Synthesis of fused indoline-cyclobutanone derivatives via an intramolecular [2+2] cycloaddition

We thank the EPSRC Centre for Doctoral Training in Critical Resource Catalysis (CRITICAT, grant code EP/L016419/1, R.M.N.) for funding. We thank the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007–2013) ERC grant agreement no. 279850 (A.D.S.). A.D.S. thanks the Royal Society for a Wolfson Research Merit Award. We also thank the EPSRC UK National Mass Spectrometry Service at Swansea. The research data supporting this publication can be accessed at https://doi.org/10.17630/00aff760-0732-438f-a9d1-30c7cf3a87a0A serendipitously-discovered process for the synthesis of heterocyclic products containing a novel fused indoline-cyclobutanone ring system is reported. This process is believed to take place through in situ generation of a ketene intermediate, followed by intramolecular [2+2] cycloaddition with a pendant enamide. The formation of a ketene intermediate in this process is significant as the reaction conditions employed are analogous to those commonly used in tertiary amine Lewis base catalysis, where the potential intermediacy of ketenes is an important consideration that is often overlooked.PostprintPeer reviewe

Effectiveness of an intervention at construction worksites on work engagement, social support, physical workload, and need for recovery: results from a cluster randomized controlled trial

<p>Abstract</p> <p>Background</p> <p>To prolong sustainable healthy working lives of construction workers, a worksite prevention program was developed which aimed to improve the health and work ability of construction workers. The aim of the current study was to investigate the effectiveness of this program on social support at work, work engagement, physical workload and need for recovery.</p> <p>Methods</p> <p>Fifteen departments from six construction companies participated in this cluster randomized controlled trial; 8 departments (n=171 workers) were randomized to an intervention group and 7 departments (n=122 workers) to a control group. The intervention consisted of two individual training sessions of a physical therapist to lower the physical workload, a Rest-Break tool to improve the balance between work and recovery, and two empowerment training sessions to increase the influence of the construction workers at the worksite. Data on work engagement, social support at work, physical workload, and need for recovery were collected at baseline, and at three, six and 12 months after the start of the intervention using questionnaires.</p> <p>Results</p> <p>No differences between the intervention and control group were found for work engagement, social support at work, and need for recovery. At 6 months follow-up, the control group reported a small but statistically significant reduction of physical workload.</p> <p>Conclusion</p> <p>The intervention neither improved social support nor work engagement, nor was it effective in reducing the physical workload and need for recovery among construction workers.</p> <p>Trial registration</p> <p>NTR1278</p

Quality of urban environment 1980-1982

Establishing the preferences, evaluations and reactions on shortcomings regarding the quality of the urban environment of the inhabitants of 3 urban regions / family situation / children / type of dwelling / number of rooms / spare rooms / rooms to let / reasons not to let out rooms / other inhabitants / balcony / garden / heating / preferences regarding and satisfaction with several aspects of neighbourhood, home and street / importance of opinion of partner or best friend / house ownership / costs of home / subsidized / tax deduction / reasonable rent or costs / difficulties paying costs of housing / safety and threatening aspects of environment / maintenance of dwelling / repairs done by respondent or others / advantages of moving / neighbourhood / park / parking facilities / evaluating ( qsort ) several aspects of house and neighbourhood / deficiencies of environment / neighbours / contacts with neighbours / family, friends and relations in and outside the neighbourhood: frequency of contacts / other social contacts / evaluation of people in the neighbourhood: preferences, dislikes / changing population of neighbourhood expected / environment: enough space, boring, different types of people, car traffic / facilities in neighbourhood: which are missing / life satisfaction in general, compared with past, future expectations / negative aspects of environment ( sort ) / occupational situation / commuting / expectations / income, compared with past, expectations / educational history / background data on partner / nature reserves: visits, frequency, travelling times etc. / leisure activities / shopping / use of centre of Utrecht for shopping, going out / safety / criminality / victim of criminality: what and where / traffic safety / environmental pollution / prefers moving / expected residence at current address / reasons for moving, expected benefits / preferred situation to move to: kind of house, neighbourhood, city, costs / health / health complaints / history: last residence, house, evaluation, reason for moving to current residence / influence on local politics / action groups / participation in local politics. File P0841c contains detailed statistical demographic background data on the three municipalities involved. Background variables: basic characteristics/ housing situation/ household characteristics/ characteristics of parental family/household/ place of work/ occupation/employment/ income/capital assets/ education/ politics/ religio