Visualizing the Impact of Europe’s Slow COVID-19 Vaccine Rollout

On 31 March 2021, the WHO Regional Office for Europe issued a formal statement of concern regarding the slow vaccine rollout across Europe [1]. The WHO noted that the “Region remains the second most affected by SARS-CoV-2 of all the world’s regions” which was worrying, especially because the more transmissible B.1.1.7 was now dominant in the region [1]. It further contrasted this with the experiences of the UK, by noting that according to data from Public Health England, “COVID-19 vaccines have saved, at the very least, over 6,000 lives among people over 70 since vaccination started in December 2020”. Beyond such statements and a general awareness that many countries within the EU, in particular, lag behind in terms of vaccination, the impact of this policy failure remains poorly understood. One issue that appears to be hampering a European-wide debate regarding this issue, is the fact that globally the link between curbing COVID-19 and progress in vaccination is not entirely straightforward. Here, we will attempt to highlight the human cost of this EU policy failure by reference to recent patterns of COVID-19 deaths across several large EU countries

Cooperating with external partners: The importance of diversity for innovation performance

Innovations are rarely generated in complete isolation. Due to the inherent uncertainty, the manifold underlying knowledge base and high financial investments, firms seek to integrate external partners for the generation of new products and processes. However there is an ongoing debate whether firms, which develop their innovations in close cooperation with external partners, such as suppliers, customers and governmental research institutions, can benefit with respect to innovation performance in contrast to firms which cooperate less. This paper aims at investigating how diversity in cooperation partners effects the firms' output innovation performance in terms of generated sales with innovative products. To address this question the authors analyze a large-scale sample of microdata from Swiss firms derived from four waves (1999, 2002, 2005, and 2008) of the Swiss innovation survey data according to the European Community Innovation Survey, applying a panel data analysis. The findings suggest, that firms with a higher diversity in cooperation partners could benefit in generating new product innovations

Free-hand sketch recognition by multi-kernel feature learning

Abstract Free-hand sketch recognition has become increasingly popular due to the recent expansion of portable touchscreen devices. However, the problem is non-trivial due to the complexity of internal structures that leads to intra-class variations, coupled with the sparsity in visual cues that results in inter-class ambiguities. In order to address the structural complexity, a novel structured representation for sketches is proposed to capture the holistic structure of a sketch. Moreover, to overcome the visual cue sparsity problem and therefore achieve state-of-the-art recognition performance, we propose a Multiple Kernel Learning (MKL) framework for sketch recognition, fusing several features common to sketches. We evaluate the performance of all the proposed techniques on the most diverse sketch dataset to date (Mathias et al., 2012), and offer detailed and systematic analyses of the performance of different features and representations, including a breakdown by sketch-super-category. Finally, we investigate the use of attributes as a high-level feature for sketches and show how this complements low-level features for improving recognition performance under the MKL framework, and consequently explore novel applications such as attribute-based retrieval

How managers can deal with complex issues: a semi-quantitative analysis method of causal loop diagrams based on matrices

The increasing complexity of the modern world creates both higher risks and new interdependencies in the socioeconomic environment. To cope with these challenges powerful new tools must be applied to find sustainable solutions. System dynamics is a field that offers potential assistance in dealing with complex issues. However, managers and politicians often lack the knowledge and necessary skills to apply quantitative methods in their decision-making process. In contrast, qualitative approaches are easily understood and handled but have limited capacities for analysis. To address this gap, we have developed a bundle of tools tailored for managers and politicians facing complex problems. These tools enable executives to recognize effective levers and assess potential consequences of specific interventions in a highly interconnected system. The approach detailed here equips decision makers with a powerful method to develop, test, and communicate strategies to find long-term sustainable solutions for complex issues in business and society

Structural brain abnormalities in postural tachycardia syndrome: A VBM-DARTEL study

Postural tachycardia syndrome (PoTS), a form of dysautonomia, is characterized by orthostatic intolerance, and is frequently accompanied by a range of symptoms including palpitations, lightheadedness, clouding of thought, blurred vision, fatigue, anxiety, and depression. Although the estimated prevalence of PoTS is approximately 5–10 times as common as the better-known condition orthostatic hypotension, the neural substrates of the syndrome are poorly characterized. In the present study, we used magnetic resonance imaging (MRI) with voxel-based morphometry (VBM) applying the diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) procedure to examine variation in regional brain structure associated with PoTS. We recruited 11 patients with established PoTS and 23 age-matched normal controls. Group comparison of gray matter volume revealed diminished gray matter volume within the left anterior insula, right middle frontal gyrus and right cingulate gyrus in the PoTS group. We also observed lower white matter volume beneath the precentral gyrus and paracentral lobule, right pre- and post-central gyrus, paracentral lobule and superior frontal gyrus in PoTS patients. Subsequent ROI analyses revealed significant negative correlations between left insula volume and trait anxiety and depression scores. Together, these findings of structural differences, particularly within insular and cingulate components of the salience network, suggest a link between dysregulated physiological reactions arising from compromised central autonomic control (and interoceptive representation) and increased vulnerability to psychiatric symptoms in PoTS patients

Input Additionality and Innovation Output Effects of R&D Subsidies

Policy makers have an increasing interest in designing appropriate public R&D policy programs to stimulate national innovativeness and competitiveness. First, this study investigates the effects of public R&D subsidies on firms’ R&D investments accounting for the collaboration pattern of the subsidized firms. Second, this representative analysis further puts light on the effectiveness of the publicly induced R&D investment, and examines if the policy-induced investments translate into higher innovation performance, thereby disentangling between radical and incremental innovation. The treatment effects analysis uses firm level data from five waves (1999, 2002, 2005, 2008, and 2011) of the Swiss innovation survey. The findings show that on average the receipt of an R&D subsidy translate into higher firm R&D investments. While the results do not exhibit any additional systemic positive support for collaboration in the presence of a subsidy, the publicly induced R&D investment mainly foster radical innovation output

Hydrogel patterns in microfluidic devices by do-it-yourself UV-photolithography suitable for very large-scale integration

The interest in large-scale integrated (LSI) microfluidic systems that perform highthroughput biological and chemical laboratory investigations on a single chip is steadily growing. Such highly integrated Labs-on-a-Chip (LoC) provide fast analysis, high functionality, outstanding reproducibility at low cost per sample, and small demand of reagents. One LoC platform technology capable of LSI relies on specific intrinsically active polymers, the so-called stimuli-responsive hydrogels. Analogous to microelectronics, the active components of the chips can be realized by photolithographic micro-patterning of functional layers. The miniaturization potential and the integration degree of the microfluidic circuits depend on the capability of the photolithographic process to pattern hydrogel layers with high resolution, and they typically require expensive cleanroom equipment. Here, we propose, compare, and discuss a cost-efficient do-it-yourself (DIY) photolithographic set-up suitable to micro-pattern hydrogel-layers with a resolution as needed for very large-scale integrated (VLSI) microfluidics. The achievable structure dimensions are in the lower micrometer scale, down to a feature size of 20 µm with aspect ratios of 1:5 and maximum integration densities of 20,000 hydrogel patterns per cm. Furthermore, we demonstrate the effects of miniaturization on the efficiency of a hydrogel-based microreactor system by increasing the surface area to volume (SA:V) ratio of integrated bioactive hydrogels. We then determine and discuss a correlation between ultraviolet (UV) exposure time, cross-linking density of polymers, and the degree of immobilization of bioactive components. © 2020 by the authors

Pennsylvania Folklife Vol. 23, No. 4

• Cultural Learning Through Game Structure: A Study of Pennsylvania German Children\u27s Games • Nipsy : The Ethnography of a Traditional Game of Pennsylvania\u27s Anthracite Region • The Game as Creator of the Group in an Italian-American Community • Pennsylvania Town Views of a Century Ago • The Barber\u27s Ghost : A Legend Becomes a Folktale • Grain Harvesting in the Nineteenth Century • My Experience With the Dialect • Harvest on the Pennsylvania Farm: Folk-Cultural Questionnaire No. 34https://digitalcommons.ursinus.edu/pafolklifemag/1058/thumbnail.jp