN-γ release by NK cells is limited

Implementing the circular economy by tracing the sustainable impact

Sustainability is one of the most critical issues today. Thus, the unsustainable consumption of resources, such as raw materials, CO2 emissions, and the Linear Economy needs to be changed. One framework for a more sustainable economy is the Circular Economy. Although the concept of the Circular Economy has been around since the 1990s, yet we are still far from enabling a Circular Economy. Therefore, a turnaround to the current linear economy as well as a change in society is necessary. In this paper, we get down to the essence of the status quo in the Circular Economy, identify the main barriers, such as lack of information, unsustainable economic models, ignorance, missing incentives, and propose software-driven solutions to tackle these challenges. Our solution extends the service description language by introducing the sustainability impact factor. The goal is to motivate end-users towards a more sustainable behavior without making massive restrictions on their lives

The impact of tinnitus distress on cognition

Tinnitus is the chronic perception of a phantom sound with different levels of related distress. Past research has elucidated interactions of tinnitus distress with audiological, affective and further clinical variables. The influence of tinnitus distress on cognition is underinvestigated. Our study aims at investigating specific influences of tinnitus distress and further associated predictors on cognition in a cohort of n = 146 out-ward clinical tinnitus patients. Age, educational level, hearing loss, Tinnitus Questionnaire (TQ) score, tinnitus duration, speech in noise (SIN), stress, anxiety and depression, and psychological well-being were included as predictors of a machine learning regression approach (elastic net) in three models with scores of a multiple choice vocabulary test (MWT-B), or two trail-making tests (TMT-A and TMT-B), as dependent variables. TQ scores predicted lower MWT-B scores and higher TMT-B test completion time. Stress, emotional, and psychological variables were not found to be relevant predictors in all models with the exception of small positive influences of SIN and depression on TMT-B. Effect sizes were small to medium for all models and predictors. Results are indicative of specific influence of tinnitus distress on cognitive performance, especially on general or crystallized intelligence and executive functions. More research is needed at the delicate intersection of tinnitus distress and cognitive skills needed in daily functioning