Simulation of waviness in neutron guides

As the trend of neutron guide designs points towards longer and more complex guides, imperfections such as waviness becomes increasingly important. Simulations of guide waviness has so far been limited by a lack of reasonable waviness models. We here present a stochastic description of waviness and its implementation in the McStas simulation package. The effect of this new implementation is compared to the guide simulations without waviness and the simple, yet unphysical, waviness model implemented in McStas 1.12c and 2.0

Vitamin D Status among Pulmonary TB Patients and Non-TB Controls: A Cross-Sectional Study from Mwanza, Tanzania.

Little is known about vitamin D status in low-income populations burdened with infectious diseases. Hence, there is a need for data on correlates of serum 25-hydroxy vitamin D (S-25(OH)D) and its validity during infections. To assess the role of pulmonary TB (PTB) and HIV as correlates of S-25(OH)D. Age-sex-matched cross-sectional study among PTB patients and non-TB controls. PTB patients were categorized as sputum negative (PTB-) and positive (PTB+) by culture. Non-TB controls were randomly selected among age-sex-matched neighbours to PTB+ patients. Height, weight, arm circumference and triceps skinfold were measured, and body mass index (BMI), arm fat (AFA) and muscle area (AMA) computed. HIV status, and S-25(OH)D, C-reactive protein (S-CRP) and α1-acid glycoprotein (S-AGP) were determined. Linear regression analysis with controls and PTB patients combined was used to identify correlates of S-25(OH)D. S-25(OH)D data were available on 97.8% (1570) of 1605 participants. Mean (SD) S-25(OH)D was 84.4 (25.6) nmol/L with 39.6% <75 nmol/L among 347 non-TB controls. Time of recruitment, sex, PTB and HIV, and elevated S-AGP were correlates of S-25(OH)D. S-25(OH)D was 24.8 (95% CI 18.6;30.9) nmol/L higher in PTB compared to controls among females, but only 9.8 (95% CI:4.5;15.2) nmol/L among males (interaction p<0.0001). Females had 13.8 (95% CI:8.2;21.9) nmol/L lower S-25(OH)D than males, and HIV infected individuals had 8.5 (95% CI:4.9;12.1) higher S-25(OH)D compared to uninfected. Elevated S-AGP was a positive correlate of S-25(OH)D. Low BMI was associated with S-25(OH)D, but not with infections or S-AGP in the model. While S-25(OH)D may decline transiently during a mild acute phase response, it may increase if the acute phase response leads to loss of fat. The validity of S-25(OH)D as a marker of vitamin D status may be affected by infections

Interaction of carbon clusters with Ni(100) : Application to the nucleation of carbon nanotubes

In order to understand the first stages of the nucleation of carbon nanotubes in catalytic processes, we present a tight-binding Monte Carlo study of the stability and cohesive mechanisms of different carbon structures deposited on nickel (100) surfaces. Depending on the geometry, we obtain contrasted results. On the one hand, the analysis of the local energy distributions of flat carbon sheets, demonstrate that dangling bonds remain unsaturated in spite of the presence of the metallic catalyst. Their adhesion results from the energy gain of the surface Ni atoms located below the carbon nanostructure. On the other hand, carbon caps are stabilized by the presence of carbon atoms occupying the hollow sites of the fcc nickel structure suggesting the saturation of the dangling bonds

Erythema nodosum and the risk of tuberculosis in a high incidence setting

Objective: This study estimates the erythema nodosum (EN) incidence in a tuberculosis (TB) endemic setting and evaluates the likelihood of a subsequent TB diagnosis among individuals with Mycobacterium tuberculosis infection (MTI) with or without EN. Design: We estimated EN incidence rates (IRs) in East Greenland in 2010–2011 and conducted a cohort study following all individuals who tested positive for MTI from 1 January 2010 until 31 December 2012. A personal identifier allowed individual follow-up in the mandatory TB register. MTI was defined by a positive interferon-gamma release assay. TB incidence rate ratios (IRRs) among participants with or without EN were estimated with the Cox proportional hazard model. Results: We identified 38 EN cases corresponding to an IR of 500/100,000 inhabitants/year. All cases were among individuals with MTI. The EN IR was 11.79 (95% CI 5.73–24.27) times higher for BCG-unvaccinated compared with BCG-vaccinated individuals. The TB IRR was 25 (95% CI 11–60) within 1 month of EN compared to individuals without EN. Conclusion: This study documents a high EN incidence in a TB endemic region. EN occurred only in individuals with MTI, and predominantly among BCG-unvaccinated individuals. EN was significantly associated with a TB diagnosis within 1 month of diagnosis

Neurofilament Light in Cerebrospinal Fluid is Associated With Disease Staging in European Lyme Neuroborreliosis

BACKGROUND: Drivers of differences in disease presentation and symptom duration in Lyme neuroborreliosis (LNB) are currently unknown. OBJECTIVES: We hypothesized that neurofilament light (NfL) in cerebrospinal fluid (CSF) would predict disease location and sequelae in a historic LNB cohort. DESIGN: Using a cross-sectional design and archived CSF samples from 185 patients diagnosed with LNB, we evaluated the content of NfL in the total cohort and in a subgroup of 84 patients with available clinical and paraclinical information. METHODS: Individuals were categorized according to disease location: a. Central nervous system (CNS) with stroke (N=3), b. CNS without stroke (N=11), c. Peripheral nervous system (PNS) with cranial nerve palsy (CNP) (N=40) d. PNS without CNP (N=30). Patients with hospital follow-up more than 6 months after completed antibiotic therapy were categorized as having LNB associated sequelae (N=15). RESULTS: At diagnosis concentration of NfL exceeded the upper reference level in 60% (105/185), especially among individuals above 30 years. Age-adjusted NfL was not found to be associated with symptom duration. Age-adjusted NfL was significantly higher among individuals with CNS involvement. Category a. (stroke) had significantly higher NfL concentrations in CSF compared to all other categories, category b. (CNS involvement without stroke) had significantly higher values compared to the categories of PNS involvement. We found no significant difference between the categories with PNS involvement (with or without CNP). Significantly higher NfL was found among patients with follow-up in hospital setting. CONCLUSION: Comparison of NfL concentrations between the 4 groups of LNB disease manifestations based on clinical information revealed a hierarchy of neuron damage according to disease location and suggested evolving mechanisms with accelerated injury especially when disease is complicated by stroke. Higher values of NfL among patients with need of follow-up in hospital setting suggest NfL could be useful to identify rehabilitative needs

Palaeomagnetism of three dyke swarms in Nansen Land, north Greenland (83° N)

Three basic dyke swarms of post-Ellesmerian (post-Early Carboniferous) age in Nansen Land (83° N, 43° W) are still not dated numerically, but cross-cutting relationships show Group 1 to be older than Group 2, while Group 3 is the freshest and likely the youngest. Group 1 (the most northerly swarm) strikes N-S; Group 2 NW-SE, and Group 3 (the most southerly swarm) E-W. From more than 200 dykes 234 specimens from 28 sites were investigated palaeomagnetically. Group 1 dykes show unexpected shallow inclinations with a cleaned mean direction of (Dm, Im) = (151°, −5.8°), N = 7, k = 18.5, α 95 = 13.9°. They show hydrothermal alterations, some remagnetization by lightning, and the low inclination indicates a low palaeo latitude. The palaeopole is (Plat, Plon) = (8.9° S, 14.0° W) with (dp, dm) = (7°, 14°), and is close to the North American Early Carboniferous mean pole, suggesting a syn- or early late-tectonic dyke injection. The polarity is reverse. Groups 2 and 3 of presumed Cretaceous or Tertiary age show dominantly normal and reverse polarities, respectively. Their mean directions per polarity are well grouped, with (Dm, Im) = (−30.6°, 76.7°), n = 13, k = 191.4, α 95 = 3.9°, and (Dm, Im) = (133.4°, −76.7°), n = 10, k = 87.5, α 95 = 5.9°, respectively. They are antipodal within 95% significance, and combining both swarms gives (Dm, Im) = (−37.5°, 76.8°), n = 23, k = 124.3, α 95 = 2.7°, corresponding to a mean pole of (Plat, Plon) = (70.0° N, 185.1° E) with (dp, dm) = (4.7°, 5.0°), for which the spline of Late Cretaceous-Tertiary poles for all Greenland indicates a palaeomagnetic age of 57 ± 10 Ma. This pole (in present-day coordinates) is very close to the Late Cretaceous North American pole, in accordance with the fact that Greenland belongs to the North American craton, and that the two younger swarms are essentially postdating the opening of Baffin Bay.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43921/1/11288_2004_Article_147530.pd

Energy distribution analysis of the wavepacket simulations of CH4 and CD4 scattering

The isotope effect in the scattering of methane is studied by wavepacket simulations of oriented CH4 and CD4 molecules from a flat surface including all nine internal vibrations. At a translational energy up to 96 kJ/mol we find that the scattering is still predominantly elastic, but less so for CD4. Energy distribution analysis of the kinetic energy per mode and the potential energy surface terms, when the molecule hits the surface, are used in combination with vibrational excitations and the corresponding deformation. They indicate that the orientation with three bonds pointing towards the surface is mostly responsible for the isotope effect in the methane dissociation.Comment: 20 pages LaTeX, 1 figure (eps), to be published in Surf. Sc