176 research outputs found
Photoassociation spectroscopy of a Spin-1 Bose-Einstein condensate
We report on the high resolution photoassociation spectroscopy of a Rb
spin-1 Bose-Einstein condensate to the excited
molecular states. We demonstrate the use of spin dependent photoassociation to
experimentally identify the molecular states and their corresponding initial
scattering channel. These identifications are in excellent agreement with the
eigenvalues of a hyperfine-rotational Hamiltonian. Using the observed spectra
we estimate the change in scattering length and identify photoassociation laser
light frequency ranges that maximize the change in the spin-dependent
mean-field interaction energy.Comment: 5 pages, 4 figure
Simulation Studies of Nanomagnet-Based Architecture
We report a simulation study on interacting ensembles of Co nanomagnets that
can perform basic logic operations and propagate logic signals, where the state
variable is the magnetization direction. Dipole field coupling between
individual nanomagnets drives the logic functionality of the ensemble and
coordinated arrangements of the nanomagnets allow for the logic signal to
propagate in a predictable way. Problems with the integrity of the logic signal
arising from instabilities in the constituent magnetizations are solved by
introducing a biaxial anisotropy term to the Gibbs magnetic free energy of each
nanomagnet. The enhanced stability allows for more complex components of a
logic architecture capable of random combinatorial logic, including horizontal
wires, vertical wires, junctions, fanout nodes, and a novel universal logic
gate. Our simulations define the focus of scaling trends in nanomagnet-based
logic and provide estimates of the energy dissipation and time per nanomagnet
reversal
Electron Spin for Classical Information Processing: A Brief Survey of Spin-Based Logic Devices, Gates and Circuits
In electronics, information has been traditionally stored, processed and
communicated using an electron's charge. This paradigm is increasingly turning
out to be energy-inefficient, because movement of charge within an
information-processing device invariably causes current flow and an associated
dissipation. Replacing charge with the "spin" of an electron to encode
information may eliminate much of this dissipation and lead to more
energy-efficient "green electronics". This realization has spurred significant
research in spintronic devices and circuits where spin either directly acts as
the physical variable for hosting information or augments the role of charge.
In this review article, we discuss and elucidate some of these ideas, and
highlight their strengths and weaknesses. Many of them can potentially reduce
energy dissipation significantly, but unfortunately are error-prone and
unreliable. Moreover, there are serious obstacles to their technological
implementation that may be difficult to overcome in the near term.
This review addresses three constructs: (1) single devices or binary switches
that can be constituents of Boolean logic gates for digital information
processing, (2) complete gates that are capable of performing specific Boolean
logic operations, and (3) combinational circuits or architectures (equivalent
to many gates working in unison) that are capable of performing universal
computation.Comment: Topical Revie
Graphene-passivated nickel as an oxidation-resistant electrode for spintronics.
We report on graphene-passivated ferromagnetic electrodes (GPFE) for spin devices. GPFE are shown to act as spin-polarized oxidation-resistant electrodes. The direct coating of nickel with few layer graphene through a readily scalable chemical vapor deposition (CVD) process allows the preservation of an unoxidized nickel surface upon air exposure. Fabrication and measurement of complete reference tunneling spin valve structures demonstrate that the GPFE is maintained as a spin polarizer and also that the presence of the graphene coating leads to a specific sign reversal of the magneto-resistance. Hence, this work highlights a novel oxidation-resistant spin source which further unlocks low cost wet chemistry processes for spintronics devices.R.S.W. acknowledges funding from EPSRC
(Doctoral training award). S.H. acknowledges funding from ERC
Grant InsituNANO (Project Reference 279342). P.S. acknowledges
the Institut Universitaire de France for junior fellowship
support. This research was partially supported by the EU FP7
work programme under Grant GRAFOL (Project Reference
285275).This is the accepted manuscript. The final version is available from ACS at http://pubs.acs.org/doi/abs/10.1021/nn304424x
Diaphragm: Pathophysiology and Ultrasound Imaging in Neuromuscular Disorders.
Respiratory muscles are classically involved in neuromuscular disorders, leading to a restrictive respiratory pattern. The diaphragm is the main respiratory muscle involved during inspiration. Ultrasound imaging is a noninvasive, radiation-free, accurate and safe technique allowing assessment of diaphragm anatomy and function. The authors review the pathophysiology of diaphragm in neuromuscular disorders, the methodology and indications of diaphragm ultrasound imaging as well as possible pitfalls in the interpretation of results
Giant enhancement of spin accumulation and long-distance spin precession in metallic lateral spin valves
The nonlocal spin injection in lateral spin valves is highly expected to be
an effective method to generate a pure spin current for potential spintronic
application. However, the spin valve voltage, which decides the magnitude of
the spin current flowing into an additional ferromagnetic wire, is typically of
the order of 1 {\mu}V. Here we show that lateral spin valves with low resistive
NiFe/MgO/Ag junctions enable the efficient spin injection with high applied
current density, which leads to the spin valve voltage increased hundredfold.
Hanle effect measurements demonstrate a long-distance collective 2-pi spin
precession along a 6 {\mu}m long Ag wire. These results suggest a route to
faster and manipulable spin transport for the development of pure spin current
based memory, logic and sensing devices.Comment: 23 pages, 4 figure
HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression
Maria Castro and colleagues use cell line and transgenic mouse approaches to study the mechanisms underlying the immune response to glioblastoma multiforme
Treg Depletion Inhibits Efficacy of Cancer Immunotherapy: Implications for Clinical Trials
Regulatory T lymphocytes (Treg) infiltrate human glioblastoma (GBM); are involved in tumor progression and correlate with tumor grade. Transient elimination of Tregs using CD25 depleting antibodies (PC61) has been found to mediate GBM regression in preclinical models of brain tumors. Clinical trials that combine Treg depletion with tumor vaccination are underway to determine whether transient Treg depletion can enhance anti-tumor immune responses and improve long term survival in cancer patients.Using a syngeneic intracrabial glioblastoma (GBM) mouse model we show that systemic depletion of Tregs 15 days after tumor implantation using PC61 resulted in a decrease in Tregs present in tumors, draining lymph nodes and spleen and improved long-term survival (50% of mice survived >150 days). No improvement in survival was observed when Tregs were depleted 24 days after tumor implantation, suggesting that tumor burden is an important factor for determining efficacy of Treg depletion in clinical trials. In a T cell dependent model of brain tumor regression elicited by intratumoral delivery of adenoviral vectors (Ad) expressing Fms-like Tyrosine Kinase 3 ligand (Flt3L) and Herpes Simplex Type 1-Thymidine Kinase (TK) with ganciclovir (GCV), we demonstrate that administration of PC61 24 days after tumor implantation (7 days after treatment) inhibited T cell dependent tumor regression and long term survival. Further, depletion with PC61 completely inhibited clonal expansion of tumor antigen-specific T lymphocytes in response to the treatment.Our data demonstrate for the first time, that although Treg depletion inhibits the progression/eliminates GBM tumors, its efficacy is dependent on tumor burden. We conclude that this approach will be useful in a setting of minimal residual disease. Further, we also demonstrate that Treg depletion, using PC61 in combination with immunotherapy, inhibits clonal expansion of tumor antigen-specific T cells, suggesting that new, more specific targets to block Tregs will be necessary when used in combination with therapies that activate anti-tumor immunity
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