Vitamina D ed osteoartrosi

La vitamina D ha un ruolo nel controllo di alcune vie dell’immunità innata e nell’ipostenia del quadricipite, fattori rilevanti nella patogenesi dell’osteoartrosi del ginocchio. Bassi livelli di 25(OH)D sono associati ad una aumentata progressione radiografica dell’OA. L’ipovitaminosi D è associata ad alterazioni cartilaginee evidenziabili mediante studi di imaging nell’artrosi del ginocchio. L’ipovitaminosi D non è associata ad altre localizzazioni osteoartrosiche

Private Communications Using Optical Chaos

After a brief summary of the basic methods for secure transmission using optical chaos, we report on most recent achievements, namely, on the comparison between the standard two-laser and the three-laser schemes and on the network architecture for multiuser secure transmission. From our investigations, we found that while both the basic two-laser and the three-laser schemes are suitable to secure data exchange, the three-laser scheme offers a better level of privacy due to its symmetrical topology. Moreover, while transmission based on optical chaos is usually restricted to point-to-point interconnections, a more advanced solution, derived from the well-known public key cryptography, allows for private message transmission between any couple of subscribers in a network

The Effectiveness of Physical Exercise on Bone Density in Osteoporotic Patients

Physical exercise is considered an effective means to stimulate bone osteogenesis in osteoporotic patients. The authors reviewed the current literature to define the most appropriate features of exercise for increasing bone density in osteoporotic patients. Two types emerged: (1) weight-bearing aerobic exercises, i.e., walking, stair climbing, jogging, and Tai Chi. Walking alone did not appear to improve bone mass; however it is able to limit its progressive loss. In fact, in order for the weight-bearing exercises to be effective, they must reach the mechanical intensity useful to determine an important ground reaction force. (2) Strength and resistance exercises: these are carried out with loading (lifting weights) or without (swimming, cycling). For this type of exercise to be effective a joint reaction force superior to common daily activity with sensitive muscle strengthening must be determined. These exercises appear extremely site-specific, able to increase muscle mass and BMD only in the stimulated body regions. Other suggested protocols are multicomponent exercises and whole body vibration. Multicomponent exercises consist of a combination of different methods (aerobics, strengthening, progressive resistance, balancing, and dancing) aimed at increasing or preserving bone mass. These exercises seem particularly indicated in deteriorating elderly patients, often not able to perform exercises of pure reinforcement. However, for these protocols to be effective they must always contain a proportion of strengthening and resistance exercises. Given the variability of the protocols and outcome measures, the results of these methods are difficult to quantify. Training with whole body vibration (WBV): these exercises are performed with dedicated devices, and while it seems they have effect on enhancing muscle strength, controversial findings on improvement of BMD were reported. WBV seems to provide good results, especially in improving balance and reducing the risk of falling; in this, WBV appears more efficient than simply walking. Nevertheless, contraindications typical of senility should be taken into account

Comparing transformational and instrumental leadership The influence of different leadership styles on individual employee and financial performance in Brazilian startups

Abstract Purpose – The purpose of this study is to investigate the influence of transformational and instrumental leadership on the individual performance of the employee and the financial performance in Brazilian startups. Design/methodology/approach – The adopted methodological construction strategy was structural equation modeling, with the purpose of applying the model to primary data collected from a sample of leaders of Brazilian startups (n = 126). Findings – Results suggest that when leadership types are analyzed separately, both directly influence employee performance. Originality/value – This study has four main contributions: to test the influence of the two leadership styles on employee performance and thus to help advance the theoretical understanding of leadership; to perform this test in the context of Brazilian startups; to equip professionals with more information about the effects of crucial leadership types on individual type of employee performance; and to expand knowledge for recruitment and managerial training in initial-stage companie

Simultaneous sampling of vapor and particle-phase carcinogenic polycyclic aromatic hydrocarbons on functionalized glass fiber filters

The sampling of polycyclic aromatic hydrocarbons (PAHs) in the atmosphere is often performed on filters, which retain only aerosol particles, disregarding the vapor fraction; after the filter, an adsorbent (e.g., polyurethane foam, PUF, or styrene/divinylbenzene, XAD) is sometimes used for sampling vapors not retained from the filter. However, the use of an adsorbent may lead to many disadvantages: contaminations, analysis time and costs, and size problems when developing automated or personal samplers. In this work, a functionalized glass fiber filter for the simultaneous sampling of aerosol particles and vapor fraction is presented for the sampling of PAHs in air. A low sampling efficiency was observed for 3 ring PAHs, but all carcinogenic PAHs (according to IARC) were totally retained on functionalized filters. On the other hand, a comparison with normal filter sampling was performed, and results obtained confirm that > 10% of benzo(a)pyrene can be lost from normal filters. Together with size reduction, another advantage of the functionalized filter is an enhancement in the extraction and purification recovery. © Taiwan Association for Aerosol Research

Large Differences in Aging Phenotype between Strains of the Short-Lived Annual Fish Nothobranchius furzeri

BACKGROUND: A laboratory inbred strain of the annual fish Nothobranchius furzeri shows exceptionally short life expectancy and accelerated expression of age markers. In this study, we analyze new wild-derived lines of this short-lived species. METHODOLOGY/PRINCIPAL FINDINGS: We characterized captive survival and age-related traits in F1 and F2 offspring of wild-caught N. furzeri. Wild-derived N. furzeri lines showed expression of lipofuscin and neurodegeneration at age 21 weeks. Median lifespan in the laboratory varied from to 20 to 23 weeks and maximum lifespan from 25 to 32 weeks. These data demonstrate that rapid age-dependent decline and short lifespan are natural characteristics of this species. The N. furzeri distribution range overlaps with gradients in altitude and aridity. Fish from more arid habitats are expected to experience a shorter survival window in the wild. We tested whether captive lines stemming from semi-arid and sub-humid habitats differ in longevity and expression of age-related traits. We detected a clear difference in age-dependent cognitive decline and a slight difference in lifespan (16% for median, 15% for maximum lifespan) between these lines. Finally, we observed shorter lifespan and accelerated expression of age-related markers in the inbred laboratory strain compared to these wild-derived lines. CONCLUSIONS/SIGNIFICANCE: Owing to large differences in aging phenotypes in different lines, N. furzeri could represent a model system for studying the genetic control of life-history traits in natural populations

Here we don't speak, here we whistle : mobilizing a cultural reading of cognition, sound and ecology in the design of a language support system for the Silbo Gomero

This thesis presents the study of a whistled form of language known as the Silbo Gomero (Island of La Gomera, Canarian Archipelago). After fifty years of almost total extinction this form of communication has been revived, shifting from the fields where it was once used by peasant islanders and into the space of the classroom. Here, it is integrated into the curriculum of the island’s schools while providing children with a rich cultural platform that instigates linguistic and auditory experimentation. As a response to this transformation, the need to develop didactic materials is presented as one of the main challenges encountered by the community. Taking this condition as the driver of its research, this body of work draws on phonological, bioacoustic and cognitive theories to develop a formal understanding of the Silbo Gomero in a way which aims to complement the whistler’s own experience and mastery of the language by also developing an ethnographic reading of this indigenous body of knowledge and its characteristic auditory perceptual ecology. The investigation has culminated in the design of a digital application, El Laberinto del Sonido, and its active use within the educational community of the island. Finally, emphasising the practice-based nature of the research, this thesis attempts to relocate the question of intangible heritage from a focus on cultural safeguarding and transmission to one of experimentation, where an indigenous body of knowledge not only provides new exploratory paradigms in the design of didactic materials, but also contributes towards the sustainability of culturally situated forms of apprenticeship within contemporary educational contexts.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

The CARSO (Computer Aided Response Surface Optimization) Procedure in Optimization Studies

The paper illustrates innovative ways of using the CARSO (Computer Aided Response Surface Optimization) procedure for response surfaces analyses derived by DCM4 experimental designs in multivariate spaces. Within this method, we show a new feature for optimization studies: the results of comparing their quadratic and linear models for discussing the best way to compute the most reliable predictions of future compound

Rehabilitative interventions for ischaemic digital ulcers, pain, and hand functioning in systemic sclerosis: a prospective before-after study

Background: Systemic sclerosis (SSc) is a rare connective tissue disease characterised by immune dysfunction, vasculopathy, cellular infammation, fbrosis of the skin associated with multiple internal organs involvement. Ischaemic digital ulcers (IDU) of the hands commonly occur in patients with SSc adversely afecting functional independence. Purpose: Aim of the study is to investigate the efectiveness of a rehabilitation protocol based on the combined use of ultrasound (US) therapy and therapeutic exercise in terms of ulcers healing, pain relief, and hand functioning in patients afected by SSc with IDUs. Moreover, we also investigated the safety of the proposed intervention. Study design: Prospective before-after study. Methods: We included 20 patients with IDUs secondary to SSc. All patients were treated with US combined with manual therapy, including McMennel joint manipulation, pompage mobilization technique and connective tissue massage, for 10 sessions. We evaluated softness, dyschromia, pain, and hand mobility using the Pressure Sore Status Tool (PSST), the Numerical Rating Scale (NRS), and the Duruoz Hand Index (DHI) at T0 and at the end of the treatment (T1). Results: Treatment with US combined with manual therapy signifcantly reduced ulcers depth, improved ulcers margins, and reduced periwound skin damage (median PSST score 16 at T1, p<0.0001). Moreover, signifcant benefts were reported in terms of pain relief (NRS 3 at T1; p<0.0005), and hand function (DHI score 19 at T1; p<0.0005). Finally, this approach seems to be safe, without side efects reported at the end of treatment, along with an optimal compliance. Conclusion: Therapeutic US combined with manual therapy should be used as additional intervention to manage IDUs in SSc patient