24 research outputs found
Travelers With Cutaneous Leishmaniasis Cured Without Systemic Therapy
Guidelines recommend wound care and/or local therapy as first-line treatment for cutaneous leishmaniasis. An analysis of a referral treatment program in 135 travelers showed that this approach was feasible in 62% of patients, with positive outcome in 83% of evaluable patient
Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry
OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc).
METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers.
RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group.
CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies
Methotrexate efficacy and tolerance in plaque psoriasis. A prospective real-life multicentre study in France
International audienc
Errance mĂ©dicale des patients atteints dâhidradĂ©nite suppurĂ©e : un problĂšme majeur et persistant. Ătude « R-ENS Verneuil »
International audienceObjectiveTo provide physicians with an understanding of the factors behind significant delays in the diagnosis of hidradenitis suppurativa (HS) in France.Patients and methodsThis prospective multicentre national study conducted from October 2015 to March 2016 included all patients consulting for HS. Patient data were collected by means of a standardized questionnaire. Univariate and multivariate analyses were conducted to collect factors associated with a significant time to diagnosis of at least 5.5 years, defined as the period between the onset of initial clinical signs and the time of formal diagnosis.ResultsThe 16 participating centres enrolled 312 patients (62% women), of average age 35 years. The average age at onset of HS was 22 years. Before formal diagnosis by a dermatologist (64% of cases), 170 (54%), 114 (37%) and 45 (15%) patients had previously consulted at least 3, 5 and 10 general physicians, respectively. The average time between the initial clinical signs of HS, the first dermatology visit and the definitive diagnosis was 6.2 and 8.4 years, respectively. Active smoking (OR adjusted 1.85; P = 0.027) and disease onset at a younger age (adjusted OR 0.92; P < 0.001) were both associated with significant delays in diagnosis.ConclusionThese results emphasized misdiagnosis among HS patients but did not evidence any association between either sociodemographic or economic characteristics and the existence of significant times to diagnosis.ObjectifLâobjectif principal de cette Ă©tude Ă©tait dâanalyser les facteurs associĂ©s Ă lâexistence dâun dĂ©lai diagnostique significatif chez les patients atteints dâhidradĂ©nite suppurĂ©e (HS) en France.Malades et mĂ©thodesCette Ă©tude nationale prospective multicentrique rĂ©alisĂ©e dâoctobre 2015 Ă mars 2016 incluait tous les patients consultant pour une HS. Les donnĂ©es concernant les patients Ă©taient recueillies Ă lâaide dâun questionnaire standardisĂ©. Des analyses univariĂ©e et multivariĂ©e ont Ă©tĂ© effectuĂ©es afin de recueillir les facteurs associĂ©s Ă un dĂ©lai diagnostique significatif, dĂ©fini comme un dĂ©lai dâau moins 5,5 ans entre les premiers signes de la maladie et son diagnostic formel.RĂ©sultatsLes 16 centres ont inclus 312 patients (62 % de femmes) dâĂąge moyen 35 ans. LâĂąge moyen de dĂ©but de lâHS Ă©tait de 22 ans. Respectivement 170 (54 %), 114 (37 %) et 45 (15 %) patients avaient consultĂ© au moins 3, 5 et 10 mĂ©decins avant le diagnostic formel, qui Ă©tait posĂ© par un dermatologue dans 64 % des cas. Les premiers signes dâHS Ă©taient apparus en moyenne 6,2 ans avant la premiĂšre consultation de dermatologie et 8,4 ans avant le diagnostic. Un tabagisme actif (Odd Ratio (OR) ajustĂ© 1,85; p = 0,027) et un dĂ©but des signes Ă un Ăąge plus prĂ©coce (OR ajustĂ© 0,92; p < 0,001) Ă©taient associĂ©s Ă un dĂ©lai diagnostique significatif.ConclusionCes rĂ©sultats soulignent lâerrance mĂ©dicale des patients atteints dâHS, mais ne montrent pas dâassociation entre les caractĂ©ristiques sociodĂ©mographiques ou Ă©conomiques des patients et lâexistence dâun dĂ©lai diagnostique significatif