Forces and pressures induced on circular plates by a single lifting jet in ground effect

NASA Ames is conducting a program to develop improved methods for predicting suckdown and hot-gas ingestion on jet V/STOL aircraft when they are in ground effect. As part of that program a data base is being created that provides a systematic variation of parameters so that current empirical prediction procedures can be modified. The first series of tests in this program is complete. This report is one of three that presents the data obtained from tests conducted at Lockheed Aeronautical Systems - Rye Canyon Facility and the High Bay area of the 40 by 80 foot Wind Tunnel at Ames Research Center. Suckdown on two circular plates is examined

Suckdown, fountain lift, and pressures induced on several tandem jet V/STOL configurations

As part of a program to improve the methods for predicting the suckdown and hot gas ingestion for jet V/STOL aircraft in ground effect, a data base is being created that provides a systematic variation of parameters so that a new empirical prediction procedure can be developed. The first series of tests in this program was completed. Suckdown, fountain lift, and pressures induced on several two-jet V/STOL configurations are described. It is one of three reports that present the data obtained from tests conducted at Lockheed Aeronautical Systems-Rye Canyon Facility and in the High Bay area of the 40 by 80 foot wind tunnel complex at NASA Ames Research Center

TTF-1/p63-positive poorly differentiated NSCLC: A histogenetic hypothesis from the basal reserve cell of the terminal respiratory unit

TTF-1 is expressed in the alveolar epithelium and in the basal cells of distal terminal bronchioles. It is considered the most sensitive and specific marker to define the adenocarcinoma arising from the terminal respiratory unit (TRU). TTF-1, CK7, CK5/6, p63 and p40 are useful for typifying the majority of non-small-cell lung cancers, with TTF and CK7 being typically expressed in adenocarcinomas and the latter three being expressed in squamous cell carcinoma. As tumors with coexpression of both TTF-1 and p63 in the same cells are rare, we describe different cases that coexpress them, suggesting a histogenetic hypothesis of their origin. We report 10 cases of poorly differentiated non-small-cell lung carcinoma (PD-NSCLC). Immunohistochemistry was performed by using TTF-1, p63, p40 (∆Np63), CK5/6 and CK7. EGFR and BRAF gene mutational analysis was performed by using real-time PCR. All the cases showed coexpression of p63 and TTF-1. Six of them showing CK7+ and CK5/6− immunostaining were diagnosed as “TTF-1+ p63+ adenocarcinoma”. The other cases of PD-NSCLC, despite the positivity for CK5/6, were diagnosed as “adenocarcinoma, solid variant”, in keeping with the presence of TTF-1 expression and p40 negativity. A “wild type” genotype of EGFR was evidenced in all cases. TTF1 stained positively the alveolar epithelium and the basal reserve cells of TRU, with the latter also being positive for p63. The coexpression of p63 and TTF-1 could suggest the origin from the basal reserve cells of TRU and represent the capability to differentiate towards different histogenetic lines. More aggressive clinical and morphological features could characterize these “basal-type tumors” like those in the better known “basal-like” cancer of the breast

Cardiovascular and cancer mortality in relation to dietary polychlorinated biphenyls and marine polyunsaturated fatty acids: A nutritional-toxicological aspect of fish consumption

Background. Co-exposure to environmental contaminants present in fish could mitigate the beneficial effects of fish consumption and possibly explain the lack of association observed for mortality in some geographical regions. Objective. To assess the independent associations of dietary exposure to polychlorinated biphenyls (PCBs) and long-chain omega-3 fish fatty acids intake with cardiovascular and cancer mortality. Methods. We used the prospective population-based Swedish Mammography Cohort and the Cohort of Swedish Men comprising 32 952 women and 36 545 men, free from cancer, cardiovascular disease and diabetes at baseline in 1998. Validated estimates of dietary PCBs and long-chain omega-3 fish fatty acids [i.e. eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] intake were obtained via a food frequency questionnaire at baseline. Information on death was ascertained through register linkage. Results. During a mean follow-up of 15.5 years, we ascertained 16 776 deaths. We observed for cardiovascular mortality, comparing extreme quintiles in multivariable models mutually adjusted for PCBs and EPA-DHA, dose-dependent associations for dietary PCB exposure, hazard ratio (HR) 1.31 (CI 95%: 1.08 to 1.57; P-trend 0.005) and for dietary EPA-DHA intake, HR 0.79 (CI 95%: 0.66 to 0.95; P-trend 0.041). For cancer mortality, no clear associations were discerned. Conclusion. The beneficial effect of fish consumption on the cardiovascular system seems compromised by co-exposure to PCBs – one likely explanation for the inconsistent associations observed between fish consumption and mortalityThe Swedish Research Council under the grant no 2017-00822 and 2017-00644 (SIMPLER) supported the stud

Electron Beam Ion Source Pre-Injector Diagnostics

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A vision-based fully automated approach to robust image cropping detection

The definition of valid and robust methodologies for assessing the authenticity of digital information is nowadays critical to contrast social manipulation through the media. A key research topic in multimedia forensics is the development of methods for detecting tampered content in large image collections without any human intervention. This paper introduces AMARCORD (Automatic Manhattan-scene AsymmetRically CrOpped imageRy Detector), a fully automated detector for exposing evidences of asymmetrical image cropping on Manhattan-World scenes. The proposed solution estimates and exploits the camera principal point, i.e., a physical feature extracted directly from the image content that is quite insensitive to image processing operations, such as compression and resizing, typical of social media platforms. Robust computer vision techniques are employed throughout, so as to cope with large sources of noise in the data and improve detection performance. The method leverages a novel metric based on robust statistics, and is also capable to decide autonomously whether the image at hand is tractable or not. The results of an extensive experimental evaluation covering several cropping scenarios demonstrate the effectiveness and robustness of our approac

Constrained dogleg methods for nonlinear systems with simple bounds

We focus on the numerical solution of medium scale bound-constrained systems of nonlinear equations. In this context, we consider an affine-scaling trust region approach that allows a great flexibility in choosing the scaling matrix used to handle the bounds. The method is based on a dogleg procedure tailored for constrained problems and so, it is named Constrained Dogleg method. It generates only strictly feasible iterates. Global and locally fast convergence is ensured under standard assumptions. The method has been implemented in the Matlab solver CoDoSol that supports several diagonal scalings in both spherical and elliptical trust region frameworks. We give a brief account of CoDoSol and report on the computational experience performed on a number of representative test problem

5.16 Left Ventricular Geometry In Chronic Kidney Disease

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