First reports of computed tomographic colonography for the screening of colorectal polyps in acromegalic patients

*Aim:* To analyze the CTC performance for the screening of colorectal polyps in acromegalic patients. 

*Materials and Methods:* A prospective study of 21 acromegalic patients, 12 male and 9 female, average age 49, who underwent CTC and CC. CTC was performed with a GE Helical Multislice Computed Tomography Apparatus. The colonoscopy was performed, in the same day, without previous knowledge of the CTC diagnostics. The study evaluated the capacity of CTC to detect patients with colorectal polyps and identify each colorectal lesion described by CC. 

*Results:* In two patients (2/21), CC was incomplete. However, in all patients CTC was complete. In Phase I (“Per Patient”), CTC diagnosed 8 of the 9 patients with colorectal polyps and showed 88% sensitivity, 75% specificity and 81% accuracy. In Phase II (“Per Polyp”), out of the 21 acromegalic patients included in this study, 12 presented normal findings at CC. A total of 19 polyps were identified in 9 patients. 10 of the 19 polyps were smaller than 10 mm, and 9 were equal to or larger than 10. CTC identified 7 of the 9 polyps ≥ 10 mm described by CC and only 6 of the 10 small polyps identified at CC were detected by CTC. The histological analysis of resected lesions revealed 12 tubular adenomas, 6 hyperplastic polyps and 1 colonic tubulo-villous adenoma with an adenocarcinoma focus. 

*Conclusion:* In this study, CTC was performed without complications and a complete and safe colorectal evaluation was possible in all acromegalic patients. Moreover, CTC showed good sensitivity to identify acromegalic patients with colorectal polyps

DEFICIÊNCIA INTELECTUAL E O ATENDIMENTO EDUCACIONAL ESPECIALIZADO: UM RELATO DE EXPERIÊNCIA

DEFICIÊNCIA INTELECTUAL E O ATENDIMENTO EDUCACIONAL ESPECIALIZADO: UM RELATO DE EXPERIÊNCI

DEFICIÊNCIA INTELECTUAL E O ATENDIMENTO EDUCACIONAL ESPECIALIZADO: UM RELATO DE EXPERIÊNCIA

DEFICIÊNCIA INTELECTUAL E O ATENDIMENTO EDUCACIONAL ESPECIALIZADO: UM RELATO DE EXPERIÊNCI

Extensive Natural Epigenetic Variation At A De Novo Originated Gene.

Epigenetic variation, such as heritable changes of DNA methylation, can affect gene expression and thus phenotypes, but examples of natural epimutations are few and little is known about their stability and frequency in nature. Here, we report that the gene Qua-Quine Starch (QQS) of Arabidopsis thaliana, which is involved in starch metabolism and that originated de novo recently, is subject to frequent epigenetic variation in nature. Specifically, we show that expression of this gene varies considerably among natural accessions as well as within populations directly sampled from the wild, and we demonstrate that this variation correlates negatively with the DNA methylation level of repeated sequences located within the 5'end of the gene. Furthermore, we provide extensive evidence that DNA methylation and expression variants can be inherited for several generations and are not linked to DNA sequence changes. Taken together, these observations provide a first indication that de novo originated genes might be particularly prone to epigenetic variation in their initial stages of formation.9e100343

Do masculine men smell better? An association between skin color masculinity and female preferences for body odor

This work was supported by Fundação para a Ciência e a Tecnologia and Programa Operacional de Potencial Humano/Fundo Social Europeu (SFRH/BD/77592/2011 to M.L.C.).A recent study claimed face skin color as a sexually dimorphic variable that influences attractiveness preferences in mate choice. Thereby, skin color may assume the role of a mate quality signal influencing attractiveness preferences. As body odor is linked to attractiveness, this study aimed to explore whether the odors of men with more masculine facial skin color would be evaluated more positively than odors from less masculine men. Female raters were presented with body odors of 18 men and were asked to rate them in various characteristics. Multilevel modelling revealed that the odors of the donors with more masculine color were rated not only as more attractive, more pleasant, and sexier, but also healthier. This indicates that odor associated with men with more masculine skin color is attractive, just as other sexually dimorphic traits. Furthermore, we found a negative relation between skin color masculinity and perceived odor maleness. Regarding this last finding, a new discussion is introduced with respect to the influence of cognitive stereotypes in odor judgments. Altogether, the study supports the possibility that chemosensory signals may be communicating signs of mate quality associated with masculinity.PostprintPeer reviewe

HIPOPLASIA DO ESMALTE COMO FATOR DE RISCO PARA O DESENVOLVIMENTO DA DOENÇA CÁRIE

Introdução: a hipoplasia do esmalte é uma formação incompleta ou defeituosa da matriz orgânica do esmalte dentário em desenvolvimento, provocando deficiências e irregularidades na superfície do tecido dentário, tendo como causa fatores sistêmicos, genéticos e etiológicos. Pacientes com higiene bucal comprometida, principalmente jovens, podem favorecer a maior ação do biofilme bacteriano e consequentemente aumentar as chances de desenvolver lesões cariosas. Objetivo: promoção de saúde bucal em paciente portador de hipoplasia do esmalte. Caso clínico: paciente de 21 anos, gênero masculino, com os dentes acometidos com hipoplasia, manchados desde o seu irrompimento, com presença de mancha marrom na cúspide disto- vestibular do dente 16, mancha esbranquiçada no terço incisal da face vestibular do dente 21 e cálculo supragengival no sextante cinco. Durante o tratamento foi realizado PSR (Avaliação Periodontal Simplificada), índice O’leary inicial, instrução de higiene bucal, raspagem supragengival do sextante 5, reavaliação periodontal, índice O’Leary final e correção das técnicas de higiene bucal. Ao final do tratamento obteve-se uma diminuição considerável do índice O’leary final. Conclusão: o profissional deve estar preparado para realizar um correto diagnóstico, para que se obtenha o prognóstico mais adequado e o tratamento mais favorável

The other side of recovery: validation of the Portuguese version of the subjective experiences of psychosis scale.

BACKGROUND: The aim of this study was to develop and validate a Portuguese version of The Subjective Experiences of Psychosis Scale (SEPS) for use in Portuguese-speaking populations in order to provide a self-report instrument to assess and monitor dimensions of psychotic experiences, translating patient's perspective and experience in terms of recovery from psychosis. METHODS: The sample consisted of 30 participants with psychotic disorders who had recently experienced delusions or hallucinations. The SEPS was completed along with other observer-based assessments and self-report questionnaires, such as the Brief Psychiatric Rating Scale, the Insight and Treatment Attitudes Questionnaire and the Function Assessment Short Test. RESULTS: Two main factors representing the positive and negative components of each subscale were identified. We obtained good internal consistency and test-retest reliability for the positive and negative components of all subscales. The subscales of SEPS correlated with observer-based assessments and self-report questionnaires. CONCLUSIONS: The Portuguese version of the SEPS is a useful tool in the assessment and monitoring of psychotic symptoms

Nativism Revisited: A review of Eric H. Lenneberg's Biological Foundations of Language

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/96685/1/jeab.1968.11-497.pd

The Role of Task Comprehension in Children's Problem-Solving

PHDPsychologyUniversity of Michiganhttps://deepblue.lib.umich.edu/bitstream/2027.42/150858/1/psychdiss065.pd

A inclusão escolar de alunos com deficiência a partir da perspectiva de Paulo Freire e Carlos Skliar: um estudo bibliográfico

Dissertação de mestrado apresentada ao Programa de Pós-Graduação em Educação da Universidade do Extremo Sul Catarinense – UNESC, como requisito para a obtenção do título de Mestre em Educação.Esta dissertação é um estudo bibliográfico que apresenta o seguinte problema de pesquisa: Quais as contribuições de Paulo Freire e Carlos Skliar em relação à inclusão escolar de alunos com deficiência na escola? Diante disso, o objetivo geral deste estudo foi: Analisar as contribuições de Paulo Freire e Carlos Skliar em relação à inclusão escolar de alunos com deficiência na escola. E como objetivos específicos: Problematizar a inclusão escolar a partir do conceito de “diálogo” de Paulo Freire; Problematizar a inclusão escolar a partir do conceito de “alteridade” de Carlos Skliar e Compreender as implicações da inclusão escolar de pessoas com deficiência a partir do “diálogo” e da “alteridade”. A construção do referencial teórico ocorreu a partir da contribuição de diversos autores, com embasamento fundamental em Paulo Freire e Carlos Skliar. Considera-se com este estudo, que os conceitos de diálogo e alteridade, a partir de Freire e Skliar, acarretam em novas possibilidades e caminhos sobre questões de exclusão das diferenças e incentivam novos debates educativos. Freire contribui com a educação inclusiva ao ressaltar a necessidade de agir sobre a realidade social, com o objetivo de modificá-la, ação que é interação, colaboração a partir do diálogo. E a alteridade que Skliar nos apresenta acarreta em questionamentos sobre quem é o “outro” a ser incluído, o que questiona o padrão de normalidade. Os desafios para a educação implicam desenvolver revisões contínuas e profundas no empenho de se reconhecer a alteridade e promover o diálogo, na busca de não mais ser necessário buscar a inclusão, por não haver mais exclusões, não haver mais “o outro” a quem se deva incluir e por todos terem o direito de dizer a sua palavra em comunidade