4,647 research outputs found
Scientific Value of Real-Time Global Positioning System Data
The Global Positioning System (GPS) is an example of a Global Navigation Satellite System (GNSS) that provides an essential complement to other geophysical networks because of its high precision, sensitivity to the longestâperiod bands, ease of deployment, and ability to measure displacement and atmospheric properties over local to global scales. Recent and ongoing technical advances, combined with decreasing equipment and data acquisition costs, portend rapid increases in accessibility of data from expanding global geodetic networks. Scientists and the public are beginning to have access to these highârate, continuous data streams and eventâspecific information within seconds to minutes rather than days to months. These data provide the opportunity to observe Earth system processes with greater accuracy and detail, as they occur
Crowdsourced earthquake early warning
Earthquake early warning (EEW) can reduce harm to people and infrastructure from earthquakes and tsunamis, but it has not been implemented in most high earthquake-risk regions because of prohibitive cost. Common consumer devices such as smartphones contain low-cost versions of the sensors used in EEW. Although less accurate than scientific-grade instruments, these sensors are globally ubiquitous. Through controlled tests of consumer devices, simulation of an M_w (moment magnitude) 7 earthquake on Californiaâs Hayward fault, and real data from the M_w 9 Tohoku-oki earthquake, we demonstrate that EEW could be achieved via crowdsourcing
Langevin network model of myosin
Langevin mode theory and the coarse-grained elastic network model (ENM) for proteins are combined to yield the Langevin network model (LNM). Hydrodynamic radii of 6 Ă
were assigned to each R-carbon on the basis of matching experimental translational and rotational diffusion constants of lysozyme, myoglobin, and hemoglobin with those calculated using a rigid body bead model with hydrodynamic interactions described by the Rotne-Prager tensor. LNM analysis of myosin II indicates that all ENM-like modes are overdamped at water viscosities. The low-frequency LNM modes in the pre-power stroke structure (PDB code: 1VOM) are substantially less mixed than the corresponding modes of the post-power stroke structure (1Q5G). Results from a four-bead model of the myosin "lever arm" indicate that coupling between modes increases as the array departs from linearity and are consistent with the results for 1VOM and 1Q5G. The decay times for all overdamped Langevin modes are shorter than the calculated rotational tumbling times found for lysozyme and myosin
Antarctic Climate Change and the Environment: A Decadal Synopsis and Recommendations for Action
Scientific evidence is abundantly clear and convincing that due to the current trajectory of human-derived emissions of CO2 and other greenhouse gases, the atmosphere and ocean will continue to warm, the ocean will continue to acidify, atmospheric and ocean circulation patterns will be altered, the cryosphere will continue to lose ice in all forms, and sea level will rise
Scientific Value of Real-Time Global Positioning System Data
The Global Positioning System (GPS) is an example of a Global Navigation Satellite System (GNSS) that provides an essential complement to other geophysical networks because of its high precision, sensitivity to the longestâperiod bands, ease of deployment, and ability to measure displacement and atmospheric properties over local to global scales. Recent and ongoing technical advances, combined with decreasing equipment and data acquisition costs, portend rapid increases in accessibility of data from expanding global geodetic networks. Scientists and the public are beginning to have access to these highârate, continuous data streams and eventâspecific information within seconds to minutes rather than days to months. These data provide the opportunity to observe Earth system processes with greater accuracy and detail, as they occur
Spitzer Space Telescope observations of the Carina Nebula: The steady march of feedback-driven star formation
We report the first results of imaging the Carina Nebula with Spitzer/IRAC,
providing a catalog of point sources and YSOs based on SED fits. We discuss
several aspects of the extended emission, including dust pillars that result
when a clumpy molecular cloud is shredded by massive star feedback. There are
few "extended green objects" (EGOs) normally taken as signposts of outflow
activity, and none of the HH jets detected optically are seen as EGOs. A
population of "extended red objects" tends to be found around OB stars, some
with clear bow-shocks. These are dusty shocks where stellar winds collide with
flows off nearby clouds. Finally, the relative distributions of O stars and
subclusters of YSOs as compared to dust pillars shows that while some YSOs are
located within pillars, many more stars and YSOs reside just outside pillar
heads. We suggest that pillars are transient phenomena, part of a continuous
outwardly propagating wave of star formation driven by massive star feedback.
As pillars are destroyed, they leave newly formed stars in their wake, which
are then subsumed into the young OB association. Altogether, the current
generation of YSOs shows no strong deviation from a normal IMF. The number of
YSOs suggests a roughly constant star-formation rate over the past 3Myr,
implying that star formation in pillars constitutes an important mechanism to
construct unbound OB associations. Accelerated pillars may give birth to O-type
stars that, after several Myr, could appear to have formed in isolation.Comment: 25 pages, 15 figures, MNRAS accepte
Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies.
IntroductionQuantitative in vivo measurement of brain amyloid burden is important for both research and clinical purposes. However, the existence of multiple imaging tracers presents challenges to the interpretation of such measurements. This study presents a direct comparison of Pittsburgh compound B-based and florbetapir-based amyloid imaging in the same participants from two independent cohorts using a crossover design.MethodsPittsburgh compound B and florbetapir amyloid PET imaging data from three different cohorts were analyzed using previously established pipelines to obtain global amyloid burden measurements. These measurements were converted to the Centiloid scale to allow fair comparison between the two tracers. The mean and inter-individual variability of the two tracers were compared using multivariate linear models both cross-sectionally and longitudinally.ResultsGlobal amyloid burden measured using the two tracers were strongly correlated in both cohorts. However, higher variability was observed when florbetapir was used as the imaging tracer. The variability may be partially caused by white matter signal as partial volume correction reduces the variability and improves the correlations between the two tracers. Amyloid burden measured using both tracers was found to be in association with clinical and psychometric measurements. Longitudinal comparison of the two tracers was also performed in similar but separate cohorts whose baseline amyloid load was considered elevated (i.e., amyloid positive). No significant difference was detected in the average annualized rate of change measurements made with these two tracers.DiscussionAlthough the amyloid burden measurements were quite similar using these two tracers as expected, difference was observable even after conversion into the Centiloid scale. Further investigation is warranted to identify optimal strategies to harmonize amyloid imaging data acquired using different tracers
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