Análisis Organizacional y Financiero del uso de Prácticas Sustentables en Empresas Industriales Hidalguenses

El propósito de la presente investigación, se orienta en conocer si las prácticas sustentables (ahorro de energía eléctrica), realizadas en una muestra de 10 empresas industriales pertenecientes a dos municipios del Estado de Hidalgo, México, influyen en sus estructuras financieras. Para alcanzar los objetivos planteados se calculan dos índices, uno relativo al desarrollo de prácticas sustentables (IPS) y otro, relativo al aspecto financiero (IFIN), ambos similares al propuesto por (Céspedes, (2001); Carrillo, (2014); Vázquez et al., (2011). Losresultados de la aplicación del modelo de regresión lineal, muestran una relación estadísticamente significativa de tipo positivo entre el Índice Financiero (IFIN) y las variables relativas al grado de escolaridad del responsable, número de trabajadores, el (IPS). En definitiva, los resultados nos podrían permitir inferir, en que las empresas que implementan prácticas sustentables, impactan sustancialmente sus estructuras financieras. This paper focuses on ascertaining if the sustainable practices (saving of electrical energy), carried out in a sample of 10 industrial companies belonging to two municipalities of the State of Hidalgo, Mexico, have a significant influence on their financial structures. To achieve the proposed objectives, two indices were calculated, one related to the development of sustainable practices (IPS) and the other related to the financial aspect (IFIN). Both were similar to the one proposed by Céspedes (2001), Carrillo (2014), and Vázquez et al. (2011). The results of the application of the linear regression model show a statistically significant positive relationship between the Financial Index (IFIN) and the variables related to the level of education of the person responsible, number of workers, and the IPS. The results show that companies that implement sustainable practices have a substantial impact on their financial structures

Influencia Del Comité De Auditoría En El Desempeño Financiero Organizacional, En Empresas Mexicanas Cotizadas (2010-2014)

The purpose of this paper is to know the level of compliance with corporate practices related to the audit function, contained in the Code of Best Corporate Practices, issued by the National Banking and Securities Commission and influence on organizational financial performance (specifically on financial profitability), for this, a sample of 405 questionnaires of best corporate practices, belonging to 125 non-financial companies, are listed on the Mexican Stock Exchange during the period, 2010-2014. The results of the application of the linear regression model, could allow us to affirm that the Audit Function (INDEX_FA), increases the financial profitability of the organizations, which is a great success on the part of the Mexican regulators

Realfood and cancer: analysis of the reliability and quality of YouTube content

This study analyzes the quality and reliability of videos related to nutrition and cancer on YouTube. Study Design: An observational, retrospective, cross-sectional, time-limited study analyzing activity on the social network YouTube was proposed. Methods: The information from the videos was extracted through an API search tool, using the NodeXL software. The criteria to select the videos on YouTube were the keywords “real food”, “realfood”, and “cancer” and the hashtags #realfood and #cancer were present, videos in English and videos available on 1 December 2022. Results: The DISCERN value in the total number of videos viewed was 2.25 (±0.88) points, indicating low reliability. The videos uploaded by HRU represented only 20.8%. Videos suggesting that the use of foods defined as “real food” could cure cancer without the intervention of any other treatment accounted for 12.5%. Videos that provided external links to scientific/technical evidence verifying the information represented only 13.89% of the total number of videos. Of these videos, 70% corresponded to HRU. The DISCERN value for videos from HRU users was 3.05 (0.88), a value that reflects a good reliability of videos from these users. Conclusions: This study provides information on the content and quality of the videos that we can find on YouTube. We found videos of non-health users who do not base their content on any scientific evidence, with the danger that this entails for the population, but it also highlights that the videos published by HRU have greater reliability and quality, being better perceived by the population, so it is important to encourage healthcare professionals and health institutions to share verified information on YouTube.This research was funded by Fundación Banco Santander and Fundación Alfonso X el Sabio, grant number 1014011. Partial funding for open access charge: Universidad de Málag

Proyecto de una revista anual ilustrada basada en poemarios de poetas contemporáneos

Creación, diseño y edición de una publicación periódica anual realizada por estudiantes de la Facultad de Bellas Artes, que fomente el aprendizaje significativo, autónomo y crítico de los lenguajes poéticos contemporáneos en conexión con los lenguajes propios de los estudios de las artes visuales

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Anomalous protein-DNA interactions behind neurological disorders

Aggregation, nuclear location, and nucleic acid interaction are common features shared by a number of proteins related to neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, transmissible spongiform encephalopathy, Huntington's disease, spinobulbar muscular atrophy, dentatorubro-pallidoluysian atrophy, and several spinocerebellar ataxias. β-Amyloid peptides, tau protein, α-synuclein, superoxide dismutase1, prion protein, huntingtin, atrophin1, androgen receptor, and several ataxins are proteins prone to becoming aggregated, to translocate inside cell nucleus, and to bind DNA. In this chapter, we review those common features suggesting that neurological diseases too may share a transcriptional disorder, making it an important contribution to the origin of the disease. © 2013 Elsevier Inc.SAF2006-02424 y P2009/TIC-1476 from the Spanish Government and Comunidad de Madrid.Peer Reviewe

Thermodynamics of the interaction between Alzheimer's disease related Tau protein and DNA

Tau hyperphosphorylation can be considered as one of the hallmarks of Alzheimer's disease and other tauophaties. Besides its well-known role as a microtubule associated protein, Tau displays a key function as a protector of genomic integrity in stress situations. Phosphorylation has been proven to regulate multiple processes including nuclear translocation of Tau. In this contribution, we are addressing the physicochemical nature of DNA-Tau interaction including the plausible influence of phosphorylation. By means of surface plasmon resonance (SPR) we measured the equilibrium constant and the free energy, enthalpy and entropy changes associated to the Tau-DNA complex formation. Our results show that unphosphorylated Tau binding to DNA is reversible. This fact is in agreement with the protective role attributed to nuclear Tau, which stops binding to DNA once the insult is over. According to our thermodynamic data, oscillations in the concentration of dephosphorylated Tau available to DNA must be the variable determining the extent of Tau binding and DNA protection. In addition, thermodynamics of the interaction suggest that hydrophobicity must represent an important contribution to the stability of the Tau-DNA complex. SPR results together with those from Tau expression in HEK cells show that phosphorylation induces changes in Tau protein which prevent it from binding to DNA. The phosphorylation-dependent regulation of DNA binding is analogous to the Tau-microtubules binding inhibition induced by phosphorylation. Our results suggest that hydrophobicity may control Tau location and DNA interaction and that impairment of this Tau-DNA interaction, due to Tau hyperphosphorylation, could contribute to Alzheimer's pathogenesis. © 2014 Camero et al.Spanish Government and Comunidad de Madrid. CIBERNED (Centro de Investigación Biomédica en Red de Enfermedades NeurodegenerativasPeer Reviewe

Specific binding of DNA to aggregated forms of Alzheimer's disease amyloid peptides

Anomalous protein aggregation is closely associated to age-related mental illness. Extraneuronal plaques, mainly composed of aggregated amyloid peptides, are considered as hallmarks of Alzheimer's disease. According to the amyloid cascade hypothesis, this disease starts as a consequence of an abnormal processing of the amyloid precursor protein resulting in an excess of amyloid peptides. Nuclear localization of amyloid peptide aggregates together with amyloid-DNA interaction, have been repeatedly reported. In this paper we have used surface plasmon resonance and electron microscopy to study the structure and behavior of different peptides and proteins, including β-lactoglobulin, bovine serum albumin, myoglobin, histone, casein and the amyloid-β peptides related to Alzheimer's disease Aβ25-35 and Aβ1-40. The main purpose of this study is to investigate whether proneness to DNA interaction is a general property displayed by aggregated forms of proteins, or it is an interaction specifically related to the aggregated forms of those particular proteins and peptides related to neurodegenerative diseases. Our results reveal that those aggregates formed by amyloid peptides show a particular proneness to interact with DNA. They are the only aggregated structures capable of binding DNA, and show more affinity for DNA than for other polyanions like heparin and polyglutamic acid, therefore strengthening the hypothesis that amyloid peptides may, by means of interaction with nuclear DNA, contribute to the onset of Alzheimer's disease. © 2013 Elsevier B.V.Peer Reviewe