145 research outputs found
Extra Dimensions, Isosinglet Charged Leptons and Neutrino Factories
Isosinglet fermions naturally arise in a variety of extensions of the
Standard Model, in particular in models with extra dimensions. In this paper,
we study the effect of the addition of a new isosinglet charged lepton to the
standard spectrum, with special emphasis on implications for neutrino
asymmetries to be measured at future neutrino factories. Lepton flavour
violation in neutral current and lepton universality constraints are
extensively discussed. We show that new physics effects in CP
asymmetries are significantly enhanced due to leptonic maximal mixings but
still too small to give a signature at future neutrino factories. A signal for
CP asymmetries in channel due to new physics could be
observed at if lepton flavour violating decays are seen in
a very close future in B-factories like BELLE experiment.Comment: 30 page
Non-unitary Leptonic Mixing and Leptogenesis
We investigate the relation between non-unitarity of the leptonic mixing
matrix and leptogenesis. We discuss how all parameters of the canonical type-I
seesaw mechanism can, in principle, be reconstructed from the neutrino mass
matrix and the deviation of the effective low-energy leptonic mixing matrix
from unitary. When the mass M' of the lightest right-handed neutrino is much
lighter than the masses of the others, we show that its decay asymmetries
within flavour-dependent leptogenesis can be expressed in terms of two
contributions, one depending on the unique dimension five (d=5) operator
generating neutrino masses and one depending on the dimension six (d=6)
operator associated with non-unitarity. In low-energy seesaw scenarios where
small lepton number violation explains the smallness of neutrino masses, the
lepton number conserving d=6 operator contribution generically dominates over
the d=5 operator contribution which results in a strong enhancement of the
flavour-dependent decay asymmetries without any resonance effects. To calculate
the produced final baryon asymmetry, the flavour equilibration effects directly
related to non-unitarity have to be taken into account. In a simple realization
of this non-unitarity driven leptogenesis, the lower bound on M' is found to be
about 10^8 GeV at the onset of the strong washout regime, more than one order
of magnitude below the bound in "standard" thermal leptogenesis.Comment: 19 pages, REVTeX4, 2 eps and 2 axodraw figure
Matter effects and CP violating neutrino oscillations with non-decoupling heavy neutrinos
The evolution equation for active and sterile neutrinos propagating in
general anisotropic or polarized background environment is found and solved for
a special case when heavy neutrinos do not decouple, resulting in non-unitary
mixing among light neutrino states. Then new CP violating neutrino oscillation
effects appear. In contrast to the standard unitary neutrino oscillations these
effects can be visible even for two flavour neutrino transitions and even if
one of the elements of the neutrino mixing matrix is equal to zero. They do not
necessarily vanish with and they are different for various
pairs of flavour neutrino transitions (), (), (). Neutrino oscillations in vacuum and Earth's
matter are calculated for some fixed baseline experiments and a comparison
between unitary and non-unitary oscillations are presented. It is shown, taking
into account the present experimental constraints, that heavy neutrino states
can affect CP and T asymmetries. This is especially true in the case of
oscillations.Comment: 18 pages, 6 fig
Measurement of the muon decay spectrum with the ICARUS liquid Argon TPC
Examples are given which prove the ICARUS detector quality through relevant
physics measurements. We study the muon decay energy spectrum from a sample of
stopping muon events acquired during the test run of the ICARUS T600 detector.
This detector allows the spatial reconstruction of the events with fine
granularity, hence, the precise measurement of the range and dE/dx of the muon
with high sampling rate. This information is used to compute the calibration
factors needed for the full calorimetric reconstruction of the events. The
Michel rho parameter is then measured by comparison of the experimental and
Monte Carlo simulated muon decay spectra, obtaining rho = 0.72 +/- 0.06(stat.)
+/- 0.08(syst.). The energy resolution for electrons below ~50 MeV is finally
extracted from the simulated sample, obtaining (Emeas-Emc)/Emc =
11%/sqrt(E[MeV]) + 2%.Comment: 16 pages, 8 figures, LaTex, A4. Some text and 1 figure added. Final
version as accepted for publication in The European Physical Journal
Non-standard Hamiltonian effects on neutrino oscillations
We investigate non-standard Hamiltonian effects on neutrino oscillations,
which are effective additional contributions to the vacuum or matter
Hamiltonian. Since these effects can enter in either flavor or mass basis, we
develop an understanding of the difference between these bases representing the
underlying theoretical model. In particular, the simplest of these effects are
classified as ``pure'' flavor or mass effects, where the appearance of such a
``pure'' effect can be quite plausible as a leading non-standard contribution
from theoretical models. Compared to earlier studies investigating particular
effects, we aim for a top-down classification of a possible ``new physics''
signature at future long-baseline neutrino oscillation precision experiments.
We develop a general framework for such effects with two neutrino flavors and
discuss the extension to three neutrino flavors, as well as we demonstrate the
challenges for a neutrino factory to distinguish the theoretical origin of
these effects with a numerical example. We find how the precision measurement
of neutrino oscillation parameters can be altered by non-standard effects alone
(not including non-standard interactions in the creation and detection
processes) and that the non-standard effects on Hamiltonian level can be
distinguished from other non-standard effects (such as neutrino decoherence and
decay) if we consider specific imprint of the effects on the energy spectra of
several different oscillation channels at a neutrino factory.Comment: 30 pages, 6 figures, LaTeX, final version, published in Eur.Phys.J.
Quantification of cell cycle kinetics by EdU (5-ethynyl-2âČ-deoxyuridine)-coupled-fluorescence-intensity analysis
Copyright: Pereira et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.We propose a novel single-deoxynucleoside-based assay that is easy to perform and provides accurate values for the absolute length (in units of time) of each of the cell cycle stages (G1, S and G2/M). This flow-cytometric assay takes advantage of the excellent stoichiometric properties of azide-fluorochrome detection of DNA substituted with 5-ethynyl-2'-deoxyuridine (EdU). We show that by pulsing cells with EdU for incremental periods of time maximal EdU-coupled fluorescence is reached when pulsing times match the length of S phase. These pulsing times, allowing labelling for a full S phase of a fraction of cells in asynchronous populations, provide accurate values for the absolute length of S phase. We characterized additional, lower intensity signals that allowed quantification of the absolute durations of G1 and G2 phases.Importantly, using this novel assay data on the lengths of G1, S and G2/M phases are obtained in parallel. Therefore, these parameters can be estimated within a time frame that is shorter than a full cell cycle. This method, which we designate as EdU-Coupled Fluorescence Intensity (E-CFI) analysis, was successfully applied to cell types with distinctive cell cycle features and shows excellent agreement with established methodologies for analysis of cell cycle kinetics.JoĂŁo A. Ferreira received support from a Calouste Gulbenkian Foundation grant (96526) and Pedro Pereira is an FCT fellow (SFRH/BD/45502/2008). Evguenia Bekman is the recipient of an IMM-Lisbon fellowship (iMM/BPD/60-2016; project PTDC/BEXBCM/5899/2014).info:eu-repo/semantics/publishedVersio
No supra-additive effects of goserelin and radiotherapy on clonogenic survival of prostate carcinoma cells in vitro
<p>Abstract</p> <p>Background</p> <p>Oncological results of radiotherapy for locally advanced prostate cancer (PC) are significantly improved by simultaneous application of LHRH analoga (e.g. goserelin). As 85% of PC express LHRH receptors, we investigated the interaction of goserelin incubation with radiotherapy under androgen-deprived conditions in vitro.</p> <p>Methods</p> <p>LNCaP and PC-3 cells were stained for LHRH receptors. Downstream the LHRH receptor, changes in protein expression of c-fos, phosphorylated p38 and phosphorylated ERK1/2 were analyzed by means of Western blotting after incubation with goserelin and irradiation with 4 Gy. Both cell lines were incubated with different concentrations of goserelin in hormone-free medium. 12 h later cells were irradiated (0 â 4 Gy) and after 12 h goserelin was withdrawn. Endpoints were clonogenic survival and cell viability (12 h, 36 h and 60 h after irradiation).</p> <p>Results</p> <p>Both tested cell lines expressed LHRH-receptors. Changes in protein expression demonstrated the functional activity of goserelin in the tested cell lines. Neither in LNCaP nor in PC-3 any significant effects of additional goserelin incubation on clonogenic survival or cell viability for all tested concentrations in comparison to radiation alone were seen.</p> <p>Conclusion</p> <p>The clinically observed increase in tumor control after combination of goserelin with radiotherapy in PC cannot be attributed to an increase in radiosensitivity of PC cells by goserelin in vitro.</p
- âŠ