Tumbling Towers as Turning Points: Will 9/11 Usher in a New Civil Rights Era for Gay Men and Lesbians in the United States?

This article examines the events of 9/11, and the potential resultant shifts in attitude, policies, and laws in the United States, through the lens of civil rights extended to gay and lesbian citizens. It seeks, but does not purport to definitively discover, the true meaning of the phrase life will never be the same. It asks, but does not purport to fully answer, whether historians a century or two hence will look back on 9/11 as the turning point when the United States began to fulfill its promise of liberty to all people, or whether this date will be earmarked as the time when the United States, wounded and weary, rejected individual civil liberties in favor of a restrictive but arguably safer society. The next section of this article, Section II, provides a brief status report on the civil rights of gay men and lesbians in the United States prior to 9/11. Additionally, Section II provides information in terms of the legal status of gays and lesbians and public attitudes about this segment of the U.S. population. Section III looks at how the nation has reacted to 9/11, and highlights the polar opposite reactions of those who seek to preserve civil liberties in this time of crisis and those who cite 9/11 as justification for significantly restricting these liberties. Section IV examines the situation through the narrower focus of civil rights extended to, and those denied to, gay and lesbian citizens of the United States. In addition to examining the important role gay and lesbian people played in 9/11 events, Section IV recounts the struggle of gay and lesbian people seeking eligibility for remedies routinely afforded their heterosexual counterparts. Section IV also identifies two other civil rights areas that may be affected by the events of 9/11: anti- discrimination in employment law and hate crime legislation. Section V provides a brief conclusion

Orally Bioavailable Dual MMP-1/MMP-14 Sparing, MMP-13 Selective Alpha-sulfone Hydroxamates

A series of phenyl piperidine α-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing of MMP-1 and MMP-14 (MT1-MMP) and exhibit oral bioavailability in rats

Finiteness and children with specific language impairment: an exploratory study

Children with specific language impairment (SLI) are well known for their difficulties in mastering the inflectional paradigms; in the case of learning German they also have problems with the appropriate verb position, in particular with the verb in second position. This paper explores the possibilities of applying a broader concept of finiteness to data from children with SLI in order to put their deficits, or rather their skills, into a wider perspective. The concept, as developed by Klein (1998, 2000), suggests that finiteness is tied to the assertion that a certain state of affairs is valid with regard to some topic time; that is, finiteness relates the propositional content to the topic component. Its realization involves the interaction of various grammatical devices and, possibly, lexical means like temporal adverbs. Furthermore, in the acquisition of finiteness it has been found that scope particles play a major role in both first- and second-language learning. The purpose of this paper is to analyze to what extent three German-learning children with SLI have mastered these grammatical and lexical means and to pinpoint the phase in the development of finiteness they have reached. The data to be examined are mostly narrative and taken from conversations and experiments. It will be shown that each child chooses a different developmental path to come to grips with the interaction of these devices

Fifty Years of Scientific Ocean Drilling

Author Posting. © Oceanography Society , 2019. This article is posted here by permission of Oceanography Society for personal use, not for redistribution. The definitive version was published in Becker, K., Austin, J. A., Jr., Exon, N., Humphris, S., Kastner, M., McKenzie, J. A., Miller, K. G., Suyehiro, K., & Taira, A. Fifty years of scientific ocean drilling. Oceanography, 32(1), (2019):17-21, doi:10.5670/oceanog.2019.110.Nearly a century after the first systematic study of the global ocean and seafloor by HMS Challenger (1871–1876), US scientists began to drill beneath the seafloor to unlock the secrets of the ~70% of Earth’s surface covered by the seas. Fifty years of scientific ocean drilling by teams of international partners has provided unparalleled advancements in Earth sciences. Here, we briefly review the history, impacts, and scientific achievements of five decades of coordinated scientific ocean drilling

Global Emergency Medicine: A Review of the Literature From 2012

Objectives The Global Emergency Medicine Literature Review ( GEMLR ) conducts an annual search of peer‐reviewed and grey literature relevant to global emergency medicine ( EM ) to identify, review, and disseminate the most important new research in this field to a worldwide audience of academics and clinical practitioners. Methods This year, our search identified 4,818 articles written in six languages. These articles were distributed among 20 reviewers for initial screening based on their relevance to the field of global EM . Two additional reviewers searched and screened the grey literature. A total of 224 articles were deemed appropriate by at least one reviewer and were approved by their editor for formal scoring of overall quality and importance. Results Of the 224 articles that met our predetermined inclusion criteria, 56% were categorized as Emergency Care in Resource‐limited Settings, 18% as EM development, and 26% as Disaster and Humanitarian Response. A total of 28 articles received scores of 16 or higher and were selected for formal summary and critique. Inter‐rater reliability for two reviewers using our scoring system was good, with an intraclass correlation coefficient of 0.625 (95% confidence interval = 0.512 to 0.711). Conclusions In 2012 there were more disaster and humanitarian response articles than in previous years. As in prior years, the majority of articles addressed the acute management of infectious diseases or the care of vulnerable populations such as children and pregnant women. Resumen Medicina de Urgencias y Emergencias Global: Una Revisión de la Literatura de 2012 Objetivos La revisión de la literatura publicada en Medicina de Urgencias y Emergencias ( MUE ) global comporta una búsqueda anual de los trabajos relevantes para la MUE global, tanto publicados tras revisión por pares como corresponedientes a literatura gris. La finalidad es identificar, revisar y diseminar las investigaciones novedosas más importantes en este campoa médicos clínicos y universitarios de todo el mundo. Metodología Este año, nuestra búsqueda identificó 4.818 artículos escritos en seis lenguas. Estos artículos se distribuyeron entre 20 revisores para el despistaje inicial basándose en su relevancia para el campo de la MUE global. Dos revisores adicionales buscaron y filtraron la literatura gris. Un total de 224 artículos se consideraron apropiados por al menos un revisor, y se aprobaron por su editor para la puntuación formal de la calidad e importancia totales. Resultados De los 224 artículos que cumplieron nuestros criterios de inclusión predeterminados, un 56% se clasificaron como atención de urgencias y emergencias en ámbitos de recursos limitados, un 18% como desarrollo de la MUE y un 26% como catástrofes y respuesta humanitaria. Un total de 28 artículos recibieron una puntuación de 16 o más y se seleccionaron para el resumen y la crítica formal. La fiabilidad interobservador para los 2 revisores usando nuestro sistema de puntuación fue buena, con un coeficiente de correlación intraclase de 0,625 ( IC 95% = 0,512 a 0,711). Conclusiones En 2012 hubo más artículos sobre catástrofes y respuesta humanitaria que en años anteriores. Como en los años previos, la mayoría de los artículos valoraron el manejo agudo de enfermedades infecciosas o la atención de poblaciones vulnerables como los niños y las mujeres embarazadas.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99685/1/acem12173.pd

ARHGEF9 disease: Phenotype clarification and genotype-phenotype correlation.

ObjectiveWe aimed to generate a review and description of the phenotypic and genotypic spectra of ARHGEF9 mutations.MethodsPatients with mutations or chromosomal disruptions affecting ARHGEF9 were identified through our clinics and review of the literature. Detailed medical history and examination findings were obtained via a standardized questionnaire, or if this was not possible by reviewing the published phenotypic features.ResultsA total of 18 patients (including 5 females) were identified. Six had de novo, 5 had maternally inherited mutations, and 7 had chromosomal disruptions. All females had strongly skewed X-inactivation in favor of the abnormal X-chromosome. Symptoms presented in early childhood with delayed motor development alone or in combination with seizures. Intellectual disability was severe in most and moderate in patients with milder mutations. Males with severe intellectual disability had severe, often intractable, epilepsy and exhibited a particular facial dysmorphism. Patients with mutations in exon 9 affecting the protein's PH domain did not develop epilepsy.ConclusionsARHGEF9 encodes a crucial neuronal synaptic protein; loss of function of which results in severe intellectual disability, epilepsy, and a particular facial dysmorphism. Loss of only the protein's PH domain function is associated with the absence of epilepsy

Constitutional Classifications and the Gay Gene

What I am going to talk about is the use of genetic information to classify individuals for purposes of the law, and more specifically, the impact of the so-called gay gene on legal classifications. What is really important here, and the reason I need to offer you a primer on constitutional law, is so that we all start on the same page by understanding how our laws, starting with the federal constitution, classify people for the purpose of bestowing or denying rights and benefits. This leads us to an understanding of why people object to various classifications, and an appreciation of the power of the courts in determining if certain classifications are appropriate. I am, in a way, laying the groundwork for subsequent speakers who will more fully address how genetic classifications may be developed as we learn more and more from the human genome project about the specific genes that make us who we are

Research into the Origin and Spread of Wool Production between the Near East and Central Europe

The objective of the research group Textile Revolution is to contribute to research on the still largely unclear introduction of wool production in later Neolithic and Chalcolithic societies from Western Asia to Central Europe. Since direct evidence of wool depends on rare conditions of preservation, a multi-proxy approach based on different kinds of indirect evidence was chosen. The previous history of research on early wool production as well as the domestication history of sheep are reviewed briefly. Anthropogenic impacts on the landscape, possibly related to intensified grazing, are one kind of indirect evidence that we take into account. For the later part of the presumably long-lasting development of wool production, written sources are available, the earliest of which date to the Late Uruk and Jemdet Nasr periods (end of the 4th to beginning of the 3rd millennium BCE) in Mesopotamia. Indirect archaeological evidence consists of the tools used in textile production, among which spindle whorls and loom weights occur most frequently. Since they are not a priori specific to the type of fibre, be it linen or wool, statistical evaluations of metric data are necessary. Zooarchaeological analysis of large samples of animal bones from a wide spectrum of sites and time slices is a further crucial element of our multi-proxy approach. Both the demographic composition of herds and metric data indicating changes in animal size can yield indirect evidence for incipient or increasing importance of wool production. This article offers an overview of these different sources and methods, specific to the disciplines involved, and presents some preliminary results