Features of emotional intelligence of gifted high school students with different educational profiles

The article examines the features of the formation of various scales of emotional intelligence in gifted high school students with different educational profiles. Emotional intelligence is considered as one of the types of intelligence in the cognitive development of a student’s personality. The study sample consisted of 138 senior schoolchildren from classes with various educational profiles: physics and mathematics - 26 people, social sciences and humanities - 34 people, biological and chemical studies - 22 people, IT technology and engineering - 32 people, architecture and art - 24 people . The research methods were survey method, diagnostic techniques, statistical methods. Based on the results of the study, the educational profiles of senior schoolchildren were identified, and the features of the development of emotional intelligence scales characteristic of each profile were highlighted. The findings can be used in pedagogical practice for psychological support of the education of schoolchildren in secondary schools and colleges

Secondary raw materials of coffee plant processing are an alternative source of pectin substances

The article presents the results of studies of the content of pectin substances of secondary raw materials of coffee processing – pulp (СP). СP includes both the shell (skin, epidermis, exocarp) and the pulp itself (mesocarp). Industrial coffee varieties cultivated and processed in different regions of Ethiopia were selected as the object of research. The research results have shown that the coffee waste generated can be considered as a source of pectin substances for the development of functional nutrition products

АНАЛИЗ ПОВЕДЕНИЯ РОССИЙСКИХ ПОТРЕБИТЕЛЕЙ ПАРФЮМЕРИИ И КОСМЕТИКИ

The article describes the results of a marketing research of a network of perfumery and cosmetics stores. The purpose of this work was the description of the results of a survey of customers of perfumery and cosmetics shops, which help to clarify the marketing policy of a chain of stores. In conducting the study, sociological and static research methods were used.The novelty of the results obtained is to clarify the characteristics of buyers that are important for marketing activities, such as sources of information about perfumery and cosmetics stores and factors of their choice, customer awareness of the characteristics of perfumery and cosmetic products and their interest in new products, customer loyalty to the chain stores and evaluation their competitiveness. It was concluded that the largest share of buyers prefer products of the medium and mass segment, and outdoor advertising and information on the Internet are the most effective means of promotion. The main conclusions are the trends of individualization of the “mass market” and increasing customer attention to the quality of service. The results of the work are of practical interest for the development of solutions in the field of marketing activities of the company.В статье дано описание результатов маркетингового исследования сети магазинов парфюмерии и косметики. Целью данной работы разработка рекомендаций для совершенствования маркетинговой политики розничных торговцев косметикой на основе анализа результатов проведенного опроса. При проведении исследования использовались социологические и статистические методы исследований.Новизна полученных результатов работы заключается в уточнении важных для маркетинговой деятельности характеристик покупателей, таких как источники получения информации о магазинах парфюмерии и косметики и факторы их выбора, осведомленность клиентов о характеристиках парфюмерно-косметической продукции и заинтересованность их в новинках, лояльность покупателей к магазинам сети и оценка их конкурентоспособность. Сделаны выводы, что наибольшая доля покупателей предпочитает продукцию среднего и массового сегмента, а наиболее эффективными способами продвижения являются наружная реклама и информация в сети интернет. В качестве основных выводов указаны тенденции индивидуализации «масс-маркета» и усиления внимания клиентов к качеству сервиса. Результаты работы представляют практический интерес для разработки решений в области маркетинговой деятельности компании

The TOSCA Registry for Tuberous Sclerosis-Lessons Learnt for Future Registry Development in Rare and Complex Diseases.

Introduction: The TuberOus SClerosis registry to increase disease Awareness (TOSCA) is an international disease registry designed to provide insights into the clinical characteristics of patients with Tuberous Sclerosis Complex (TSC). The aims of this study were to identify issues that arose during the design, execution, and publication phases of TOSCA, and to reflect on lessons learnt that may guide future registries in rare and complex diseases. Methods: A questionnaire was designed to identify the strengths, weaknesses, and issues that arose at any stage of development and implementation of the TOSCA registry. The questionnaire contained 225 questions distributed in 7 sections (identification of issues during registry planning, during the operation of the registry, during data analysis, during the publication of the results, other issues, assessment of lessons learnt, and additional comments), and was sent by e-mail to 511 people involved in the registry, including 28 members of the Scientific Advisory Board (SAB), 162 principal investigators (PIs), and 321 employees of the sponsor belonging to the medical department or that were clinical research associate (CRA). Questionnaires received within the 2 months from the initial mailing were included in the analysis. Results: A total of 53 (10.4%) questionnaires were received (64.3% for SAB members, 12.3% for PIs and 4.7% for employees of the sponsor), and the overall completeness rate for closed questions was 87.6%. The most common issues identified were the limited duration of the registry (38%) and issues related to handling of missing data (32%). In addition, 25% of the respondents commented that biases might have compromised the validity of the results. More than 80% of the respondents reported that the registry improved the knowledge on the natural history and manifestations of TSC, increased disease awareness and helped to identify relevant information for clinical research in TSC. Conclusions: This analysis shows the importance of registries as a powerful tool to increase disease awareness, to produce real-world evidence, and to generate questions for future research. However, there is a need to implement strategies to ensure patient retention and long-term sustainability of patient registries, to improve data quality, and to reduce biases

Behavior and Impact of Zirconium in the Soil–Plant System: Plant Uptake and Phytotoxicity

Because of the large number of sites they pollute, toxic metals that contaminate terrestrial ecosystems are increasingly of environmental and sanitary concern (Uzu et al. 2010, 2011; Shahid et al. 2011a, b, 2012a). Among such metals is zirconium (Zr), which has the atomic number 40 and is a transition metal that resembles titanium in physical and chemical properties (Zaccone et al. 2008). Zr is widely used in many chemical industry processes and in nuclear reactors (Sandoval et al. 2011; Kamal et al. 2011), owing to its useful properties like hardness, corrosion-resistance and permeable to neutrons (Mushtaq 2012). Hence, the recent increased use of Zr by industry, and the occurrence of the Chernobyl and Fukashima catastrophe have enhanced environmental levels in soil and waters (Yirchenko and Agapkina 1993; Mosulishvili et al. 1994 ; Kruglov et al. 1996)

Методы развития лексических навыков при обучении иностранному языку в цифровой среде

В статье рассматриваются определения лексических навыков и цифровой среды, методы развития словарного запаса и анализируются результаты опроса про наиболее актуальные методы пополнения словарного запаса. В этой статье обсуждаются современные методы расширения словарного запаса у учащихся в цифровой среде, отбираются наиболее эффективные и современные способы путем анализа каждого метода и опроса студентов.The article discusses definitions of lexical skills and the digital environment, methods of vocabulary development and analyzes the results of a survey on the most relevant methods of vocabulary replenishment. This article depicts modern methods of expanding students' vocabulary in a digital environment, selects the most effective and modern ways by analyzing each method and interviewing students

Clinical Characteristics of Subependymal Giant Cell Astrocytoma in Tuberous Sclerosis Complex.

Background: This study evaluated the characteristics of subependymal giant cell astrocytoma (SEGA) in patients with tuberous sclerosis complex (TSC) entered into the TuberOus SClerosis registry to increase disease Awareness (TOSCA). Methods: The study was conducted at 170 sites across 31 countries. Data from patients of any age with a documented clinical visit for TSC in the 12 months preceding enrollment or those newly diagnosed with TSC were entered. Results: SEGA were reported in 554 of 2,216 patients (25%). Median age at diagnosis of SEGA was 8 years (range, 18 years. SEGA were symptomatic in 42.1% of patients. Symptoms included increased seizure frequency (15.8%), behavioural disturbance (11.9%), and regression/loss of cognitive skills (9.9%), in addition to those typically associated with increased intracranial pressure. SEGA were significantly more frequent in patients with TSC2 compared to TSC1 variants (33.7 vs. 13.2 %, p < 0.0001). Main treatment modalities included surgery (59.6%) and mammalian target of rapamycin (mTOR) inhibitors (49%). Conclusions: Although SEGA diagnosis and growth typically occurs during childhood, SEGA can occur and grow in both infants and adults

TOSCA – first international registry to address knowledge gaps in the natural history and management of tuberous sclerosis complex

Abstract Background Tuberous sclerosis complex (TSC) is a rare, multisystem, genetic disorder with an estimated prevalence between 1/6800 and 1/15000. Although recent years have seen huge progress in understanding the pathophysiology and in the management of TSC, several questions remain unanswered. A disease registry could be an effective tool to gain more insights into TSC and thus help in the development of improved management strategies. Methods TuberOus SClerosis registry to increase disease Awareness (TOSCA) is a multicentre, international disease registry to assess manifestations, interventions, and outcomes in patients with TSC. Patients of any age diagnosed with TSC, having a documented visit for TSC within the preceding 12 months, or newly diagnosed individuals are eligible. Objectives include mapping the course of TSC manifestations and their effects on prognosis, identifying patients with rare symptoms and co-morbidities, recording interventions and their outcomes, contributing to creation of an evidence-base for disease assessment and therapy, informing further research on TSC, and evaluating the quality of life of patients with TSC. The registry includes a ‘core’ section and subsections or ‘petals’. The ‘core’ section is designed to record general information on patients’ background collected at baseline and updated annually. Subsections will be developed over time to record additional data related to specific disease manifestations and will be updated annually. The registry aimed to enrol approximately 2000 patients from about 250 sites in 31 countries. The initial enrolment period was of 24 months. A follow-up observation period of up to 5 years is planned. Results A pre-planned administrative analysis of ‘core’ data from the first 100 patients was performed to evaluate the feasibility of the registry. Results showed a high degree of accuracy of the data collection procedure. Annual interim analyses are scheduled. Results of first interim analysis will be presented subsequent to data availability in 2014. Implications The results of TOSCA will assist in filling the gaps in understanding the natural history of TSC and help in planning better management and surveillance strategies. This large-scale international registry to study TSC could serve as a model to encourage planning of similar registries for other rare diseases

Rare manifestations and malignancies in tuberous sclerosis complex: findings from the TuberOus SClerosis registry to increAse disease awareness (TOSCA).

BACKGROUND: Tuberous sclerosis complex (TSC) is a rare multisystem autosomal dominant disorder caused by pathogenic variants in either the TSC1 or TSC2 gene. Common manifestations of TSC have been grouped into major and minor clinical diagnostic criteria and assessed in clinical routine workup. However, case studies point towards the existence of rare disease manifestations and to the potential association of TSC with malignant tumors. In this study we sought to characterize rare manifestations and malignancies using a large cohort of patients. METHODS: TuberOus SClerosis registry to increAse disease awareness (TOSCA) is a multicenter, international disease registry collecting clinical manifestations and characteristics of patients with TSC, both retrospectively and prospectively. We report rates and characteristics of rare manifestations and malignancies in patients with TSC who had enrolled in the TOSCA registry. We also examined these manifestations by age, sex, and genotype (TSC1 or TSC2). RESULTS: Overall, 2211 patients with TSC were enrolled in the study. Rare manifestations were reported in 382 (17.3%) study participants and malignancies in 65 (2.9%). Of these rare manifestations, the most frequent were bone sclerotic foci (39.5%), scoliosis (23%), thyroid adenoma (5.5%), adrenal angiomyolipoma (4.5%), hemihypertrophy and pancreatic neuroendocrine tumors (pNET; both 3.1%). These rare manifestations were more commonly observed in adults than children (66.2% vs. 22.7%), in females versus males (58.4% vs. 41.6%; except for scoliosis: 48.9% vs. 51.1%), and in those with TSC2 versus TSC1 (67.0% vs. 21.1%; except for thyroid adenoma: 42.9% vs. 57.1%). In the 65 individuals with reported malignancies, the most common were renal cell carcinoma (47.7%), followed by breast (10.8%) and thyroid cancer (9.2%). Although malignancies were more common in adult patients, 26.1% were reported in children and 63.1% in individuals < 40 years. TSC1 mutations were over-represented in individuals with malignancies compared to the overall TOSCA cohort (32.1% vs. 18.5%). CONCLUSION: Rare manifestations were observed in a significant proportion of individuals with TSC. We recommend further examination of rare manifestations in TSC. Collectively, malignancies were infrequent findings in our cohort. However, compared to the general population, malignant tumors occurred earlier in age and some tumor types were more common