Ben Reynolds in a Sophomore Recital

This is the sophomore piano recital of Ben Reynolds, held on March 13, 1998, in the McBeth Recital Hall in the Mabee Fine Arts Center

Public Archaeology: sharing best practice. Case studies from Wales

In 2013, Cadw published the 'Cadw Community Archaeology Framework'. This defined community archaeology practice in Wales, and outlined: a range of aims; a definition and context for community archaeology; a background to community archaeology; a vision for community archaeology; and a commitment to working with partners and communities. In 2018, five years after the publication of this document, the authors undertook a survey of the state of public archaeology practice in Wales in response to this document in order to identify best practice case studies, and from these to draw together, and share, consistent themes. Data collection took the form of a series of structured interviews with the Welsh Archaeological Trusts, as well as drawing on the authors' own experiences of public archaeology practice. We also include observations from our own practice at the Bryn Celli Ddu public archaeology landscape project. We aim to produce an inclusive, outward-facing series of research recommendations, designed to build on the Cadw/Welsh Government Framework in order to identify and support best practice, and to facilitate its dissemination

Public Archaeology: sharing best practice. Case studies from Wales

In 2013, Cadw published the 'Cadw Community Archaeology Framework'. This defined community archaeology practice in Wales, and outlined: a range of aims; a definition and context for community archaeology; a background to community archaeology; a vision for community archaeology; and a commitment to working with partners and communities. In 2018, five years after the publication of this document, the authors undertook a survey of the state of public archaeology practice in Wales in response to this document in order to identify best practice case studies, and from these to draw together, and share, consistent themes. Data collection took the form of a series of structured interviews with the Welsh Archaeological Trusts, as well as drawing on the authors' own experiences of public archaeology practice. We also include observations from our own practice at the Bryn Celli Ddu public archaeology landscape project. We aim to produce an inclusive, outward-facing series of research recommendations, designed to build on the Cadw/Welsh Government Framework in order to identify and support best practice, and to facilitate its dissemination

Characteristics of induced regulatory T cells and bystander suppression

Regulatory T cells expressing the transcription factor Foxp3 have a critical role in the maintenance of tolerance to both self and innocuous exogenous antigens. Humans and mice die from overwhelming autoimmunity in the absence of Foxp3+ Treg whilst administration of regulatory T cells has shown promise therapeutically in ameliorating autoimmunity in several animal models. Regulatory T cells arise naturally in the thymus (nTreg) but may also be induced from naïve Foxp3- cells in the presence of TGF-β (iTreg), both in vitro and in vivo. This thesis focuses on in vitro generated mouse iTreg, testing the hypothesis that they are able to effect bystander suppression; iTreg activated by a given antigen are able to suppress other responding cells with different antigen reactivities. Chapter 3 details an in vitro assay system using iTreg and responder cells recognising different antigens (TCR transgenic cells). Evidence for bystander suppression is presented and that did not require the presence of iTreg-relevant antigen but did require iTreg-relevant MHC Class II. The kinetics of iTreg suppression are discussed, with evidence presented that iTreg exert their effects early in co-culture. Chapter 4 identifies the production of three pro-inflammatory cytokines by iTreg - IFN-γ, GM-CSF, and TNF. These were not involved in the in vitro suppressive mechanism, but early abrogation of TGF-β signalling did inhibit suppression. Chapter 5 describes the in vivo function of iTreg under various experimental protocols. iTreg did not limit initial proliferation of naïve T cells in response to antigen but did limit the development of effector cells producing pro-inflammatory cytokines. Exposure to a pro-inflammatory environment in vivo led to iTreg producing IFN-γ and TNF, but not GM-CSF. This could be replicated in vitro by exposure to IL-6, IL-12 or IL-27. Finally, evidence for bystander suppression by iTreg in vivo is presented, with a reduction in effector cells producing pro-inflammatory cytokines shown in an allergic airways diease model

Aggregation Patterns in Stressed Bacteria

We study the formation of spot patterns seen in a variety of bacterial species when the bacteria are subjected to oxidative stress due to hazardous byproducts of respiration. Our approach consists of coupling the cell density field to a chemoattractant concentration as well as to nutrient and waste fields. The latter serves as a triggering field for emission of chemoattractant. Important elements in the proposed model include the propagation of a front of motile bacteria radially outward form an initial site, a Turing instability of the uniformly dense state and a reduction of motility for cells sufficiently far behind the front. The wide variety of patterns seen in the experiments is explained as being due the variation of the details of the initiation of the chemoattractant emission as well as the transition to a non-motile phase.Comment: 4 pages, REVTeX with 4 postscript figures (uuencoded) Figures 1a and 1b are available from the authors; paper submitted to PRL

New aspects of the continuous phase transition in the scalar noise model (SNM) of collective motion

In this paper we present our detailed investigations on the nature of the phase transition in the scalar noise model (SNM) of collective motion. Our results confirm the original findings of Vicsek et al. [Phys. Rev. Lett. 75 (1995) 1226] that the disorder-order transition in the SNM is a continuous, second order phase transition for small particle velocities ($v\leq 0.1$). However, for large velocities ($v\geq 0.3$) we find a strong anisotropy in the particle diffusion in contrast with the isotropic diffusion for small velocities. The interplay between the anisotropic diffusion and the periodic boundary conditions leads to an artificial symmetry breaking of the solutions (directionally quantized density waves) and a consequent first order transition like behavior. Thus, it is not possible to draw any conclusion about the physical behavior in the large particle velocity regime of the SNM.Comment: 13 pages, 11 figure

Genetic evaluation of paediatric nephrocalcinosis: phenotype-driven genetic panels reveal a rare diagnosis

Monogenic causes of paediatric nephrocalcinosis are associated with extensive phenotypic variability. We report a 14-year-old male who presented at eight years of age with incidentally identified nephrocalcinosis alongside growth impairment and dental anomalies. Extensive genetic investigation confirmed a molecular diagnosis of Bartter syndrome type II (BSII). This is exceptional in both late presentation and the presence of amelogenesis imperfecta, a very rare association of inherited tubulopathies. Details of the nephrocalcinosis gene panel analysed and associated phenotypes are presented to highlight the utility of a phenotype-driven genetic panel in resolving an atypical presentation of nephrocalcinosis, allowing precise diagnosis, tailored therapy and prognostication