Hydrodynamics and the fluctuation theorem

The fluctuation theorem is a pivotal result of statistical physics. It quantifies the probability of observing fluctuations which are in violation of the second law of thermodynamics. More specifically, it quantifies the ratio of the probabilities of observing entropy-producing and entropy-consuming fluctuations measured over a finite volume and time span in terms of the rate of entropy production in the system, the measurement volume and time. We study the fluctuation theorem in computer simulations of planar shear flow. The simulations are performed employing the method of multiparticle collision dynamics which captures both thermal fluctuations and hydrodynamic interactions. The main outcome of our analysis is that the fluctuation theorem is verified at any averaging time provided that the measurement volume exhibits a specific dependence on a hydrodynamic time scale.Comment: 4 pages, 3 figures, to appear on Physical Review Letter

Dispersion-theoretical analysis of the nucleon electromagnetic form factors

The structure of the proton and the neutron is of fundamental importance for the study of the strong interaction dynamics over a wide range of momentum transfers. The nucleon form factors encode information on the internal structure of the nucleon as probed by the electromagnetic interaction, and, to a certain extent, reflect the charge and magnetisation distributions within the proton and the neutron. In this thesis we report on our investigation of the electromagnetic form factors of the proton and the neutron with dispersion relation techniques, including known experimental input on the ππ, K¯K and the ρπ continua and perturbative QCD constraints. We include new experimental data on the pion form factor and the nucleon form factors in our simultaneous analysis of all four form factors in both the space- and the timelike regions for all momentum transfers, and perform Monte-Carlo sampling in order to obtain theoretical uncertainty bands. Finally, we discuss the implications of our results on the pion cloud of the nucleon, the nucleon radii and the Okubo-Zweig-Iizuka rule, and present our results of a model-independent approach to estimating two-photon effects in elastic electron-proton scattering

Hydrogen Dynamics in Superprotonic CsHSO4

We present a detailed study of proton dynamics in the hydrogen-bonded superprotonic conductor CsHSO4 from first-principles molecular dynamics simulations, isolating the subtle interplay between the dynamics of the O--H chemical bonds, the O...H hydrogen bonds, and the SO4 tetrahedra in promoting proton diffusion. We find that the Grotthus mechanism of proton transport is primarily responsible for the dynamics of the chemical bonds, whereas the reorganization of the hydrogen-bond network is dominated by rapid angular hops in concert with small reorientations of the SO4 tetrahedra. Frequent proton jumping across the O--H...O complex is countered by a high rate of jump reversal, which we show is connected to the dynamics of the SO4 tetrahedra, resulting in a diminished CsHSO4/CsDSO4 isotope effect. We also find evidence of multiple timescales for SO4 reorientation events, leading to distinct diffusion mechanisms along the different crystal lattice directions. Finally, we employ graph-theoretic techniques to characterize the topology of the hydrogen-bond network and demonstrate a clear relationship between certain connectivity configurations and the likelihood for diffusive jump events.Comment: 12 pages, 10 figure

The size of the proton - closing in on the radius puzzle

We analyze the recent electron-proton scattering data from Mainz using a dispersive framework that respects the constraints from analyticity and unitarity on the nucleon structure. We also perform a continued fraction analysis of these data. We find a small electric proton charge radius, r_E^p = 0.84_{-0.01}^{+0.01} fm, consistent with the recent determination from muonic hydrogen measurements and earlier dispersive analyses. We also extract the proton magnetic radius, r_M^p = 0.86_{-0.03}^{+0.02} fm, consistent with earlier determinations based on dispersion relations.Comment: 4 pages, 2 figures, fit improved, small modifications, section on continued fractions modified, conclusions on the proton charge radius unchanged, version accepted for publication in European Physical Journal

Dispersion analysis of the nucleon form factors including meson continua

Dispersion relations provide a powerful tool to analyse the electromagnetic form factors of the nucleon for all momentum transfers. Constraints from meson-nucleon scattering data, unitarity, and perturbative QCD can be included in a straightforward way. In particular, we include the 2pi, rho-pi, and KKbar continua as independent input in our analysis and provide an error band for our results. Moreover, we discuss two different methods to include the asymptotic constraints from perturbative QCD. We simultaneously analyze the world data for all four form factors in both the space-like and time-like regions and generally find good agreement with the data. We also extract the nucleon radii and the omega-NN coupling constants. For the radii, we generally find good agreement with other determinations with the exception of the electric charge radius of the proton which comes out smaller. The omega-NN vector coupling constant is determined relatively well by the fits, but for the tensor coupling constant even the sign can not be determined.Comment: 24 pages, 9 figure

Hadron structure at small momentum transfer

Giving three examples, the form factors of the nucleon, the polarisability of the charged pion and the interference of the $S_{11}(1535)$ with the $D_{13}(1520)$ excitation of the nucleon in the $\eta p$-decay channel, it is argued that the hadron structure at low momentum transfer is highly significant for studying QCD.Comment: 7 pages, 9 figures. Contribution to the International School of Nuclear Physics, 29th Ccourse, "Quarks in Hadrons and Nuclei", Erice, Sicily, 16 - 24 September 200

Proton charge and magnetic rms radii from the elastic epep scattering data

The elastic electron-proton scattering data are analysed in order to determine proton charge and magnetic rms radii, r_E and r_M. Along with the usual statistical error, we try to estimate a systematic error in the radii, caused by the inadequacy of particular form factor parameterization employed. The range of data to use in the analysis is chosen so as to minimize the total (statistical + systematic) error. We obtain r_E = 0.912 +- 0.009 (stat) +- 0.007 (syst) fm, and r_M = 0.876 +- 0.010 (stat) +- 0.016 (syst) fm. The cross-section data were corrected for two-photon exchange. We found that without such corrections obtained r_E and r_M are somewhat smaller while the quality of fit is worse.Comment: 6 pages, 4 figures. Numbers slightly changed due to discovered error in minimization program. Sec.III revised, discussion of G_E behaviour added

Multiplexed nanoplasmonic biosensor for one-step simultaneous detection of Chlamydia trachomatis and Neisseria gonorrhoeae in urine.

Development of rapid and multiplexed diagnostic tools is a top priority to address the current epidemic problem of sexually transmitted diseases. Here we introduce a novel nanoplasmonic biosensor for simultaneous detection of the two most common bacterial infections: Chlamydia trachomatis and Neisseria gonorrhoeae. Our plasmonic microarray is composed of gold nanohole sensor arrays that exhibit the extraordinary optical transmission (EOT), providing highly sensitive analysis in a label-free configuration. The integration in a microfluidic system and the precise immobilization of specific antibodies on the individual sensor arrays allow for selective detection and quantification of the bacteria in real-time. We achieved outstanding sensitivities for direct immunoassay of urine samples, with a limit of detection of 300 colony forming units (CFU)/mL for C. trachomatis and 1500CFU/mL for N. gonorrhoeae. The multiplexing capability of our biosensor was demonstrated by analyzing different urine samples spiked with either C. trachomatis or N. gonorrhoeae, and also containing both bacteria. We could successfully detect, identify and quantify the levels of the two bacteria in a one-step assay, without the need for DNA extraction or amplification techniques. This work opens up new possibilities for the implementation of point-of-care biosensors that enable fast, simple and efficient diagnosis of sexually transmitted infections

Phase-sensitive plasmonic biosensor using a portable and large field-of-view interferometric microarray imager

Nanophotonics, and more specifically plasmonics, provides a rich toolbox for biomolecular sensing, since the engineered metasurfaces can enhance light–matter interactions to unprecedented levels. So far, biosensing associated with high-quality factor plasmonic resonances has almost exclusively relied on detection of spectral shifts and their associated intensity changes. However, the phase response of the plasmonic resonances have rarely been exploited, mainly because this requires a more sophisticated optical arrangement. Here we present a new phase-sensitive platform for high-throughput and label-free biosensing enhanced by plasmonics. It employs specifically designed Au nanohole arrays and a large field-of-view interferometric lens-free imaging reader operating in a collinear optical path configuration. This unique combination allows the detection of atomically thin (angstrom-level) topographical features over large areas, enabling simultaneous reading of thousands of microarray elements. As the plasmonic chips are fabricated using scalable techniques and the imaging reader is built with low-cost off-the-shelf consumer electronic and optical components, the proposed platform is ideal for point-of-care ultrasensitive biomarker detection from small sample volumes. Our research opens new horizons for on-site disease diagnostics and remote health monitoring.Peer ReviewedPostprint (published version