Variable-delay feedback control of unstable steady states in retarded time-delayed systems

We study the stability of unstable steady states in scalar retarded time-delayed systems subjected to a variable-delay feedback control. The important aspect of such a control problem is that time-delayed systems are already infinite-dimensional before the delayed feedback control is turned on. When the frequency of the modulation is large compared to the system's dynamics, the analytic approach consists of relating the stability properties of the resulting variable-delay system with those of an analogous distributed delay system. Otherwise, the stability domains are obtained by a numerical integration of the linearized variable-delay system. The analysis shows that the control domains are significantly larger than those in the usual time-delayed feedback control, and that the complexity of the domain structure depends on the form and the frequency of the delay modulation.Comment: 13 pages, 8 figures, RevTeX, accepted for publication in Physical Review

Topographical anisotropy and wetting of ground stainless steel surfaces

Microscopic and physico-chemical methods were used for a comprehensive surface characterization of different mechanically modified stainless steel surfaces. The surfaces were analyzed using high-resolution confocal microscopy, resulting in detailed information about the topographic properties. In addition, static water contact angle measurements were carried out to characterize the surface heterogeneity of the samples. The effect of morphological anisotropy on water contact angle anisotropy was investigated. The correlation between topography and wetting was studied by means of a model of wetting proposed in the present work, that allows quantifying the air volume of the interface water drop-stainless steel surface

Radiative damping: a case study

We are interested in the motion of a classical charge coupled to the Maxwell self-field and subject to a uniform external magnetic field, B. This is a physically relevant, but difficult dynamical problem, to which contributions range over more than one hundred years. Specifically, we will study the Sommerfeld-Page approximation which assumes an extended charge distribution at small velocities. The memory equation is then linear and many details become available. We discuss how the friction equation arises in the limit of "small" B and contrast this result with the standard Taylor expansion resulting in a second order equation for the velocity of the charge.Comment: 4 figure

Low-Density Granulocytes Are a Novel Immunopathological Feature in Both Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

Objective: To investigate whether low-density granulocytes (LDGs) are an immunophenotypic feature of patients with multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD). Methods: Blood samples were collected from 20 patients with NMOSD and 17 patients with MS, as well as from 15 patients with Systemic Lupus Erythematosus (SLE) and 23 Healthy Donors (HD). We isolated peripheral blood mononuclear cells (PBMCs) with density gradient separation and stained the cells with antibodies against CD14, CD15, CD16, and CD45, and analyzed the cells by flow cytometry or imaging flow cytometry. We defined LDGs as CD14-CD15(high) and calculated their share in total PBMC leukocytes (CD45+) as well as the share of CD16(hi) LDGs. Clinical data on disease course, medication, and antibody status were obtained. Results: LDGs were significantly more common in MS and NMOSD than in HDs, comparable to SLE samples (median values HD 0.2%, MS 0.9%, NMOSD 2.1%, SLE 4.3%). 0/23 of the HDs, but 17/20 NMOSD and 11/17 MS samples as well as 13/15 SLE samples had at least 0.7 % LDGs. NMOSD patients without continuous immunosuppressive treatment had significantly more LDGs compared to their treated counterparts. LDG nuclear morphology ranged from segmented to rounded, suggesting a heterogeneity within the group. Conclusion: LDGs are a feature of the immunophenotype in some patients with MS and NMOSD

5-Oxoprolin (Pyroglutaminsäure) Azidose unter Paracetamol - Eine Differentialdiagnose der metabolischen Azidose mit erhöhter Anionenlücke

Zusammenfassung. In seltenen Fällen ist eine metabolische Azidose mit stark erweiterter Anionenlücke bei chronischer Paracetamol Therapie auf eine 5-Oxoprolin (Pyroglutaminsäure) Akkumulation zurück zu führen. Begleitende Risikofaktoren, wie Malnutrition, Alkoholabusus, Nieren- oder Lebererkrankungen, Komedikation mit Flucloxacillin, Vigabatrin, Netilmicin oder Sepsis wurden beschrieben. Eine medikamentös induzierte Inhibition der Glutathion Synthetase oder der 5-Oxoprolinase führt zur 5-Oxoprolinerhöhung in Serum und Urin. Andere häufigere Differentialdiagnosen, wie Laktatazidose, Intoxikationen oder Ketoazidose sollten ausgeschlossen werden. Potentiell auslösende Medikamente sollten gestoppt werden, während 5-Oxoprolinkonzentrationen quantifiziert werden können. Bisher unbekannten oder in der Fachinformation des betreffenden Medikamentes ungenügend erwähnte unerwünschte Arzneimittelwirkungen sollten einem regionalen Pharmacovigilance Zentrum zur Signaldetektion gemeldet werden. 5-Oxoprolin Azidose wird demnächst als potentiell unerwünschte Arzneimittelreaktion in den Schweizer Fachinformationen von Paracetamol aufgenommen. </jats:p

Thaumasite form of sulfate attack in limestone cement mortars: A study on long term efficiency of mineral admixtures

Concrete and mortar made from limestone cement may exhibit a lack of durability due to the formation of thaumasite. The addition of minerals that improve the concrete durability is expected to slow down the formation of thaumasite. in this work the effect of natural pozzolana, fly ash, ground granulated blast-furnace slag and metakaolin on the thaumasite formation in limestone cement mortar is examined. A limestone cement, containing 15% w/w limestone, was used. Mortar specimens were prepared by replacing a part of limestone cement with the above minerals. The specimens were immersed in a 1.8% MgSO4 solution and cured at 5 and 25 degrees C. The status of the samples after a storage period of 5 years was reported based on visual inspection, compressive strength, mass measurements, ultrasonic pulse velocity measurements and analytical techniques. It is concluded that the use of specific minerals, as partial replacement of cement, inhibits thaumasite formation in limestone cement mortar. (C) 2008 Elsevier Ltd. All rights reserved

Evaluating range-expansion models for calculating nonnative species' expansion rate

Species range shifts associated with environmental change or biological invasions are increasingly important study areas. However, quantifying range expansion rates may be heavily influenced by methodology and/or sampling bias. We compared expansion rate estimates of Roesel's bush-cricket (Metrioptera roeselii, Hagenbach 1822), a nonnative species currently expanding its range in south-central Sweden, from range statistic models based on distance measures (mean, median, 95th gamma quantile, marginal mean, maximum, and conditional maximum) and an area-based method (grid occupancy). We used sampling simulations to determine the sensitivity of the different methods to incomplete sampling across the species' range. For periods when we had comprehensive survey data, range expansion estimates clustered into two groups: (1) those calculated from range margin statistics (gamma, marginal mean, maximum, and conditional maximum: similar to 3 km/year), and (2) those calculated from the central tendency (mean and median) and the area-based method of grid occupancy (similar to 1.5 km/year). Range statistic measures differed greatly in their sensitivity to sampling effort; the proportion of sampling required to achieve an estimate within 10% of the true value ranged from 0.17 to 0.9. Grid occupancy and median were most sensitive to sampling effort, and the maximum and gamma quantile the least. If periods with incomplete sampling were included in the range expansion calculations, this generally lowered the estimates (range 16-72%), with exception of the gamma quantile that was slightly higher (6%). Care should be taken when interpreting rate expansion estimates from data sampled from only a fraction of the full distribution. Methods based on the central tendency will give rates approximately half that of methods based on the range margin. The gamma quantile method appears to be the most robust to incomplete sampling bias and should be considered as the method of choice when sampling the entire distribution is not possible

Normal volumes and microstructural integrity of deep gray matter structures in AQP4+ NMOSD

OBJECTIVE: To assess volumes and microstructural integrity of deep gray matter structures in a homogeneous cohort of patients with neuromyelitis optica spectrum disorder (NMOSD). METHODS: This was a cross-sectional study including 36 aquaporin-4 antibody-positive (AQP4 Ab-positive) Caucasian patients with NMOSD and healthy controls matched for age, sex, and education. Volumetry of deep gray matter structures (DGM; thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala, nucleus accumbens) was performed using 2 independent automated methods. Microstructural integrity was assessed based on diffusion tensor imaging. RESULTS: Both volumetric analysis methods consistently revealed similar volumes of DGM structures in patients and controls without significant group differences. Moreover, no differences in DGM microstructural integrity were observed between groups. CONCLUSIONS: Deep gray matter structures are not affected in AQP4 Ab-positive Caucasian patients with NMOSD. NMOSD imaging studies should be interpreted with respect to Ab status, educational background, and ethnicity of included patients