1,268 research outputs found
Seroprevalence of Blood-Borne Infections Among Blood Donors in Venezuela, 2001–2002
Proses reproduksi wanita menurut ilmu pengetahuan modern yang selama ini diyakini oleh para ilmuwan Barat ternyata sudah dijelaskan puluhan abad silam oleh al-Qur’an dan hadis. Teori reproduksi dan penciptaan manusia dari sudut pandang Islam dan sains ternyata tidak bertentangan, bahkan saling melengkapi satu dengan yang lain. Hadis nabi yang menjelaskan reproduksi wanita dan proses penciptaan manusia merupakan penjelas dari al-Qur’an dan diperkuat oleh data-data ilmiah sains teknologi. Berangkat dari itulah, artikel ini coba mengkaji tentang reproduksi wanita dengan pendekatan hadis tematik. Sebab pembahasan tematik ini sangat urgen untuk mengembangkan wawasan tentang hadis dalam membahas satu tema tertentu secara tuntas. Female reproduction processes according to modern science that had been believed by Western scientists were already described dozens of centuries ago by the Qur’an and hadith. Theory of reproduction and the creation of man from the viewpoint of Islam and science were not at odds, even complement each other. Hadith which describes a woman’s reproduction and the process of creation of man is explanatory of the Qur’an and reinforced by scientific data science technology. Start from it, this article try to examines the female reproductive with thematic hadith approach. For the thematic discussion is very urgent to develop an insight into the traditions in discussing a particular theme completely.</p
Plasmacytoid dendritic cells of melanoma patients present exogenous proteins to CD4+ T cells after FcγRII-mediated uptake
Plasmacytoid dendritic cells (pDCs) contribute to innate antiviral immune responses by producing type I interferons. Although human pDCs can induce T cell responses upon viral infection, it remains unclear if pDCs can present exogenous antigens. Here, we show that human pDCs exploit FcγRII (CD32) to internalize antigen–antibody complexes, resulting in the presentation of exogenous antigen to T cells. pDCs isolated from melanoma patients vaccinated with autologous monocyte-derived peptide- and keyhold limpet hemocyanin (KLH)–loaded dendritic cells, but not from nonvaccinated patients or patients that lack a humoral response against KLH, were able to stimulate KLH-specific T cell proliferation. Interestingly, we observed that internalization of KLH by pDCs depended on the presence of serum from vaccinated patients that developed an anti-KLH antibody response. Anti-CD32 antibodies inhibited antigen uptake and presentation, demonstrating that circulating anti-KLH antibodies binding to CD32 mediate KLH internalization. We conclude that CD32 is an antigen uptake receptor on pDCs and that antigen presentation by pDCs is of particular relevance when circulating antibodies are present. Antigen presentation by pDCs may thus modulate the strength and quality of the secondary phase of an immune response
Cosmic distance-duality as probe of exotic physics and acceleration
In cosmology, distances based on standard candles (e.g. supernovae) and
standard rulers (e.g. baryon oscillations) agree as long as three conditions
are met: (1) photon number is conserved, (2) gravity is described by a metric
theory with (3) photons travelling on unique null geodesics. This is the
content of distance-duality (the reciprocity relation) which can be violated by
exotic physics. Here we analyse the implications of the latest cosmological
data sets for distance-duality. While broadly in agreement and confirming
acceleration we find a 2-sigma violation caused by excess brightening of SN-Ia
at z > 0.5, perhaps due to lensing magnification bias. This brightening has
been interpreted as evidence for a late-time transition in the dark energy but
because it is not seen in the d_A data we argue against such an interpretation.
Our results do, however, rule out significant SN-Ia evolution and extinction:
the "replenishing" grey-dust model with no cosmic acceleration is excluded at
more than 4-sigma despite this being the best-fit to SN-Ia data alone, thereby
illustrating the power of distance-duality even with current data sets.Comment: 6 pages, 4 colour figures. Version accepted as a Rapid Communication
in PR
V-shaped pyranylidene/triphenylamine-based chromophores with enhanced photophysical, electrochemical and nonlinear optical properties
We report the synthesis and comprehensive study of two chromophores based on 4H-pyranylidene moiety as a part of the p-conjugated spacer. Triphenylamine (TPA) acts as donor and tricarbonitrile-based electron-accepting groups complete these V-shaped D-A-D architectures (A, acceptor; D, donor). Their electrochemical, photophysical and nonlinear optical properties are analyzed in detail by using a joint experimental and theoretical approach. The two chromophores exhibit near-infrared fluorescence, large Stokes shift, enhanced emission in tetrahydrofuran/water mixtures and good photostability. Additionally, the dimerization of triphenylamine groups to tetraphenylbenzidine (TPB) takes place upon electrochemical and chemical oxidation showing their peculiar electrochemical behavior and film formation capabilities. Interestingly, high molecular first hyperpolarizabilities and two-photon absorption cross-sections were found, highlighting their potential applications in electro-optical devices. Overall, our work demonstrates that these near-infrared (NIR) fluorescent chromophores are versatile materials with a myriad of applications ranging from optoelectronics to biological applications. © 2021 The Royal Society of Chemistry
The Relativistic Factor in the Orbital Dynamics of Point Masses
There is a growing population of relativistically relevant minor bodies in
the Solar System and a growing population of massive extrasolar planets with
orbits very close to the central star where relativistic effects should have
some signature. Our purpose is to review how general relativity affects the
orbital dynamics of the planetary systems and to define a suitable relativistic
correction for Solar System orbital studies when only point masses are
considered. Using relativistic formulae for the N body problem suited for a
planetary system given in the literature we present a series of numerical
orbital integrations designed to test the relevance of the effects due to the
general theory of relativity in the case of our Solar System. Comparison
between different algorithms for accounting for the relativistic corrections
are performed. Relativistic effects generated by the Sun or by the central star
are the most relevant ones and produce evident modifications in the secular
dynamics of the inner Solar System. The Kozai mechanism, for example, is
modified due to the relativistic effects on the argument of the perihelion.
Relativistic effects generated by planets instead are of very low relevance but
detectable in numerical simulations
Differential neuronal vulnerability identifies IGF-2 as a protective factor in ALS
The fatal disease amyotrophic lateral sclerosis (ALS) is characterized by the loss of somatic motor neurons leading to muscle wasting and paralysis. However, motor neurons in the oculomotor nucleus, controlling eye movement, are for unknown reasons spared. We found that insulin-like growth factor 2 (IGF-2) was maintained in oculomotor neurons in ALS and thus could play a role in oculomotor resistance in this disease. We also showed that IGF-1 receptor (IGF-1R), which mediates survival pathways upon IGF binding, was highly expressed in oculomotor neurons and on extraocular muscle endplate. The addition of IGF-2 induced Akt phosphorylation, glycogen synthase kinase-3\u3b2 phosphorylation and \u3b2-catenin levels while protecting ALS patient motor neurons. IGF-2 also rescued motor neurons derived from spinal muscular atrophy (SMA) patients from degeneration. Finally, AAV9::IGF-2 delivery to muscles of SOD1G93A ALS mice extended life-span by 10%, while preserving motor neurons and inducing motor axon regeneration. Thus, our studies demonstrate that oculomotor-specific expression can be utilized to identify candidates that protect vulnerable motor neurons from degeneration
Condensate cosmology -- dark energy from dark matter
Imagine a scenario in which the dark energy forms via the condensation of
dark matter at some low redshift. The Compton wavelength therefore changes from
small to very large at the transition, unlike quintessence or metamorphosis. We
study CMB, large scale structure, supernova and radio galaxy constraints on
condensation by performing a 4 parameter likelihood analysis over the Hubble
constant and the three parameters associated with Q, the condensate field:
Omega_Q, w_f and z_t (energy density and equation of state today, and redshift
of transition). Condensation roughly interpolates between Lambda CDM (for large
z_t) and sCDM (low z_t) and provides a slightly better fit to the data than
Lambda CDM. We confirm that there is no degeneracy in the CMB between H and z_t
and discuss the implications of late-time transitions for the Lyman-alpha
forest. Finally we discuss the nonlinear phase of both condensation and
metamorphosis, which is much more interesting than in standard quintessence
models.Comment: 13 pages, 13 colour figures. Final version with discussion of TE
cross-correlation spectra for condensation and metamorphosis in light of the
WMAP result
Stability analysis of agegraphic dark energy in Brans-Dicke cosmology
Stability analysis of agegraphic dark energy in Brans-Dicke theory is
presented in this paper. We constrain the model parameters with the
observational data and thus the results become broadly consistent with those
expected from experiment. Stability analysis of the model without best fitting
shows that universe may begin from an unstable state passing a saddle point and
finally become stable in future. However, with the best fitted model, There is
no saddle intermediate state. The agegraphic dark energy in the model by itself
exhibits a phantom behavior. However, contribution of cold dark matter on the
effective energy density modifies the state of teh universe from phantom phase
to quintessence one. The statefinder diagnosis also indicates that the universe
leaves an unstable state in the past, passes the LCDM state and finally
approaches the sable state in future.Comment: 15 pages, 12 figure
Asymmetries between the production of D+ and D- mesons from 500 GeV/c pi- nucleon interactions as a function of xF and pt**2
We present asymmetries between the production of D+ and D- mesons in Fermilab
experiment E791 as a function of xF and pt**2. The data used here consist of
74,000 fully-reconstructed charmed mesons produced by a 500 GeV/c pi- beam on C
and Pt foils. The measurements are compared to results of models which predict
differences between the production of heavy-quark mesons that have a light
quark in common with the beam (leading particles) and those that do not
(non-leading particles). While the default models do not agree with our data,
we can reach agreement with one of them, PYTHIA, by making a limited number of
changes to parameters used
New explanation of the strange baryon rapidity distributions in ultra-relativistic nucleus-nucleus collisions
A model of multiparticle production in hadronic collisions at
ultra-relativistic energies, based on the assumption of independent string
fragmentation, reproduces the rapidity spectra of and
in sulphur-sulphur collisions reported by the NA35 Collaboration. This is
achieved after a reconsideration of the intermediate multi-string states and
the structure of the diquarks. Nuclear stopping power is also studied through
the computation of the rapidity spectra.Comment: Final version as it will appear in Nucl. Phys. A. It contains 27
pages including 12 figure
- …